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EP2185521
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EP About this file: EP2185521
| EP2185521 - COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 03.03.2017 Database last updated on 19.10.2024 | |
| Former | Examination is in progress Status updated on 27.11.2016 | Most recent event Tooltip | 03.03.2017 | Application deemed to be withdrawn | published on 05.04.2017 [2017/14] | Applicant(s) | For all designated states Diaxonhit 63-65 boulevard Masséna 75013 Paris / FR | [2013/50] |
| Former [2011/30] | For all designated states EXONHIT SA 63-65 boulevard Masséna 75013 Paris / FR | ||
| Former [2010/20] | For all designated states Exonhit Therapeutics SA 26, rue Brunel 75017 Paris / FR | Inventor(s) | 01 /
LEBLOND, Bertrand 3 rue du Dahomey F-75011 Paris / FR | 02 /
BEAUSOLEIL, Eric 5 bis, rue Chauvelot F-75015 Paris / FR | 03 /
CHAUVIGNAC, Cédric 19 avenue Verdier F-92120 Montrouge / FR | 04 /
TAVERNE, Thierry 21 rue Michel Ange Résidence "Le Vallon" F-62280 Saint Martin Boulogne-sur-Mer / FR | 05 /
PICARD, Virginie 7 rue Saint Jean F-75017 Paris / FR | 06 /
DE OLIVEIRA, Catherine 17 rue Lucie F-94310 Orly / FR | 07 /
SCHWEIGHOFFER, Fabien 36 avenue du Val de Beauté F-94130 Nogent Sur Marne / FR | [2010/20] | Representative(s) | Sekhri, Redha, et al Cabinet Becker & Associés 25, rue Louis le Grand 75002 Paris / FR | [N/P] |
| Former [2010/20] | Sekhri, Redha, et al Cabinet Becker & Associés 25, rue Louis Le Grand 75002 Paris / FR | Application number, filing date | 08786102.7 | 11.07.2008 | [2010/20] | WO2008EP59134 | Priority number, date | EP20070301230 | 12.07.2007 Original published format: EP 07301230 | [2010/20] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2009007457 | Date: | 15.01.2009 | Language: | EN | [2009/03] | Type: | A2 Application without search report | No.: | EP2185521 | Date: | 19.05.2010 | Language: | EN | The application published by WIPO in one of the EPO official languages on 15.01.2009 takes the place of the publication of the European patent application. | [2010/20] | Search report(s) | International search report - published on: | EP | 26.03.2009 | Classification | IPC: | C07D217/10, C07D217/20, A61K31/4375, A61K31/47, A61K31/472, A61K31/473, A61P7/02, A61P9/10, A61P9/12, A61P25/28, A61P27/02, A61P35/00 | [2010/20] | CPC: |
A61K31/4375 (EP,US);
A61K31/47 (EP,US);
A61K31/472 (EP,US);
A61K31/473 (EP,US);
A61P25/00 (EP);
A61P25/28 (EP);
A61P27/02 (EP);
A61P35/00 (EP);
A61P7/00 (EP);
A61P7/02 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
A61P9/12 (EP);
C07D217/10 (EP,US);
C07D217/20 (EP,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2010/20] | Title | German: | VERBINDUNGEN UND VERFAHREN ZUM MODULIEREN VON RHO-GTPASEN | [2010/20] | English: | COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES | [2010/20] | French: | COMPOSANTS ET PROCÉDÉS DE MODULATION DE RHO GTPASES | [2010/20] | Entry into regional phase | 11.02.2010 | National basic fee paid | 11.02.2010 | Designation fee(s) paid | 11.02.2010 | Examination fee paid | Examination procedure | 11.02.2010 | Amendment by applicant (claims and/or description) | 11.02.2010 | Examination requested [2010/20] | 01.02.2011 | Despatch of a communication from the examining division (Time limit: M06) | 10.08.2011 | Reply to a communication from the examining division | 05.09.2014 | Despatch of a communication from the examining division (Time limit: M04) | 14.01.2015 | Reply to a communication from the examining division | 20.06.2016 | Despatch of a communication from the examining division (Time limit: M04) | 01.11.2016 | Application deemed to be withdrawn, date of legal effect [2017/14] | 28.11.2016 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2017/14] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.02.2011 | Fees paid | Renewal fee | 27.07.2010 | Renewal fee patent year 03 | 27.07.2011 | Renewal fee patent year 04 | 10.07.2012 | Renewal fee patent year 05 | 04.07.2013 | Renewal fee patent year 06 | 29.07.2014 | Renewal fee patent year 07 | 26.06.2015 | Renewal fee patent year 08 | Penalty fee | Additional fee for renewal fee | 31.07.2016 | 09 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [X]EP0495610 (TOSOH CORP [JP]) [X] 14-22,24 * page 3 * * page 10, lines 8-23 * * pages 53,54; claims 1,2 *; | [X]EP0528553 (TOSOH CORP [JP]) [X] 14-22,24 * page 3, lines 24-52 * * page 4, line 57 - page 5, line 7 *; | [X]CS225598 (VALENTA VLADIMIR, et al) [X] 14-22,24 * page 1; compound I * * page 2; compound III * * page 2; example 1 *; | [X]EP0110372 (HOECHST AG [DE]) [X] 14-22,24 * example 1 * * page 4; compound III * * pages 12,13 *; | [Y]US5786362 (KRONGRAD ARNON [US]) [Y] 23,25 * column 1, lines 46-65 * * column 8, line 39 - column 9, line 14 * * claims 1,2 *; | [Y]CN1486694 ; | [A]WO9729106 (UNIV RUTGERS [US], et al) [A] 1-25 * page 3, line 30 - page 4, line 10 * * figures Scheme,1 * * table 1 * * claims 1-35 *; | [A]US2002035090 (ZELDIS JEROME B [US], et al) [A] 1-25 * page 1, paragraph 1 * * page 4, paragraph 44 * * page 5, paragraphs 44,45 * * page 11, paragraphs 89,90 * * claims 1-5 *; | [A]WO2006029577 (EMY OF MEDICAL SCIENCES INST O [CN], et al) [A] 1-25 * page 5, paragraphs 16,17 * * page 7, paragraph 18 *; | [A]EP0513997 (CHINOIN GYOGYSZER ES VEGYESZET [HU]) [A] 1-25 * page 1, lines 1-13 * * page 1, lines 29-35 *; | [A]US5137912 (TENG CHE-MING [TW], et al) [A] 1-25 * abstract * * column 2, lines 41-68 * * claims 1,2 * | [PXY] - LIANG K W ET AL, Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells, EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, PAGE(S) 343 - 354, (20080820), ISSN 0014-2999, XP023438293 [PXY] 1-13 * abstract * * page 348, column L, lines 6-23 * * page 350, column L, lines 6-19 * * page 350, column R, line 27 - page 354, column R, line 8 * * figure 5 * [Y] 25 DOI: http://dx.doi.org/10.1016/j.ejphar.2008.06.034 | [Y] - PAN JING ET AL, "PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes", JOURNAL OF CELLULAR PHYSIOLOGY, (200502), vol. 202, no. 2, ISSN 0021-9541, pages 536 - 553, XP002478647 [Y] 1-13,25 * abstract * * page 540, column R, line 11 - page 541, column L, line 5 * DOI: http://dx.doi.org/10.1002/jcp.20151 | [Y] - MONTESSUIT C ET AL, "Activation of Ras by phorbol esters in cardiac myocytes - Role of guanine nucleotide exchange factor", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, (19991022), vol. 460, no. 1, ISSN 0014-5793, pages 57 - 60, XP004342719 [Y] 1-13,25 * abstract * * page 60, column L, lines 30-32 * DOI: http://dx.doi.org/10.1016/S0014-5793(99)01223-5 | [X] - MAKHEY D ET AL, "Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons", BIOORGANIC AND MEDICINAL CHEMISTRY 199606 GB, (199606), vol. 4, no. 6, ISSN 0968-0896, pages 781 - 791, XP002511123 [X] 14-22,24 * abstract * * page 783, column L; figure 2; compounds 15, 14A,14B * * page 790, column L, lines 9-52 * DOI: http://dx.doi.org/10.1016/0968-0896(96)00054-5 | [Y] - DATABASE WPI, 0, Derwent World Patents Index, vol. 2004, no. 42, Database accession no. 2004-441504, XP002478650 & CN1486694 A 20040407 (QIN J) [Y] 23,25 * abstract * | [A] - IWASA K ET AL, "In vitro cytotoxicity of the protoberberine-type alkaloids.", JOURNAL OF NATURAL PRODUCTS JUL 2001, (200107), vol. 64, no. 7, ISSN 0163-3864, pages 896 - 898, XP002462488 [A] 1-25 * abstract * * figure 1 * * table 1 * * compounds 1-5 * DOI: http://dx.doi.org/10.1021/np000554f | [A] - LOPUS M ET AL, "The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding: A possible mechanism for its antiproliferative activity", FEBS JOURNAL 200605 GB, (200605), vol. 273, no. 10, ISSN 1742-464X 1742-4658, pages 2139 - 2150, XP002478646 [A] 1-25 * abstract * * page 2140, column L, line 10 - column R, line 26 * * figure 1 * DOI: http://dx.doi.org/10.1111/j.1742-4658.2006.05227.x | Examination | - MAKHEY D ET AL, "Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, (19960601), vol. 4, no. 6, doi:10.1016/0968-0896(96)00054-5, ISSN 0968-0896, pages 781 - 791, XP002511123 DOI: http://dx.doi.org/10.1016/0968-0896(96)00054-5 | - BADIA, D. DOMINGUEZ, E. TELLITU, I., "Silicon mediated Isoquinoline Synthesis: Preparation and stereochemical Characterization of 4-Hydroxy-3-phenylisoquinolines", TETRAHDRON, Great Britain, (19920327), vol. 48, no. 21, pages 4419 - 4429 |