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Extract from the Register of European Patents

EP About this file: EP2157415

EP2157415 - Microscopy imaging system and method employing stimulated Raman spectroscopy as a contrast mechanism [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.06.2016
Database last updated on 14.09.2024
Most recent event   Tooltip22.06.2018Lapse of the patent in a contracting state
New state(s): MK		published on 25.07.2018  [2018/30]
Applicant(s)For all designated states
President and Fellows of Harvard College
17 Quincy Street
Cambridge, MA 02138 / US
[2015/31]
Former [2010/08]For all designated states
President and Fellows of Harvard College
17 Quincy Street
Cambridge, MA 02138 / US
Inventor(s)01 / Xie, Xiaoliang Sunney
135 Grant Street
Lexington, MA 02420 / US
02 / Freudiger, Christian
141 Charles Street No. 5
Boston, MA 02114 / US
03 / Min, Wei
540 Memorial Drive, Apt. 204
Cambridge, MA 02139 / US
 [2010/08]
Representative(s)Pfenning, Meinig & Partner mbB
Patent- und Rechtsanwälte
Theresienhöhe 11a
80339 München / DE
[N/P]
Former [2015/31]Pfenning, Meinig & Partner GbR
Patent- und Rechtsanwälte
Theresienhöhe 11a
80339 München / DE
Former [2010/08]Pfenning, Meinig & Partner GbR
Patent- und Rechtsanwälte Theresienhöhe 13
80339 München / DE
Application number, filing date09010121.305.08.2009
[2010/08]
Priority number, dateUS2008019674622.08.2008         Original published format: US 196746
[2010/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2157415
Date:24.02.2010
Language:EN
[2010/08]
Type: B1 Patent specification 
No.:EP2157415
Date:29.07.2015
Language:EN
[2015/31]
Search report(s)(Supplementary) European search report - dispatched on:EP11.01.2010
ClassificationIPC:G01J3/44, G01N21/65
[2010/08]
CPC:
G01J3/44 (EP,US); G01N21/65 (EP,US); G01N2021/653 (EP,US);
G01N2021/655 (EP,US); G01N2021/656 (EP,US); G01N2201/08 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2015/31]
Former [2010/08]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:Mikroskopie-Bildgebungssystem und Verfahren, das stimulierte Raman-Spektroskopie als einen Kontrastmechanismus einsetzt[2010/08]
English:Microscopy imaging system and method employing stimulated Raman spectroscopy as a contrast mechanism[2010/08]
French:Système d'imagerie de microscopie et procédé employant une spectroscopie de Raman stimulée en tant que mécanisme de contraste[2010/08]
Examination procedure28.08.2009Examination requested  [2010/08]
03.05.2010Despatch of a communication from the examining division (Time limit: M04)
13.09.2010Reply to a communication from the examining division
30.03.2012Despatch of a communication from the examining division (Time limit: M04)
08.08.2012Reply to a communication from the examining division
19.01.2015Cancellation of oral proceeding that was planned for 20.01.2015
20.01.2015Date of oral proceedings (cancelled)
26.02.2015Communication of intention to grant the patent
17.06.2015Fee for grant paid
17.06.2015Fee for publishing/printing paid
17.06.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  03.05.2010
Opposition(s)02.05.2016No opposition filed within time limit [2016/27]
Fees paidRenewal fee
25.08.2011Renewal fee patent year 03
27.08.2012Renewal fee patent year 04
27.08.2013Renewal fee patent year 05
27.08.2014Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.08.2009
AT29.07.2015
BG29.07.2015
CY29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
MK29.07.2015
MT29.07.2015
NL29.07.2015
PL29.07.2015
RO29.07.2015
SE29.07.2015
SI29.07.2015
SK29.07.2015
SM29.07.2015
TR29.07.2015
IE05.08.2015
LU05.08.2015
BE31.08.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
[2018/30]
Former [2018/02]HU05.08.2009
AT29.07.2015
BG29.07.2015
CY29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
MT29.07.2015
NL29.07.2015
PL29.07.2015
RO29.07.2015
SE29.07.2015
SI29.07.2015
SK29.07.2015
SM29.07.2015
TR29.07.2015
IE05.08.2015
LU05.08.2015
BE31.08.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2017/39]HU05.08.2009
AT29.07.2015
BG29.07.2015
CY29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
MT29.07.2015
NL29.07.2015
PL29.07.2015
RO29.07.2015
SE29.07.2015
SI29.07.2015
SK29.07.2015
SM29.07.2015
TR29.07.2015
IE05.08.2015
BE31.08.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2017/21]AT29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
MT29.07.2015
NL29.07.2015
PL29.07.2015
RO29.07.2015
SE29.07.2015
SI29.07.2015
SK29.07.2015
IE05.08.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/36]AT29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
NL29.07.2015
PL29.07.2015
RO29.07.2015
SE29.07.2015
SI29.07.2015
SK29.07.2015
IE05.08.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/33]AT29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
NL29.07.2015
PL29.07.2015
RO29.07.2015
SE29.07.2015
SK29.07.2015
IE05.08.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/23]AT29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
NL29.07.2015
PL29.07.2015
RO29.07.2015
SE29.07.2015
SK29.07.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/22]AT29.07.2015
CZ29.07.2015
DK29.07.2015
EE29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
MC29.07.2015
NL29.07.2015
PL29.07.2015
SE29.07.2015
CH31.08.2015
LI31.08.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/21]AT29.07.2015
DK29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
IT29.07.2015
LT29.07.2015
LV29.07.2015
NL29.07.2015
PL29.07.2015
SE29.07.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/20]AT29.07.2015
DK29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
LT29.07.2015
LV29.07.2015
NL29.07.2015
PL29.07.2015
SE29.07.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/14]AT29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
LT29.07.2015
LV29.07.2015
NL29.07.2015
PL29.07.2015
SE29.07.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/11]AT29.07.2015
ES29.07.2015
FI29.07.2015
HR29.07.2015
LT29.07.2015
LV29.07.2015
PL29.07.2015
SE29.07.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/10]ES29.07.2015
FI29.07.2015
HR29.07.2015
LT29.07.2015
LV29.07.2015
PL29.07.2015
SE29.07.2015
NO29.10.2015
GR30.10.2015
IS29.11.2015
PT30.11.2015
Former [2016/09]FI29.07.2015
LT29.07.2015
LV29.07.2015
NO29.10.2015
GR30.10.2015
Former [2016/08]LT29.07.2015
NO29.10.2015
Former [2016/07]LT29.07.2015
Documents cited:Search[DY]  - PLOETZ E ET AL, "Femtosecond stimulated Raman microscopy", APPLIED PHYSICS B ; LASERS AND OPTICS, SPRINGER, BERLIN, DE, (20070412), vol. 87, no. 3, ISSN 1432-0649, pages 389 - 393, XP019515599 [DY] 1-23 * page 390 - page 392; figures 1,2 *

DOI:   http://dx.doi.org/10.1007/s00340-007-2630-x
 [Y]  - ANDREAS VOLKMER, "Vibrational imaging and microspectroscopies based on coherent anti-Stokes Raman scattering (CARS)", FRISNO-8, Ein Bokek, URL: http://www.weizmann.ac.il/conferences/frisno8/presentations05/monday/Volkmer.pdf, (20050225), XP002561572 [Y] 1-23 * pages 23-25 *
 [Y]  - SAIKAN S ET AL, "Inverse Raman spectroscopy in dye solutions with synchronized cw picosecond lasers", OPTICS COMMUNICATIONS, NORTH-HOLLAND PUBLISHING CO. AMSTERDAM, NL, vol. 51, no. 6, ISSN 0030-4018, (19841015), pages 420 - 424, (19841015), XP024537303 [Y] 1-23 * pages 420-421; figure 1 * * page 423 *

DOI:   http://dx.doi.org/10.1016/0030-4018(84)90130-5
 [Y]  - GANIKHANOV F ET AL, "High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy", Optics Letters Opt. Soc. America USA, (20060615), vol. 31, no. 12, ISSN 0146-9592, pages 1872 - 1874, XP002561573 [Y] 1-23 * page 1873; figure 1c *

DOI:   http://dx.doi.org/10.1364/OL.31.001872
Examination   - EXTER M V ET AL, "Observation of the phase of a Raman oscillation", OPTICS COMMUNICATIONS, NORTH-HOLLAND PUBLISHING CO. AMSTERDAM, NL, vol. 70, no. 5, doi:10.1016/0030-4018(89)90146-6, ISSN 0030-4018, (19890401), pages 433 - 438, (19890401), XP024476891

DOI:   http://dx.doi.org/10.1016/0030-4018(89)90146-6
    - VAN EXTER M ET AL, "What is measured in a time-resolved stimulated Raman experiment?", OPTICS COMMUNICATIONS, NORTH-HOLLAND PUBLISHING CO. AMSTERDAM, NL, vol. 56, no. 3, doi:10.1016/0030-4018(85)90115-4, ISSN 0030-4018, (19851201), pages 191 - 196, (19851201), XP024444928

DOI:   http://dx.doi.org/10.1016/0030-4018(85)90115-4
    - B. LEVINE ET AL, "Ultrahigh sensitivity stimulated Raman gain spectroscopy", IEEE JOURNAL OF QUANTUM ELECTRONICS, (19800101), vol. 16, no. 1, doi:10.1109/JQE.1980.1070342, ISSN 0018-9197, pages 85 - 89, XP055113513

DOI:   http://dx.doi.org/10.1109/JQE.1980.1070342
    - T.R. CORLE, G.S. KINO, Confocal scanning optical microscopy and related imaging systems, SAN DIEGO, ACADEMIC PRESS, ISBN 0-12-408750-7
    - PLOETZ E ET AL, "Femtosecond stimulated Raman microscopy", APPLIED PHYSICS B ; LASERS AND OPTICS, SPRINGER, BERLIN, DE, (20070412), vol. 87, no. 3, doi:10.1007/S00340-007-2630-X, ISSN 1432-0649, pages 389 - 393, XP019515599

DOI:   http://dx.doi.org/10.1007/s00340-007-2630-x
by applicantUS6798507
 US6809814
 US2008037595
 US7352458
 US7414729
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