blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2308883

EP2308883 - New derivatives of thieno[2,3-b]pyridine and 5,6,7,8 tetrahydrothieno[2,3 b]quinoline in particular useful in the treatment of malaria [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  09.03.2012
Database last updated on 02.07.2024
Most recent event   Tooltip09.03.2012Application deemed to be withdrawnpublished on 11.04.2012  [2012/15]
Applicant(s)For all designated states
Centre National de la Recherche Scientifique
3, rue Michel Ange
75794 Paris Cedex 16 / FR
[N/P]
Former [2011/15]For all designated states
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
3, rue Michel Ange
75794 Paris Cedex / FR
Inventor(s)01 / MEIJER, Laurent
16 rue de Bir-Hakeim
29680, ROSCOFF / FR
02 / KUNICK, Conrad
Stremelkamp 48 A
21149, HAMBURG / DE
03 / BRANDT, Wiebke
Maschplatz 4
38114, BRAUNSCHWEIG / DE
04 / DOERIG, Christian
14 rue de la Gare
1110, MORGES / CH
 [2011/15]
Representative(s)Le Coupanec, Pascale A.M.P.
Nony
11 rue Saint-Georges
75009 Paris / FR
[N/P]
Former [2011/15]Le Coupanec, Pascale A.M.P.
Nony & Associés 3, rue de Penthièvre
75008 Paris / FR
Application number, filing date09172257.905.10.2009
[2011/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2308883
Date:13.04.2011
Language:EN
[2011/15]
Search report(s)(Supplementary) European search report - dispatched on:EP18.05.2010
ClassificationIPC:C07D495/04, C07D495/14, A61K31/4365, A61K31/519, A61P33/06
[2011/15]
CPC:
C07D495/04 (EP); A61P33/06 (EP); C07D495/14 (EP);
Y02A50/30 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2011/15]
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:Neue Derivate aus Thieno[2,3-B]pyridin und 5,6,7,8 Tetrahydrothieno[2,3]chinolin, insbesondere nützlich zur Malariabehandlung[2011/15]
English:New derivatives of thieno[2,3-b]pyridine and 5,6,7,8 tetrahydrothieno[2,3 b]quinoline in particular useful in the treatment of malaria[2011/15]
French:Nouveaux dérivés de thiéno[2,3-b]pyridine et 5,6,7,8 tétrahydrothiéno[2,3 b]quinoline utiles en particulier pour le traitement du paludisme[2011/15]
Examination proceduredeletedCommunication of intention to grant the patent
14.10.2011Application deemed to be withdrawn, date of legal effect  [2012/15]
25.11.2011Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2012/15]
Fees paidRenewal fee
26.10.2011Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]US2009163545  (GOLDFARB DAVID SCOTT [US]) [X] 1,4,9,12 * the whole document *;
 [X]  - MAY BARNABY C H ET AL, "Structure-Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds: Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, (20070101), vol. 50, no. 1, ISSN 0022-2623, pages 65 - 73, XP007907074 [X] 1-2,9,12 * Scheme 2; page 66 *

DOI:   http://dx.doi.org/10.1021/jm061045z
    [ ] - "Supporting Information of: Structure-Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds: Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, (20070101), vol. 50, no. 1, pages S1 - S11, XP002567547 [ ] * page S10 *
 [X]  - V. D. DYACHENKO, S. G. KRIVOKOLYSKO, YU. A. SHARANIN AND V. P. LITVINOV, "New method for the synthesis of 6-amino-4-aryl-3,5-dicyano-3,4-dihydropyridine-2(1H)-thiones by recyclization of 4-aryl-2,6-diamino-4H-thiopyranes", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, (199707), vol. 33, no. 7, doi:10.1007/BF02253028, pages 793 - 798, XP002566749 [X] 1-3,9,11-12 * page 794; compounds VIIIh-k *

DOI:   http://dx.doi.org/10.1007/BF02253028
 [X]  - "3,6-diamino-4-(2-thienyl)-thieno[2.3-b]pyridine-2,5-dicarbonitrile (RN: 717843-95-3)", CHEMCATS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20090707), Database accession no. 2080793508 CHEMCATS, URL: STN, XP002566750 [X] 1,4,8-9,12 * the whole document *
    [ ] - Specs Compounds For Screening, SPECS, (20090707) [ ] * the whole document *
 [X]  - "[3-amino-4-(2-chlorophenyl)-5,6,7,8-tetrahydrothieno[2.3-b]quinolin-2-yl]phenylmethanone (RN: 573941-67-0)", CHEMCATS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20090706), Database accession no. 2094030527 CHEMCATS, URL: STN, XP002566751 [X] 1,6,9,12 * order Number: STOCK4S-13866 *
    [ ] - Ambiter Stock Screening Collection, Ambiter, (20090706) [ ] * the whole document *
 [X]  - MATROSOVA S V ET AL, "Cyclization reactions of nitriles", RUSSIAN CHEMICAL BULLETIN, SPRINGER NEW YORK LLC, US; RU, (19910701), vol. 40, no. 7, ISSN 1066-5285, pages 1456 - 1459, XP009128875 [X] 1-2,9,12 * page 1457; compound Xa *

DOI:   http://dx.doi.org/10.1007/BF00961252
 [X]  - DYACHENKO AND A D DYACHENKO V D, "Synthesis of 4-Alkyl(aryl, hetaryl)-2-thioxo-5,6,7,8-tetrahydroquinol ine-3-carbonitriles and Their Derivatives by Cross-Recyclization of 4-Alkyl(aryl, hetaryl)-2,6-diamino-4Hthiopyran-3,5-dicarbonitriles with 4-(Cyclohex-1-en-1-yl)-morpholine, Alkyl Halides, and Cyclohexanone", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, CONSULTANTS BUREAU, US, vol. 44, no. 3, ISSN 1070-4280, (20080301), pages 412 - 420, (20080418), XP009128897 [X] 1,11-12 * page 413; compound Xa *

DOI:   http://dx.doi.org/10.1007/s11178-008-3017-0
 [X]  - DYACHENKO V D ET AL, "Single Stage Synthesis of 2-Alkynylthio(seleno)-4-Hetaryl-3-Cyano-5,6 ,7,8-Tetrahydroquinolines", CHEMISTRY OF HETEROCYCLIC COMPOUNDS,, (19980101), vol. 33, no. 10, pages 1203 - 1208, XP002521011 [X] 1,9,12 * page 1203; compounds IXa,b *

DOI:   http://dx.doi.org/10.1007/BF02290871
 [X]  - YU A SHARANIN ET AL, "A NEW SYNTHESIS OF SUBSTITUTED PYRIDINE-2(1H)-THIONES AND HETEROCYCLIC COMPOUNDS BASED ON THEM", JOURNAL OF ORGANIC CHEMISTRY OF THE USSR, M A I K NAUKA - INTERPERIODICA, RU, (19820901), vol. 18, no. 9, ISSN 0022-3271, pages 1760 - 1763, XP009128896 [X] 1,9,12 * page 1760; compound V *
 [X]  - "(3-amino-4-furan-2-yl-5,6,7,8-tetrahydrothieno[2.3-b]quinoline-2-yl)-phenylmethanone", BEILSTEIN, BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE, (1984), XP002566959 [X] 1,9,12 * the whole document *
    [ ] - ZHURNAL ORGANICHESKOI KHIMII, (1984), pages 1828 - 1837
 [X]  - "(3-amino-4-furan-2-yl-5,6,7,8-tetrahydrothieno[2.3-b]quinoline-2-yl)-(4-fluorophenyl)-methanone", BEILSTEIN, BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE, (1984), XP002566960 [X] 1,9,12 * the whole document *
    [ ] - ZHURNAL ORGANICHESKOI KHIMII, (1984), vol. 20, no. 9, pages 2002 - 2011
 [X]  - "(3-amino-4-furan-2-yl-5,6,7,8-tetrahydrothieno[2.3-b]quinoline-2-yl)-(4-chlorophenyl)-methanone", BEILSTEIN, BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE, (1984), XP002566961 [X] 1,9,12 * the whole document *
 [X]  - "(3-amino-4-furan-2-yl-5,6,7,8-tetrahydrothieno[2.3-b]quinoline-2-yl)-(4-bromophenyl)-methanone", BEILSTEIN, BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE, (1984), XP002566962 [X] 1,9,12 * the whole document *
 [X]  - "(3-amino-4-furan-2-yl-5,6,7,8-tetrahydrothieno[2.3-b]quinoline-2-yl)-(2,4-dimethylphenyl)-methanone", BEILSTEIN, BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE, (1984), XP002566963 [X] 1,9,12 * the whole document *
 [AD]  - SHARANIN Y ET AL, "CYCLIZATION REACTIONS OF NITRILES LIV.* SYNTHESIS AND PROPERTIES OF 6-AMINO-4-ARYL-3,5-DICYANOPYRIDIN-2(1H)-ONES, THE CORRESPONDING THIONES, THE PYRIDYLIDENEMALONONUTRIELES, AND THEIR HYDROGENATED ANALOGS", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, CONSULTANTS BUREAU, US, (19940101), vol. 30, no. 4, ISSN 1070-4280, pages 620 - 626, XP009128934 [AD] 1-10,12 * page 621; compounds XII (l), XIII (I) *
 [A]  - VANGAPANDU SUTYANARYANA ET AL, "Recent advances in antimalarial drug development", MEDICINAL RESEARCH REVIEWS, NEW YORK, NY, US, (20070101), vol. 27, no. 1, ISSN 0198-6325, pages 65 - 107, XP009128888 [A] 1-12 * the whole document *
by applicant   - BIOCHIMICA ET BIOPHYSICA ACTA, (2004), vol. 1697, pages 181 - 196
    - RUSS. J. ORG. CHEM., (1994), vol. 30, pages 620 - 626
    - PRIMOT ET AL., PROTEIN EXPRESSION AND PURIFICATION, (2000), vol. 20, pages 394 - 404
    - BAIN J ET AL., "The selectivity of protein kinase inhibitors: a further update", BIOCHEM J., (2007), vol. 408, pages 297 - 315
    - KARAMAN MW ET AL., "A quantitative analysis of kinase inhibitor selectivity", NAT BIOTECHNOL., (200801), vol. 26, no. 1, pages 127 - 32
    - GARDNER, M.J. ET AL., "Genome sequence of the human malaria parasite Plasmodium falciparum.", NATURE, (2002), vol. 419, pages 498 - 511
    - CARLTON, J.M. ET AL., "Comparative genomics of the neglected human malaria parasite Plasmodium vivax", NATURE, (2008), vol. 455, pages 799 - 803
    - PAIN, A. ET AL., "The genome of the simian and human malaria parasite Plasmodium knowlesi.", NATURE, (2008), vol. 455, pages 799 - 803
    - QIN, C.L.; TANG, J.; KIM, K., "Cloning and in vitro expression of TPK3, a Toxoplasma gondii homologue of shaggy/glycogen synthase kinase-3 kinases", MOL. BIOCHEM. PARASITOL., (1998), vol. 93, pages 273 - 283
    - OJO, K.K. ET AL., "Glycogen synthse kinase 3 is a potential drug target for African trypanosomiasis.", ANTIMICROBIOL. AGENTS CHEMOTHER., (2008), vol. 52, pages 3710 - 3717
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.