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Extract from the Register of European Patents

EP About this file: EP2370584

EP2370584 - Use of microRNAs to control virus helper nucleic acids [Right-click to bookmark this link]
Former [2011/40]USE OF MICRORNAS TO CONTROL VIRUS HELPER NUCLEIC ACIDS
[2014/02]
StatusNo opposition filed within time limit
Status updated on  11.09.2015
Database last updated on 30.10.2024
Most recent event   Tooltip22.06.2018Lapse of the patent in a contracting state
New state(s): MK		published on 25.07.2018  [2018/30]
Applicant(s)For all designated states
Alphavax, Inc.
2 Triangle Drive
Research Triangle Park, NC 27709 / US
[2011/40]
Inventor(s)01 / COFFIELD III, Vernon, McNeil
1016 Quiet Ridge Circle
Raleigh North Carolina 27614 / US
02 / KAMRUD, Kurt, I.
2209 WinPost Lane
Apex North Carolina 27502 / US
03 / SMITH, Jonathan, F.
104 Bronzewood Court
Cary North Carolina 27511 / US
 [2011/40]
Representative(s)Leißler-Gerstl, Gabriele
Hoefer & Partner
Patentanwälte mbB
Pilgersheimer Strasse 20
81543 München / DE
[N/P]
Former [2014/45]Leissler-Gerstl, Gabriele
Hoefer & Partner
Patentanwälte
Pilgersheimer Strasse 20
81543 München / DE
Former [2011/40]Leissler-Gerstl, Gabriele
Hoefer & Partner Patentanwälte Pilgersheimer Straße 20
D-81543 München / DE
Application number, filing date09764663.225.11.2009
WO2009US65900
Priority number, dateUS20080118954P01.12.2008         Original published format: US 118954 P
[2011/40]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010065414
Date:10.06.2010
Language:EN
[2010/23]
Type: A1 Application with search report 
No.:EP2370584
Date:05.10.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 10.06.2010 takes the place of the publication of the European patent application.
[2011/40]
Type: B1 Patent specification 
No.:EP2370584
Date:05.11.2014
Language:EN
[2014/45]
Search report(s)International search report - published on:EP10.06.2010
ClassificationIPC:C12N15/85, C12N15/86, C12N7/04, C12N5/10, A61K39/12
[2011/40]
CPC:
C12N15/85 (EP,US); A61K48/0041 (US); A61K39/12 (US);
A61P37/04 (EP); C07K14/005 (US); C12N15/86 (EP,US);
A61K2039/5258 (EP,US); C12N2770/36143 (EP,US); C12N2800/40 (EP,US);
C12N2800/50 (EP,US); C12N2820/60 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2014/45]
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:Verwendung von mikro-RNS zur Kontrolle von Virus Helfernukleinsäuren[2014/45]
English:Use of microRNAs to control virus helper nucleic acids[2014/45]
French:Utilisation de micro-ARN pour le contrôle d'acides nucléiques d'aide de virus[2014/45]
Former [2011/40]VERWENDUNG VON MICRORNAS ZUR KONTROLLE VON VIRUSHELFERNUKLEINSÄUREN
Former [2011/40]USE OF MICRORNAS TO CONTROL VIRUS HELPER NUCLEIC ACIDS
Former [2011/40]UTILISATION DE MICROARN POUR CONTRÔLER DES ACIDES NUCLÉIQUES AUXILIAIRES DE VIRUS
Entry into regional phase28.06.2011National basic fee paid 
28.06.2011Designation fee(s) paid 
28.06.2011Examination fee paid 
Examination procedure28.06.2011Examination requested  [2011/40]
20.01.2012Amendment by applicant (claims and/or description)
09.08.2012Despatch of a communication from the examining division (Time limit: M04)
13.11.2012Reply to a communication from the examining division
16.01.2014Communication of intention to grant the patent
15.05.2014Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
28.05.2014Communication of intention to grant the patent
24.09.2014Fee for grant paid
24.09.2014Fee for publishing/printing paid
24.09.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  09.08.2012
Opposition(s)06.08.2015No opposition filed within time limit [2015/42]
Fees paidRenewal fee
14.11.2011Renewal fee patent year 03
13.11.2012Renewal fee patent year 04
18.11.2013Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.11.2009
AT05.11.2014
BG05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
MC05.11.2014
MK05.11.2014
MT05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SI05.11.2014
SK05.11.2014
SM05.11.2014
TR05.11.2014
LU25.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
[2018/30]
Former [2016/33]HU25.11.2009
AT05.11.2014
BG05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
MC05.11.2014
MT05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SI05.11.2014
SK05.11.2014
SM05.11.2014
TR05.11.2014
LU25.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2016/32]HU25.11.2009
AT05.11.2014
BG05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
MC05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SI05.11.2014
SK05.11.2014
SM05.11.2014
TR05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2016/28]AT05.11.2014
BG05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
MC05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SI05.11.2014
SK05.11.2014
SM05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2016/22]AT05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
MC05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SI05.11.2014
SK05.11.2014
SM05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2016/12]AT05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
MC05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SI05.11.2014
SK05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/39]AT05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
MC05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SK05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/37]AT05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
SK05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/36]AT05.11.2014
CY05.11.2014
CZ05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
NL05.11.2014
PL05.11.2014
RO05.11.2014
SE05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/35]AT05.11.2014
CY05.11.2014
DK05.11.2014
EE05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
NL05.11.2014
PL05.11.2014
SE05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/30]AT05.11.2014
CY05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
NL05.11.2014
PL05.11.2014
SE05.11.2014
BE30.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/26]AT05.11.2014
CY05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
NL05.11.2014
PL05.11.2014
SE05.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/25]AT05.11.2014
FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
NL05.11.2014
PL05.11.2014
SE05.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/24]FI05.11.2014
HR05.11.2014
LT05.11.2014
LV05.11.2014
NL05.11.2014
PL05.11.2014
SE05.11.2014
NO05.02.2015
GR06.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/23]FI05.11.2014
LT05.11.2014
NL05.11.2014
NO05.02.2015
IS05.03.2015
PT05.03.2015
Former [2015/22]LT05.11.2014
NO05.02.2015
PT05.03.2015
Former [2015/21]LT05.11.2014
NO05.02.2015
Former [2015/20]LT05.11.2014
Cited inInternational search[A]WO2004085660  (ALPHAVAX INC [US], et al) [A] 1-84* the whole document *;
 [Y]  - PUSHKO P ET AL, "Replicon-Helper Systems from Attenuated Venezuelan Equine Encephalitis Virus: Expression of Heterologous Genesin Vitroand Immunization against Heterologous Pathogensin Vivo", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, (19971222), vol. 239, no. 2, ISSN 0042-6822, pages 389 - 401, XP004452378 [Y] 1-84 * the whole document *

DOI:   http://dx.doi.org/10.1006/viro.1997.8878
 [Y]  - DWIGHT BARNES ET AL, "Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines", CELL HOST AND MICROBE,, vol. 4, no. 3, ISSN 1934-6069, (20080911), pages 239 - 248, (20080910), XP002544788 [Y] 1-84 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.chom.2008.08.003
 [A]  - KELLY ELIZABETH J ET AL, "Engineering microRNA responsiveness to decrease virus pathogenicity", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 14, no. 11, ISSN 1078-8956, (20081101), pages 1278 - 1283, (20081026), XP002544787 [A] 1-84 * the whole document *

DOI:   http://dx.doi.org/10.1038/NM.1776
by applicantWO2004085660
    - PUSHKO ET AL., "Replicon-Helper Systems from Attenuated Venezuelan Equine Encephalitis Virus: Expression of Heterologous Genes in Vitro and Immunization against Heterologous Pathogens in Vivo", VIROLOGY, (1997), vol. 239, no. 2, doi:doi:10.1006/viro.1997.8878, pages 389 - 401, XP002139493

DOI:   http://dx.doi.org/10.1006/viro.1997.8878
    - BARNES ET AL., "Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines", CELL HOST AND MICROBE, (20080911), vol. 4, no. 3, doi:doi:10.1016/j.chom.2008.08.003, pages 239 - 248, XP002544788

DOI:   http://dx.doi.org/10.1016/j.chom.2008.08.003
    - KELLY ET AL., "Engineering microRNA responsiveness to decrease virus pathogenicity", NATURE MEDICINE, NATURE PUBLISHING GROUP, (20081101), vol. 14, no. 11, pages 1278 - 1283
    - KINNEY ET AL., VIROLOGY, (1989), vol. 170, pages 19 - 30
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