EP2194068 - CYCLODEXTRIN COMPOUND MODIFIED WITH FOLIC ACID, PROCESS FOR PRODUCTION THEREOF, DRUG DELIVERY AGENT FOR TARGETING DRUG DELIVERY SYSTEM, PHARMACEUTICAL COMPOSITION, AND IMAGING AGENT [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 21.02.2014 Database last updated on 09.09.2024 | Most recent event Tooltip | 17.07.2015 | Lapse of the patent in a contracting state New state(s): HU, LU | published on 19.08.2015 [2015/34] | Applicant(s) | For all designated states Nanodex INC. 14-9 Fujisawa 4-chome Fujisawa-shi Kanagawa 251-0052 / JP | [2010/23] | Inventor(s) | 01 /
HATTORI, Kenjiro 14-9 Fujisawa 4-chome Fujisawa-shi Kanagawa 251-0052 / JP | [2010/23] | Representative(s) | Gulde & Partner Patent- und Rechtsanwaltskanzlei mbB Wallstrasse 58/59 10179 Berlin / DE | [N/P] |
Former [2013/16] | Gulde Hengelhaupt Ziebig & Schneider Patentanwälte - Rechtsanwälte Wallstrasse 58/59 10179 Berlin / DE | ||
Former [2010/23] | Gulde Hengelhaupt Ziebig & Schneider Patentanwälte - Rechtsanwälte Wallstrasse 58/59 10179 Berlin / DE | Application number, filing date | 08833790.2 | 26.09.2008 | [2010/23] | WO2008JP67566 | Priority number, date | JP20070256527 | 28.09.2007 Original published format: JP 2007256527 | [2010/23] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2009041666 | Date: | 02.04.2009 | Language: | JA | [2009/14] | Type: | A1 Application with search report | No.: | EP2194068 | Date: | 09.06.2010 | Language: | EN | [2010/23] | Type: | B1 Patent specification | No.: | EP2194068 | Date: | 17.04.2013 | Language: | EN | [2013/16] | Search report(s) | International search report - published on: | JP | 02.04.2009 | (Supplementary) European search report - dispatched on: | EP | 05.12.2011 | Classification | IPC: | C08B37/16, A61K31/704, A61K47/48, C07D475/04 | [2010/23] | CPC: |
C07D475/04 (EP,US);
A61K47/549 (EP,US);
A61K47/551 (EP,US);
A61K47/6951 (EP,US);
A61K49/0002 (EP,US);
A61K49/0043 (EP,US);
A61K49/0063 (EP,US);
A61K49/0404 (EP,US);
A61K49/0433 (EP,US);
A61K51/0406 (EP,US);
A61K51/1268 (EP,US);
B82Y5/00 (EP,US);
C08B37/0012 (EP,US)
(-)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2010/23] | Title | German: | MIT FOLSÄURE MODIFIZIERTE CYCLODEXTRINVERBINDUNG, VERFAHREN ZU IHRER HERSTELLUNG, WIRKSTOFFFREISETZUNGSMITTEL FÜR EIN ZIELGERICHTETES WIRKSTOFFFREISETZUNGSSYSTEM, PHARMAZEUTISCHE ZUSAMMENSETZUNG UND BILDGEBUNGSMITTEL | [2010/23] | English: | CYCLODEXTRIN COMPOUND MODIFIED WITH FOLIC ACID, PROCESS FOR PRODUCTION THEREOF, DRUG DELIVERY AGENT FOR TARGETING DRUG DELIVERY SYSTEM, PHARMACEUTICAL COMPOSITION, AND IMAGING AGENT | [2010/23] | French: | COMPOSÉ DE CYCLODEXTRINE MODIFIÉ PAR L'ACIDE FOLIQUE, PROCÉDÉ POUR LE PRODUIRE, AGENT DE DÉLIVRANCE DE MÉDICAMENT POUR LE CIBLAGE D'UN SYSTÈME DE DÉLIVRANCE DE MÉDICAMENT, COMPOSITION PHARMACEUTIQUE ET AGENT D'IMAGERIE | [2010/23] | Entry into regional phase | 24.03.2010 | Translation filed | 24.03.2010 | National basic fee paid | 24.03.2010 | Search fee paid | 24.03.2010 | Designation fee(s) paid | 24.03.2010 | Examination fee paid | Examination procedure | 24.03.2010 | Examination requested [2010/23] | 13.06.2012 | Amendment by applicant (claims and/or description) | 09.11.2012 | Communication of intention to grant the patent | 08.03.2013 | Fee for grant paid | 08.03.2013 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 09.11.2012 | Opposition(s) | 20.01.2014 | No opposition filed within time limit [2014/13] | Fees paid | Renewal fee | 27.09.2010 | Renewal fee patent year 03 | 30.09.2011 | Renewal fee patent year 04 | 27.09.2012 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 26.09.2008 | AT | 17.04.2013 | BE | 17.04.2013 | CY | 17.04.2013 | CZ | 17.04.2013 | DK | 17.04.2013 | EE | 17.04.2013 | FI | 17.04.2013 | HR | 17.04.2013 | IT | 17.04.2013 | LT | 17.04.2013 | LV | 17.04.2013 | MC | 17.04.2013 | MT | 17.04.2013 | NL | 17.04.2013 | PL | 17.04.2013 | RO | 17.04.2013 | SE | 17.04.2013 | SI | 17.04.2013 | SK | 17.04.2013 | TR | 17.04.2013 | BG | 17.07.2013 | NO | 17.07.2013 | GR | 18.07.2013 | ES | 28.07.2013 | IS | 17.08.2013 | PT | 19.08.2013 | IE | 26.09.2013 | LU | 26.09.2013 | CH | 30.09.2013 | LI | 30.09.2013 | [2015/34] |
Former [2015/32] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
CZ | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
IT | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
MC | 17.04.2013 | ||
MT | 17.04.2013 | ||
NL | 17.04.2013 | ||
PL | 17.04.2013 | ||
RO | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
SK | 17.04.2013 | ||
TR | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
IE | 26.09.2013 | ||
CH | 30.09.2013 | ||
LI | 30.09.2013 | ||
Former [2014/34] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
CZ | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
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IT | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
MC | 17.04.2013 | ||
NL | 17.04.2013 | ||
PL | 17.04.2013 | ||
RO | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
SK | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
IE | 26.09.2013 | ||
CH | 30.09.2013 | ||
LI | 30.09.2013 | ||
Former [2014/33] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
CZ | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
IT | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
MC | 17.04.2013 | ||
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PL | 17.04.2013 | ||
RO | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
SK | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
IE | 26.09.2013 | ||
Former [2014/20] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
CZ | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
IT | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
MC | 17.04.2013 | ||
NL | 17.04.2013 | ||
PL | 17.04.2013 | ||
RO | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
SK | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2014/14] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
CZ | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
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IT | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
NL | 17.04.2013 | ||
PL | 17.04.2013 | ||
RO | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
SK | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2014/11] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
CZ | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
IT | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
PL | 17.04.2013 | ||
RO | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
SK | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2014/10] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
CZ | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
PL | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
SK | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2014/09] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
DK | 17.04.2013 | ||
EE | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
PL | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2013/52] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
CY | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
PL | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2013/51] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
FI | 17.04.2013 | ||
HR | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
PL | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2013/50] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
FI | 17.04.2013 | ||
LT | 17.04.2013 | ||
LV | 17.04.2013 | ||
PL | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
BG | 17.07.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2013/49] | AT | 17.04.2013 | |
BE | 17.04.2013 | ||
FI | 17.04.2013 | ||
LT | 17.04.2013 | ||
SE | 17.04.2013 | ||
SI | 17.04.2013 | ||
NO | 17.07.2013 | ||
GR | 18.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2013/48] | AT | 17.04.2013 | |
LT | 17.04.2013 | ||
NO | 17.07.2013 | ||
ES | 28.07.2013 | ||
IS | 17.08.2013 | ||
PT | 19.08.2013 | ||
Former [2013/47] | LT | 17.04.2013 | |
NO | 17.07.2013 | ||
PT | 19.08.2013 | Documents cited: | Search | [Y] - HIRAYAMA F ET AL, "Cyclodextrin-based controlled drug release system", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL, vol. 36, no. 1, doi:10.1016/S0169-409X(98)00058-1, ISSN 0169-409X, (19990301), pages 125 - 141, (19990210), XP002616323 [Y] 1-7 * the whole document * DOI: http://dx.doi.org/10.1016/S0169-409X(98)00058-1 | [YD] - CALICETI P ET AL, "SYNTHESIS AND PHYSICOCHEMICAL CHARACTERIZATION OF FOLATE-CYCLODEXTRIN BIOCONJUGATE FOR ACTIVE DRUG DELIVERY", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, (20030901), vol. 14, no. 5, doi:10.1021/BC034080I, ISSN 1043-1802, pages 899 - 908, XP001170950 [YD] 1-7 * the whole document * DOI: http://dx.doi.org/10.1021/bc034080i | International search | [A]JP2006502301 | [A] - SALMASO, S. ET AL., "Specific Antitumor Targetable p-Cyclodextrin-Poly(ethylene Glycol) -Folic Acid Drug Delivery Bioconjugate", BIOCONJUGATE CHEM, (2004), vol. 15, no. 5, pages 997 - 1004, XP008131939 DOI: http://dx.doi.org/10.1021/BC034186D | [A] - CALICETI, P. ET AL., "Synthesis and Physicochemical Characterization of Folate- Cyclodextrin Bioconjugate for Active Drug Delivery", BIOCONJUGATE CHEM, (2003), vol. 14, no. 5, pages 899 - 908, XP001170950 DOI: http://dx.doi.org/10.1021/bc034080i | by applicant | JP2007256527 | - S. WANG; PHILIP S. LOW, J. CONTROL. RELEASE, (1998), vol. 53, pages 39 - 48 | - PHILIP S. LOW; WALTER A. HENNE; DEREK D. DOOMEWEERD, ACCOUNTS CHEM. RESEARCH, (2008), vol. 41, pages 120 - 129 | - PHILIP S. LOW; WAITER A. HENNE; DEREK D. DOOMEWEERD, ACCOUNTS CHEM. RESEARCH, (2008), vol. 41, pages 120 - 129 | - Y C. LEE; R. T. LEE, ACC. CHEM. RES, (1995), vol. 28 | - P. CALICETI; S. SALMASO; A, SEMENZATO; T. CAROFIGLIO; R. FORNASIER; M. FERMEGLIA; M. FERRONE; S. PRICL, BIOCONJUATE CHEM., (2003), vol. 14, pages 899 - 908 | - S. SALMASO; A. SEMENZATO; P. CALICETI; J. HOEBEKE; F.SONVICO; C.DUBERNET; P. COUVREUR, BIOCONJUGATE CHEM., (2004), vol. 15, pages 997 - 1004 | - S.SALMASO; S. SARA; A. SEMENZATO; P. CALICETI, J. DRUG TARGETING, (2007), vol. 15, no. 6, pages 379 - 390 | - P. CALICETI; S. SALMASO; A, SEMENZATO; T. CAROFIGLIO; R. FORNASIER; M. FERINEGLIA; M. FERRONE; S. PRICL, BIOCONJUGATE CHEM., (2003), vol. 14, pages 899 - 908 | - K. HATTORI; A. KENMOKU; T. MIZUGUCHI; D. IKEDA; M. MIZUNO; T. INAZU, J. INCLUSION PHENOM. MACROCYCLIC CHEM., (2006), vol. 56, pages 9 - 16 | - Z. LUKA; S. PAKHOMOVA; L. V. LOUKACHEVITCH; M. EGLI; M. E. NEWCOMER; C. WAGNER, J. BIOL. CHEM., (2007), vol. 282, pages 4069 - 4075 | - M. KUNISHIMA; C. KAWACHI; J. MORITA; K. TERAO; F. IWASAKI; S. TANI, TETRAHEDRON, (1999), vol. 55, pages 13159 - 13170 | - AOKI, R. ARAI; K. HATTORI, J. INCLUSION PHENOM., (2004), vol. 50, pages 115 - 120 | - K. HATTORI; A. KENMOKU; T. MIZUGUCHI; D. IKEDA; M. MIZUNO; T. INAZU, J. INCLUSION PHENOM. MACROCYCLIC CHEMISTRY, (2006), vol. 56, pages 9 - 16 |