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Extract from the Register of European Patents

EP About this file: EP2350122

EP2350122 - METHODS OF ENHANCING TRANSLOCATION OF CHARGED ANALYTES THROUGH TRANSMEMBRANE PROTEIN PORES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.02.2017
Database last updated on 09.09.2024
Most recent event   Tooltip21.09.2018Lapse of the patent in a contracting state
New state(s): MT		published on 24.10.2018  [2018/43]
Applicant(s)For all designated states
Oxford University Innovation Limited
Buxton Court
3 West Way
Botley
Oxford OX2 0SZ / GB
[2016/32]
Former [2012/08]For all designated states
Isis Innovation Limited
Ewert House Ewert Place
Summertown, Oxford OX2 7SQ / GB
Former [2011/31]For all designated states
Isis Innovation Ltd
Ewert House Ewert Place Summertown
Oxford, Oxfordshire OX2 7SG / GB
Inventor(s)01 / MAGLIA, Giovanni
Katholieke Universiteit Leuven
Oud Markt 13
Bus 5005
3000 Leuven / BE
02 / BAYLEY, John, Hagan, Pryce
University of Oxford
Department of Chemistry
South Parks Road
Oxford OX1 3QZ / GB
 [2011/38]
Former [2011/31]01 / MAGLIA, Giovanni
University of Oxford Department of Chemistry South Parks Road
Oxford OX1 3QZ / GB
02 / BAYLEY, John, Hagan, Pryce
University of Oxford Department of Chemistry South Parks Road
Oxford OX1 3QZ / GB
Representative(s)Chapman, Lee Phillip, et al
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
[2016/13]
Former [2011/31]Chapman, Lee Phillip, et al
J.A. Kemp & Co. 14 South Square Gray's Inn
London WC1R 5JJ / GB
Application number, filing date09764551.913.11.2009
[2011/31]
WO2009GB02666
Priority number, dateGB2008002092714.11.2008         Original published format: GB 0820927
[2011/31]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010055307
Date:20.05.2010
Language:EN
[2010/20]
Type: A1 Application with search report 
No.:EP2350122
Date:03.08.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 20.05.2010 takes the place of the publication of the European patent application.
[2011/31]
Type: B1 Patent specification 
No.:EP2350122
Date:30.03.2016
Language:EN
[2016/13]
Search report(s)International search report - published on:EP20.05.2010
ClassificationIPC:C12Q1/68, C12N15/31, C07K14/245, G01N33/68, G01N27/06, G01N27/447, G01N33/487
[2015/41]
CPC:
G01N33/48721 (EP,US); C07K14/245 (EP,US); C12Q1/6869 (EP,US);
G01N27/447 (US); G01N33/6872 (EP,US); G01N2333/705 (EP,US)
C-Set:
C12Q1/6869, C12Q2565/631 (EP,US)
Former IPC [2011/31]C07K14/31, C12N15/31, C12Q1/68, G01N33/68, G01N27/06
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2016/13]
Former [2011/31]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:VERFAHREN ZUR VERBESSERUNG DER TRANSLOKATION GELADENER ANALYTE DURCH TRANSMEMBRANE PROTEINPOREN[2011/31]
English:METHODS OF ENHANCING TRANSLOCATION OF CHARGED ANALYTES THROUGH TRANSMEMBRANE PROTEIN PORES[2011/31]
French:PROCÉDÉS D'AMÉLIORATION DE LA TRANSLOCATION D'ANALYTES CHARGÉS À TRAVERS DES PORES PROTÉIQUES TRANSMEMBRANAIRES[2011/31]
Entry into regional phase26.05.2011National basic fee paid 
26.05.2011Designation fee(s) paid 
26.05.2011Examination fee paid 
Examination procedure26.05.2011Examination requested  [2011/31]
13.01.2012Amendment by applicant (claims and/or description)
15.05.2012Despatch of a communication from the examining division (Time limit: M04)
14.09.2012Reply to a communication from the examining division
11.03.2013Despatch of a communication from the examining division (Time limit: M04)
19.07.2013Reply to a communication from the examining division
12.02.2014Despatch of a communication from the examining division (Time limit: M06)
21.08.2014Reply to a communication from the examining division
26.11.2014Despatch of a communication from the examining division (Time limit: M06)
08.05.2015Reply to a communication from the examining division
07.10.2015Communication of intention to grant the patent
01.02.2016Fee for grant paid
01.02.2016Fee for publishing/printing paid
01.02.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.05.2012
Opposition(s)03.01.2017No opposition filed within time limit [2017/10]
Fees paidRenewal fee
29.11.2011Renewal fee patent year 03
29.11.2012Renewal fee patent year 04
19.11.2013Renewal fee patent year 05
25.11.2014Renewal fee patent year 06
26.11.2015Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU13.11.2009
AT30.03.2016
BE30.03.2016
BG30.03.2016
CY30.03.2016
CZ30.03.2016
DK30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
IT30.03.2016
LT30.03.2016
LV30.03.2016
MC30.03.2016
MK30.03.2016
PL30.03.2016
RO30.03.2016
SE30.03.2016
SI30.03.2016
SK30.03.2016
SM30.03.2016
TR30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
PT01.08.2016
IE13.11.2016
MT13.11.2016
LU30.11.2016
[2018/43]
Former [2018/38]HU13.11.2009
AT30.03.2016
BE30.03.2016
BG30.03.2016
CY30.03.2016
CZ30.03.2016
DK30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
IT30.03.2016
LT30.03.2016
LV30.03.2016
MC30.03.2016
MK30.03.2016
PL30.03.2016
RO30.03.2016
SE30.03.2016
SI30.03.2016
SK30.03.2016
SM30.03.2016
TR30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
PT01.08.2016
IE13.11.2016
LU30.11.2016
Former [2018/29]HU13.11.2009
AT30.03.2016
BE30.03.2016
CY30.03.2016
CZ30.03.2016
DK30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
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LT30.03.2016
LV30.03.2016
MC30.03.2016
MK30.03.2016
PL30.03.2016
RO30.03.2016
SE30.03.2016
SI30.03.2016
SK30.03.2016
SM30.03.2016
TR30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
PT01.08.2016
IE13.11.2016
LU30.11.2016
Former [2018/28]HU13.11.2009
AT30.03.2016
BE30.03.2016
CY30.03.2016
CZ30.03.2016
DK30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
IT30.03.2016
LT30.03.2016
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MC30.03.2016
MK30.03.2016
PL30.03.2016
RO30.03.2016
SE30.03.2016
SI30.03.2016
SK30.03.2016
SM30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
PT01.08.2016
IE13.11.2016
LU30.11.2016
Former [2017/51]AT30.03.2016
BE30.03.2016
CZ30.03.2016
DK30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
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LV30.03.2016
PL30.03.2016
RO30.03.2016
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SI30.03.2016
SK30.03.2016
SM30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
PT01.08.2016
IE13.11.2016
LU30.11.2016
Former [2017/48]AT30.03.2016
BE30.03.2016
CZ30.03.2016
DK30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
IT30.03.2016
LT30.03.2016
LV30.03.2016
PL30.03.2016
RO30.03.2016
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SM30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
PT01.08.2016
LU30.11.2016
Former [2017/37]AT30.03.2016
BE30.03.2016
CZ30.03.2016
DK30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
IT30.03.2016
LT30.03.2016
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SM30.03.2016
NO30.06.2016
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IS30.07.2016
PT01.08.2016
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EE30.03.2016
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IT30.03.2016
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SE30.03.2016
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SM30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
PT01.08.2016
Former [2017/03]AT30.03.2016
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EE30.03.2016
ES30.03.2016
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IT30.03.2016
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SM30.03.2016
NO30.06.2016
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IS30.07.2016
PT01.08.2016
Former [2016/51]AT30.03.2016
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EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
LT30.03.2016
LV30.03.2016
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RO30.03.2016
SE30.03.2016
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SM30.03.2016
NO30.06.2016
GR01.07.2016
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PT01.08.2016
Former [2016/50]AT30.03.2016
CZ30.03.2016
EE30.03.2016
ES30.03.2016
FI30.03.2016
HR30.03.2016
LT30.03.2016
LV30.03.2016
PL30.03.2016
RO30.03.2016
SE30.03.2016
SK30.03.2016
SM30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
Former [2016/49]EE30.03.2016
FI30.03.2016
HR30.03.2016
LT30.03.2016
LV30.03.2016
PL30.03.2016
SE30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
Former [2016/48]FI30.03.2016
HR30.03.2016
LT30.03.2016
LV30.03.2016
SE30.03.2016
NO30.06.2016
GR01.07.2016
IS30.07.2016
Former [2016/39]FI30.03.2016
HR30.03.2016
LT30.03.2016
LV30.03.2016
SE30.03.2016
NO30.06.2016
GR01.07.2016
Former [2016/36]FI30.03.2016
HR30.03.2016
LT30.03.2016
NO30.06.2016
GR01.07.2016
Former [2016/35]FI30.03.2016
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NO30.06.2016
GR01.07.2016
Cited inInternational search[A]WO2007057668  (ISIS INNOVATION [GB], et al) [A] 1-26 * the whole document *;
 [A]WO2007084103  (TEXAS A & M UNIV SYS [US], et al) [A] 1-26 * the whole document *;
 [X]  - GU LI-QUN ET AL, "Prolonged residence time of a noncovalent molecular adapter, beta-Cyclodextrin, within the lumen of mutant alpha-hemolysin pores", JOURNAL OF GENERAL PHYSIOLOGY, (200111), vol. 118, no. 5, ISSN 0022-1295, pages 481 - 493, XP002568389 [X] 17-23 * the whole document *

DOI:   http://dx.doi.org/10.1085/jgp.118.5.481
 [I]  - HENRICKSON S E ET AL, "Driven DNA transport into an asymmetric nanometer-scale pore.", PHYSICAL REVIEW LETTERS 2 OCT 2000, (20001002), vol. 85, no. 14, ISSN 0031-9007, pages 3057 - 3060, XP002568385 [I] 1-26 * page 3059, column 1, paragraph 2 - column 2, paragraph 1 *

DOI:   http://dx.doi.org/10.1103/PhysRevLett.85.3057
 [I]  - MERZLYAK PETR G ET AL, "Conductance and ion selectivity of a mesoscopic protein nanopore probed with cysteine scanning mutagenesis", BIOPHYSICAL JOURNAL, (200511), vol. 89, no. 5, ISSN 0006-3495, pages 3059 - 3070, XP002568386 [I] 1,8-24 * the whole document *

DOI:   http://dx.doi.org/10.1529/biophysj.105.066472
 [A]  - ASTIER YANN ET AL, "Toward single molecule DNA sequencing: direct identification of ribonucleoside and deoxyribonucleoside 5'-monophosphates by using an engineered protein nanopore equipped with a molecular adapter", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, NEW YORK, USA, (20060208), vol. 128, no. 5, ISSN 0002-7863, pages 1705 - 1710, XP002503447 [A] 1-26 * the whole document *

DOI:   http://dx.doi.org/10.1021/JA057123+
 [A]  - GU LI-QUN ET AL, "Electroosmotic enhancement of the binding of neutral molecule to a transmembrane pore.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20031223), vol. 100, no. 26, ISSN 0027-8424, pages 15498 - 15503, XP002568387 [A] 1-26 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.2531778100
 [A]  - COMAI MASSIMILIANO ET AL, "Protein engineering modulates the transport properties and ion selectivity of the pores formed by staphylococcal gamma-haemolysins in lipid membranes", MOLECULAR MICROBIOLOGY, (200206), vol. 44, no. 5, ISSN 0950-382X, pages 1251 - 1267, XP002568388 [A] 1-26 * the whole document *

DOI:   http://dx.doi.org/10.1046/j.1365-2958.2002.02943.x
 [XP]  - MAGLIA GIOVANNI ET AL, "Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (200812), vol. 105, no. 50, ISSN 0027-8424, pages 19720 - 19725, XP002568390 [XP] 1-26 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.0808296105
ExaminationWO2010004273
    - CHELEY S ET AL, "Stochastic Sensing of Nanomolar Inositol 1,4,5-Trisphosphate with an Engineered Pore", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 9, no. 7, doi:10.1016/S1074-5521(02)00172-2, ISSN 1074-5521, (20020701), pages 829 - 838, (20020701), XP026919871

DOI:   http://dx.doi.org/10.1016/S1074-5521(02)00172-2
    - P.C. Jordan, "How pore mouth charge distributions alter the permeability of transmembrane ionic channels", Biophysical Journal, (19870201), vol. 51, no. 2, doi:10.1016/S0006-3495(87)83336-2, ISSN 0006-3495, pages 297 - 311, XP055026611

DOI:   http://dx.doi.org/10.1016/S0006-3495(87)83336-2
    - Aaron J. Wolfe ET AL, "Catalyzing the Translocation of Polypeptides through Attractive Interactions", Journal of the American Chemical Society, (20071101), vol. 129, no. 45, doi:10.1021/ja0749340, ISSN 0002-7863, pages 14034 - 14041, XP055054401

DOI:   http://dx.doi.org/10.1021/ja0749340
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.