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EP About this file: EP2302050

EP2302050 - METHOD FOR ASSESSING EMBRYOTOXICITY [Right-click to bookmark this link]
Former [2011/13]	METHOD FOR EVALUATION OF DEVELOPMENTAL TOXICITY
	[2016/26]
Status	No opposition filed within time limit Status updated on 22.02.2019 Database last updated on 07.10.2024
Former	The patent has been granted Status updated on 16.03.2018
Former	Grant of patent is intended Status updated on 29.10.2017
Former	Examination is in progress Status updated on 19.04.2017
Former	Grant of patent is intended Status updated on 29.11.2016
Most recent event Tooltip	10.07.2020	Lapse of the patent in a contracting state New state(s): IS	published on 12.08.2020 [2020/33]
Applicant(s)	For all designated states Sumitomo Chemical Company, Limited 27-1, Shinkawa 2-chome Chuo-ku Tokyo 104-8260 / JP
	[2011/13]
Inventor(s)	01 / SUZUKI, Noriyuki c/o SUMITOMO CHEMICAL COMPANY, LIMITED 1-98 Kasugadenaka 3-chome Konohana-ku Osaka-shi Osaka 554-8558 / JP
	02 / SAITO, Koichi c/o SUMITOMO CHEMICAL COMPANY, LIMITED 1-98 Kasugadenaka 3-chome Konohana-ku Osaka-shi Osaka 554-8558 / JP
	03 / ANDO, Satoshi c/o SUMITOMO CHEMICAL COMPANY, LIMITED 1-98 Kasugadenaka 3-chome Konohana-ku Osaka-shi Osaka 554-8558 / JP
	04 / HORIE, Nobuyuki c/o SUMITOMO CHEMICAL COMPANY, LIMITED 1-98 Kasugadenaka 3-chome Konohana-ku Osaka-shi Osaka 554-8558 / JP
	[2018/16]
Former [2012/35]	01 / SUZUKI, Noriyuki 2-27-401 Shimoyoshihara-cho Nishinomiya-shi Hyogo 662-0956 / JP
	02 / SAITO, Koichi 4-3-20-405, Nakanoshima Kita-ku Osaka-shi Osaka / JP
	03 / ANDO, Satoshi 2-10-2-233 Sonehigashino-cho Toyonaka-shi Osaka 561-0802 / JP
	04 / HORIE, Nobuyuki 14-11 Koshien6ban-cho Nishinomiya-shi Hyogo 663-8176 / JP
Former [2011/13]	01 / SUZUKI, Noriyuki 2-27-401 Shimoyoshihara-cho Nishinomiya-shi Hyogo 662-0956 / JP
	02 / SAITO, Koichi 4-3-20-405, Nakanoshima, Kita-ku Osaka-shi Osaka / JP
	03 / ANDO, Satoshi 2-10-2-233 Sonehigashino-cho Toyonaka-shi Osaka 561-0802 / JP
	04 / HORIE, Nobuyuki 14-11 Koshien6ban-cho Nishinomiya-shi Hyogo 663-8176 / JP
Representative(s)	Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
	[2018/16]
Former [2011/13]	Vossius & Partner Siebertstrasse 4 81675 München / DE
Application number, filing date	09758444.5	02.06.2009
	[2011/13]
	WO2009JP60410
Priority number, date	JP20080145433	03.06.2008 Original published format: JP 2008145433
	[2011/13]
Filing language	JA
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2009148177
	Date:	10.12.2009
	Language:	JA
	[2009/50]
	Type:	A1 Application with search report
	No.:	EP2302050
	Date:	30.03.2011
	Language:	EN
	[2011/13]
	Type:	B1 Patent specification
	No.:	EP2302050
	Date:	18.04.2018
	Language:	EN
	[2018/16]
Search report(s)	International search report - published on:	JP	10.12.2009
	(Supplementary) European search report - dispatched on:	EP	27.12.2011
Classification	IPC:	C12N15/09, A01K67/027, C12N5/10, C12Q1/02, C12Q1/68	[2011/13]
	CPC:	C12Q1/6883 (EP,US); C12N5/0603 (US); C12Q1/6809 (EP,US); G01N33/5014 (EP,US); A01K2217/052 (EP,US); A01K2227/105 (EP,US); (+) A01K2267/0393 (EP,US); C12Q2600/142 (EP,US) (-)
	C-Set:	C12Q1/6809, C12Q2545/113 (EP,US)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2018/16]
Former [2011/13]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR
Title	German:	VERFAHREN ZUR BEWERTUNG VON EMBRYOTOXIZITÄT	[2017/45]
	English:	METHOD FOR ASSESSING EMBRYOTOXICITY	[2017/45]
	French:	PROCÉDÉ D'ÉVALUATION D'EMBRYOTOXICITÉ	[2017/45]
	Former [2011/13]	VERFAHREN ZUR BEWERTUNG ENTWICKLUNGSBIOLOGISCHER TOXIZITÄT
	Former [2011/13]	METHOD FOR EVALUATION OF DEVELOPMENTAL TOXICITY
	Former [2011/13]	PROCÉDÉ D'ÉVALUATION DE LA TOXICITÉ LIÉE AU DÉVELOPPEMENT
Entry into regional phase	28.12.2010	Translation filed
	28.12.2010	National basic fee paid
	28.12.2010	Search fee paid
	28.12.2010	Designation fee(s) paid
	28.12.2010	Examination fee paid
Examination procedure	28.12.2010	Examination requested [2011/13]
	29.08.2012	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
	08.11.2012	Amendment by applicant (claims and/or description)
	16.07.2015	Despatch of a communication from the examining division (Time limit: M06)
	21.01.2016	Reply to a communication from the examining division
	30.11.2016	Communication of intention to grant the patent
	10.04.2017	Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
	10.04.2017	Fee for grant paid
	10.04.2017	Fee for publishing/printing paid
	04.05.2017	Despatch of a communication from the examining division (Time limit: M01)
	14.06.2017	Reply to a communication from the examining division
	30.10.2017	Communication of intention to grant the patent
	08.03.2018	Receipt of the translation of the claim(s)
Divisional application(s)	EP17180299.4 / EP3296396
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 16.07.2015
Opposition(s)	21.01.2019	No opposition filed within time limit [2019/13]
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
	08.11.2012	Request for further processing filed
	08.11.2012	Full payment received (date of receipt of payment) Request granted
	23.11.2012	Decision despatched
Fees paid	Renewal fee
	27.06.2011	Renewal fee patent year 03
	27.03.2012	Renewal fee patent year 04
	24.06.2013	Renewal fee patent year 05
	24.06.2014	Renewal fee patent year 06
	24.06.2015	Renewal fee patent year 07
	23.06.2016	Renewal fee patent year 08
	26.06.2017	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	02.06.2009
	AT	18.04.2018
	CY	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	MK	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SI	18.04.2018
	SK	18.04.2018
	TR	18.04.2018
	IE	02.06.2018
	LU	02.06.2018
	MT	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	IS	18.08.2018
	PT	20.08.2018
	[2020/33]
Former [2020/31]	HU	02.06.2009
	AT	18.04.2018
	CY	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	MK	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SI	18.04.2018
	SK	18.04.2018
	TR	18.04.2018
	IE	02.06.2018
	LU	02.06.2018
	MT	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2020/28]	HU	02.06.2009
	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SI	18.04.2018
	SK	18.04.2018
	TR	18.04.2018
	IE	02.06.2018
	LU	02.06.2018
	MT	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2020/16]	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SI	18.04.2018
	SK	18.04.2018
	TR	18.04.2018
	IE	02.06.2018
	LU	02.06.2018
	MT	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2020/08]	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SI	18.04.2018
	SK	18.04.2018
	IE	02.06.2018
	LU	02.06.2018
	MT	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/26]	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SI	18.04.2018
	SK	18.04.2018
	IE	02.06.2018
	LU	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/19]	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SK	18.04.2018
	IE	02.06.2018
	LU	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/17]	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SK	18.04.2018
	LU	02.06.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/15]	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	MC	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SK	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/10]	AT	18.04.2018
	CZ	18.04.2018
	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	PL	18.04.2018
	RO	18.04.2018
	SE	18.04.2018
	SK	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/09]	DK	18.04.2018
	EE	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	PL	18.04.2018
	SE	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/08]	DK	18.04.2018
	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	PL	18.04.2018
	SE	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2019/03]	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	PL	18.04.2018
	SE	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
	PT	20.08.2018
Former [2018/52]	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	PL	18.04.2018
	SE	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
	GR	19.07.2018
Former [2018/51]	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	LV	18.04.2018
	PL	18.04.2018
	SE	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
Former [2018/50]	ES	18.04.2018
	FI	18.04.2018
	HR	18.04.2018
	LT	18.04.2018
	PL	18.04.2018
	SE	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
Former [2018/49]	ES	18.04.2018
	FI	18.04.2018
	LT	18.04.2018
	PL	18.04.2018
	SE	18.04.2018
	BG	18.07.2018
	NO	18.07.2018
Former [2018/47]	ES	18.04.2018
	FI	18.04.2018
	LT	18.04.2018
	NO	18.07.2018
Documents cited:	Search	[A]WO0034525 (VISTAGEN INC [US], et al) [A] 1-20 * claim 1 *;
		[A] - MCFADDEN DAVID G ET AL, "The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner", DEVELOPMENT, COMPANY OF BIOLOGISTS, CAMBRIDGE, GB, (20050101), vol. 132, no. 1, doi:10.1242/DEV.01562, ISSN 0950-1991, pages 189 - 201, XP002463355 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1242/dev.01562
		[ ] - RININGER J A ET AL, "Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, (20001201), vol. 5, no. 12, doi:10.1016/S1359-6446(00)01597-X, ISSN 1359-6446, pages 560 - 568, XP002249959 [ ] * the whole document * DOI: http://dx.doi.org/10.1016/S1359-6446(00)01597-X
		[A] - RININGER J A ET AL, "Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, (20001201), vol. 5, no. 12, doi:10.1016/S1359-6446(00)01597-X, ISSN 1359-6446, pages 560 - 568, XP002249959 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1016/S1359-6446(00)01597-X
	International search	[X] - VASICEK R. ET AL., "Expression of the human Handl gene in trophoblastic cells is transcriptionally regulated by activating and repressing specificity protein (Sp)-elements.", GENE, (2003), vol. 302, pages 115 - 127, XP004402161 DOI: http://dx.doi.org/10.1016/S0378-1119(02)01096-X
		[A] - HOLLENBERG S.M. ET AL., "Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system.", MOL. CELL. BIOL., (1995), vol. 15, pages 3813 - 3822, XP008140818
		[A] - CSERJESI P. ET AL., "Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development.", DEV. BIOL., (1995), vol. 170, pages 664 - 678, XP008140819 DOI: http://dx.doi.org/10.1006/dbio.1995.1245
		[A] - KOSAZUMA T. ET AL., "Organ culture of the fetal mouse palate for screening the developmental toxicity of chemicals: a validation study.", CONGENIT. ANOM., (2004), vol. 44, pages 60 - 71, XP008140868 DOI: http://dx.doi.org/10.1111/j.1741-4520.2004.00010.x
		[A] - LASCHINSKI G. ET AL., "Cytotoxicity test using blastocyst-derived euploid embryonal stem cells: a new approach to in vitro teratogenesis screening.", REPROD. TOXICOLOGY, (1991), vol. 5, pages 57 - 64, XP023821169 DOI: http://dx.doi.org/10.1016/0890-6238(91)90111-R
		[A] - SEILER A. ET AL., "Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test.", REPROD. TOXICOL., (2004), vol. 18, pages 231 - 240, XP002493702 DOI: http://dx.doi.org/10.1016/j.reprotox.2003.10.015
		[A] - NEMETH K.A. ET AL., "Searching for biomarkers of developmental toxicity with microarrays: normal eye morphogenesis in rodent embryos.", TOXICOL. APPL. PHARMACOL., (2005), vol. 206, pages 219 - 228, XP004964692 DOI: http://dx.doi.org/10.1016/j.taap.2004.12.013
		[A] - ADLER S. ET AL., "First steps in establishing a developmental toxicity test method based on human embryonic stem cells.", TOXICOL. IN VITRO, (200802), vol. 22, pages 200 - 211, XP022393683 DOI: http://dx.doi.org/10.1016/j.tiv.2007.07.013
	Examination	US2006292695
		- ZUR NIEDEN N ET AL, "Molecular markers in embryonic stem cells", TOXICOLOGY IN VITRO, ELSEVIER SCIENCE, GB, vol. 15, no. 4-5, ISSN 0887-2333, (20010801), pages 455 - 461, (20010801), XP027359650
	by applicant	- H. SPIELMANN; I. POHL; B. DORING; M. LIEBSCH; F. MOLDENHAUER, VITRO TOXICOLOGY, (1997), vol. 10, no. 1, pages L19 - 127
		- E. GENSCHOW; H. SPIELMANN; G. SCHOLZ; 1. POHL; A. SEILER; N. CLEMANN; S. BREMER; K. BECKER, ATLA, (2004), vol. 32, pages 209 - 244
		- E. GENSCHOW; H. SPIELMANN; G. SCHOLZ; A. SEILER; N. BROWN; A. PIERSMA; M. BRADY; N. CLEMANN; H. HUUSKONEN; F. PAILLARD, ATLA, (2002), vol. 30, pages L51 - 176
		- TAKAHASHI K; YAMANAKA S, CELL, (2006), vol. 126, no. 4, pages 663 - 676
		- TAKAHASHI K; TANABE K; OHNUKI M; NARITA M; ICHISAKA T; TOMODA K; YAMANAKA S, CELL, (2007), vol. 131, no. 5, pages 861 - 872
		- YU J; VODYANIK MA; SMUGA-OTTO K; ANTOSIEWICZ-BOURGET J; FRANE JL; TIAN S; NIE J; JONSDOTTIR GA; RUOTTI V; STEWART R, SCIENCE, (2007), vol. 318, no. 5858, pages 1917 - 1920
		- NAKAGAWA M; KOYANAGI M; TANABE K; TAKAHASHI K; ICHISAKA T; AOI T; OKITA K; MOCHIDUKI Y; TAKIZAWA N; YAMANAKA S, NAT BIOTECHNOL., (2008), vol. 26, no. 1, pages 101 - 106
		- A. SEILER; A. VISAN; R. BUESEN; E. GENSCHOW; H. SPIELMANN, REPRODUCTIVE TOXICOLOGY, (2004), vol. 18, pages 231 - 240
		- DNA Microarray and Up-to-date PCR Method
		- NAT GENET., (200212), vol. 32, no. 526-32
		- SAMBROOK, J; RUSSELL, D.W., Molecular Cloning, vol. 3

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