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Extract from the Register of European Patents

EP About this file: EP2245198

EP2245198 - SELECTION OF NUCLEIC ACIDS BY SOLUTION HYBRIDIZATION TO OLIGONUCLEOTIDE BAITS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 09.06.2017 Database last updated on 19.10.2024
Most recent event Tooltip	09.06.2017	Application deemed to be withdrawn	published on 12.07.2017 [2017/28]
Applicant(s)	For all designated states Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge, MA 02139 / US
	For all designated states Whitehead Institute for Biomedical Research Nine Cambridge Center Cambridge, MA 02142 / US
	For all designated states President and Fellows of Harvard College 17 Quincy Street Cambridge, MA 02138 / US
	[2015/07]
Former [2010/44]	For all designated states Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge, MA 02139 / US
Inventor(s)	01 / GNIRKE, Andreas 89 Overbrook Drive Wellesley MA 02484 / US
	02 / NUSBAUM, Chad 9 Victoria Circle Newton MA 02459 / US
	03 / LANDER, Eric, S. 74R Fayerweather Street Cambridge MA 02138 / US
	[2010/44]
Representative(s)	Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
	[N/P]
Former [2013/51]	Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT / GB
Former [2010/44]	White, Nina Louise Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT / GB
Application number, filing date	09708005.5	04.02.2009
	[2010/44]
	WO2009US00707
Priority number, date	US20080063489	04.02.2008 Original published format: US 63489
	US20090206386	30.01.2009 Original published format: US 206386
	[2010/44]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2009099602
	Date:	13.08.2009
	Language:	EN
	[2009/33]
	Type:	A1 Application with search report
	No.:	EP2245198
	Date:	03.11.2010
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 13.08.2009 takes the place of the publication of the European patent application.
	[2010/44]
Search report(s)	International search report - published on:	EP	13.08.2009
Classification	IPC:	C12Q1/68	[2010/44]
	CPC:	C12Q1/6869 (EP,US); C12Q1/6811 (US)
	C-Set:	C12Q1/6869, C12Q2537/101 (EP,US)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2010/44]
Title	German:	SELEKTION VON NUKLEINSÄUREN DURCH LÖSUNGSHYBRIDISIERUNG AN OLIGONUKLEOTIDKÖDER	[2010/44]
	English:	SELECTION OF NUCLEIC ACIDS BY SOLUTION HYBRIDIZATION TO OLIGONUCLEOTIDE BAITS	[2010/44]
	French:	SÉLECTION D'ACIDES NUCLÉIQUES PAR HYBRIDATION EN SOLUTION EN AMORCES OLIGONUCLÉOTIDIQUES	[2010/44]
Entry into regional phase	02.09.2010	National basic fee paid
	02.09.2010	Designation fee(s) paid
	02.09.2010	Examination fee paid
Examination procedure	02.09.2010	Examination requested [2010/44]
	04.11.2010	Amendment by applicant (claims and/or description)
	11.02.2011	Despatch of a communication from the examining division (Time limit: M06)
	22.08.2011	Reply to a communication from the examining division
	14.01.2013	Despatch of a communication from the examining division (Time limit: M06)
	24.07.2013	Reply to a communication from the examining division
	14.04.2014	Despatch of a communication from the examining division (Time limit: M06)
	23.10.2014	Reply to a communication from the examining division
	01.12.2014	Despatch of a communication from the examining division (Time limit: M06)
	10.06.2015	Reply to a communication from the examining division
	20.08.2015	Despatch of a communication from the examining division (Time limit: M06)
	30.03.2016	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2017/28]
	07.06.2016	Reply to a communication from the examining division
	13.01.2017	Date of oral proceedings
	25.01.2017	Despatch of communication that the application is refused, reason: substantive examination {1}
	04.02.2017	Application deemed to be withdrawn, date of legal effect [2017/28]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 11.02.2011
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	07.06.2016	Request for further processing filed
	07.06.2016	Full payment received (date of receipt of payment) Request granted
	17.06.2016	Decision despatched
Fees paid	Renewal fee
	23.02.2011	Renewal fee patent year 03
	24.02.2012	Renewal fee patent year 04
	27.02.2013	Renewal fee patent year 05
	27.02.2014	Renewal fee patent year 06
	26.02.2015	Renewal fee patent year 07
	26.02.2016	Renewal fee patent year 08
	Penalty fee
	Additional fee for renewal fee
	28.02.2017	09 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[X] - BASHIARDES STAVROS ET AL, "Direct genomic selection.", NATURE METHODS JAN 2005, (200501), vol. 2, no. 1, ISSN 1548-7091, pages 63 - 69, XP002525087 [X] 1-78,102-109 * figure 1 * * the whole document * DOI: http://dx.doi.org/10.1038/nmeth0105-63
		[X] - PORRECA GREGORY J ET AL, "Multiplex amplification of large sets of human exons.", NATURE METHODS NOV 2007, (200711), vol. 4, no. 11, ISSN 1548-7091, pages 931 - 936, XP002525088 [X] 79-101 * figure 1 * * the whole document * DOI: http://dx.doi.org/10.1038/NMETH1110
		[PX] - GNIRKE ANDREAS ET AL, "Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing", NATURE BIOTECHNOLOGY, (200902), vol. 27, no. 2, ISSN 1087-0156, pages 182 - 189, XP002525089 [PX] 1-109 * figure 1 * * the whole document * DOI: http://dx.doi.org/10.1038/NBT.1523
	Examination	US6013440
		US2004259146
		- DAHL FREDRIK ET AL, "Multigene amplification and massively parallel sequencing for cancer mutation discovery", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (20070529), vol. 104, no. 22, doi:10.1073/PNAS.0702165104, ISSN 0027-8424, pages 9387 - 9392, XP002530544 DOI: http://dx.doi.org/10.1073/PNAS.0702165104
		- HODGES E ET AL, "Genome-wide in situ exon capture for selective resequencing", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 39, no. 12, doi:10.1038/NG.2007.42, ISSN 1061-4036, (20071201), pages 1522 - 1527, (20071104), XP002580277 DOI: http://dx.doi.org/10.1038/NG.2007.42
		- WEILER J ET AL, "COMBINING THE PREPARATION OF LIGONUCLEOTIDE ARRAYS AND SYNTHESIS OF HIGH-QUALITY PRIMERS", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, (19961215), vol. 243, no. 2, doi:10.1006/ABIO.1996.0509, ISSN 0003-2697, pages 218 - 227, XP000684351 DOI: http://dx.doi.org/10.1006/abio.1996.0509
		- DUNBAR ET AL, "Applications of Luminex(R) xMAP(TM) technology for rapid, high-throughput multiplexed nucleic acid detection", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 363, no. 1-2, ISSN 0009-8981, (20060101), pages 71 - 82, (20060101), XP027877582
		- YE F ET AL, "FLUORESCENT MICROSPHERE-BASED READOUT TECHNOLOGY FOR MULTIPLEXED HUMAN SINGLE NUCLEOTIDE POLYMORPHISM ANALYSIS AND BACTERIAL INDENTIFICATION", HUMAN MUTATION, JOHN WILEY & SONS, INC, US, (20010101), vol. 17, no. 4, doi:10.1002/HUMU.28, ISSN 1059-7794, pages 305 - 316, XP001118024 DOI: http://dx.doi.org/10.1002/humu.28
		- IANNONE M A ET AL, "MULTIPLEXED SINGLE NUCLEOTIDE POLYMORPHISM GENOTYPING BY OLIGONUCLEOTIDE LIGATION AND FLOW CYTOMETRY", CYTOMETRY, ALAN LISS, NEW YORK, US, (20000101), vol. 39, no. 2, doi:10.1002/(SICI)1097-0320(20000201)39:2<131::AID-CYTO6>3.0.CO;2-U, ISSN 0196-4763, pages 131 - 140, XP001073442 DOI: http://dx.doi.org/10.1002/(SICI)1097-0320(20000201)39:2<131::AID-CYTO6>3.0.CO;2-U
		- CHEN J ET AL, "A MICROSPHERE-BASED ASSAY FOR MULTIPLEXED SINGLE NUCLEOTIDE POLYMORPHISM ANALYSIS USING SINGLE BASE CHAIN EXTENSION", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, WOODBURY, NY, US, (20000401), vol. 10, no. 4, doi:10.1101/GR.10.4.549, ISSN 1088-9051, pages 549 - 557, XP000927257 DOI: http://dx.doi.org/10.1101/gr.10.4.549
		- CHOU CHENG-CHUNG ET AL, "Optimization of probe length and the number of probes per gene for optimal microarray analysis of gene expression", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD, GB, (20040101), vol. 32, no. 12, ISSN 0305-1048, pages e99/1 - E99/8, XP002401323
		- ANDREAS GNIRKE ET AL, "Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing", NATURE BIOTECHNOLOGY, GALE GROUP INC, vol. 27, no. 2, doi:10.1038/NBT.1523, ISSN 1087-0156, (20090201), pages 182 - 189, (20090201), XP002658414 DOI: http://dx.doi.org/10.1038/nbt.1523
		- M. Clamp ET AL, "Distinguishing protein-coding and noncoding genes in the human genome", Proceedings of the National Academy of Sciences, US, (20071204), vol. 104, no. 49, doi:10.1073/pnas.0709013104, ISSN 0027-8424, pages 19428 - 19433, XP055289006 DOI: http://dx.doi.org/10.1073/pnas.0709013104

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