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Extract from the Register of European Patents

EP About this file: EP2070939

EP2070939 - Modulators of pharmacological agents [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.02.2015
Database last updated on 28.03.2024
Most recent event   Tooltip06.02.2015No opposition filed within time limitpublished on 11.03.2015  [2015/11]
Applicant(s)For all designated states
Duke University
Office of Licensing & Ventures
2812 Erwin Road, Suite 306
Box 90083
Durham, NC 27705 / US
[2014/27]
Former [2009/25]For all designated states
Duke University
Office of Science and Technology, P.O. Box 90083
Durham, NC 27708-0083 / US
Inventor(s)01 / Sullenger, Bruce A.
St. Andrews Court
Durham, NC 27707 / US
02 / Rusconi, Christopher
1429 Pennsylvania Avenue
Durham, NC 27705 / US
 [2014/14]
Former [2009/25]01 / Sullenger, Bruce A.
St. Andrews Court
Durham, NC 27707 / US
02 / Rusconi, Christopher
1429 Pennsylvania Avenue
Durham, NC 27705 / US
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[N/P]
Former [2014/14]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Former [2009/35]HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
Former [2009/25]HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
Application number, filing date09156205.828.05.2002
[2009/25]
Priority number, dateUS20010293231P25.05.2001         Original published format: US 293231 P
US20010331037P07.11.2001         Original published format: US 331037 P
[2009/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2070939
Date:17.06.2009
Language:EN
[2009/25]
Type: B1 Patent specification 
No.:EP2070939
Date:02.04.2014
Language:EN
[2014/14]
Search report(s)(Supplementary) European search report - dispatched on:EP08.05.2009
ClassificationIPC:C12N15/113, C12N15/115
[2013/41]
CPC:
C12N15/113 (EP,US); C12N15/1137 (US); A61P25/00 (EP);
A61P25/02 (EP); A61P25/14 (EP); A61P3/08 (EP);
A61P31/00 (EP); A61P35/00 (EP); A61P37/02 (EP);
A61P37/04 (EP); A61P37/06 (EP); A61P39/02 (EP);
A61P43/00 (EP); A61P7/00 (EP); A61P7/02 (EP);
A61P7/04 (EP); C12N15/115 (EP,US); C12Y304/21022 (EP,US);
C12N2310/321 (EP,US); C12N2310/322 (EP,US); C12N2310/3515 (EP,US) (-)
C-Set:
C12N2310/321, C12N2310/3521 (EP,US)
Former IPC [2009/25]C07H21/04, C12Q1/68
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2009/25]
TitleGerman:Modulatoren von pharmakologischen Wirkstoffen[2009/25]
English:Modulators of pharmacological agents[2009/25]
French:Modulateurs d'agents pharmacologiques[2009/25]
Examination procedure25.03.2009Examination requested  [2009/25]
05.02.2010Despatch of a communication from the examining division (Time limit: M06)
09.08.2010Reply to a communication from the examining division
16.09.2010Despatch of a communication from the examining division (Time limit: M06)
04.05.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
14.07.2011Reply to a communication from the examining division
29.10.2013Communication of intention to grant the patent
17.02.2014Fee for grant paid
17.02.2014Fee for publishing/printing paid
Parent application(s)   TooltipEP02739409.7  / EP1401853
Divisional application(s)EP10181597.5  / EP2364990
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20020739409) is  13.10.2006
Opposition(s)06.01.2015No opposition filed within time limit [2015/11]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
14.07.2011Request for further processing filed
14.07.2011Full payment received (date of receipt of payment)
Request granted
28.07.2011Decision despatched
Fees paidRenewal fee
25.03.2009Renewal fee patent year 03
25.03.2009Renewal fee patent year 04
25.03.2009Renewal fee patent year 05
25.03.2009Renewal fee patent year 06
25.03.2009Renewal fee patent year 07
25.03.2009Renewal fee patent year 08
26.05.2010Renewal fee patent year 09
27.05.2011Renewal fee patent year 10
30.03.2012Renewal fee patent year 11
10.05.2013Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY02.04.2014
[2014/47]
Documents cited:Search[A]WO0127263  (AGENCY IND SCIENCE TECHN [JP], et al);
 [A]  - RUSCONI C P ET AL, "BLOCKING THE INITIATION OF COAGULATION BY RNA APTAMERS TO FACTOR VIIA", THROMBOSIS AND HAEMOSTASIS, STUTTGART, DE, (200011), vol. 84, no. 5, ISSN 0340-6245, pages 841 - 848, XP008021933
 [A]  - OSBORNE SCOTT E ET AL, "Aptamers as therapeutic and diagnostic reagents: Problems and prospects", CURRENT OPINION IN CHEMICAL BIOLOGY, (199706), vol. 1, no. 1, ISSN 1367-5931, pages 5 - 9, XP002280742

DOI:   http://dx.doi.org/10.1016/S1367-5931(97)80102-0
 [A]  - HICKE BRIAN J ET AL, "Escort aptamers: A delivery service for diagnosis and therapy", JOURNAL OF CLINICAL INVESTIGATION, (200010), vol. 106, no. 8, ISSN 0021-9738, pages 923 - 928, XP002280743

DOI:   http://dx.doi.org/10.1172/JCI11324
 [A]  - WHITE REBEKAH R ET AL, "Developing aptamers into therapeutics", JOURNAL OF CLINICAL INVESTIGATION, (200010), vol. 106, no. 8, ISSN 0021-9738, pages 929 - 934, XP002280744

DOI:   http://dx.doi.org/10.1172/JCI11325
by applicantUS5621092
 US4415732
 US4458066
 US4500707
 US4668777
 US4973679
 WO9119813
 US5153319
 US5180818
 US5245022
 US5270163
 US5278302
 US5453496
 US5459015
 US5472841
 US5475096
 US5476766
 US5496938
 US5503978
 US5512462
 US5527894
 US5534408
 US5539082
 US5543293
 US5565327
 US5567588
 US5580737
 US5582981
 US5585269
 US5587468
 US5595877
 US5597696
 US5599917
 US5602244
 EP0593901
 US5622828
 US5629155
 US5629407
 US5631156
 US5631146
 US5635615
 US5637461
 US5637682
 US5637459
 US5639868
 US5639428
 US5641629
 US5648214
 US5650275
 US5654151
 US5656739
 US5656467
 US5658738
 US5660985
 US5660855
 US5663064
 US5668264
 US5668265
 US5670637
 US5670633
 US5674685
 US5681702
 US5683867
 US5686242
 US5686592
 US5688935
 US5688670
 US5693502
 US5696249
 US5698442
 US5698426
 US5698401
 US5705337
 US5707796
 US5712375
 US5723323
 US5723594
 US5723592
 US5723289
 US5726017
 US5726014
 US5731144
 US5731424
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 US6329146
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 US6387620
    - TUERK ET AL., SCIENCE, (1990), vol. 249, pages 505 - 10
    - FLOEGE ET AL., AM J PATHOL, (1999), vol. 154, pages 169 - 179
    - OSTENDORFET, J CLIN INVEST, (1999), vol. 104, pages 913 - 923
    - OSTENDORF ET AL., J CLIN INVEST, (1999), vol. 104, pages 913 - 923
    - GRIFFIN ET AL., BLOOD, (1993), vol. 81, pages 3271 - 3276
    - HICKE ET AL., J CLIN INVEST, (2000), vol. 106, pages 923 - 928
    - WILLIS ET AL., BIOCONJUG CHEM, (1998), vol. 9, pages 573 - 582
    - TUCKER ET AL., J CHROMATOGRBIOMED SCI APPL, (1999), vol. 732, pages 203 - 212
    - WATSON ET AL., ANTISENSE NUCLEIC ACID DRUG DEV, (2000), vol. 10, pages 63 - 75
    - WILLIAMS ET AL., PROC. NATL. ACAD. SCI., (1997), vol. 94, page 11285
    - LEVA, CHEM. BIOL., (2002), vol. 9, page 351
    - RISCONI ET AL., THROMBOSIS AND HAEMOSTASIS, (2000), vol. 83, pages 841 - 848
    - WHITE ET AL., J. CLIN INVEST, (2000), vol. 106, pages 929 - 34
    - ISHIZAKI ET AL., NAT MED, (1996), vol. 2, pages 1386 - 1389
    - LEE ET AL., NAT BIOTECHNOL, (1997), vol. 15, pages 41 - 45
    - ALDAZ-CARROLL L ET AL., "Apical loop-internal loop interactions: a new RNA-RNA recognition motif identified through in vitro selection against RNA hairpins of the hepatitis C virus mRNA", BIOCHEMISTRY, (20020507), vol. 41, no. 18, pages 5883 - 93
    - DARFEUILLE F ET AL., "RNA and N3'-->P5' kissing aptamers targeted to the trans-activation responsive (TAR) RNA of the human immunodeficiency virus-I", NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS, (200104), vol. 20, no. 4-7, pages 441 - 9
    - COLLIN D ET AL., "NMR characterization of a kissing complex formed between the TAR RNA element of HIV-1 and a DNA aptamer", NUCLEIC ACIDS RES., (20000901), vol. 28, no. 17, pages 3386 - 91
    - DUCONGE F; DI PRIMO C; TOULME JJ., "Is a closing "GA pair" a rule for stable loop-loop RNA complexes", JBIOL CHEM., (20000714), vol. 275, no. 28, pages 21287 - 94
    - DUCONGE F; TOULME JJ, "In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HTV-1", RNA, (199912), vol. 5, no. 12, pages 1605 - 14
    - BOIZIAU C ET AL., "DNA aptamers selected against the HIV-1 trans-activation-responsive RNA element form RNA-DNA kissing complexes", J BID CHEM., (19990430), vol. 274, no. 18, pages 12730 - 7
    - LE TINEVEZ R; MISHRA RK; TOULME JJ., "Selective inhibition of cell-free translation by oligonucleotides targeted to a mRNA hairpin structure", NUCLEIC ACIDS RES., (19980515), vol. 26, no. 10, pages 2273 - 8
    - HICKE ET AL., J. CLIN. INVEST., (2000), vol. 06, page 923
    - RINGQUIST ET AL., CYTOMETRY, (1998), vol. 33, page 394
    - HICKE ET AL., J. CLIN. INVEST., (2000), vol. 106, page 923
    - WONG; LOHMAN, PROC. NATL ACAD. SCI. 'USA, (1993), vol. 90, pages 5428 - 5432
    - CACECI, M. ET AL., BYTE, (1984), vol. 9, pages 340 - 362
    - HWANG ET AL., PROC. NATL. ACAD. SCI. USA, (1999), vol. 96, page 12997
    - DAVIS ET AL., RNA World, COLD SPRING HARBOR LABORATORY PRESS, (1993), page 185
    - WERSTUCK ET AL., SCIENDE, (1998), vol. 282, page 296
    - CHASE ET AL., ANN. REV. BIOCHEM., (1986), vol. 56, page 103
    - EICHORN ET AL., J. AM. CHEM. SOC., (1968), vol. 90, page 7323
    - DALE ET AL., BIOCHEMISTRY, (1975), vol. 14, page 2447
    - LIPPARD ET AL., ACC. CHEM. RES., (1978), vol. 11, page 211
    - XIA ET AL., BIOCHEM., (1998), vol. 37, page 14719
    - EGUCHI ET AL., "Antigensis RNA", ANNU. REV. BIOCHEM., (1991), vol. 60, page 631
    - OKANO, J., NEUROCHEIN, (1991), vol. 56, page 560
    - MANOHARAN, BIOCHEM. BIOPHYS. ACTA, (1999), vol. 1489, page 117
    - HERDEWIJA, ANTISENSE NUCLEIC ACID DRUG DEVELOPMENT, (2000), vol. 10, page 297
    - MAIER ET AL., ORGANIC LETTERS, (2000), vol. 2, page 1819
    - "Pibozyme Protocols", Molecular Biology, HUMANA PRESS, (1997), vol. 74
    - NIELSEN ET AL., SCIENCE, (1991), vol. 254, page 1497
    - QIN ET AL., ANTISENSE NUCLEIC ACID DRUG DEV., (2000), vol. 10, page 11
    - SUMMERTON, ANTISENSE NUCLEIC ACID DRUG DEV., (1997), vol. 7, page 187
    - SUMMERTON ET AL., ANTISENSE NUCLEIC ACID DRUG DEV., (1997), vol. 7, page 63
    - TAYLOR ET AL., J BIOL CHEM., (1996), vol. 271, page 17445
    - PARTRIDGE ET AL., ANTISENSE NUCLEIC ACID DRUG DEV., (1996), vol. 6, page 169
    - NIELSEN ET AL., J BIOMOL STRUCT DYN, (1999), vol. 17, page 175
    - PETERSEN ET AL., J MOL RECOGNIT, (2000), vol. 13, page 44
    - NIELSEN ET AL., BIOCONJUG CHERN, (2000), vol. 11, page 228
    - FRONTIERS IN BIOSCIENCE, vol. 4, (19991101), pages D782 - 786, URL: www.bioscience.org/1999/v4/d/soomets/fulltet.htm
    - "Antisense Research and Application", Boca Raton, CRC PRESS, pages 363 - 373
    - HYRUP, B. ET AL., "Modification of the binding affinity of peptide nucleic acids (PNA). PNA with extended backbones consisting of 2-Aminoethyl--Alamne or 3-Aminopropylglycine units", J. CHEM. SOC. CHEM. COMMUN., (1993), pages 519 - 519
    - DEMIDOV, V. ET AL., "Sequence selective double strand DNA cleavage by PNA targeting using nuclease S1", NUCLEIC ACIDS RES., (1993), vol. 21, pages 2103 - 2107
    - NIELSEN, P.E., "Peptide Nucleic Acid (PNA) A model structure for the primordial genetic material", ORIGINS OF LIFE, (1993), vol. 23, pages 323 - 327
    - EGHOLM, M. ET AL., "Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences", J. CHEM. SOC. CHEN. COMMUN, (1993), pages 800 - 801
    - KIM, S.K. ET AL., "Right-handed triplex formed between peptide nucleic acid PNA-T8 and poly(dA) shown by linear and circular dichroism spectroscopy", J. AMER. CHEN. SOC., (1993), vol. 115, pages 6477 - 6481
    - EGHOLM, M. ET AL., "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen bonding rules", NATURE, (1993), vol. 365, pages 556 - 568
    - BUCHARDT, 0. ET AL., "Peptide Nucleic Acids (PNA) and their potential applications in medicine and biotechnology", TRENDS BIOTECHNOLOGY, (1993), vol. 11, pages 384 - 386
    - ALDRIAN-HERRADA, G. ET AL., NUCLEIC ACID RES., (1998), vol. 26, page 4920
    - PARDRIDGE, W. ET AL., PNAS, (1995), vol. 92, pages 5592 - 5596
    - CHINNERY, P. F. ET AL., GENE THER., (1999), vol. 6, pages 1919 - 28
    - SCARFI, S. ET AL., "Synthesis, uptake, and intracellular metabolism of a hydrophobic tetrapeptide- peptide nucleic acid (PNA)-biotin molecule", BIOCHEM BIOPHYS RES COMMUN, (1997), vol. 236, pages 323 - 326
    - BIOCONJUGATE CHEM, (1997), vol. 8, pages 481 - 499
    - NIELSEN, P. E. ET AL., SCIENCE, (1991), vol. 254, pages 1497 - 1500
    - EGHOLM, M. ET AL., "Peptide nucleic acids (PNA). Oligonucleotide analogues with an achiral peptide backbone", JAM CHEM SOC, (1992), vol. 114, pages 1895 - 1897
    - NIELSEN, P. E.; M. EGHOLM; O. BUCHARDT, "Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone", BIOCONJUGATE CHEMISTRY 5, (1994), pages 3 - 7
    - EGHOLM, M. ET AL., "Recognition of guanine and adenine in DNA by cytosine and thymine containing peptide nucleic acid", JAM CHEM SOC, (1992), vol. 114, pages 9677 - 9678
    - EGHOLM, M. ET AL., "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules [see comments]", NATURE, (1993), vol. 365, pages 566 - 568
    - WITTUNG, P. ET AL., "DNA- like double helix formed by peptide nucleic acid", NATURE, (1994), vol. 368, pages 561 - 563
    - BROWN, S. C. ET AL., "NMR solution structure of a peptide nucleic acid complexed with RNA", SCIENCE, (1994), vol. 265, pages 777 - 780
    - DEMIDOV, V. V. ET AL., "Stability of peptide nucleic acids in human serum and cellular extracts", BIOCHEMICAL PHARMACOLOGY, (1994), vol. 48, pages 1310 - 1313
    - PEFFER, N. J. ET AL., "Strand-invasion of duplex DNA by peptide nucleic acid oligomers", PROC NAT ACAD SCI USA, (1993), vol. 90, pages 10648 - 10652
    - TETRAHEDRON, (1998), vol. 54, pages 3607 - 3630
    - HWANG ET AL., PROC NATL ACAD SCI USA, (1999), vol. 96, page 12997
    - SULLENGER ET AL., MOL. CELL BIOL., (1990), vol. 10, page 6512
    - RUSCONI ET AL., THROMBOSIS AND HAEMOSTASIS, (2000), vol. 83, pages 841 - 848
    - WARKENTIN ET AL., THROMB HAEMOST, (1998), vol. 79, pages 1 - 7
    - WARKENTIN ET AL., THRAMB HAEMOST, (1998), vol. 79, pages 1 - 7
    - GREINACHER ET AL., CIRCULATION, (1999), vol. 99, pages 73 - 80
    - LEWIS ET AL., CIRCULATION, (2001), vol. 103, pages 1838 - 1843
    - ORTEL ET AL., THROMB HAEMOST, (1992), vol. 67, pages 292 - 296
 US19900536428
 US19920931473
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