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Extract from the Register of European Patents

EP About this file: EP2285951

EP2285951 - MESENCHYMAL STEM CELLS FOR THE TREATMENT OF CNS DISEASES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.05.2019
Database last updated on 26.07.2024
FormerThe patent has been granted
Status updated on  01.06.2018
FormerGrant of patent is intended
Status updated on  30.01.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Ramot at Tel-Aviv University Ltd.
P.O. Box 39296
61392 Tel Aviv / IL
For all designated states
Brainstorm Cell Therapeutics Ltd.
12 Bazel Street
P.O. Box 10019 Kiryat Arie
49001 Petach-Tikva / IL
[2012/09]
Former [2011/08]For all designated states
Ramot at Tel-Aviv University Ltd.
P.O. Box 39296
61392 Tel Aviv / IL
For all designated states
Brainstorm Cell Therapeutics Inc.
12 Bazel Street P.O. Box 10019 Kiryat Arie
49001 Petach-Tikva / IL
Inventor(s)01 / KADOURI, Avinoam
4 David Avidan Street
49710 Petach-Tikva / IL
02 / BAR-ILAN, Avihay
12 Kitzis Street
69481 Tel-Aviv / IL
03 / MELAMED, Eldad
44 Tagor Street
69341 Tel-Aviv / IL
04 / OFFEN, Daniel
c/o Ramot at Tel-Aviv University Ltd.
P.O Box 39296
6139201 Tel-Aviv / IL
05 / SADAN, Ofer
4/10 Alexander Penn Street
69641 Tel-Aviv / IL
06 / BAHAT-STROMZA, Merav
40 HaMizmor Street
3751070 Pardes Chana-Karkur / IL
 [2018/24]
Former [2011/08]01 / KADOURI, Avinoam
4 David Avidan Street
49710 Petach-Tikva / IL
02 / BAR-ILAN, Avihay
14 Kitzis Street
69481 Tel-Aviv / IL
03 / MELAMED, Eldad
44 Tagor Street
69341 Tel-Aviv / IL
04 / OFFEN, Daniel
38955 Kfar HaRoe / IL
05 / SADAN, Ofer
4/10 Alexander Penn Street
69641 Tel-Aviv / IL
06 / BAHAT-STROMZA, Merav
c/o Tzachi Stromza 209 Derech HaYam Street
34890 Haifa / IL
Representative(s)Dennemeyer & Associates S.A.
Postfach 70 04 25
81304 München / DE
[2018/27]
Former [2014/09]Dennemeyer & Associates S.A.
Poccistrasse 11
80336 München / DE
Former [2014/05]Speich, Stéphane, et al
Dennemeyer & Associates S.A.
55, rue des Bruyères
1274 Luxembourg-Howald / LU
Former [2011/08]Dennemeyer & Associates S.A.
55, rue des Bruyères
1274 Howald / LU
Application number, filing date09754337.526.05.2009
[2011/08]
WO2009IL00525
Priority number, dateUS20080071970P28.05.2008         Original published format: US 71970 P
[2011/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009144718
Date:03.12.2009
Language:EN
[2009/49]
Type: A1 Application with search report 
No.:EP2285951
Date:23.02.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 03.12.2009 takes the place of the publication of the European patent application.
[2011/08]
Type: B1 Patent specification 
No.:EP2285951
Date:04.07.2018
Language:EN
[2018/27]
Search report(s)International search report - published on:EP03.12.2009
ClassificationIPC:A61K35/28, A61P25/02
[2018/01]
CPC:
A61K38/185 (EP,US); A61K35/28 (EP,US); A61P25/02 (EP);
A61P25/28 (EP,US); C12N5/0618 (EP,US); C12N5/0662 (EP,US);
C12N5/0663 (EP,US); C12N5/0664 (EP,US); C12N5/0665 (EP,US);
C12N5/0666 (EP,US); C12N5/0667 (EP,US); C12N5/0668 (EP,US);
A61K35/12 (EP,US); C12N2500/84 (EP,US); C12N2501/01 (EP,US);
C12N2501/11 (EP,US); C12N2501/115 (EP,US); C12N2501/135 (EP,US);
C12N2506/1346 (US); C12N2506/1353 (EP,US); C12N5/0669 (US) (-)
Former IPC [2011/10]A61K35/28
Former IPC [2011/08]C12N5/08, A61K35/28, A61P25/28
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/27]
Former [2011/08]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:MESENCHYMALE STAMMZELLEN ZUR BEHANDLUNG VON ERKRANKUNGEN DES ZENTRALNERVENSYSTEMS[2011/08]
English:MESENCHYMAL STEM CELLS FOR THE TREATMENT OF CNS DISEASES[2011/08]
French:CELLULES SOUCHES MÉSENCHYMATEUSES DESTINÉES AU TRAITEMENT DE TROUBLES DU SNC[2011/08]
Entry into regional phase25.11.2010National basic fee paid 
25.11.2010Designation fee(s) paid 
25.11.2010Examination fee paid 
Examination procedure25.11.2010Amendment by applicant (claims and/or description)
25.11.2010Examination requested  [2011/08]
19.04.2011Despatch of a communication from the examining division (Time limit: M04)
17.08.2011Reply to a communication from the examining division
25.06.2013Despatch of a communication from the examining division (Time limit: M04)
30.10.2013Reply to a communication from the examining division
04.03.2015Despatch of a communication from the examining division (Time limit: M04)
06.07.2015Reply to a communication from the examining division
11.04.2016Despatch of a communication from the examining division (Time limit: M04)
17.06.2016Reply to a communication from the examining division
31.01.2018Communication of intention to grant the patent
11.05.2018Fee for grant paid
11.05.2018Fee for publishing/printing paid
11.05.2018Receipt of the translation of the claim(s)
Divisional application(s)EP13164650.7  / EP2620493
EP19155870.9  / EP3514229
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.04.2011
Opposition(s)05.04.2019No opposition filed within time limit [2019/24]
Fees paidRenewal fee
24.05.2011Renewal fee patent year 03
22.05.2012Renewal fee patent year 04
27.05.2013Renewal fee patent year 05
26.05.2014Renewal fee patent year 06
21.05.2015Renewal fee patent year 07
20.05.2016Renewal fee patent year 08
23.05.2017Renewal fee patent year 09
25.05.2018Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.05.2009
AT04.07.2018
CY04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
MK04.07.2018
MT04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
[2022/31]
Former [2021/34]HU26.05.2009
AT04.07.2018
CY04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
MT04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
Former [2021/32]HU26.05.2009
AT04.07.2018
CY04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
Former [2021/26]AT04.07.2018
CY04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
Former [2020/29]AT04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
Former [2020/16]AT04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2020/07]AT04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/37]AT04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SI04.07.2018
SK04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/24]AT04.07.2018
EE04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
SK04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/22]AT04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RO04.07.2018
SE04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/12]AT04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
SE04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/11]AT04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
PL04.07.2018
SE04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/10]AT04.07.2018
FI04.07.2018
LT04.07.2018
PL04.07.2018
SE04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/08]FI04.07.2018
LT04.07.2018
NO04.10.2018
IS04.11.2018
Former [2019/07]LT04.07.2018
Cited inInternational search[DXY]US2005265983  (MELAMED ELDAD [IL], et al) [DX] 1-20,37,39-44 * examples 2,6,16,20 * [Y] 21-34,38;
 [DXY]WO2006134602  (UNIV RAMOT [IL], et al) [DX] 1-20,35,39-44 * example 1 * [Y] 21-34,38;
 [XDY]WO2007066338  (UNIV RAMOT [IL], et al) [XD] 1-20,36,39-44 * example 3 * [Y] 21-34,38;
 [XY]  - BLONDHEIM N R ET AL, "Human mesenchymal stem cells express neural genes, suggesting a neural predisposition.", STEM CELLS AND DEVELOPMENT, (200604), vol. 15, no. 2, ISSN 1547-3287, pages 141 - 164, XP009079870 [X] 1-20,37,39-44 * the whole document * [Y] 21-34,38

DOI:   http://dx.doi.org/10.1089/scd.2006.15.141
 [Y]  - DOUCET C ET AL, "Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications.", JOURNAL OF CELLULAR PHYSIOLOGY, (200511), vol. 205, no. 2, ISSN 0021-9541, pages 228 - 236, XP002545728 [Y] 21-34,38 * the whole document *

DOI:   http://dx.doi.org/10.1002/JCP.20391
 [Y]  - BERNARDO M E ET AL, "Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute.", JOURNAL OF CELLULAR PHYSIOLOGY, (200704), vol. 211, no. 1, ISSN 0021-9541, pages 121 - 130, XP002545729 [Y] 21-34,38 * the whole document *

DOI:   http://dx.doi.org/10.1002/JCP.20911
 [Y]  - REINISCH A ET AL, "Humanized system to propagate cord blood-derived multipotent mesenchymal stromal cells for clinical application.", REGENERATIVE MEDICINE, (200707), vol. 2, no. 4, ISSN 1746-076X, pages 371 - 382, XP002545730 [Y] 21-34,38 * the whole document *

DOI:   http://dx.doi.org/10.2217/17460751.2.4.371
 [Y]  - SCHALLMOSER K ET AL, "Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells.", TRANSFUSION, (200708), vol. 47, no. 8, ISSN 0041-1132, pages 1436 - 1446, XP002553488 [Y] 21-34,38 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1537-2995.2007.01220.x
 [Y]  - CAPELLI C ET AL, "Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts.", BONE MARROW TRANSPLANTATION, (200710), vol. 40, no. 8, ISSN 0268-3369, pages 785 - 791, XP002545732 [Y] 21-34,38 * the whole document *

DOI:   http://dx.doi.org/10.1038/sj.bmt.1705798
 [Y]  - LANGE C ET AL, "Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine.", JOURNAL OF CELLULAR PHYSIOLOGY, (200710), vol. 213, no. 1, ISSN 0021-9541, pages 18 - 26, XP002545733 [Y] 21-34,38 * the whole document *

DOI:   http://dx.doi.org/10.1002/jcp.21081
 [PX]  - SADAN O ET AL, "Migration of neurotrophic factors-secreting mesenchymal stem cells toward a quinolinic acid lesion as viewed by magnetic resonance imaging.", STEM CELLS, (200810), vol. 26, no. 10, ISSN 1549-4918, pages 2542 - 2551, XP002545734 [PX] 1-20,35-37,39-44 * the whole document *

DOI:   http://dx.doi.org/10.1634/stemcells.2008-0240
 [PX]  - SADAN O ET AL, "Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases.", THE ISRAEL MEDICAL ASSOCIATION JOURNAL, (200904), vol. 11, no. 4, ISSN 1565-1088, pages 201 - 204, XP002545735 [PX] 1-20,35-37,39-44 * the whole document *
 [A]  - WAGNER W & HO A H, "Mesenchymal stem cell preparations--comparing apples and oranges.", STEM CELL REVIEWS, (200712), vol. 3, no. 4, ISSN 1550-8943, pages 239 - 248, XP002545736

DOI:   http://dx.doi.org/10.1007/s12015-007-9001-1
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