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Extract from the Register of European Patents

EP About this file: EP2123672

EP2123672 - Modulation of IL-2- and IL-15- mediated T cell responses [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  01.04.2011
Database last updated on 15.06.2024
Most recent event   Tooltip01.04.2011Application deemed to be withdrawnpublished on 04.05.2011  [2011/18]
Applicant(s)For all designated states
Beth Israel Deaconess Medical Center, Inc.
One Deaconess Road
Boston, MA 02215 / US
[2009/48]
Inventor(s)01 / Li, Xian Chang
17 Hemlock Road
Newton, MA 02215 / US
02 / Strom, Terry
22 Kennard Road
Brookline, MA 02445 / US
03 / Zheng, Xin Xiao
5701 Centre Avenue Apartment 1212
Pittsburgh, PA 15206 / US
 [2009/48]
Representative(s)Lahrtz, Fritz, et al
Patentanwälte
Isenbruck Bösl Hörschler PartG mbB
Prinzregentenstraße 68
81675 München / DE
[N/P]
Former [2011/01]Lahrtz, Fritz, et al
Isenbruck Bösl Hörschler LLP Patentanwälte Prinzregentenstrasse 68
81675 München / DE
Former [2010/16]Redl, Gerda, et al
Tech Gate Vienna Donau-City-Straße 1
1220 Wien / AT
Former [2009/48]Bösl, Raphael Konrad
Isenbruck Bösl Hörschler Wichmann LLP Prinzregentenstrasse 68
81675 München / DE
Application number, filing date09004784.614.09.2001
[2009/48]
Priority number, dateUS20000232251P14.09.2000         Original published format: US 232251 P
[2009/48]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2123672
Date:25.11.2009
Language:EN
[2009/48]
Search report(s)(Supplementary) European search report - dispatched on:EP16.10.2009
ClassificationIPC:C07K14/54, C07K14/55, C07K14/715, C12N15/62, C07K19/00, C07K16/24, C07K16/28, A61K38/20, A61K39/395, A61P37/06
[2009/48]
CPC:
C07K14/55 (EP,US); A61K38/2013 (EP,US); A61K38/2086 (EP,US);
A61P1/00 (EP); A61P17/00 (EP); A61P17/06 (EP);
A61P19/02 (EP); A61P19/04 (EP); A61P19/08 (EP);
A61P21/00 (EP); A61P21/04 (EP); A61P25/00 (EP);
A61P29/00 (EP); A61P3/10 (EP); A61P31/18 (EP);
A61P35/00 (EP); A61P37/02 (EP); A61P37/06 (EP);
A61P43/00 (EP); A61P5/14 (EP); A61P5/30 (EP);
C07K14/5443 (EP,US); C07K2319/00 (EP,US); C07K2319/30 (EP,US) (-)
C-Set:
A61K38/2013, A61K2300/00 (US,EP);
A61K38/2086, A61K2300/00 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2009/48]
Extension statesAL31.03.2009
LT31.03.2009
LV31.03.2009
MK31.03.2009
RO31.03.2009
SI31.03.2009
TitleGerman:Modulation von IL-2- und IL-15-vermittelten T-Zellantworten[2009/48]
English:Modulation of IL-2- and IL-15- mediated T cell responses[2009/48]
French:Modulation des réponses de lymphocytes T induites par IL-2- et IL-15[2009/48]
Examination procedure31.03.2009Examination requested  [2009/48]
22.04.2010Despatch of a communication from the examining division (Time limit: M06)
03.11.2010Application deemed to be withdrawn, date of legal effect  [2011/18]
09.12.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2011/18]
Parent application(s)   TooltipEP01973022.5  / EP1349873
Fees paidRenewal fee
31.03.2009Renewal fee patent year 03
31.03.2009Renewal fee patent year 04
31.03.2009Renewal fee patent year 05
31.03.2009Renewal fee patent year 06
31.03.2009Renewal fee patent year 07
31.03.2009Renewal fee patent year 08
25.09.2009Renewal fee patent year 09
27.09.2010Renewal fee patent year 10
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XY]WO9741232  (BETH ISRAEL HOSPITAL [US]) [X] 14 * SEQ ID NO: 6, SEQ ID NO: 7; page 47, paragraph 1 - page 53, paragraph 1; figures 8,10,15; claim - * * page 15, paragraph 2 - page 20, paragraph 2 * * page 43 * [Y] 3-9,13;
 [A]WO9836768  (VLAAMS INTERUNIV INST BIOTECH [BE], et al) [A] * example -; claim - *;
 [X]  - YON SU KIM ET AL, "Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fcgamma2a protein blocks delayed-type hypersensitivity", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, (19980615), vol. 160, no. 12, ISSN 0022-1767, pages 5742 - 5748, XP002185136 [X] 1-12 * the whole document *
 [XY]  - BULFONE-PAUS SILVIA ET AL, "Differential regulation of human T lymphoblast functions by IL-2 and IL-15.", CYTOKINE, (1997), vol. 9, no. 7, ISSN 1043-4666, pages 507 - 513, XP002230804 [X] 1,2,10-12 * page 510, column R, paragraph 2 - page 511, column R, paragraph 3; figures 1,3 * [Y] 3-9

DOI:   http://dx.doi.org/10.1006/cyto.1996.0194
 [YD]  - ZHENG X X ET AL, "IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 OCT 1999, (19991001), vol. 163, no. 7, ISSN 0022-1767, pages 4041 - 4048, XP002230805 [YD] 13 * the whole document *
 [X]  - TINUBU S A ET AL, "HUMANIZED ANTIBODY DIRECTED TO THE IL-2 RECEPTOR BETA-CHAIN PROLONGS PRIMATE CARDIAC ALLOGRAFT SURVIVAL", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, (1994), vol. 153, ISSN 0022-1767, pages 4330 - 4338, XP002004292 [X] 1,6-9 * the whole document *
 [X]  - GUEX-CROSIER Y ET AL, "Humanized anti-IL-2 and anti-IL-15 receptor antibodies in the treatment of uveoretinitis in a monkey model.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996 Annual Meeting of the Association for Research in Vision and Ophthalmology;Fort Lauderdale, Florida, USA; April 21-26, 1996, (1996), vol. 37, no. 3, ISSN 0146-0404, page S896, XP008013716 [X] 1,5-8 * the whole document *
 [X]  - WALDMANN T A ET AL, "The use of antibodies against the IL-2 receptor in transplantation", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, (199810), vol. 10, no. 5, ISSN 0952-7915, pages 507 - 512, XP004327272 [X] 1,6-9 * page 509, column L, paragraph 4 - page 510, column R, paragraph 3 *

DOI:   http://dx.doi.org/10.1016/S0952-7915(98)80215-X
 [A]  - KIM Y S ET AL, "IMMUNOGLOBULIN-CYTOKINE FUSION MOLECULES: THE NEW GENERATION OF IMMUNOMODULATING AGENTS", TRANSPLANTATION PROCEEDINGS, ORLANDO, FL, US, (1998), vol. 30, no. 8, ISSN 0041-1345, pages 4031 - 4036, XP001031432 [A] * page 4035, column R, paragraph 2; table 4 *

DOI:   http://dx.doi.org/10.1016/S0041-1345(98)01330-X
 [A]  - RUECKERT RENE ET AL, "IL-15-IgG2b fusion protein accelerates and enhances a Th2 but not a Th1 immune response in vivo, while IL-2-IgG2b fusion protein inhibits both.", EUROPEAN JOURNAL OF IMMUNOLOGY, (199810), vol. 28, no. 10, ISSN 0014-2980, pages 3312 - 3320, XP002230807 [A] * the whole document *

DOI:   http://dx.doi.org/10.1002/(SICI)1521-4141(199810)28:10<3312::AID-IMMU3312>3.3.CO;2-9
 [T]  - MORELON EMMANUEL ET AL, "Sirolimus: A new promising immunosuppressive drug. Towards a rationale for its use in renal transplantation", NEPHROLOGY DIALYSIS TRANSPLANTATION, (200101), vol. 16, no. 1, ISSN 0931-0509, pages 18 - 20, XP002546164 [T] * the whole document *

DOI:   http://dx.doi.org/10.1093/ndt/16.1.18
 [PX]  - PHILLIPS K E ET AL, "IL-2Ralpha-directed Monoclonal Antibodies Provide Effective Therapy in a Murine Model of Adult T-Cell Leukemia by a Mechanism other than Blockade of IL-2/IL-2Ralpha Interaction", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, (20001215), vol. 60, ISSN 0008-5472, pages 6977 - 6984, XP002978176 [PX] 1-14 * the whole document *
by applicant   - LENARDO, NATURE, (1991), vol. 353, pages 858 - 861
    - DOOMS ET AL., J IMMUNOL., (1998), vol. 161, pages 2141 - 2150
    - BULFONE ET AL., NATURE MEDICINE, (1997), vol. 3, pages 1124 - 1128
    - KU ET AL., SCIENCE, (2000), vol. 288, pages 675 - 678
    - HORAK ET AL., IMMUNOL. REV., (1995), vol. 148, pages 35 - 44
    - KENNEDY ET AL., J. EXP. MED., (2000), vol. 191, pages 771 - 780
    - LODOLCE ET AL., IMMUNITY, (1998), vol. 2, pages 669 - 676
    - SUGAMURA ET AL., ANN. REV. IMMUNOL., (1996), vol. 14, pages 179 - 205
    - GIRI ET AL., EMBO J, (1995), vol. 14, pages 3654 - 3663
    - CHAE ET AL., J IMMUNOL., (1996), vol. 157, pages 2813 - 2819
    - ISHII ET AL., INT. IMMUNOL., (1994), vol. 6, pages 1273 - 1277
    - LI ET AL., J IMMUNOL., (1998), vol. 161, pages 890 - 896
    - MORRISON ET AL., THE IMMUNOLOGIST, (1994), vol. 2, pages 119 - 124
    - BREKKE ET AL., THE IMMUNOLOGIST, (1994), vol. 2, page 125
    - BLANAR ET AL., SCIENCE, (1992), vol. 256, page 1014
    - LECLAIR ET AL., PROC. NATL. ACAD SCI. USA, (1992), vol. 89, page 8145
    - ZHENG ET AL., J. IMMUNOL., (1999), vol. 163, pages 4041 - 4048
    - TU ET AL., J. IMMUNOL., (2000), vol. 165, pages 1331 - 1336
    - TSUDA ET AL., J IMMUNOL. METH., (2000), vol. 236, pages 37 - 51
    - BERTOLINO ET AL., INT. IMMUNOL., (1999), vol. 11, pages 1225 - 1238
    - TAKAHASHI, J. IMMUNOL., (1999), vol. 162, pages 5037 - 5040
    - PILLING ET AL., EUR. J. IMMUNOL., (1999), vol. 29, pages 1041 - 1050
    - CHU ET AL., J. IMMUNOL., (1999), vol. 162, pages 1896 - 1903
    - WEINBERG ET AL., SEMIN IMMUNOL., (1998), vol. 10, pages 471 - 480
    - ONO ET AL., J. THORAC. CARDIOVASC. SURG., (1969), vol. 57, page 225
    - CONY ET AL., TRANSPLANTATIOFI, (1973), vol. 16, page 343
    - GOTOH ET AL., TRANSPLANTATION, (1986), vol. 42, page 387
    - BIELSCHOWSKY ET AL., PROC. UNIV. OTAGO MED SCH., (1959), vol. 37, page 9
    - DATA, NATURE, (1976), vol. 263, page 412
    - EASTCOTT ET AL., J IMMUNOL., (1983), vol. 131, page 2232
    - THEOFILOPOULOS ET AL., ADV. IMMUNOL., (1985), vol. 37, page 269
    - CHERNAJOVSKY ET AL., GENE THERAPY, (1995), vol. 2, pages 731 - 735
    - COLE ET AL., SCIENCE, (1968), vol. 160, page 1357
    - LENNON ET AL., ANN. N. Y. ACAD SCI., (1976), vol. 274, page 283
    - ROSENBERG ET AL., GENE, (1987), vol. 56, page 125
    - LEE; NATHANS, J. BIOL CHEM., (1988), vol. 263, page 3521
    - Eukaryotic Viral Vectors, CSH LABORATORY PRESS
    - BLANAR, SCIENCE, (1992), vol. 256, page 1014
    - LECLAIR ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, page 8145
    - ANDERSON ET AL., J. BIOL CHEM., (1995), vol. 270, page 29862
    - GIRI ET AL., EMBO J., (1995), vol. 14, page 3654
    - LECLAIR ET AL., PROC. NATL. ACAD SCI. USA, (1989), vol. 89, page 8145
    - CHAE ET AL., J. IMMUNOL., (1996), vol. 157, pages 2813 - 2819
    - KIM ET AL., J IMMZMOL., (1998), vol. 161, pages 5742 - 5748
    - LI ET AL., J IMMUNOL., (2000), vol. 164, pages 1193 - 1199
    - WELLS ET AL., J CLIN. INVEST., (1997), vol. 100, pages 3173 - 3183
    - CHAE, J IMMUNOL., (1996), vol. 157, pages 2813 - 2819
    - LI, NATURE MEDICINE, (1999), vol. 5, pages 1298 - 1302
    - HEMAR ET AL., J CELL. BIOL., (1995), vol. 129, pages 55 - 64
    - TAGAYA ET AL., IMMUNITY, (1996), vol. 4, pages 329 - 336
    - NAKAJIMA ET AL., J EXP. MED., (1997), vol. 185, pages 189 - 195
    - LI ET AL., J. IMMUNOL., (1999), vol. 163, pages 2500 - 2507
    - NAKAJIMA ET AL., J. EXP. MED., (1997), vol. 185, pages 189 - 195
    - KIM ET AL., J. IMMUNOL., (1998), vol. 161, pages 5742 - 5748
 US20000232251
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.