EP2350122 - METHODS OF ENHANCING TRANSLOCATION OF CHARGED ANALYTES THROUGH TRANSMEMBRANE PROTEIN PORES [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 03.02.2017 Database last updated on 09.09.2024 | Most recent event Tooltip | 21.09.2018 | Lapse of the patent in a contracting state New state(s): MT | published on 24.10.2018 [2018/43] | Applicant(s) | For all designated states Oxford University Innovation Limited Buxton Court 3 West Way Botley Oxford OX2 0SZ / GB | [2016/32] |
Former [2012/08] | For all designated states Isis Innovation Limited Ewert House Ewert Place Summertown, Oxford OX2 7SQ / GB | ||
Former [2011/31] | For all designated states Isis Innovation Ltd Ewert House Ewert Place Summertown Oxford, Oxfordshire OX2 7SG / GB | Inventor(s) | 01 /
MAGLIA, Giovanni Katholieke Universiteit Leuven Oud Markt 13 Bus 5005 3000 Leuven / BE | 02 /
BAYLEY, John, Hagan, Pryce University of Oxford Department of Chemistry South Parks Road Oxford OX1 3QZ / GB | [2011/38] |
Former [2011/31] | 01 /
MAGLIA, Giovanni University of Oxford Department of Chemistry South Parks Road Oxford OX1 3QZ / GB | ||
02 /
BAYLEY, John, Hagan, Pryce University of Oxford Department of Chemistry South Parks Road Oxford OX1 3QZ / GB | Representative(s) | Chapman, Lee Phillip, et al J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB | [2016/13] |
Former [2011/31] | Chapman, Lee Phillip, et al J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ / GB | Application number, filing date | 09764551.9 | 13.11.2009 | [2011/31] | WO2009GB02666 | Priority number, date | GB20080020927 | 14.11.2008 Original published format: GB 0820927 | [2011/31] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2010055307 | Date: | 20.05.2010 | Language: | EN | [2010/20] | Type: | A1 Application with search report | No.: | EP2350122 | Date: | 03.08.2011 | Language: | EN | The application published by WIPO in one of the EPO official languages on 20.05.2010 takes the place of the publication of the European patent application. | [2011/31] | Type: | B1 Patent specification | No.: | EP2350122 | Date: | 30.03.2016 | Language: | EN | [2016/13] | Search report(s) | International search report - published on: | EP | 20.05.2010 | Classification | IPC: | C12Q1/68, C12N15/31, C07K14/245, G01N33/68, G01N27/06, G01N27/447, G01N33/487 | [2015/41] | CPC: |
G01N33/48721 (EP,US);
C07K14/245 (EP,US);
C12Q1/6869 (EP,US);
G01N27/447 (US);
G01N33/6872 (EP,US);
G01N2333/705 (EP,US)
| C-Set: |
C12Q1/6869, C12Q2565/631 (EP,US)
|
Former IPC [2011/31] | C07K14/31, C12N15/31, C12Q1/68, G01N33/68, G01N27/06 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2016/13] |
Former [2011/31] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR | Extension states | AL | Not yet paid | BA | Not yet paid | RS | Not yet paid | Title | German: | VERFAHREN ZUR VERBESSERUNG DER TRANSLOKATION GELADENER ANALYTE DURCH TRANSMEMBRANE PROTEINPOREN | [2011/31] | English: | METHODS OF ENHANCING TRANSLOCATION OF CHARGED ANALYTES THROUGH TRANSMEMBRANE PROTEIN PORES | [2011/31] | French: | PROCÉDÉS D'AMÉLIORATION DE LA TRANSLOCATION D'ANALYTES CHARGÉS À TRAVERS DES PORES PROTÉIQUES TRANSMEMBRANAIRES | [2011/31] | Entry into regional phase | 26.05.2011 | National basic fee paid | 26.05.2011 | Designation fee(s) paid | 26.05.2011 | Examination fee paid | Examination procedure | 26.05.2011 | Examination requested [2011/31] | 13.01.2012 | Amendment by applicant (claims and/or description) | 15.05.2012 | Despatch of a communication from the examining division (Time limit: M04) | 14.09.2012 | Reply to a communication from the examining division | 11.03.2013 | Despatch of a communication from the examining division (Time limit: M04) | 19.07.2013 | Reply to a communication from the examining division | 12.02.2014 | Despatch of a communication from the examining division (Time limit: M06) | 21.08.2014 | Reply to a communication from the examining division | 26.11.2014 | Despatch of a communication from the examining division (Time limit: M06) | 08.05.2015 | Reply to a communication from the examining division | 07.10.2015 | Communication of intention to grant the patent | 01.02.2016 | Fee for grant paid | 01.02.2016 | Fee for publishing/printing paid | 01.02.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 15.05.2012 | Opposition(s) | 03.01.2017 | No opposition filed within time limit [2017/10] | Fees paid | Renewal fee | 29.11.2011 | Renewal fee patent year 03 | 29.11.2012 | Renewal fee patent year 04 | 19.11.2013 | Renewal fee patent year 05 | 25.11.2014 | Renewal fee patent year 06 | 26.11.2015 | Renewal fee patent year 07 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 13.11.2009 | AT | 30.03.2016 | BE | 30.03.2016 | BG | 30.03.2016 | CY | 30.03.2016 | CZ | 30.03.2016 | DK | 30.03.2016 | EE | 30.03.2016 | ES | 30.03.2016 | FI | 30.03.2016 | HR | 30.03.2016 | IT | 30.03.2016 | LT | 30.03.2016 | LV | 30.03.2016 | MC | 30.03.2016 | MK | 30.03.2016 | PL | 30.03.2016 | RO | 30.03.2016 | SE | 30.03.2016 | SI | 30.03.2016 | SK | 30.03.2016 | SM | 30.03.2016 | TR | 30.03.2016 | NO | 30.06.2016 | GR | 01.07.2016 | IS | 30.07.2016 | PT | 01.08.2016 | IE | 13.11.2016 | MT | 13.11.2016 | LU | 30.11.2016 | [2018/43] |
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IE | 13.11.2016 | ||
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IE | 13.11.2016 | ||
LU | 30.11.2016 | ||
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NO | 30.06.2016 | ||
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IS | 30.07.2016 | ||
PT | 01.08.2016 | ||
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NO | 30.06.2016 | ||
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IS | 30.07.2016 | ||
PT | 01.08.2016 | ||
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NO | 30.06.2016 | ||
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GR | 01.07.2016 | Cited in | International search | [A]WO2007057668 (ISIS INNOVATION [GB], et al) [A] 1-26 * the whole document *; | [A]WO2007084103 (TEXAS A & M UNIV SYS [US], et al) [A] 1-26 * the whole document *; | [X] - GU LI-QUN ET AL, "Prolonged residence time of a noncovalent molecular adapter, beta-Cyclodextrin, within the lumen of mutant alpha-hemolysin pores", JOURNAL OF GENERAL PHYSIOLOGY, (200111), vol. 118, no. 5, ISSN 0022-1295, pages 481 - 493, XP002568389 [X] 17-23 * the whole document * DOI: http://dx.doi.org/10.1085/jgp.118.5.481 | [I] - HENRICKSON S E ET AL, "Driven DNA transport into an asymmetric nanometer-scale pore.", PHYSICAL REVIEW LETTERS 2 OCT 2000, (20001002), vol. 85, no. 14, ISSN 0031-9007, pages 3057 - 3060, XP002568385 [I] 1-26 * page 3059, column 1, paragraph 2 - column 2, paragraph 1 * DOI: http://dx.doi.org/10.1103/PhysRevLett.85.3057 | [I] - MERZLYAK PETR G ET AL, "Conductance and ion selectivity of a mesoscopic protein nanopore probed with cysteine scanning mutagenesis", BIOPHYSICAL JOURNAL, (200511), vol. 89, no. 5, ISSN 0006-3495, pages 3059 - 3070, XP002568386 [I] 1,8-24 * the whole document * DOI: http://dx.doi.org/10.1529/biophysj.105.066472 | [A] - ASTIER YANN ET AL, "Toward single molecule DNA sequencing: direct identification of ribonucleoside and deoxyribonucleoside 5'-monophosphates by using an engineered protein nanopore equipped with a molecular adapter", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, NEW YORK, USA, (20060208), vol. 128, no. 5, ISSN 0002-7863, pages 1705 - 1710, XP002503447 [A] 1-26 * the whole document * DOI: http://dx.doi.org/10.1021/JA057123+ | [A] - GU LI-QUN ET AL, "Electroosmotic enhancement of the binding of neutral molecule to a transmembrane pore.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20031223), vol. 100, no. 26, ISSN 0027-8424, pages 15498 - 15503, XP002568387 [A] 1-26 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.2531778100 | [A] - COMAI MASSIMILIANO ET AL, "Protein engineering modulates the transport properties and ion selectivity of the pores formed by staphylococcal gamma-haemolysins in lipid membranes", MOLECULAR MICROBIOLOGY, (200206), vol. 44, no. 5, ISSN 0950-382X, pages 1251 - 1267, XP002568388 [A] 1-26 * the whole document * DOI: http://dx.doi.org/10.1046/j.1365-2958.2002.02943.x | [XP] - MAGLIA GIOVANNI ET AL, "Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (200812), vol. 105, no. 50, ISSN 0027-8424, pages 19720 - 19725, XP002568390 [XP] 1-26 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.0808296105 | Examination | WO2010004273 | - CHELEY S ET AL, "Stochastic Sensing of Nanomolar Inositol 1,4,5-Trisphosphate with an Engineered Pore", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 9, no. 7, doi:10.1016/S1074-5521(02)00172-2, ISSN 1074-5521, (20020701), pages 829 - 838, (20020701), XP026919871 DOI: http://dx.doi.org/10.1016/S1074-5521(02)00172-2 | - P.C. Jordan, "How pore mouth charge distributions alter the permeability of transmembrane ionic channels", Biophysical Journal, (19870201), vol. 51, no. 2, doi:10.1016/S0006-3495(87)83336-2, ISSN 0006-3495, pages 297 - 311, XP055026611 DOI: http://dx.doi.org/10.1016/S0006-3495(87)83336-2 | - Aaron J. Wolfe ET AL, "Catalyzing the Translocation of Polypeptides through Attractive Interactions", Journal of the American Chemical Society, (20071101), vol. 129, no. 45, doi:10.1021/ja0749340, ISSN 0002-7863, pages 14034 - 14041, XP055054401 DOI: http://dx.doi.org/10.1021/ja0749340 |