blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2265583

EP2265583 - SPIROINDOLINONE DERIVATIVES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.08.2012
Database last updated on 17.09.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU		published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[N/P]
Former [2010/52]For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
Inventor(s)01 / LIU, Jin-Jun
50 Highmount Avenue
Warren New Jersey 07059 / US
 [2010/52]
Representative(s)Klein, Thomas
F. Hoffmann-La Roche AG
Patent Department
Grenzacherstrasse 124
4070 Basel / CH
[N/P]
Former [2011/41]Klein, Thomas
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel / CH
Former [2010/52]Klein, Thomas
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel / CH
Application number, filing date09722134.509.03.2009
[2010/52]
WO2009EP52737
Priority number, dateUS2008003779919.03.2008         Original published format: US 37799
[2010/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009115425
Date:24.09.2009
Language:EN
[2009/39]
Type: A1 Application with search report 
No.:EP2265583
Date:29.12.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 24.09.2009 takes the place of the publication of the European patent application.
[2010/52]
Type: B1 Patent specification 
No.:EP2265583
Date:12.10.2011
Language:EN
[2011/41]
Search report(s)International search report - published on:EP24.09.2009
ClassificationIPC:C07D209/96
[2010/52]
CPC:
C07D413/04 (EP,US); A61P35/00 (EP); C07D209/96 (EP,US);
C07D401/04 (EP,US); C07D405/04 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/52]
TitleGerman:SPIROINDOLINON-DERIVATE[2010/52]
English:SPIROINDOLINONE DERIVATIVES[2010/52]
French:DÉRIVÉS DE SPIROINDOLINONE[2010/52]
Entry into regional phase19.10.2010National basic fee paid 
19.10.2010Designation fee(s) paid 
19.10.2010Examination fee paid 
Examination procedure19.10.2010Examination requested  [2010/52]
23.11.2010Amendment by applicant (claims and/or description)
09.05.2011Communication of intention to grant the patent
11.08.2011Fee for grant paid
11.08.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  09.05.2011
Opposition(s)13.07.2012No opposition filed within time limit [2012/38]
Fees paidRenewal fee
10.03.2011Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.03.2009
AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
FI12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
MK12.10.2011
MT12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
TR12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
IE09.03.2012
LU09.03.2012
MC31.03.2012
[2014/34]
Former [2014/27]AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
FI12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
MK12.10.2011
MT12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
TR12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
IE09.03.2012
LU09.03.2012
MC31.03.2012
Former [2014/21]AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
FI12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
MK12.10.2011
MT12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
TR12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
IE09.03.2012
MC31.03.2012
Former [2013/35]AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
FI12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
MK12.10.2011
MT12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
IE09.03.2012
MC31.03.2012
Former [2013/29]AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
FI12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
MK12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
IE09.03.2012
MC31.03.2012
Former [2013/12]AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
MK12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
IE09.03.2012
MC31.03.2012
Former [2013/08]AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
IE09.03.2012
MC31.03.2012
Former [2013/07]AT12.10.2011
BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
MC31.03.2012
Former [2012/47]BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
MC31.03.2012
Former [2012/37]BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
PL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/36]BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
RO12.10.2011
SE12.10.2011
SI12.10.2011
SK12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/35]BE12.10.2011
CY12.10.2011
CZ12.10.2011
DK12.10.2011
EE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
SE12.10.2011
SI12.10.2011
BG12.01.2012
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/34]BE12.10.2011
CY12.10.2011
CZ12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
SE12.10.2011
SI12.10.2011
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/28]BE12.10.2011
CY12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
SE12.10.2011
SI12.10.2011
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/27]BE12.10.2011
HR12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
SE12.10.2011
SI12.10.2011
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/24]BE12.10.2011
LT12.10.2011
LV12.10.2011
NL12.10.2011
SE12.10.2011
SI12.10.2011
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/23]BE12.10.2011
LT12.10.2011
NL12.10.2011
NO12.01.2012
GR13.01.2012
IS12.02.2012
PT13.02.2012
Former [2012/21]BE12.10.2011
LT12.10.2011
NO12.01.2012
IS12.02.2012
Former [2012/20]LT12.10.2011
NO12.01.2012
Cited inInternational search[A]WO9715556  (SANOFI SA [FR], et al) [A] 1-11 * page 3, line 5 - page 5, line 6; compound 3 * * page 25, line 14 - page 27, line 7 * * claims 16-18 *;
 [PA]WO2008055812  (HOFFMANN LA ROCHE [CH], et al) [PA] 1-11* the whole document *;
 [A]  - ASHIMORI A,. OVERMAN L., JOURNAL OF ORGANIC CHEMISTRY, (20020501), vol. 57, no. 17, pages 4571 - 4572, XP002527583 [A] 1-11 * p.4571 scheme 2 compound 3 *

DOI:   http://dx.doi.org/10.1021/jo00043a005
 [A]  - ASHIMORI A ET AL, "CATALYTIC ASYMMETRIC SYNTHESIS OF QUATERNARY CARBON CENTERS. EXPLORATORY INVESTIGATIONS OF INTRAMOLECULAR HECK REACTIONS OF (E)-ALPHA,BETA-UNSATURATED 2-HALOANILIDES AND ANALOGUES TO FORM ENANTIEONRICHED SPIROCYCLIC PRODUCTS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, (19980708), vol. 120, ISSN 0002-7863, pages 6477 - 6487, XP001038246 [A] 1-11 * p.6480 scheme 3 * * page 6482; compound 8 *

DOI:   http://dx.doi.org/10.1021/ja980786p
 [A]  - JOHNSON R S ET AL, "The Alkaloids of Gelsenium sempervirens. Part IV. Derivatives of pyridine, isoquinoline, and indol-2(3H)-one as possible initial materials for synthesis of Gelsemine", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, (19000101), ISSN 0300-922X, pages 796 - 800, XP002156747 [A] 1-11 * page 797; compound XIV *
 [A]  - DING KE ET AL, "Structure-based design of potent non-peptide MDM2 inhibitors.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 27 JUL 2005, (20050727), vol. 127, no. 29, ISSN 0002-7863, pages 10130 - 10131, XP002527584 [A] 1-11 * page 10131; compounds 1A-1F *

DOI:   http://dx.doi.org/10.1021/JA051147Z
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.