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Extract from the Register of European Patents

EP About this file: EP2367816

EP2367816 - ISATIN DERIVATIVES FOR USE AS IN VIVO IMAGING AGENTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.09.2017
Database last updated on 11.04.2026
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
Imperial Innovations Limited
Electrical and Electronic Engineering Building Level 12, Imperial College London Exhibition Road
London SW7 2AZ / GB
For all designated states
Hammersmith Imanet Limited
Cyclotron Building
Hammersmith Hospital
Du Cane Road
London W12 0NN / GB
[2011/39]
Inventor(s)01 / ABOAGYE, Eric, Ofori
89 Severn Drive
Enfield
Middlesex EN1 4LY / GB
02 / SMITH, Graham
23 Paveley Court
30 Langstone Way
Mill Hill
London NW7 1GR / GB
03 / NGUYEN, Quang-Dé
158 Ladbroke Grove
London W10 5NA / GB
04 / ARSTAD, Erik
15 Caird Street
London W10 4RP / GB
05 / GLASER, Matthias, Eberhard
29 Eldon Road
London N22 5DX / GB
 [2011/39]
Representative(s)Venner, Julia Ann, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[N/P]
Former [2016/45]Venner, Julia Ann, et al
Kilburn & Strode LLP
20 Red Lion Street
London WC1R 4PJ / GB
Former [2011/39]Venner, Julia Ann, et al
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Application number, filing date09785058.004.09.2009
[2016/45]
WO2009GB02132
Priority number, dateGB2008001629405.09.2008         Original published format: GB 0816294
GB2008001807602.10.2008         Original published format: GB 0818076
[2011/39]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010026388
Date:11.03.2010
Language:EN
[2010/10]
Type: A1 Application with search report 
No.:EP2367816
Date:28.09.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 11.03.2010 takes the place of the publication of the European patent application.
[2011/39]
Type: B1 Patent specification 
No.:EP2367816
Date:09.11.2016
Language:EN
[2016/45]
Search report(s)International search report - published on:EP11.03.2010
ClassificationIPC:C07D403/12, C07D403/14, C07D405/14, A61K31/404, A61K51/00, A61P25/28
[2011/39]
CPC:
C07D403/12 (EP,KR,US); A61K31/404 (KR); A61K51/04 (KR);
A61P1/16 (EP); A61P19/02 (EP); A61P25/28 (EP);
A61P37/06 (EP); A61P43/00 (EP); A61P7/00 (EP);
A61P9/10 (EP); C07D403/14 (EP,US); C07D405/14 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2016/45]
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:ISATIN DERIVATE ZUR VERWENDUNG ALS IN VIVO ABBILDUNGSMITTEL[2015/22]
English:ISATIN DERIVATIVES FOR USE AS IN VIVO IMAGING AGENTS[2011/39]
French:DÉRIVÉS D'ISATINE POUR UTILISATION EN TANT QU'AGENTS D'IMAGERIE IN VIVO[2011/39]
Former [2011/39]SATINDERIVATE ZUR VERWENDUNG ALS MITTEL FÜR DIER DIE IN-VIVO-BILDDARSTELLUNG
Entry into regional phase31.03.2011National basic fee paid 
31.03.2011Designation fee(s) paid 
31.03.2011Examination fee paid 
Examination procedure31.03.2011Amendment by applicant (claims and/or description)
31.03.2011Examination requested  [2011/39]
06.11.2012Despatch of a communication from the examining division (Time limit: M04)
29.11.2012Despatch of a communication from the examining division (Time limit: M06)
07.06.2013Reply to a communication from the examining division
06.12.2013Despatch of a communication from the examining division (Time limit: M06)
09.06.2014Reply to a communication from the examining division
07.08.2014Despatch of a communication from the examining division (Time limit: M06)
17.02.2015Reply to a communication from the examining division
17.07.2015Communication of intention to grant the patent
26.11.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
18.12.2015Communication of intention to grant the patent
12.04.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
11.05.2016Communication of intention to grant the patent
20.09.2016Fee for grant paid
20.09.2016Fee for publishing/printing paid
20.09.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  06.11.2012
Opposition(s)10.08.2017No opposition filed within time limit [2017/42]
Fees paidRenewal fee
29.09.2011Renewal fee patent year 03
27.09.2012Renewal fee patent year 04
26.09.2013Renewal fee patent year 05
25.09.2014Renewal fee patent year 06
25.09.2015Renewal fee patent year 07
28.09.2016Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU04.09.2009
AT09.11.2016
BE09.11.2016
CY09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
MC09.11.2016
MK09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SI09.11.2016
SK09.11.2016
SM09.11.2016
TR09.11.2016
BG09.02.2017
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
[2020/15]
Former [2019/51]HU04.09.2009
AT09.11.2016
BE09.11.2016
CY09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
MC09.11.2016
MK09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SI09.11.2016
SK09.11.2016
SM09.11.2016
BG09.02.2017
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2019/46]HU04.09.2009
AT09.11.2016
BE09.11.2016
CY09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
MC09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SI09.11.2016
SK09.11.2016
SM09.11.2016
BG09.02.2017
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2019/31]HU04.09.2009
AT09.11.2016
BE09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
MC09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SI09.11.2016
SK09.11.2016
SM09.11.2016
BG09.02.2017
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2018/29]AT09.11.2016
BE09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
MC09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SI09.11.2016
SK09.11.2016
SM09.11.2016
BG09.02.2017
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/52]AT09.11.2016
BE09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SI09.11.2016
SK09.11.2016
SM09.11.2016
BG09.02.2017
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/38]AT09.11.2016
BE09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SK09.11.2016
SM09.11.2016
BG09.02.2017
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/37]AT09.11.2016
BE09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
IT09.11.2016
LT09.11.2016
LV09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SK09.11.2016
SM09.11.2016
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/36]AT09.11.2016
BE09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
LT09.11.2016
LV09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
SK09.11.2016
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/35]AT09.11.2016
CZ09.11.2016
DK09.11.2016
EE09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
LT09.11.2016
LV09.11.2016
NL09.11.2016
PL09.11.2016
RO09.11.2016
SE09.11.2016
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/33]AT09.11.2016
DK09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
LT09.11.2016
LV09.11.2016
NL09.11.2016
PL09.11.2016
SE09.11.2016
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/26]AT09.11.2016
ES09.11.2016
FI09.11.2016
HR09.11.2016
LT09.11.2016
LV09.11.2016
NL09.11.2016
PL09.11.2016
SE09.11.2016
NO09.02.2017
GR10.02.2017
IS09.03.2017
PT09.03.2017
Former [2017/12]LV09.11.2016
Cited inInternational search[YA]   D. ZHOU ET. AL.: "Synthesis, radiolabeling, and in vivo evaluation of an 18F labeled isatin analog for imaging caspase-3 activation in apoptosis.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 5041 - 5046, XP025107212 [Y] 1-6,8-11,15-36 * page 5043, scheme 1 * [A] 7,12-14,37-40

DOI:   http://dx.doi.org/10.1016/j.bmcl.2006.07.045
 [DYA]   K. KOPKA ET. AL.: "5-Pyrrolidinylsulfinyl Isatins as a Potential Tool for the Molecular Imaging of Caspases in Apoptosis.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 23, 2006, pages 6704 - 6715, XP002551895 [DY] 1-6,8-11,15-36 * tables 1,2 * [A] 7,12-14,37-40

DOI:   http://dx.doi.org/10.1021/jm051217c
 [T]   G. SMITH ET. AL.: "Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[18F]fluoroethylazide.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2 December 2008 (2008-12-02), pages 8057 - 8067, XP002551896 [T] 1-40 * figures 1-8; table 1 *

DOI:   http://dx.doi.org/10.1021/jm801107u
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