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Extract from the Register of European Patents

EP About this file: EP2231621

EP2231621 - PROCESS FOR PREPARING N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDES [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 08.09.2017 Database last updated on 11.09.2024
Most recent event Tooltip	21.09.2018	Lapse of the patent in a contracting state New state(s): MT	published on 24.10.2018 [2018/43]
Applicant(s)	For all designated states Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US
	[2016/44]
Former [2012/33]	For all designated states Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway NJ 07065-0907 / US
Former [2010/39]	For all designated states Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065 / US
Inventor(s)	01 / HUMPHREY, Guy, R. 126 East Lincoln Avenue Rahway New Jersey 07065-0907 / US
	02 / MILLER, Ross, A. 126 East Lincoln Avenue Rahway New Jersey 07065-0907 / US
	03 / MALIGRES, Peter, E. 126 East Lincoln Avenue Rahway New Jersey 07065-0907 / US
	04 / WEISSMAN, Steven 126 East Lincoln Avenue Rahway New Jersey 07065-0907 / US
	[2010/39]
Representative(s)	Horgan, James Michael Frederic Merck Sharp & Dohme Corp. 120 Moorgate London, EC2M 6UR / GB
	[N/P]
Former [2016/44]	Horgan, James Michael Frederic Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon EN11 9BU / GB
Former [2010/39]	Horgan, James Michael Frederic Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon EN11 9BU / GB
Application number, filing date	08869559.8	22.12.2008
	[2010/39]
	WO2008US87929
Priority number, date	US20080010421	08.01.2008 Original published format: US 10421
	[2010/39]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2009088729
	Date:	16.07.2009
	Language:	EN
	[2009/29]
	Type:	A1 Application with search report
	No.:	EP2231621
	Date:	29.09.2010
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 16.07.2009 takes the place of the publication of the European patent application.
	[2010/39]
	Type:	B1 Patent specification
	No.:	EP2231621
	Date:	02.11.2016
	Language:	EN
	[2016/44]
Search report(s)	International search report - published on:	EP	16.07.2009
Classification	IPC:	C07D239/52, C07D413/12	[2010/39]
	CPC:	C07D413/12 (EP,US); A61P31/18 (EP); A61P43/00 (EP); C07D239/52 (EP,US); Y02P20/55 (EP,US)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2016/44]
Former [2010/39]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR
Title	German:	HERSTELLUNGSVERFAHREN VON N-SUBSTITUIERTEN HYDROXYPYRIMIDINON-CARBOXAMIDEN	[2010/39]
	English:	PROCESS FOR PREPARING N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDES	[2010/39]
	French:	PROCÉDÉ DE PRÉPARATION D'HYDROXYPYRIMIDINONE CARBOXAMIDES N-SUBSTITUÉS	[2010/39]
Entry into regional phase	09.08.2010	National basic fee paid
	09.08.2010	Designation fee(s) paid
	09.08.2010	Examination fee paid
Examination procedure	11.06.2010	Amendment by applicant (claims and/or description)
	09.08.2010	Examination requested [2010/39]
	07.05.2012	Despatch of a communication from the examining division (Time limit: M06)
	19.03.2013	Reply to a communication from the examining division
	30.01.2015	Despatch of a communication from the examining division (Time limit: M06)
	07.09.2015	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	12.11.2015	Reply to a communication from the examining division
	23.05.2016	Communication of intention to grant the patent
	19.09.2016	Fee for grant paid
	19.09.2016	Fee for publishing/printing paid
	19.09.2016	Receipt of the translation of the claim(s)
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 07.05.2012
Opposition(s)	03.08.2017	No opposition filed within time limit [2017/41]
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	12.11.2015	Request for further processing filed
	12.11.2015	Full payment received (date of receipt of payment) Request granted
	25.11.2015	Decision despatched
	The application is deemed to be withdrawn due to failure to reply to the examination report
	13.03.2013	Request for further processing filed
	13.03.2013	Full payment received (date of receipt of payment) Request granted
	18.09.2013	Decision despatched
Fees paid	Renewal fee
	22.11.2010	Renewal fee patent year 03
	07.12.2011	Renewal fee patent year 04
	07.12.2012	Renewal fee patent year 05
	06.12.2013	Renewal fee patent year 06
	05.12.2014	Renewal fee patent year 07
	07.12.2015	Renewal fee patent year 08
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	22.12.2008
	AT	02.11.2016
	BE	02.11.2016
	CY	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	MC	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SI	02.11.2016
	SK	02.11.2016
	TR	02.11.2016
	IE	22.12.2016
	LU	22.12.2016
	MT	22.12.2016
	CH	31.12.2016
	LI	31.12.2016
	FR	02.01.2017
	BG	02.02.2017
	GB	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
	DE	01.07.2017
	[2018/43]
Former [2018/29]	HU	22.12.2008
	AT	02.11.2016
	BE	02.11.2016
	CY	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	MC	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SI	02.11.2016
	SK	02.11.2016
	TR	02.11.2016
	IE	22.12.2016
	LU	22.12.2016
	CH	31.12.2016
	LI	31.12.2016
	FR	02.01.2017
	BG	02.02.2017
	GB	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
	DE	01.07.2017
Former [2018/28]	HU	22.12.2008
	AT	02.11.2016
	BE	02.11.2016
	CY	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	MC	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SI	02.11.2016
	SK	02.11.2016
	IE	22.12.2016
	LU	22.12.2016
	CH	31.12.2016
	LI	31.12.2016
	FR	02.01.2017
	BG	02.02.2017
	GB	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
	DE	01.07.2017
Former [2018/14]	AT	02.11.2016
	BE	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	MC	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SI	02.11.2016
	SK	02.11.2016
	IE	22.12.2016
	LU	22.12.2016
	CH	31.12.2016
	LI	31.12.2016
	FR	02.01.2017
	BG	02.02.2017
	GB	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
	DE	01.07.2017
Former [2017/50]	AT	02.11.2016
	BE	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	MC	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SI	02.11.2016
	SK	02.11.2016
	IE	22.12.2016
	LU	22.12.2016
	CH	31.12.2016
	LI	31.12.2016
	FR	02.01.2017
	BG	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
	DE	01.07.2017
Former [2017/49]	AT	02.11.2016
	BE	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	MC	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SI	02.11.2016
	SK	02.11.2016
	IE	22.12.2016
	LU	22.12.2016
	CH	31.12.2016
	LI	31.12.2016
	FR	02.01.2017
	BG	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/42]	AT	02.11.2016
	BE	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	MC	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SK	02.11.2016
	BG	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/38]	AT	02.11.2016
	BE	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SK	02.11.2016
	BG	02.02.2017
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/37]	AT	02.11.2016
	BE	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	IT	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SK	02.11.2016
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/36]	AT	02.11.2016
	BE	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	SK	02.11.2016
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/35]	AT	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	EE	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	RO	02.11.2016
	SE	02.11.2016
	BE	31.12.2016
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/34]	AT	02.11.2016
	CZ	02.11.2016
	DK	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	SE	02.11.2016
	BE	31.12.2016
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/33]	AT	02.11.2016
	DK	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	SE	02.11.2016
	BE	31.12.2016
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/26]	AT	02.11.2016
	ES	02.11.2016
	FI	02.11.2016
	HR	02.11.2016
	LT	02.11.2016
	LV	02.11.2016
	NL	02.11.2016
	PL	02.11.2016
	SE	02.11.2016
	BE	31.12.2016
	NO	02.02.2017
	GR	03.02.2017
	IS	02.03.2017
	PT	02.03.2017
Former [2017/12]	LV	02.11.2016
Cited in	International search	[DY]US2006122205 (BELYK KEVIN M [US], et al) [DY] 1-30 * paragraph [0203] - paragraph [0248]; example 1; claim 45 *;
		[DY]WO03035077 (ANGELETTI P IST RICHERCHE BIO [IT], et al) [DY] 1-30 * examples 18,19; claim -; compound 24 *;
		[PY] - SUMMA V ET AL, "Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection", JOURNAL OF MEDICINAL CHEMISTRY, (20080903), vol. 51, no. 18, pages 5843 - 5855, XP002508035 [PY] 1-30 * Schemes 1,2; in particular compound 27; page 5854 * DOI: http://dx.doi.org/10.1021/jm800245z

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