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Extract from the Register of European Patents

EP About this file: EP2339030

EP2339030 - SCREENING METHOD FOR LIVER X RECEPTOR AGONISTS AND APPLICATION THEREOF [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  05.12.2014
Database last updated on 14.09.2024
Most recent event   Tooltip05.12.2014Refusal of applicationpublished on 07.01.2015  [2015/02]
Applicant(s)For all designated states
Golden Biotechnology Corporation
15F, No.27-6, Sec.2 Jhong-Jheng E.Rd. Danshuei Township Taipei Hsien
Taiwan / CN
[2011/26]
Inventor(s)01 / LIU, Sheng-Yung
15F No.27-6 Sec.2 Jhong-Jheng E.Road.
Danshuei Township
Taipei County 25170 Taiwan / CN
02 / WEN, Wu-Che
15F No.27-6 Sec.2 Jhong-Jheng E.Road.
Danshuei Township
Taipei County 25170 Taiwan / CN
03 / KUO, Mao-Tien
15F No.27-6 Sec.2 Jhong-Jheng E.Road.
Danshuei Township
Taipei County 25170 Taiwan / CN
 [2012/04]
Former [2011/26]01 / LIU, Sheng-Yun
15F No.27-6 Sec.2 Jhong-Jheng E.Road. Danshuei Township
Taipei County 25170 Taiwan / CN
02 / WEN, Wu-Che
15F No.27-6 Sec.2 Jhong-Jheng E.Road. Danshuei Township
Taipei County 25170 Taiwan / CN
03 / KUO, Mao-Tien
15F No.27-6 Sec.2 Jhong-Jheng E.Road. Danshuei Township
Taipei County 25170 Taiwan / CN
Representative(s)Cole, William Gwyn, et al
Avidity IP
Broers Building
Hauser Forum
21 J J Thomson Avenue
Cambridge CB3 0FA / GB
[N/P]
Former [2011/26]Cole, William Gwyn, et al
HLBBshaw Merlin House Falconry Court Baker's Lane
Epping, Essex CM16 5DQ / GB
Application number, filing date09753423.426.05.2009
[2011/26]
WO2009CN00587
Priority number, dateCN2008110980830.05.2008         Original published format: CN200810109808
[2011/26]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009143705
Date:03.12.2009
Language:ZH
[2009/49]
Type: A1 Application with search report 
No.:EP2339030
Date:29.06.2011
Language:EN
[2011/26]
Search report(s)International search report - published on:CN03.12.2009
(Supplementary) European search report - dispatched on:EP17.10.2011
ClassificationIPC:C12Q1/68, C12N15/09, G01N33/50, B01D11/00, A61K36/29
[2011/26]
CPC:
G01N33/6875 (EP); A61K36/71 (EP); C12Q1/6897 (EP);
C07K2319/715 (EP); C07K2319/80 (EP)
C-Set:
C12Q1/6897, C12Q2522/101 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/26]
TitleGerman:SCREENING-VERFAHREN FÜR LEBER-X-REZEPTORAGONISTEN UND ANWENDUNG DAVON[2011/26]
English:SCREENING METHOD FOR LIVER X RECEPTOR AGONISTS AND APPLICATION THEREOF[2011/26]
French:PROCÉDÉ DE CRIBLAGE POUR DES ANTAGONISTES DES RÉCEPTEURS HÉPATIQUES X ET SON APPLICATION[2011/26]
Entry into regional phase14.04.2011Translation filed 
14.04.2011National basic fee paid 
14.04.2011Search fee paid 
14.04.2011Designation fee(s) paid 
14.04.2011Examination fee paid 
Examination proceduredeletedCommunication of intention to grant the patent
14.04.2011Examination requested  [2011/26]
14.05.2012Amendment by applicant (claims and/or description)
10.08.2012Despatch of a communication from the examining division (Time limit: M04)
20.12.2012Reply to a communication from the examining division
28.01.2013Despatch of a communication from the examining division (Time limit: M04)
16.07.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
26.09.2013Reply to a communication from the examining division
27.06.2014Cancellation of oral proceeding that was planned for 01.07.2014
01.07.2014Date of oral proceedings (cancelled)
15.07.2014Despatch of communication that the application is refused, reason: substantive examination [2015/02]
25.07.2014Application refused, date of legal effect [2015/02]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.08.2012
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
26.09.2013Request for further processing filed
26.09.2013Full payment received (date of receipt of payment)
Request granted
14.10.2013Decision despatched
The application is deemed to be withdrawn due to failure to file the translation
14.04.2011Request for further processing filed
14.04.2011Full payment received (date of receipt of payment)
Request granted
01.06.2011Decision despatched
The application is deemed to be withdrawn due to non-payment of the search fee
14.04.2011Request for further processing filed
14.04.2011Full payment received (date of receipt of payment)
Request granted
29.04.2011Decision despatched
The application is deemed to be withdrawn due to non-payment of the filing fee
14.04.2011Request for further processing filed
14.04.2011Full payment received (date of receipt of payment)
Request granted
29.04.2011Decision despatched
The application is deemed to be withdrawn due to non-payment of the examination fee
14.04.2011Request for further processing filed
14.04.2011Full payment received (date of receipt of payment)
Request granted
29.04.2011Decision despatched
The application is deemed to be withdrawn due to non-payment of designation fees
TR, SK, SI, SE, RO, PT, PL, NO, NL, MT, MK, MC, LV, LU, LT, IT, IS, IE, HU, HR, GR, GB, FR, FI, ES, EE, DK, DE, CZ, CY, CH, BG, BE, AT
14.04.2011Request for further processing filed
14.04.2011Full payment received (date of receipt of payment)
Request granted
29.04.2011Decision despatched
14.04.2011Request for further processing filed
14.04.2011Full payment received (date of receipt of payment)
Request granted
29.04.2011Decision despatched
Fees paidRenewal fee
25.05.2011Renewal fee patent year 03
30.03.2012Renewal fee patent year 04
10.05.2013Renewal fee patent year 05
02.05.2014Renewal fee patent year 06
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]  - JIAN-XIN LI ET AL, "Cimicifugae Rhizoma: From Origins, Bioactive Constituents to Clinical Outcomes", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, (20060101), vol. 13, ISSN 0929-8673, pages 2927 - 2951, XP007919386 [X] 1-9 * pp.2927, 2940 col.1, 2943 col.1, 2946 col.1; tables 1-2. *
 [X]  - MINGHUA QIU ET AL, "Anticomplement Activity of Cycloartane Glycosides from the Rhizome of Cimicifuga foetida", PHYTOTHERAPY RESEARCH, JOHN WILEY & SONS LTD. CHICHESTER, GB, vol. 20, doi:10.1002/PTR.1982, ISSN 0951-418X, (20060101), pages 945 - 948, (20060814), XP007919385 [X] 1-5 * materials and methods *

DOI:   http://dx.doi.org/10.1002/ptr.1982
 [X]  - YONG LIU ET AL, "Two New Cyclolanostanol Xylosides from the Aerial Parts of Cimicifuga dahurica", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 65, doi:10.1021/NP020130G, ISSN 0163-3864, (20020101), pages 1486 - 1488, (20020812), XP007919388 [X] 1-3,5,6 * materials and methods *

DOI:   http://dx.doi.org/10.1021/np020130g
 [X]  - KIM J-K ET AL, "Hepatoprotective activity of Chungpesagan-tang is related to the inhibition of [beta]-glucuronidase", NATURAL PRODUCT SCIENCES, KOREAN SOCIETY OF PHARMACOGNOSY, SEOUL, KR, (20010101), vol. 7, no. 3, ISSN 1226-3907, pages 63 - 67, XP009151945 [X] 1-3,8,9 * introduction; materials and methods *
 [X]  - QING-WEN ZHANG ET AL, "Cycloartane Glycosides from Cimicifuga dahurica", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, (20010101), vol. 49, no. 11, ISSN 0009-2363, pages 1468 - 1470, XP007919387 [X] 1-3,5,6 * p.1468 par.2 *
International search[X]CN1980919  (IRM LLC);
 [A]WO02090375  (ARCH DEV CORP ET AL.)
ExaminationCN1475269
 CN1730448
    - LIAO J F ET AL, "Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs", PROCEEDINGS OF THE NATIONAL SCIENCE COUNCIL. REPUBLIC OFCHINA. PART B. LIFE SCIENCES, NATIONAL SCIENCE COUNCIL, TAIPEI, TW, (19950701), vol. 19, no. 3, ISSN 0255-6596, pages 151 - 158, XP009151949
    - CAO PEI ET AL, "Chemical constituents from Cimicifuga foetida", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, GORDON AND BREACH, CHUR, CH, (20050401), vol. 7, no. 2, doi:10.1080/1028602042000204081, ISSN 1028-6020, pages 145 - 149, XP009151970

DOI:   http://dx.doi.org/10.1080/1028602042000204081
    - TIAN ZE ET AL, "Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma", BMC CANCER, BIOMED CENTRAL, LONDON, GB, (20071231), vol. 7, no. 1, ISSN 1471-2407, page 237, XP021034525
    - Appendino C ET AL, "New Cycloartane Glycosides from Cimicifuga dahurica", Nat. Prod. Rep. j. Nat. Prod. Chem. Common. Chem. Commun, (19990101), pages 1130 - 11331561, URL: https://www.thieme-connect.com/ejournals/pdf/10.1055/s-2006-960865.pdf, XP055095323
    - J. Plat, "Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation", The Journal of Lipid Research, (20050908), vol. 46, no. 11, doi:10.1194/jlr.M500272-JLR200, ISSN 0022-2275, pages 2468 - 2476, XP055095183

DOI:   http://dx.doi.org/10.1194/jlr.M500272-JLR200
    - Hiranthi Jayasuriya ET AL, "Diterpenoid, Steroid, and Triterpenoid Agonists of Liver X Receptors from Diversified Terrestrial Plants and Marine Sources", Journal of Natural Products, (20050801), vol. 68, no. 8, doi:10.1021/np050182g, ISSN 0163-3864, pages 1247 - 1252, XP055095184

DOI:   http://dx.doi.org/10.1021/np050182g
by applicant   - WILLY, P. J., UMESONO, K., ONG, E. S., EVANS, R. M., HEYMAN, R. A., MANGELSDORF, D. J., "LXR, a nuclear receptor that defines a distinct retinoid response pathway", GENES DEV., (1995), vol. 9, no. 9, pages 1033 - 45
    - STEFFENSEN, K.R., GUSTAFSSON, J.A., "Putative metabolic effects of the liver X receptor (LXR)", DIABETES, (2004), vol. 53, no. 1, pages 36 - 42
    - PROCTOR, G., JIANG, T., IWAHASHI, M., WANG, Z., LI, J., LEVI, M., "Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes", DIABETES, (2006), vol. 55, no. 9, pages 2502 - 9
    - KOLDAMOVA, R. P., LEFTEROV, I. M., STAUFENBIEL, M., WOLFE, D., HUANG, S., GLORIOSO, J. C., WALTER, M., ROTH, M. G., LAZO, J. S., "The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease", J BIOL CHEM. 11, (2005), vol. 280, no. 6, pages 4079 - 88
    - FUKUCHI, J., KOKONTIS, J. M., HIIPAKKA, R.A., CHUU, C.P., LIAO, S., "Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells", CANCER RES., (20041101), vol. 64, no. 21, pages 7686 - 9
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.