EP2271647 - C2-FLUORO SUBSTITUTED PIPERAZINE LINKED PYRROLO[2,1-C][1,4] BENZODIAZEPINE DIMERS AND A PROCESS FOR THE PREPARATION THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 11.10.2013 Database last updated on 24.08.2024 | Most recent event Tooltip | 04.09.2015 | Lapse of the patent in a contracting state New state(s): MT | published on 07.10.2015 [2015/41] | Applicant(s) | For all designated states Council Of Scientific & Industrial Research ̈An Indian registered body incorporated under the Registration of Societies Act (Act XXI of 1860) ̈ Anusandhan Bhawan 2 Rafi Marg. New Delhi 110 001 / IN | [2012/49] |
Former [2011/02] | For all designated states Council Of Scientific & Industrial Research ̈An Indian registered body incorporated under the Registration of Societies Act (Act XXI of 1860) ̈ Anusandhan Bhawan 2 Rafi Marg. New Delhi 110 001 / IN | Inventor(s) | 01 /
KAMAL, Ahmed Indian Institute of Chemical Technology Upppal Road Hyderabad 500 007 Andhra Pradesh / IN | 02 /
RAJENDER Indian Institute of Chemical Technology Uppal Road Hyderabad 500 007 Andhra Pradesh / IN | 03 /
KASHIREDDY, Metuku Indian Institute of Chemical Technology Uppal Road Hyderabad 500 007 Andhra Pradesh / IN | 04 /
BALAKISHAN, Gorre Indian Institute of Chemical Technology Uppal Road Hyderabad 500 007 Andhra Pradesh / IN | [2012/49] |
Former [2011/02] | 01 /
KAMAL, Ahmed Indian Institute of Chemical Technology Upppal Road Hyderabad 500 007 Andhra Pradesh / IN | ||
02 /
RAJENDER Indian Institute of Chemical Technology Uppal Road Hyderabad 500 007 Andhra Pradesh / IN | |||
03 /
KASHIREDDY, Metuku Indian Institute of Chemical Technology Uppal Road Hyderabad 500 007 Andhra Pradesh / IN | |||
04 /
BALAKISHAN, Gorre Indian Institute of Chemical Technology Uppal Road Hyderabad 500 007 Andhra Pradesh / IN | Representative(s) | Bond, Christopher William, et al Forresters IP LLP Skygarden Erika-Mann-Strasse 11 80636 München / DE | [N/P] |
Former [2012/28] | Bond, Christopher William, et al Forresters Skygarden Erika-Mann-Strasse 11 80636 München / DE | ||
Former [2012/13] | Ashton, Timothy, et al Forrester & Boehmert SkyGarden Erika-Mann-Strasse 11 80636 München / DE | ||
Former [2011/02] | Ashton, Timothy Forrester & Boehmert Pettenkoferstrasse 20-22 80336 München / DE | Application number, filing date | 08873240.9 | 31.10.2008 | [2011/02] | WO2008IN00715 | Priority number, date | IN2008DEL0608 | 11.03.2008 Original published format: IN DE06082008 | [2011/02] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2009113084 | Date: | 17.09.2009 | Language: | EN | [2009/38] | Type: | A1 Application with search report | No.: | EP2271647 | Date: | 12.01.2011 | Language: | EN | The application published by WIPO in one of the EPO official languages on 17.09.2009 takes the place of the publication of the European patent application. | [2011/02] | Type: | B1 Patent specification | No.: | EP2271647 | Date: | 05.12.2012 | Language: | EN | [2012/49] | Search report(s) | International search report - published on: | EP | 17.09.2009 | Classification | IPC: | C07D487/04, C07D519/00, A61K31/5517, A61P35/00 | [2011/02] | CPC: |
C07D487/04 (EP,US);
A61P35/00 (EP);
C07D519/00 (EP,US)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2011/02] | Title | German: | C2-FLUOR-SUBSTITUIERTE PIPERAZINGEBUNDENE PYRROLO[2,1-C][1,4]BENZODIAZEPINDIMERE UND VERFAHREN ZU DEREN HERSTELLUNG | [2011/02] | English: | C2-FLUORO SUBSTITUTED PIPERAZINE LINKED PYRROLO[2,1-C][1,4] BENZODIAZEPINE DIMERS AND A PROCESS FOR THE PREPARATION THEREOF | [2011/02] | French: | DIMÈRES DE PYRROLO[2,1-C][1,4] BENZODIAZÉPINE LIÉS UN CYCLE PIPÉRAZINE SUBSTITUÉS PAR C2-FLUORÉ ET SON PROCÉDÉ DE PRÉPARATION | [2011/02] | Entry into regional phase | 09.09.2010 | National basic fee paid | 09.09.2010 | Designation fee(s) paid | 09.09.2010 | Examination fee paid | Examination procedure | 11.01.2010 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 09.09.2010 | Examination requested [2011/02] | 17.12.2010 | Amendment by applicant (claims and/or description) | 08.04.2011 | Despatch of a communication from the examining division (Time limit: M04) | 17.08.2011 | Reply to a communication from the examining division | 02.07.2012 | Communication of intention to grant the patent | 23.10.2012 | Fee for grant paid | 23.10.2012 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 08.04.2011 | Opposition(s) | 06.09.2013 | No opposition filed within time limit [2013/46] | Fees paid | Renewal fee | 25.10.2010 | Renewal fee patent year 03 | 24.10.2011 | Renewal fee patent year 04 | 16.10.2012 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 31.10.2008 | AT | 05.12.2012 | BE | 05.12.2012 | CY | 05.12.2012 | CZ | 05.12.2012 | DK | 05.12.2012 | EE | 05.12.2012 | FI | 05.12.2012 | GR | 05.12.2012 | IT | 05.12.2012 | LT | 05.12.2012 | LV | 05.12.2012 | MC | 05.12.2012 | MT | 05.12.2012 | NL | 05.12.2012 | PL | 05.12.2012 | RO | 05.12.2012 | SE | 05.12.2012 | SI | 05.12.2012 | SK | 05.12.2012 | TR | 05.12.2012 | BG | 05.03.2013 | NO | 05.03.2013 | ES | 16.03.2013 | IS | 05.04.2013 | PT | 05.04.2013 | HR | 31.07.2013 | [2015/41] |
Former [2015/38] | HU | 31.10.2008 | |
AT | 05.12.2012 | ||
BE | 05.12.2012 | ||
CY | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
GR | 05.12.2012 | ||
IT | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
MC | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
TR | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
HR | 31.07.2013 | ||
Former [2015/34] | HU | 31.10.2008 | |
AT | 05.12.2012 | ||
BE | 05.12.2012 | ||
CY | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
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LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
MC | 05.12.2012 | ||
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PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
TR | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
HR | 31.07.2013 | ||
Former [2015/32] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CY | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
IT | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
MC | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
TR | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
HR | 31.07.2013 | ||
Former [2014/25] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CY | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
IT | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
MC | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
HR | 31.07.2013 | ||
Former [2014/09] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CY | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
IT | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
HR | 31.07.2013 | ||
Former [2014/03] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CY | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
IT | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
Former [2013/52] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CY | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
Former [2013/48] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CZ | 05.12.2012 | ||
DK | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
Former [2013/40] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CZ | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
PT | 05.04.2013 | ||
Former [2013/37] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
CZ | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
NL | 05.12.2012 | ||
PL | 05.12.2012 | ||
RO | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
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BE | 05.12.2012 | ||
CZ | 05.12.2012 | ||
EE | 05.12.2012 | ||
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
PL | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
SK | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
Former [2013/34] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
PL | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
BG | 05.03.2013 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
IS | 05.04.2013 | ||
Former [2013/33] | AT | 05.12.2012 | |
BE | 05.12.2012 | ||
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
PL | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
Former [2013/31] | AT | 05.12.2012 | |
FI | 05.12.2012 | ||
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
PL | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
Former [2013/26] | FI | 05.12.2012 | |
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
PL | 05.12.2012 | ||
SE | 05.12.2012 | ||
SI | 05.12.2012 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
Former [2013/23] | FI | 05.12.2012 | |
LT | 05.12.2012 | ||
LV | 05.12.2012 | ||
PL | 05.12.2012 | ||
SE | 05.12.2012 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
Former [2013/22] | FI | 05.12.2012 | |
LT | 05.12.2012 | ||
SE | 05.12.2012 | ||
NO | 05.03.2013 | ||
ES | 16.03.2013 | ||
Former [2013/21] | LT | 05.12.2012 | |
SE | 05.12.2012 | ||
NO | 05.03.2013 | ||
Former [2013/20] | LT | 05.12.2012 | |
NO | 05.03.2013 | Cited in | International search | [Y]WO2004087716 (COUNCIL SCIENT IND RES [IN], et al) [Y] 1-16 * page 1, line 16 - page 2, line 19 * * page 8 - page 12; examples 1-3 * * page 14 - page 16; table 2 * * claim 1 *; | [Y]WO2005063758 (COUNCIL SCIENT IND RES [IN]) [Y] 1-16 * page 1, line 15 - page 2, line 21 * * page 2; compounds DC-81 * * page 10; compounds IXA-IXG * * page 15 - page 17; tables 1-4 * * claim 1 *; | [Y]WO2007105045 (COUNCIL SCIENT IND RES [IN], et al) [Y] 1-16 * page 1, line 17 - page 3, line 3 * * page 10 - page 13; examples 1-3 * * page 14; table 1 * * claim 1 * | [Y] - KAMAL A ET AL, "DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 14, no. 2, ISSN 0968-0896, (20060115), pages 385 - 394, (20060115), XP025132916 [Y] 1-16 * page 386; figure 1; compounds 4, 6A-6D * * page 388; tables 2,3 * * page 389; figure 3 * DOI: http://dx.doi.org/10.1016/j.bmc.2005.08.020 | by applicant | - KUNIMOTO, S.; MASUDA, T.; KANBAYASHI, N.; HAMADA, M.; NAGANAWA, H.; MIYAMOTO, M.; TAKEUCHI, T.; UNEZAWA, H., J. ANTIBIOT., (1980), vol. 33, page 665 | - KOHN, K. W.; SPEOUS, C. L., J. MOL. BIOL., (1970), vol. 51, page 551 | - HURLEY, L. H.; GAIRPLA, C.; ZMIJEWSKI, M., BIOCHEM. BIOPHYS. ACTA., (1977), vol. 475, page 521 | - KAPLAN, D. J.; HURLEY, L. H., BIOCHEMISTRY, (1981), vol. 20, page 7572 | - KAMAL, A.; SRINIVAS, 0.; RAMULU, P.; RAMESH, G.; KUMAR, P. P, BIOORG. MED. CHEM. LETT., (2003), vol. 13, page 3577 | - O'NEIL, A.; THOMOSON.S.; KALINDJIAN, S. B.; JENKINS, T.C., TETRAHEDRON LETT., (2003), vol. 44, page 7809 |