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Extract from the Register of European Patents

EP About this file: EP2240506

EP2240506 - INHIBITORS OF IAP [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.11.2013
Database last updated on 03.10.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Genentech, Inc.
1 DNA Way
South San Francisco, CA 94080 / US
[2010/42]
Inventor(s)01 / NDUBAKU, Chudi
1050 Mississippi Street, 3
San Francisco, California 94107 / US
02 / FLYGARE, John A.
1419 Vancouver Avenue
Burlingame, California 94010 / US
03 / COHEN, Frederick
1551 24th Avenue
San Francisco, California 94122 / US
 [2010/46]
Former [2010/42]01 / NDUBAKU, Chudi
1050 Mississippi Street, 3
San Francisco, California 94107 / US
02 / FLYGARE, John A.
1419 Vancouver Avenue
Burlingame, California 94010 / US
03 / COHEN, Frederick
2001 McAllister Street, 143
San Francisco, California 94118 / US
Representative(s)Wytenburg, Wilhelmus Johannes, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[N/P]
Former [2010/42]Wytenburg, Wilhelmus Johannes, et al
Mewburn Ellis LLP 33 Gutter Lane
GB-London EC2V 8AS / GB
Application number, filing date09701124.109.01.2009
[2010/42]
WO2009US30674
Priority number, dateUS2008002068211.01.2008         Original published format: US 20682
[2010/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009089502
Date:16.07.2009
Language:EN
[2009/29]
Type: A1 Application with search report 
No.:EP2240506
Date:20.10.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 16.07.2009 takes the place of the publication of the European patent application.
[2010/42]
Type: B1 Patent specification 
No.:EP2240506
Date:26.12.2012
Language:EN
[2012/52]
Search report(s)International search report - published on:EP16.07.2009
ClassificationIPC:C07K5/06, C07K5/08, C07K5/062, C07K5/083, A61K38/05, A61K38/06, A61P35/00
[2010/42]
CPC:
C07K5/06026 (EP,US); A61P35/00 (EP); A61P35/02 (EP);
A61P43/00 (EP); C07K5/0806 (EP,US); A61K38/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/42]
Extension statesAL30.07.2010
BA30.07.2010
RS30.07.2010
TitleGerman:IAP-HEMMER[2010/42]
English:INHIBITORS OF IAP[2010/42]
French:INHIBITEURS DE IAP[2010/42]
Entry into regional phase30.07.2010National basic fee paid 
30.07.2010Designation fee(s) paid 
30.07.2010Examination fee paid 
Examination procedure30.07.2010Amendment by applicant (claims and/or description)
30.07.2010Examination requested  [2010/42]
25.07.2012Communication of intention to grant the patent
06.11.2012Fee for grant paid
06.11.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  25.07.2012
Opposition(s)27.09.2013No opposition filed within time limit [2013/49]
Fees paidRenewal fee
14.01.2011Renewal fee patent year 03
11.01.2012Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY26.12.2012
EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
MK26.12.2012
MT26.12.2012
RO26.12.2012
SK26.12.2012
LU09.01.2013
PL09.01.2013
MC31.01.2013
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
PT26.04.2013
[2015/34]
Former [2015/32]CY26.12.2012
EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
MK26.12.2012
MT26.12.2012
RO26.12.2012
SK26.12.2012
PL09.01.2013
MC31.01.2013
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
PT26.04.2013
Former [2014/32]CY26.12.2012
EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
MT26.12.2012
RO26.12.2012
SK26.12.2012
PL09.01.2013
MC31.01.2013
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
PT26.04.2013
Former [2014/24]CY26.12.2012
EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
RO26.12.2012
SK26.12.2012
PL09.01.2013
MC31.01.2013
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
PT26.04.2013
Former [2013/52]CY26.12.2012
EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
RO26.12.2012
SK26.12.2012
MC31.01.2013
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
PT26.04.2013
Former [2013/40]EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
RO26.12.2012
SK26.12.2012
MC31.01.2013
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
PT26.04.2013
Former [2013/37]EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
RO26.12.2012
SK26.12.2012
MC31.01.2013
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
Former [2013/35]EE26.12.2012
FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
SK26.12.2012
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
Former [2013/34]FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
BG26.03.2013
NO26.03.2013
GR27.03.2013
IS26.04.2013
Former [2013/24]FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
NO26.03.2013
GR27.03.2013
Former [2013/23]FI26.12.2012
HR26.12.2012
LT26.12.2012
LV26.12.2012
NO26.03.2013
Former [2013/22]FI26.12.2012
LT26.12.2012
NO26.03.2013
Former [2013/20]LT26.12.2012
NO26.03.2013
Cited inInternational search[X]US2006014700  (COHEN FREDERICK [US], et al) [X] 1,5-13,15-21 * formula (I); paragraph [0064]; claims 9-13,15-21 *;
 [X]WO2006069063  (GENENTECH INC [US], et al) [X] 1,2,6-21 * formula (I); page 25, line 14 - page 44, line 3; claims 9-21 *;
 [X]WO2007106192  (GENENTECH INC [US], et al) [X] 1,4,6-13,15-21 * formula (I); page 24, line 15 - page 32, line 4; claims 9-13,15-21 *;
 [X]  - BODEN C D J ET AL, "Total Synthesis of the Thiazoline-based Cyclopeptide Cyclodidemnamide", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, (19961209), vol. 37, no. 50, ISSN 0040-4039, pages 9111 - 9114, XP004070573 [X] 1,4,6 * scheme 2;;; compound 6 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(96)02099-0
 [A]  - HOLDER J R ET AL, "Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, (20021219), vol. 45, no. 26, ISSN 0022-2623, pages 5736 - 5744, XP002302531 [A] 1,6-13,15-21 * compound 13 *

DOI:   http://dx.doi.org/10.1021/jm020296e
 [A]  - KATALIN ÖSZ, KATALIN VÁRNAGY, HELGA SÜLI-VARGHA, DANIELE SANNA, GIOVANNI MICERA AND IMRE SÓVÁGÓ, "Transition metal complexes of bis(imidazol-2-yl) derivatives of dipeptides", DALTON TRANSACTIONS, (20030423), vol. 2003, pages 2009 - 2016, XP002516598 [A] 1-21 * Scheme 1; "GlyLeu-BIMA" *
 [A]  - CHRISTOPHER J MOODY, JAMES C A HUNT, "Synthesis of Virenamide b, a Cytotoxic Thiazole-Containing Peptide", JOURNAL OF ORGANIC CHEMISTRY, (19991023), vol. 64, pages 8715 - 8717, XP002524782 [A] 1-21 * compound 1 *

DOI:   http://dx.doi.org/10.1021/JO9908694
 [A]  - NAKAMURA M ET AL, "Stereochemistry and Total Synthesis of Dolastatin E", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, (19950710), vol. 36, no. 28, ISSN 0040-4039, pages 5059 - 5062, XP004027736 [A] 1,4,5,9-11,21 * compound 8 *
 [A]  - HAMADA Y ET AL, "New methods and reagents in organic synthesis. 56. Total syntheses of patellamides B and C, cytotoxic cyclic peptides from a tunicate 2. Their real structures have been determined by their syntheses", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 26, no. 42, ISSN 0040-4039, (19850101), pages 5159 - 5162, (19850101), XP022720509 [A] 1-21 * compound 15 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)98891-9
 [A]  - NORLEY M C ET AL, "Total Synthesis and Revision of Stereochemistry of Cyclodidemnamide, a Novel Cyclopeptide from the Marine Ascidian Didemnum molle", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, (19980507), vol. 39, no. 19, ISSN 0040-4039, pages 3087 - 3090, XP004115764 [A] 1-21 * compound 6 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(98)00365-7
 [A]  - CHRIS M IRELAND, AUGUSTINE R DURSO JR., ROBERT A NEWMAN, MILES P HACKER, "Antineoplastic cyclic peptides from the marine tunicate Lissoclinum patella", JOURNAL OF ORGANIC CHEMISTRY, (1982), vol. 47, no. 10, pages 1807 - 1811, XP002524783 [A] 1-21 * compounds 13, 14, 19, 20, 21 *

DOI:   http://dx.doi.org/10.1021/jo00349a002
 [A]  - YASUMASA HAMADA, MAKOTO SHIBATA, TAKAYUKI SHIOIRI, "NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 58. A SYNTHESIS OF PATELLAMIDE A, A CYTOTOXIC CYCLIC PEPTIDE FROM A TUNICATE. REVISION OF ITS PROPOSED STRUCTURE", TETRAHEDRON LETTERS, (1985), vol. 26, no. 52, pages 6501 - 6504, XP002524784 [A] 1-21 * compounds 9, 18 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)99037-3
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.