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Extract from the Register of European Patents

EP About this file: EP2190814

EP2190814 - N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.12.2017
Database last updated on 11.09.2024
FormerThe patent has been granted
Status updated on  30.12.2016
FormerGrant of patent is intended
Status updated on  23.12.2016
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
The Johns Hopkins University
3400 N. Charles Street
Baltimore, MD 21218 / US
For all designated states
Cardioxyl Pharmaceuticals, Inc.
1450 Raleigh Rd., Suite 212
Chapel Hill, NC 27517 / US
[2017/04]
Former [2010/30]For all designated states
Johns Hopkins University
3400 N. Charles St.
Baltimore MD 21218 / US
For all designated states
Cardioxyl Pharmaceuticals, INC.
Executive Plaza ll 11350 McCormick Road
Hunt Valley, Maryland 21031 / US
Former [2010/22]For all designated states
The Johns Hopkins University
Johns Hopkins Technology Transfer 100 N. Charles Street 5th Floor
Baltimore, MD 21201 / US
For all designated states
Cardioxyl Pharmaceuticals, INC.
Executive Plaza ll 11350 McCormick Road
Hunt Valley, Maryland 21031 / US
Inventor(s)01 / TOSCANO, John, P.
18 Tree FarmCourt
Glen Arm MD 21057 / US
02 / BROOKFIELD, Frederick, Arthur
114 Milton Park
Abingdon
Oxfordshire OX14 4SA / GB
03 / COHEN, Andrew, D.
Apt. 28A, 345 East 80th Street
New York, NY 10021 / US
04 / COURTNEY, Stephen, Martin
114 Milton Park
Abingdon
Oxfordshire OX14 4SA / GB
05 / FROST, Lisa, Marie
114 Milton Park
Abingdon
Oxfordshire OX14 4SA / GB
06 / KALISH, Vincent, Jacob
344 Dubois Road
Annapolis MD 21401 / US
 [2017/05]
Former [2010/22]01 / TOSCANO, John, P.
18 Tree FarmCourt
Glen Arm MD 21057 / US
02 / BROOKFIELD, Frederick, Arthur
114 Milton Park Abingdon
Oxfordshire OX14 4SA / GB
03 / COHEN, Andrew, D.
Apt. 28A, 345 East 80th Street
New York, NY 10021 / US
04 / COURTNEY, Stephen, Martin
114 Milton Park Abingdon
Oxfordshire OX14 4SA / GB
05 / FROST, Lisa, Marie
114 Milton Park Abingdon
Oxfordshire OX14 4SA / GB
06 / KALISH, Vincent, Jacob
344 Dubois Road
Annapolis MD 21401 / US
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2017/05]Wright, Simon Mark
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2010/22]Wright, Simon Mark
J.A. Kemp & Co. 14 South Square Gray's Inn
London WC1R 5JJ / GB
Application number, filing date08834117.726.09.2008
[2010/22]
WO2008US78024
Priority number, dateUS20070995636P26.09.2007         Original published format: US 995636 P
[2010/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009042970
Date:02.04.2009
Language:EN
[2009/14]
Type: A1 Application with search report 
No.:EP2190814
Date:02.06.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 02.04.2009 takes the place of the publication of the European patent application.
[2010/22]
Type: B1 Patent specification 
No.:EP2190814
Date:01.02.2017
Language:EN
[2017/05]
Search report(s)International search report - published on:EP02.04.2009
ClassificationIPC:C07C311/48, C07D295/155, C07D295/192, C07D295/16, C07D295/26, C07D333/36, C07D333/38, A61K31/18, A61K31/192, A61K31/235, A61K31/5377, A61P9/04, A61P9/10
[2016/34]
CPC:
C07C311/48 (EP,KR,US); C07D333/38 (EP,CN,US); C07C317/48 (US);
A61K31/18 (KR); A61K31/192 (KR); A61K31/235 (KR);
A61P11/00 (EP); A61P3/06 (EP); A61P3/10 (EP);
A61P43/00 (EP); A61P7/10 (EP); A61P9/00 (EP);
A61P9/04 (EP); A61P9/06 (EP); A61P9/10 (EP);
A61P9/12 (EP); C07D295/155 (EP,KR,US); C07D295/16 (EP,KR,US);
C07D295/192 (EP,US); C07D295/26 (EP,US); C07D333/26 (EP,KR,US);
C07D333/34 (KR); C07D333/36 (EP,US); C07D333/44 (CN);
C07D409/04 (CN); C07D409/06 (CN) (-)
Former IPC [2010/22]C07C311/48, C07D333/34, C07D295/192, A61K31/18, A61K31/192, A61K31/235, A61K31/5377, A61P9/04, A61P9/10, C07D333/38
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/05]
Former [2010/22]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:N-HYDROXYLSULFONAMIDDERIVATE ALS NEUE PHYSIOLOGISCH NÜTZLICHE NITROXYL-SPENDER[2010/22]
English:N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS[2010/22]
French:DÉRIVÉS DE N-HYDROXYLSULFONAMIDE UTILISÉS COMME NOUVEAUX DONNEURS DE NITROXYLE PHYSIOLOGIQUEMENT UTILES[2010/22]
Entry into regional phase19.03.2010National basic fee paid 
19.03.2010Designation fee(s) paid 
19.03.2010Examination fee paid 
Examination procedure19.03.2010Amendment by applicant (claims and/or description)
19.03.2010Examination requested  [2010/22]
02.08.2012Despatch of a communication from the examining division (Time limit: M06)
12.02.2013Reply to a communication from the examining division
04.06.2013Despatch of a communication from the examining division (Time limit: M06)
16.12.2013Reply to a communication from the examining division
11.09.2014Despatch of a communication from the examining division (Time limit: M06)
23.03.2015Reply to a communication from the examining division
23.07.2015Despatch of a communication from the examining division (Time limit: M06)
01.03.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
21.04.2016Reply to a communication from the examining division
10.08.2016Communication of intention to grant the patent
20.12.2016Fee for grant paid
20.12.2016Fee for publishing/printing paid
20.12.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.08.2012
Opposition(s)03.11.2017No opposition filed within time limit [2018/02]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
21.04.2016Request for further processing filed
21.04.2016Full payment received (date of receipt of payment)
Request granted
09.05.2016Decision despatched
Fees paidRenewal fee
14.01.2011Renewal fee patent year 03
29.09.2011Renewal fee patent year 04
12.09.2012Renewal fee patent year 05
12.09.2013Renewal fee patent year 06
12.09.2014Renewal fee patent year 07
11.09.2015Renewal fee patent year 08
13.09.2016Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
30.09.201003   M06   Fee paid on   14.01.2011
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.09.2008
AT01.02.2017
CY01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
MC01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
TR01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
IE26.09.2017
LU26.09.2017
MT26.09.2017
BE30.09.2017
CH30.09.2017
LI30.09.2017
[2020/15]
Former [2019/46]HU26.09.2008
AT01.02.2017
CY01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
MC01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
IE26.09.2017
LU26.09.2017
MT26.09.2017
BE30.09.2017
CH30.09.2017
LI30.09.2017
Former [2019/31]HU26.09.2008
AT01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
MC01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
IE26.09.2017
LU26.09.2017
MT26.09.2017
BE30.09.2017
CH30.09.2017
LI30.09.2017
Former [2018/43]AT01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
MC01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
IE26.09.2017
LU26.09.2017
MT26.09.2017
BE30.09.2017
CH30.09.2017
LI30.09.2017
Former [2018/39]AT01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
MC01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
IE26.09.2017
LU26.09.2017
BE30.09.2017
CH30.09.2017
LI30.09.2017
Former [2018/34]AT01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
MC01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
IE26.09.2017
LU26.09.2017
CH30.09.2017
LI30.09.2017
Former [2018/29]AT01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
MC01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
Former [2018/14]AT01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SI01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
Former [2017/50]AT01.02.2017
CZ01.02.2017
DK01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
Former [2017/49]AT01.02.2017
CZ01.02.2017
EE01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
IT01.02.2017
LT01.02.2017
LV01.02.2017
NL01.02.2017
PL01.02.2017
RO01.02.2017
SE01.02.2017
SK01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
Former [2017/48]AT01.02.2017
CZ01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
LT01.02.2017
LV01.02.2017
NL01.02.2017
PL01.02.2017
SE01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
Former [2017/41]AT01.02.2017
ES01.02.2017
FI01.02.2017
HR01.02.2017
LT01.02.2017
LV01.02.2017
NL01.02.2017
PL01.02.2017
SE01.02.2017
BG01.05.2017
NO01.05.2017
GR02.05.2017
IS01.06.2017
PT01.06.2017
Cited inInternational searchJP2002072459  [ ] (TOYO GOSEI KOGYO KK);
 [DA]US2004038947  (WINK DAVID A [US], et al) [DA] 1-13 * paragraph [0050]; claim 1 *;
 [DA]US6936639  (WINK DAVID A [US], et al) [DA] 1-13 * column 4, lines 29-21; claims 1,8,12,13 *;
 [X]  - H.T. NAGASAWA, ET AL., "Prodrugs of nitroxyl as potential aldehyde dehydrogenase inhibitors vis-à-vis vascular smooth muscle relaxants", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, (199505), vol. 38, no. 11, ISSN 0022-2623, pages 1865 - 1871, XP002214380 [X] 1,2,4-7 * compounds 7b, 9-11 *

DOI:   http://dx.doi.org/10.1021/jm00011a005
 [X]  - C.H. ANDREWS, ET AL., "Experimental chemotherapy of typhus. Anti-rickettsial action of p-sulphamylbenzamidine and related compounds", PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON, SERIES B, BIOLOGICAL SCIENCES, THE ROYAL SOCIETY, LONDON, GB, (19460110), vol. 133, no. 1, ISSN 0080-4649, pages 20 - 62, XP002100404 [X] 1,2,4,7 * page 55, lines 36-40 *
 [X]  - CHEMCATS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2037996565, URL: STN, XP002509259 [X] 1,4,6,7 * Order no. ken-168921 *
 [PX]  - Aurora Screening Library, SAN DIEGO, CA, US, AURORA FINE CHEMICALS, (20080613) [PX] 1,4,6,7
 [L]  - REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20070213), Database accession no. 920663-30-5, URL: STN, XP002509260
 [X]  - CHEMCATS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2033715491, URL: STN, XP002509261 [X] 1,4,6,7 * Order no. T5685187 *
 [PX]  - Enamine Screening Library, KIEV, UA, ENAMINE, (20080117) [PX] 1,4,6,7
 [L]  - REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20070413), Database accession no. 930060-37-7, URL: STN, XP002509262
 [X]  - CHEMCATS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2033522701, URL: STN, XP002509263 [X] 1,4,6,7 * Order no. EN300-11181 *
 [PX]  - Enamine Building Blocks, KIEV, UA, ENAMINE, (20080117) [PX] 1,4,6,7
 [L]  - REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20041130), Database accession no. 790725-76-7, URL: STN, XP002509264
 [DX]  - A. SCOZZAFAVA, ET AL., "Carbonic Anhydrase and matrix metalloproteinase inhibitors: sulphonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulphonamides inhibit both these zinc enzymes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, (20000913), vol. 43, no. 20, ISSN 0022-2623, pages 3677 - 3687, XP002394373 [DX] 1,2,4-7 * compound 70 *

DOI:   http://dx.doi.org/10.1021/jm000027t
 [X]  - A. SCOZZAFAVA, ET AL., "Carbonic Anhydrase and matrix metalloproteinase inhibitors: sulphonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulphonamides inhibit both these zinc enzymes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, (20010308), vol. 44, no. 6, ISSN 0022-2623, page 1016, XP002445147 [X] 1,2,4-7 * compounds 71-73 *

DOI:   http://dx.doi.org/10.1021/jm0004852
 [X]  - CAPLUS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2002:176265, URL: STN, XP002509265 [X] 1,2,4-7 * abstract *
ExaminationJPH04321671
 WO2007109175
by applicant   - MA ET AL., "Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury", PROC. NATL. ACAD. SCI., (1999), vol. 96, pages 14617 - 14622, XP002404165
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.