blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2282719

EP2282719 - COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.04.2019
Database last updated on 14.09.2024
FormerThe patent has been granted
Status updated on  27.04.2018
FormerGrant of patent is intended
Status updated on  05.11.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Revalesio Corporation
1202 East D Street
Tacoma, WA 98421 / US
[2018/15]
Former [2011/07]For all designated states
REVALESIO CORPORATION
5102 20th Street East, Bldg. 100
Tacoma, Washington 98424 / US
Inventor(s)01 / WATSON, Richard, L.
5331 N Highland Street
Ruston
Washington 98407 / US
02 / WOOD, Anthony, B.
6043 Bryan Parkway
Dallas TX 75206 / US
03 / ARCHAMBEAU, Gregory, J.
1824 Crystal Lane Loop S.e.
Puyallup WA 98372 / US
 [2018/22]
Former [2011/07]01 / WATSON, Richard, L.
1985 Cougar Trail
Mcpherson KS 67460 / US
02 / WOOD, Anthony, B.
6043 Bryan Parkway
Dallas TX 75206 / US
03 / ARCHAMBEAU, Gregory, J.
1824 Crystal Lane Loop S.e.
Puyallup WA 98372 / US
Representative(s)Teall, Charlotte, et al
Forresters IP LLP
Skygarden
Erika-Mann-Strasse 11
80636 München / DE
[2018/22]
Former [2012/13]Gowshall, Jonathan Vallance, et al
Forrester & Boehmert
SkyGarden
Erika-Mann-Strasse 11
80636 München / DE
Former [2011/07]Gowshall, Jonathan Vallance
Forrester & Boehmert Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date09739530.527.04.2009
[2011/07]
WO2009US41852
Priority number, dateUS20080048332P28.04.2008         Original published format: US 48332 P
US20080048347P28.04.2008         Original published format: US 48347 P
US2008025677423.10.2008         Original published format: US 256774
WO2008US8102123.10.2008         Original published format: PCT/US2008/081021
WO2008US8120224.10.2008         Original published format: PCT/US2008/081202
US2008025821024.10.2008         Original published format: US 258210
[2017/48]
Former [2011/07]US20080048332P28.04.2008
US20080048347P28.04.2008
US20080256774P23.10.2008
WO2008US0810223.10.2008
WO2008US0812024.10.2008
US2008025821024.10.2008
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2009134728
Date:05.11.2009
Language:EN
[2009/45]
Type: A2 Application without search report 
No.:EP2282719
Date:16.02.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 05.11.2009 takes the place of the publication of the European patent application.
[2011/07]
Type: B1 Patent specification 
No.:EP2282719
Date:30.05.2018
Language:EN
[2018/22]
Search report(s)International search report - published on:US21.01.2010
(Supplementary) European search report - dispatched on:EP07.10.2011
ClassificationIPC:A61K9/00, A61K31/573, A61K33/00
[2011/45]
CPC:
A61K31/573 (EP); A61K33/00 (EP); A61P17/02 (EP);
A61P21/02 (EP); A61P25/00 (EP); A61P25/06 (EP);
A61P25/14 (EP); A61P25/16 (EP); A61P25/28 (EP);
A61P31/18 (EP); A61P43/00 (EP); A61P9/00 (EP);
A61P9/10 (EP) (-)
C-Set:
A61K31/573, A61K2300/00 (EP);
A61K33/00, A61K2300/00 (EP)
Former IPC [2011/07]A61K9/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/22]
Former [2011/07]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON MULTIPLER SKLEROSE[2011/07]
English:COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS[2011/07]
French:COMPOSITIONS ET PROCÉDÉS POUR TRAITER LA SCLÉROSE EN PLAQUES[2011/07]
Entry into regional phase26.11.2010National basic fee paid 
26.11.2010Search fee paid 
26.11.2010Designation fee(s) paid 
26.11.2010Examination fee paid 
Examination procedure26.11.2010Examination requested  [2011/07]
04.05.2012Amendment by applicant (claims and/or description)
27.05.2013Despatch of a communication from the examining division (Time limit: M06)
06.12.2013Reply to a communication from the examining division
27.08.2014Despatch of a communication from the examining division (Time limit: M06)
31.03.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
09.06.2015Reply to a communication from the examining division
07.09.2017Cancellation of oral proceeding that was planned for 22.09.2017
22.09.2017Date of oral proceedings (cancelled)
06.11.2017Communication of intention to grant the patent
13.02.2018Fee for grant paid
13.02.2018Fee for publishing/printing paid
13.02.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  27.05.2013
Opposition(s)01.03.2019No opposition filed within time limit [2019/19]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
09.06.2015Request for further processing filed
09.06.2015Full payment received (date of receipt of payment)
Request granted
25.06.2015Decision despatched
Fees paidRenewal fee
25.04.2011Renewal fee patent year 03
25.04.2012Renewal fee patent year 04
29.04.2013Renewal fee patent year 05
28.04.2014Renewal fee patent year 06
08.04.2015Renewal fee patent year 07
30.03.2016Renewal fee patent year 08
21.04.2017Renewal fee patent year 09
23.04.2018Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU27.04.2009
AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
MK30.05.2018
MT30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IS30.09.2018
PT01.10.2018
[2022/31]
Former [2021/34]HU27.04.2009
AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
MT30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IS30.09.2018
PT01.10.2018
Former [2021/32]HU27.04.2009
AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IS30.09.2018
PT01.10.2018
Former [2021/31]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
IS30.09.2018
PT01.10.2018
Former [2020/29]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
PT01.10.2018
Former [2020/16]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
TR30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2020/02]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
MC30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/26]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SI30.05.2018
SK30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/11]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
IT30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SK30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/10]AT30.05.2018
CY30.05.2018
CZ30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
PL30.05.2018
RO30.05.2018
SE30.05.2018
SK30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/09]CY30.05.2018
DK30.05.2018
EE30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/08]CY30.05.2018
DK30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2019/03]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
NL30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2018/52]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
GR31.08.2018
Former [2018/51]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
LV30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
Former [2018/50]CY30.05.2018
ES30.05.2018
FI30.05.2018
HR30.05.2018
LT30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
Former [2018/49]CY30.05.2018
ES30.05.2018
FI30.05.2018
LT30.05.2018
SE30.05.2018
BG30.08.2018
NO30.08.2018
Former [2018/47]ES30.05.2018
FI30.05.2018
LT30.05.2018
NO30.08.2018
Documents cited:Search[Y]US2003232114  (DEKLEVA NIKOLA [YU]) [Y] 1-15 * the whole document * * paragraph [0055] *;
 [Y]WO2004022098  (NAGY TIBOR [HU], et al) [Y] 1-15 * the whole document ** claim 6 *;
 [Y]WO2008018932  (UNIV LELAND STANFORD JUNIOR [US], et al) [Y] 1-15 * the whole document * * claim 22 *;
 [YDP]WO2008052143  (REVALESIO CORP [US], et al) [YDP] 1-15 * the whole document *;
 [E]WO2009055614  (REVALESIO CORP [US], et al) [E] 1-15 * the whole document * * claim 15 *;
 [E]WO2010048455  (REVALESIO CORP [US], et al) [E] 1-15 * the whole document * * page 10, line 12 - line 27 * * claims 15,16 *
International search[Y]US2004118701  (SENKIW JAMES ANDREW [US]);
 [Y]US2004166171  (MCGRATH TERRENCE S [US], et al);
 [Y]US2006198822  (BOOTH DAVID R [AU], et al);
 [Y]  - LASSMANN., "Hypoxia-like tissue injury as a component of multiple sclerosis lesions.", J. NEUROL. SCI., (20030215), vol. 206, no. 2, pages 187 - 191, XP008137062

DOI:   http://dx.doi.org/10.1016/S0022-510X(02)00421-5
 [Y]  - VAN WINSEN ET AL., "Sensitivity to glucocorticoids is decreased in relapsing remitting multiple sclerosis.", J. CLIN. ENDOCRINOL. METAB., (200502), vol. 90, no. 2, pages 734 - 740, XP008137063
 [Y]  - RUTGEERTS ET AL., "Review artide: the limitations of corticosteroid therapy in Crohn's disease.", ALIMENT. PHARMACOL. THER., (200110), vol. 15, no. 10, pages 1515 - 1525, XP008137064

DOI:   http://dx.doi.org/10.1046/j.1365-2036.2001.01060.x
by applicantUS6386751
 WO02074767
 US2004259896
 US2006287338
 WO2007087637
 US2007219217
 US2008032997
 WO2008052143
 US2008139674
 US2008219088
 US2008281001
    - MINAGAR et al., J. Neurological Sci., (20020000), vol. 202, pages 13 - 23
    - ANTEL; OWENS, J. Neuroimmunol., (19990000), vol. 100, pages 181 - 189
    - ELLIOTT, Mol. Brain. Res., (20010000), vol. 95, pages 172 - 178
    - NAKAMURA, Biol. Pharm. Bull., (20020000), vol. 25, pages 945 - 953
    - WHITTON PS, Br J Pharmacol., (20070000), vol. 150, pages 963 - 76
    - TANSEY, Fron Bioscience, (20080000), vol. 13, pages 709 - 717
    - RUFFINI, Am J Pathol, (20040000), vol. 164, pages 1519 - 1522
    - DOS SANTOS, J Neuroinflammation, (20080000), vol. 5, page 49
    - GREIG et al., Ann NY Acad of Sci, (20060000), vol. 1035, pages 290 - 315
    - PUGLIATTI et al., Clin. Neurol. Neuros., (20020000), vol. 104, pages 182 - 191
    - DUBOIS-DALCQ et al., Neuron., (20050000), vol. 48, pages 9 - 12
    - OKSENBERG et al., JAMA, (19930000), vol. 270, pages 2363 - 2369
    - OLERUP et al., Tissue Antigens, (19910000), vol. 38, pages 1 - 3
    - BRUCK et al., J. Neurol. Sci., (20030000), vol. 206, pages 181 - 185
    - PRAT et al., J. Rehabil. Res. Dev., (20020000), vol. 39, pages 187 - 199
    - HEMMER et al., Nat. Rev. Neurosci., (20020000), vol. 3, pages 291 - 301
    - LUBETZKI et al., Curr. Opin. Neurol., (20050000), vol. 18, pages 237 - 244
    - WOLINSKY et al., Ann Neurol, (20070000), vol. 61, pages 13 - 24
    - CZLONKOWSKA, Med Sci Monit, (20020000), vol. 8, pages RA165 - 77
    - AKIYAMA, Neurobiol Aging., (20000000), vol. 21, pages 383 - 421
    - CENTONZE, Trends Pharm Sci, (20070000), vol. 28, pages 180 - 7
    - ELLIOT, Brain Res Mol Brain Res, (20010000), vol. 95, pages 172 - 8
    - FRIEND et al., Exp. Hematol., (19940000), vol. 22, pages 321 - 328
    - RAY et al., Eur. J. Immunol., (19960000), vol. 26, pages 10 - 16
    - CANDEIAS et al., Immunology Letters, (19970000), vol. 57, pages 9 - 14
    - LEVIN, J. Immunol., (19990000), vol. 162, pages 677 - 683
    - RECHE et al., J. Immunol., (20010000), vol. 167, pages 336 - 343
    - SOUMELIS et al., Nat. Immunol., (20020000), vol. 3, pages 673 - 680
    - SHAH et al., Clin. Exp. Allergy., (19950000), vol. 25, pages 1038 - 1044
    - MOFFATT, M.F.; COOKSON, W.O., Hum. Mol. Genet., (19970000), vol. 6, pages 551 - 554
    - ITO et al., J. Exp. Med., vol. 202, pages 1213 - 1223
    - YING et al., J. Immunol., (20050000), vol. 174, pages 8183 - 8190
    - PANDEY et al., Nat. Immunol., (20000000), vol. 1, pages 59 - 64
    - ISAKSEN et al., J. Immunol., (20020000), vol. 168, pages 3288 - 3294
    - YOO et al., J. Exp. Med., (20050000), vol. 202, pages 541 - 549
    - ZHOU et al., Nat. Immunol., (20050000), vol. 6, pages 1047 - 1053
    - AL-SHAMI et al., J. Exp. Med., (20050000), vol. 202, pages 829 - 839
    - YONG-JUN et al., J. Exp. Med., (20060000), vol. 203, pages 269 - 273
    - LIYUN SHI et al., Clin. Immunol., (20080000), vol. 129, pages 202 - 210
    - ROCHMAN et al., J. Immunol., (20070000), vol. 178, pages 6720 - 6724
    - OMORI M.; ZIEGLER S., J. Immunol., (20070000), vol. 178, pages 1396 - 1404
    - SUNG et al., J. Immunol., vol. 166, pages 1261 - 1271
    - LAMBRECHT et al., J. Clin. Invest., (20000000), vol. 106, pages 551 - 559
    - BRENNAN F. M., Lancet, (19890000), vol. 2, pages 244 - 7
    - HAWORTH C, Eur. J. Immunol., (19910000), vol. 21, pages 2575 - 2579
    - N. M. HOOPER et al., Biochem. J., (19970000), vol. 321, pages 265 - 279
    - SHAPIRO et al., Journal of Biological Chemistry, (19920000), vol. 267, page 4664
    - SHAPIRO et al., Journal of Biological Chemistry, (19930000), vol. 268, page 23824
    - MATSUMOTO et al., Am. J. Pathol., (19980000), vol. 153, page 109
    - ANDERSON; SHINAGAWA, Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs, (19990000), vol. 1, no. 1, pages 29 - 38
    - MATETZKY S; FISHBEIN M C et al., Circulation, (20001031), vol. 102, no. 18, pages 36 - 39
    - S. M. WILHELM et al., J. Biol. Chem., (19890000), vol. 264, no. 29, pages 17213 - 17221
    - J. Biol. Chem., (19900000), vol. 265, no. 36, page 22570
    - T. H. VU; Z. WERB, In: Matrix Metalloproteinases, Academic Press, (19980000), pages 115 - 148
    - MOL. BIOL., Am. J. Resp. Cell, (19970000), vol. 5, pages 583 - 591
    - Am J Respir Crit Care Med, (19980000), vol. 158, pages 1945 - 1950
    - J Allergy Clin Immunol, (19990000), vol. 104, pages 356 - 363
    - SIMPSON et al., "Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma", Am J Respir Crit Care Med, (20050000), vol. 172, pages 559 - 565
    - LEE et al., "A murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitor", J Allergy Clin Immunol, (20010000), vol. 108, pages 1021 - 1026
    - LEE et al., "Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma", J Allergy Clin Immunol, (20030000), vol. 111, pages 1278 - 1284
    - BECKETT R. P.; WHITTAKER M., Exp. Opin. Ther. Patents, (19980000), vol. 8, no. 3, pages 259 - 282
    - WHITTAKER M. et al., Chemical Reviews, (19990000), vol. 99, no. 9, pages 2735 - 2776
    - BERNARDO, J. Biol. Chem., (20020000), vol. 277, pages 11201 - 11207
    - PROSCH S., Virology, (19950000), vol. 208, pages 197 - 206
    - SMITH J. W., J. Clin. Oncol., (19920000), vol. 10, pages 1141 - 1152
    - CHAPMAN P. B., J. Clin. Oncol., (19870000), vol. 5, pages 1942 - 1951
    - GRONICH J., J. Clin. Invest., (19940000), vol. 93, pages 1224 - 1233
    - LIOU L. B., Clin. Exp. Rheumatol., (20010000), vol. 19, pages 515 - 523
    - SVENUNGSSON E. et al., Ann. Rheum. Dis., (20010000), vol. 60, pages 372 - 9
    - KORHONEN et al., Curr Drug Targets Inflamm Allergy, (20050000), vol. 4, no. 4, pages 471 - 9
    - SHAH et al., Env. Health Persp., vol. 106, no. 5, pages 1139 - 1143
    - AMADEU; COSTA, J. Cutan. Pathol., (20060000), vol. 33, pages 465 - 473
    - AMADEU; COSTA, J. Cutan Pathol, (20060000), vol. 33, pages 465 - 473
    - LININGTON et al., J. Neuroimmunol., (19920000), vol. 40, pages 219 - 224
    - BERGER et al., N. Engl. J. Med., (20030710), vol. 349, no. 2, pages 139 - 45
    - LEE; LEE, Bull. Kor. Chem. Soc. 2003, (20030000), vol. 24, no. 6, pages 802 - 804
    - "Chapter 6,", H. Brian Dunford,, Heme Peroxidases, H. Brian Dunford, Wiley-VCH, (19990000), vol. 6, pages 112 - 123
    - KHAJEHPOUR et al., PROTEINS: Struct, Funct, Genet., (20030000), vol. 53, pages 656 - 666
    - BUNKIN et al., Journal of Experimental and Theoretical Physics, (20070000), vol. 104, pages 486 - 498
    - Banker and Chalmers,, Pharmaceutics and Pharmacy Practice, J. B. Lippincott Co., (19820000), pages 238 - 250
    - Toissel,, ASHP Handbook on Injectable Drugs, 4th ed.,, (19860000), pages 622 - 630
    - LIU, YJ, "Thymic stromal lymphopoietin: Master switch for allergic inflammation", J Exp Med, (20060000), vol. 203, doi:doi:10.1084/jem.20051745, pages 269 - 273, XP002482347

DOI:   http://dx.doi.org/10.1084/jem.20051745
    - AL-SHAMI et al., "A role for TSLP in the development of inflammation in an asthma model", J Exp Med, (20050000), vol. 202, doi:doi:10.1084/jem.20050199, pages 829 - 839, XP002528757

DOI:   http://dx.doi.org/10.1084/jem.20050199
    - VIGNOLA et al., "Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis", Am J Respir Crit Care Med, (19980000), vol. 158, pages 1945 - 1950, XP002223183
    - HOSHINO et al., "Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma", J Allergy Clin Immunol, (19990000), vol. 104, doi:doi:10.1016/S0091-6749(99)70379-9, pages 356 - 363, XP027464703

DOI:   http://dx.doi.org/10.1016/S0091-6749(99)70379-9
    - ELWOOD et al., J Allergy Clin Immuno, (19910000), vol. 88, pages 951 - 60
    - SIROIS; BISSONNETTE, Clin Exp Immunol, (20010000), vol. 126, pages 9 - 15
    - DOLORES M CONROY; TIMOTHY J WILLIAMS, Respiratory Research, (20010000), vol. 2, pages 150 - 156
    - "New Way Chemistry for Hong Kong A-Level", Y.C. WONG; C.T. WONG, Or Standard Methods for the Examination of Water and Wastewater, vol. 4, page 248
    - AL SHAMI et al., J. Exp. Med., (20040000), pages 159 - 168
    - HUSTON et al., Curr. Allergy Asthma Rep., (20060000), vol. 6, pages 372 - 376
    - KOYAMA et al., Biochem. Biophys. Res. Commun., (20070000), vol. 357, pages 99 - 104
    - GREGORY et al., Nature Genetics, (20070729), vol. 39, pages 1083 - 1091
    - AVOLIO et al., J Neurolmmunol, (20030000), vol. 1, no. 36, pages 46 - 53
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.