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Extract from the Register of European Patents

EP About this file: EP2318013

EP2318013 - SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  21.04.2017
Database last updated on 19.10.2024
FormerExamination is in progress
Status updated on  11.01.2017
Most recent event   Tooltip21.04.2017Application deemed to be withdrawnpublished on 24.05.2017  [2017/21]
Applicant(s)For all designated states
ZIOPHARM ONCOLOGY, INC.
One First Avenue Parris Building No. 34 Navy Yard Plaza
Boston, MA 02129 / US
[2011/19]
Inventor(s)01 / WALIGORA, Frank, Walter
93 Powder House Avenue
Haverhill MD 01830 / US
02 / AMEDIO, John, C., Jr.
6 Ginny Lane
Franklin MA 02038-4116 / US
 [2011/19]
Representative(s)Dörries, Hans Ulrich, et al
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
[N/P]
Former [2011/19]Dörries, Hans Ulrich, et al
df-mp Fünf Höfe Theatinerstrasse 16
80333 München / DE
Application number, filing date09803607.230.07.2009
[2011/19]
WO2009US52295
Priority number, dateUS20080137538P31.07.2008         Original published format: US 137538 P
[2011/19]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010014841
Date:04.02.2010
Language:EN
[2010/05]
Type: A1 Application with search report 
No.:EP2318013
Date:11.05.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 04.02.2010 takes the place of the publication of the European patent application.
[2011/19]
Search report(s)International search report - published on:AU04.02.2010
(Supplementary) European search report - dispatched on:EP25.06.2013
ClassificationIPC:A61K31/675, A61K31/66, A61P35/00, C07F9/22, C07F9/24, C07F9/20
[2013/30]
CPC:
C07F9/222 (EP,CN,US); A61K31/664 (EP,CN,US); A61K31/66 (EP,US);
A61K31/675 (EP,US); A61K47/38 (CN); A61K9/0053 (CN);
A61P35/00 (EP); A61P9/00 (EP); C07F9/14 (CN);
C07F9/1406 (US); C07F9/20 (EP,US); C07F9/22 (EP,US);
C07F9/2429 (EP,US); C07F9/2458 (EP,CN,US) (-)
Former IPC [2011/19]A61K31/675, A61K31/66, A61P35/00, C07F9/22
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2011/19]
TitleGerman:SYNTHESE UND SALZFORMULIERUNGEN AUS ISOPHOSPHORAMID-SENFGAS UND ANALOGA DAVON[2011/19]
English:SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF[2011/19]
French:SYNTHÈSE ET FORMULATIONS DE SELS DE MOUTARDE D'ISOPHOSPHORAMIDE ET DE LEURS ANALOGUES[2011/19]
Entry into regional phase28.02.2011National basic fee paid 
28.02.2011Search fee paid 
28.02.2011Designation fee(s) paid 
28.02.2011Examination fee paid 
Examination procedure28.02.2011Examination requested  [2011/19]
20.01.2014Amendment by applicant (claims and/or description)
05.08.2016Despatch of a communication from the examining division (Time limit: M04)
16.12.2016Application deemed to be withdrawn, date of legal effect  [2017/21]
12.01.2017Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2017/21]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  05.08.2016
Fees paidRenewal fee
25.07.2011Renewal fee patent year 03
25.07.2012Renewal fee patent year 04
27.08.2013Renewal fee patent year 05
28.07.2014Renewal fee patent year 06
27.07.2015Renewal fee patent year 07
Penalty fee
Additional fee for renewal fee
31.07.201305   M06   Fee paid on   27.08.2013
31.07.201608   M06   Not yet paid
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Documents cited:Search[X]WO0071134  (SOUTHERN RES INST [US], et al) [X] 1-10,15,16 * claim 1 *;
 [X]WO2006047575  (DEKK TEC INC [US], et al) [X] 1-10,15,16 * paragraph [0058] - paragraph [0070]; claim 1 *;
 [XP]WO2008124097  (ZIOPHARM ONCOLOGY INC [US], et al) [XP] 1-10,15,16 * claims 1,20,21,36 *;
 [A]  - GERMANN N ET AL, "Comparative preclinical toxicology and pharmacology of isophosphoramide mustard, the active metabolite of ifosfamide", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER VERLAG, BERLIN, vol. 55, no. 2, doi:10.1007/S00280-004-0894-Y, ISSN 0344-5704, (20050101), pages 143 - 151, (20040914), XP002481280 [A] 1-10,15,16 * abstract *

DOI:   http://dx.doi.org/10.1007/s00280-004-0894-y
International searchSU427945  [ ] (INSTITUTE OF HETEROORGANIC COMPOUNDS);
 [X]WO2006047575  (DEKK TEC INC [US], et al);
 [X]  - MISIURA, K ET AL., "'Isophosphoramide mustard analogues as prodrugs for anti-cancer gene-directed enzyme-prodrug therapy (GDEPT)", ACTA BIOCHIMICA POLONICA, (2002), vol. 49, no. 1, pages 169 - 176, XP008142830
 [X]  - HAN, S.Y. ET AL., "Synthesis of O (and O) Labelled Isophosphoramide Mustard", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, (1994), vol. XXXIV, no. 3, pages 247 - 254, XP008142829

DOI:   http://dx.doi.org/10.1002/jlcr.2580340307
 [X]  - CHEMICAL ABSTRACTS, Database accession no. 81:37378, XP008143854
 [X]  - ZAKHAROV, S. ET AL., "Catalytic phosphorylation of polyfluoroalkanols. Communication 5. Catalytic phosphorylation of a-polyfluoroalkylbenzyl alcohols with phosphoryl chloride", BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR, (1976), vol. 25, no. 8, pages 1727 - 1731, XP008142866
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.