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Extract from the Register of European Patents

EP About this file: EP2324360

EP2324360 - BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITION [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  22.12.2023
Database last updated on 03.04.2025
FormerThe patent has been granted
Status updated on  29.12.2017
FormerGrant of patent is intended
Status updated on  21.12.2017
FormerExamination is in progress
Status updated on  06.12.2017
FormerGrant of patent is intended
Status updated on  30.07.2017
Most recent event   Tooltip29.12.2023Revocation of patentpublished on 31.01.2024  [2024/05]
Applicant(s)For all designated states
Banyan Biomarkers, Inc.
13400 Progress Blvd.
Alachua, FL 32615 / US
[2011/21]
Inventor(s)01 / WANG, Kevin, Ka-wang
9966 Sw 19th Lane
Gainesville, FL 32607 / US
02 / HAYES, Ronald, L.
12085 Research Drive
Alachua, FL 32615 / US
03 / MULLER, Uwe, R.
12085 Research Drive
Alachua, FL 32615 / US
04 / ZHANG, Zhiqun
12085 Research Drive
Alachua, FL 32615 / US
 [2011/21]
Representative(s)Cabinet Beau de Loménie
51 avenue Jean Jaurès
BP 7073
69301 Lyon Cedex 07 / FR
[N/P]
Former [2018/05]ABG Patentes, S.L.
Avenida de Burgos, 16D
Edificio Euromor
28036 Madrid / ES
Former [2011/21]ABG Patentes, S.L.
Avenida de Burgos 16D Edificio Euromor
28036 Madrid / ES
Application number, filing date09807153.311.08.2009
[2011/21]
WO2009US53376
Priority number, dateUS20080188554P11.08.2008         Original published format: US 188554 P
US20080097622P17.09.2008         Original published format: US 97622 P
US20090218727P19.06.2009         Original published format: US 218727 P
[2011/21]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2010019553
Date:18.02.2010
Language:EN
[2010/07]
Type: A2 Application without search report 
No.:EP2324360
Date:25.05.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 18.02.2010 takes the place of the publication of the European patent application.
[2011/21]
Type: B1 Patent specification 
No.:EP2324360
Date:31.01.2018
Language:EN
[2018/05]
Search report(s)International search report - published on:KR08.07.2010
(Supplementary) European search report - dispatched on:EP27.07.2012
ClassificationIPC:G01N33/68
[2012/31]
CPC:
G01N33/6896 (EP,US); A61B5/4064 (US); G01N33/577 (US);
G01N2800/28 (EP,US); G01N2800/2871 (EP,US); G01N2800/52 (US);
G01N2800/56 (US); G01N2800/60 (EP,US) (-)
Former IPC [2011/21]G01N33/68, G01N33/53
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2018/05]
Former [2011/21]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:VERFAHREN FÜR DEN NACHWEIS VON BIOMARKERN UND TEST FÜR NEUROLOGISCHE ERKRANKUNG[2011/21]
English:BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITION[2011/21]
French:PROCÉDÉ DE DÉTECTION DE BIOMARQUEURS ET TEST D'ÉTAT NEUROLOGIQUE[2011/21]
Entry into regional phase10.03.2011National basic fee paid 
10.03.2011Search fee paid 
10.03.2011Designation fee(s) paid 
10.03.2011Examination fee paid 
Examination procedure10.03.2011Examination requested  [2011/21]
22.02.2013Amendment by applicant (claims and/or description)
16.04.2013Despatch of a communication from the examining division (Time limit: M06)
25.10.2013Reply to a communication from the examining division
16.05.2014Despatch of a communication from the examining division (Time limit: M04)
25.09.2014Reply to a communication from the examining division
30.03.2015Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time
31.07.2017Communication of intention to grant the patent
01.12.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
01.12.2017Fee for grant paid
01.12.2017Fee for publishing/printing paid
20.12.2017Information about intention to grant a patent
20.12.2017Receipt of the translation of the claim(s)
Divisional application(s)EP18154197.0  / EP3336551
EP23168587.6  / EP4235181
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.04.2013
Opposition(s)Opponent(s)01  31.10.2018  02.11.2018  ADMISSIBLE
Taylor, David
Ablett & Stebbing
7-8 Market Place
London Greater London W1W 8AG / GB
Opponent's representative
Carpmaels & Ransford LLP, et al, et al
One Southampton Row
London WC1B 5HA / GB
 [2021/37]
Former [2021/28]
Opponent(s)01  31.10.2018  02.11.2018  ADMISSIBLE
Taylor, David
Ablett & Stebbing
7-8 Market Place
London Greater London W1W 8AG / GB
Opponent's representative
Adams, Harvey Vaughan John, et al, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Former [2019/36]
Opponent(s)01  31.10.2018  02.11.2018  ADMISSIBLE
Taylor, David
Ablett & Stebbing
7-8 Market Place
London Greater London W1W 8AG / GB
Opponent's representative
Williams, Paul Edwin, et al, et al
Lewis Silkin LLP
5 Chancery Lane
Clifford's Inn
London EC4A 1BL / GB
Former [2018/50]
Opponent(s)01  31.10.2018  02.11.2018  ADMISSIBLE
Taylor, David
Ablett & Stebbing
7-8 Market Place
London Greater London W1W 8AG / GB
Opponent's representative
Taylor, David Matthew Joseph, et al, et al
Ablett & Stebbing
7-8 Market Place
London Greater London W1W 8AG / GB
16.11.2018Invitation to proprietor to file observations on the notice of opposition
24.05.2019Reply of patent proprietor to notice(s) of opposition
03.06.2020Cancellation of oral proceeding that was planned for 25.06.2020
25.06.2020Date of oral proceedings
14.08.2020Cancellation of oral proceeding that was planned for 09.10.2020
09.10.2020Date of oral proceedings
18.06.2021Date of oral proceedings
15.07.2021Despatch of interlocutory decision in opposition
15.07.2021Despatch of minutes of oral proceedings
13.12.2023Legal effect of revocation of patent [2024/05]
22.12.2023Despatch of communication that the patent will be revoked
Appeal following opposition24.09.2021Appeal received No.  T1780/21
24.09.2021Payment of appeal fee
24.11.2021Statement of grounds filed
13.12.2023Result of appeal procedure: REVOCATION OF PATENT AT PROPRIETOR'S REQUEST
22.12.2023Despatch of the decision of the Board of Appeal
Fees paidRenewal fee
25.08.2011Renewal fee patent year 03
27.08.2012Renewal fee patent year 04
27.08.2013Renewal fee patent year 05
08.06.2015Renewal fee patent year 06
03.08.2017Renewal fee patent year 07
29.08.2016Renewal fee patent year 08
14.08.2017Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
31.08.201406   M06   Fee paid on   08.06.2015
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.08.2009
CY31.01.2018
CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
MK31.01.2018
NL31.01.2018
PL31.01.2018
PT31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
TR31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
LU11.08.2018
MT11.08.2018
BE31.08.2018
[2020/31]
Former [2020/27]HU11.08.2009
CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
PT31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
TR31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
LU11.08.2018
MT11.08.2018
BE31.08.2018
Former [2020/16]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
TR31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
LU11.08.2018
MT11.08.2018
BE31.08.2018
Former [2020/08]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
LU11.08.2018
MT11.08.2018
BE31.08.2018
Former [2019/38]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
LU11.08.2018
BE31.08.2018
Former [2019/21]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
LU11.08.2018
Former [2019/15]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
Former [2019/13]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/52]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/50]CZ31.01.2018
EE31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
SK31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/40]HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
BG30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/39]HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
GR01.05.2018
IS31.05.2018
Former [2018/37]HR31.01.2018
LT31.01.2018
NL31.01.2018
PL31.01.2018
GR01.05.2018
Former [2018/36]HR31.01.2018
LT31.01.2018
NL31.01.2018
PL31.01.2018
Former [2018/35]HR31.01.2018
LT31.01.2018
NL31.01.2018
Documents cited:Search[XI]WO2005106038  (UNIV FLORIDA [US]) [X] 1-4,6-9,11,13-15 * claims 1, 8, 12-13, page 23, lines 23-26, page 80, line 30 - page 85, line 25 *[I] 10,12;
 [X]  - P. E. VOS ET AL, "Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury", NEUROLOGY, (20040427), vol. 62, no. 8, doi:10.1212/01.WNL.0000120550.00643.DC, ISSN 0028-3878, pages 1303 - 1310, XP055030077 [X] 1,2,4,6-8,13-15 * abstract, page 1304, left-hand column, 3rd and 4th full paragraphs, page 1309 *

DOI:   http://dx.doi.org/10.1212/01.WNL.0000120550.00643.DC
 [X]  - MISSLER, U., ET AL, "Measurement of Glial Fibrillary Acidic Protein in Human Blood: Analytical Method and Preliminary Clinical Results", CLINICAL CHEMISTRY, (1999), vol. 45, no. 1, pages 138 - 141, XP002677842 [X] 1-4,6-8,13-15 * page 138, right-hand column, 3rd paragraph, page 139, right-hand column, 2nd full paragraph - page 140, left-hand column, 2nd full paragraph. *
International search[A]US2002147998  (MCCONLOGUE LISA C [US], et al);
 [X]EP1519194  (ROCHE DIAGNOSTICS GMBH [DE], et al);
 [X]US2005260697  (WANG KEVIN K [US], et al);
 [A]  - ANNALISA DEL PRETE, THROMB. HAEMOST., (2006), vol. 95, pages 22 - 28, XP008144118

DOI:   http://dx.doi.org/10.1160/TH05-10-0974
ExaminationWO2010019553
    - VERCAUTEREN ET AL, "Proteomic approaches in brain research and neuropharmacology", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, (20041001), vol. 500, no. 1-3, doi:10.1016/J.EJPHAR.2004.07.039, ISSN 0014-2999, pages 385 - 398, XP005480430

DOI:   http://dx.doi.org/10.1016/j.ejphar.2004.07.039
OppositionWO2005029088
 WO2005106038
 EP2245466
    - "MAP2 Gene (Protein Coding)", GeneCards
    - AURELL et al., "Determination of S-100 and Glial Fibrillary Acidic Protein Concentrations in Cerebrospinal Fluid After Brain Infarction", Stroke, (19910000), vol. 22, pages 1254 - 1258, XP055615310

DOI:   http://dx.doi.org/10.1161/01.str.22.10.1254
    - HERMANN et al., "Release of glial tissue-specific proteins after acute stroke: A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein", Stroke, (20000000), vol. 31, pages 2670 - 2677, XP002958818
    - VOS et al., "Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury", Neurology, (20040000), vol. 62, pages 1303 - 1310, XP055030077

DOI:   http://dx.doi.org/10.1212/01.WNL.0000120550.00643.DC
    - PELINKA et al., "Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma", J Trauma, (20040000), vol. 57, no. 5, pages 1006 - 1012, XP009511820

DOI:   http://dx.doi.org/10.1097/01.TA.0000108998.48026.C3
    - NYLÉN et al., "Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome", J Neurol Sci, (20060115), vol. 240, pages 85 - 91, XP005215587

DOI:   http://dx.doi.org/10.1016/j.jns.2005.09.007
    - YAMAUCHI et al., "Ubiquitin-Mediated Stress Response in the Spinal Cord After Transient Ischemia", Stroke, (20080000), vol. 39, pages 1883 - 1889, XP055615327

DOI:   http://dx.doi.org/10.1161/STROKEAHA.106.455832
    - PAPA et al., "Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury", JAMA Neurol, (20160000), vol. 73, no. 5, pages 551 - 560, XP009506256

DOI:   http://dx.doi.org/10.1001/jamaneurol.2016.0039
    - WILSON VAN VOORHIS et al., "Understanding Power and Rules of Thumb for Determining Sample Sizes", Tutorials in Quantitative Methods for Psychology, (20070000), vol. 3, no. 2, pages 43 - 50, XP055615335

DOI:   http://dx.doi.org/10.20982/tqmp.03.2.p043
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