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Extract from the Register of European Patents

EP About this file: EP2271647

EP2271647 - C2-FLUORO SUBSTITUTED PIPERAZINE LINKED PYRROLO[2,1-C][1,4] BENZODIAZEPINE DIMERS AND A PROCESS FOR THE PREPARATION THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.10.2013
Database last updated on 24.08.2024
Most recent event   Tooltip04.09.2015Lapse of the patent in a contracting state
New state(s): MT		published on 07.10.2015  [2015/41]
Applicant(s)For all designated states
Council Of Scientific & Industrial Research
̈An Indian registered body incorporated under the Registration of Societies Act (Act XXI of 1860) ̈ Anusandhan Bhawan 2 Rafi Marg.
New Delhi 110 001 / IN
[2012/49]
Former [2011/02]For all designated states
Council Of Scientific & Industrial Research
̈An Indian registered body incorporated under the Registration of Societies Act (Act XXI of 1860) ̈ Anusandhan Bhawan 2 Rafi Marg.
New Delhi 110 001 / IN
Inventor(s)01 / KAMAL, Ahmed
Indian Institute of Chemical Technology
Upppal Road
Hyderabad 500 007 Andhra Pradesh / IN
02 / RAJENDER
Indian Institute of Chemical Technology
Uppal Road
Hyderabad 500 007 Andhra Pradesh / IN
03 / KASHIREDDY, Metuku
Indian Institute of Chemical Technology
Uppal Road
Hyderabad 500 007 Andhra Pradesh / IN
04 / BALAKISHAN, Gorre
Indian Institute of Chemical Technology
Uppal Road
Hyderabad 500 007 Andhra Pradesh / IN
 [2012/49]
Former [2011/02]01 / KAMAL, Ahmed
Indian Institute of Chemical Technology Upppal Road
Hyderabad 500 007 Andhra Pradesh / IN
02 / RAJENDER
Indian Institute of Chemical Technology Uppal Road
Hyderabad 500 007 Andhra Pradesh / IN
03 / KASHIREDDY, Metuku
Indian Institute of Chemical Technology Uppal Road
Hyderabad 500 007 Andhra Pradesh / IN
04 / BALAKISHAN, Gorre
Indian Institute of Chemical Technology Uppal Road
Hyderabad 500 007 Andhra Pradesh / IN
Representative(s)Bond, Christopher William, et al
Forresters IP LLP
Skygarden
Erika-Mann-Strasse 11
80636 München / DE
[N/P]
Former [2012/28]Bond, Christopher William, et al
Forresters
Skygarden
Erika-Mann-Strasse 11
80636 München / DE
Former [2012/13]Ashton, Timothy, et al
Forrester & Boehmert
SkyGarden
Erika-Mann-Strasse 11
80636 München / DE
Former [2011/02]Ashton, Timothy
Forrester & Boehmert Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date08873240.931.10.2008
[2011/02]
WO2008IN00715
Priority number, dateIN2008DEL060811.03.2008         Original published format: IN DE06082008
[2011/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009113084
Date:17.09.2009
Language:EN
[2009/38]
Type: A1 Application with search report 
No.:EP2271647
Date:12.01.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 17.09.2009 takes the place of the publication of the European patent application.
[2011/02]
Type: B1 Patent specification 
No.:EP2271647
Date:05.12.2012
Language:EN
[2012/49]
Search report(s)International search report - published on:EP17.09.2009
ClassificationIPC:C07D487/04, C07D519/00, A61K31/5517, A61P35/00
[2011/02]
CPC:
C07D487/04 (EP,US); A61P35/00 (EP); C07D519/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/02]
TitleGerman:C2-FLUOR-SUBSTITUIERTE PIPERAZINGEBUNDENE PYRROLO[2,1-C][1,4]BENZODIAZEPINDIMERE UND VERFAHREN ZU DEREN HERSTELLUNG[2011/02]
English:C2-FLUORO SUBSTITUTED PIPERAZINE LINKED PYRROLO[2,1-C][1,4] BENZODIAZEPINE DIMERS AND A PROCESS FOR THE PREPARATION THEREOF[2011/02]
French:DIMÈRES DE PYRROLO[2,1-C][1,4] BENZODIAZÉPINE LIÉS UN CYCLE PIPÉRAZINE SUBSTITUÉS PAR C2-FLUORÉ ET SON PROCÉDÉ DE PRÉPARATION[2011/02]
Entry into regional phase09.09.2010National basic fee paid 
09.09.2010Designation fee(s) paid 
09.09.2010Examination fee paid 
Examination procedure11.01.2010Request for preliminary examination filed
International Preliminary Examining Authority: EP
09.09.2010Examination requested  [2011/02]
17.12.2010Amendment by applicant (claims and/or description)
08.04.2011Despatch of a communication from the examining division (Time limit: M04)
17.08.2011Reply to a communication from the examining division
02.07.2012Communication of intention to grant the patent
23.10.2012Fee for grant paid
23.10.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.04.2011
Opposition(s)06.09.2013No opposition filed within time limit [2013/46]
Fees paidRenewal fee
25.10.2010Renewal fee patent year 03
24.10.2011Renewal fee patent year 04
16.10.2012Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU31.10.2008
AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
GR05.12.2012
IT05.12.2012
LT05.12.2012
LV05.12.2012
MC05.12.2012
MT05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
TR05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
HR31.07.2013
[2015/41]
Former [2015/38]HU31.10.2008
AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
GR05.12.2012
IT05.12.2012
LT05.12.2012
LV05.12.2012
MC05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
TR05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
HR31.07.2013
Former [2015/34]HU31.10.2008
AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
IT05.12.2012
LT05.12.2012
LV05.12.2012
MC05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
TR05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
HR31.07.2013
Former [2015/32]AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
IT05.12.2012
LT05.12.2012
LV05.12.2012
MC05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
TR05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
HR31.07.2013
Former [2014/25]AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
IT05.12.2012
LT05.12.2012
LV05.12.2012
MC05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
HR31.07.2013
Former [2014/09]AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
IT05.12.2012
LT05.12.2012
LV05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
HR31.07.2013
Former [2014/03]AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
IT05.12.2012
LT05.12.2012
LV05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
Former [2013/52]AT05.12.2012
BE05.12.2012
CY05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
Former [2013/48]AT05.12.2012
BE05.12.2012
CZ05.12.2012
DK05.12.2012
EE05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
Former [2013/40]AT05.12.2012
BE05.12.2012
CZ05.12.2012
EE05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
PT05.04.2013
Former [2013/37]AT05.12.2012
BE05.12.2012
CZ05.12.2012
EE05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
NL05.12.2012
PL05.12.2012
RO05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
Former [2013/35]AT05.12.2012
BE05.12.2012
CZ05.12.2012
EE05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
PL05.12.2012
SE05.12.2012
SI05.12.2012
SK05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
Former [2013/34]AT05.12.2012
BE05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
PL05.12.2012
SE05.12.2012
SI05.12.2012
BG05.03.2013
NO05.03.2013
ES16.03.2013
IS05.04.2013
Former [2013/33]AT05.12.2012
BE05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
PL05.12.2012
SE05.12.2012
SI05.12.2012
NO05.03.2013
ES16.03.2013
Former [2013/31]AT05.12.2012
FI05.12.2012
LT05.12.2012
LV05.12.2012
PL05.12.2012
SE05.12.2012
SI05.12.2012
NO05.03.2013
ES16.03.2013
Former [2013/26]FI05.12.2012
LT05.12.2012
LV05.12.2012
PL05.12.2012
SE05.12.2012
SI05.12.2012
NO05.03.2013
ES16.03.2013
Former [2013/23]FI05.12.2012
LT05.12.2012
LV05.12.2012
PL05.12.2012
SE05.12.2012
NO05.03.2013
ES16.03.2013
Former [2013/22]FI05.12.2012
LT05.12.2012
SE05.12.2012
NO05.03.2013
ES16.03.2013
Former [2013/21]LT05.12.2012
SE05.12.2012
NO05.03.2013
Former [2013/20]LT05.12.2012
NO05.03.2013
Cited inInternational search[Y]WO2004087716  (COUNCIL SCIENT IND RES [IN], et al) [Y] 1-16 * page 1, line 16 - page 2, line 19 * * page 8 - page 12; examples 1-3 * * page 14 - page 16; table 2 * * claim 1 *;
 [Y]WO2005063758  (COUNCIL SCIENT IND RES [IN]) [Y] 1-16 * page 1, line 15 - page 2, line 21 * * page 2; compounds DC-81 * * page 10; compounds IXA-IXG * * page 15 - page 17; tables 1-4 * * claim 1 *;
 [Y]WO2007105045  (COUNCIL SCIENT IND RES [IN], et al) [Y] 1-16 * page 1, line 17 - page 3, line 3 * * page 10 - page 13; examples 1-3 * * page 14; table 1 * * claim 1 *
 [Y]  - KAMAL A ET AL, "DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 14, no. 2, ISSN 0968-0896, (20060115), pages 385 - 394, (20060115), XP025132916 [Y] 1-16 * page 386; figure 1; compounds 4, 6A-6D * * page 388; tables 2,3 * * page 389; figure 3 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2005.08.020
by applicant   - KUNIMOTO, S.; MASUDA, T.; KANBAYASHI, N.; HAMADA, M.; NAGANAWA, H.; MIYAMOTO, M.; TAKEUCHI, T.; UNEZAWA, H., J. ANTIBIOT., (1980), vol. 33, page 665
    - KOHN, K. W.; SPEOUS, C. L., J. MOL. BIOL., (1970), vol. 51, page 551
    - HURLEY, L. H.; GAIRPLA, C.; ZMIJEWSKI, M., BIOCHEM. BIOPHYS. ACTA., (1977), vol. 475, page 521
    - KAPLAN, D. J.; HURLEY, L. H., BIOCHEMISTRY, (1981), vol. 20, page 7572
    - KAMAL, A.; SRINIVAS, 0.; RAMULU, P.; RAMESH, G.; KUMAR, P. P, BIOORG. MED. CHEM. LETT., (2003), vol. 13, page 3577
    - O'NEIL, A.; THOMOSON.S.; KALINDJIAN, S. B.; JENKINS, T.C., TETRAHEDRON LETT., (2003), vol. 44, page 7809
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.