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Extract from the Register of European Patents

EP About this file: EP2338988

EP2338988 - EVALUATION/SCREENING METHOD FOR DISEASES ASSOCIATED WITH D-AMINO ACID UTILIZING DAO1-/- MOUSE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.07.2016
Database last updated on 12.10.2024
Most recent event   Tooltip17.08.2018Lapse of the patent in a contracting state
New state(s): BG		published on 19.09.2018  [2018/38]
Applicant(s)For all designated states
Kyushu University, National University Corporation
10-1, Hakozaki 6-chome
Higashi-ku
Fukuoka-shi, Fukuoka 812-8581 / JP
For all designated states
Shiseido Company, Ltd.
5-5 Ginza 7-chome Chuo-ku
Tokyo 104-8010 / JP
[2015/38]
Former [2011/26]For all designated states
Kyushu University, National University Corporation
10-1, Hakozaki 6-chome Higashi-ku Fukuoka-shi
Fukuoka 812-8581 / JP
For all designated states
Shiseido Company, Ltd.
5-5 Ginza 7-chome Chuo-ku
Tokyo 104-8010 / JP
Inventor(s)01 / HAMASE, Kenji
c/o Kyusyu University
National University Corporation
10-1, Hakozaki 6-chome
Higashi-ku
Fukuoka-shi Fukuoka 812-8581 / JP
02 / ZAITSU, Kiyoshi
c/o Kyusyu University
National University Corporation
10-1, Hakozaki 6-chome
Higashi-ku
Fukuoka-shi Fukuoka 812-8581 / JP
03 / MITA, Masashi
c/o Shiseido Company LTD.
5-5, Ginza 7-chome
Chuo-ku
Tokyo 104-8010 / JP
04 / ASHIDA, Yutaka
c/o Shiseido Research Center (Kanazawa Hakkei)
2-12-1, Fukuura
Kanazawa-ku
Yokohama-shi Kanagawa 236-0004 / JP
05 / TOUJO, Yousuke
c/o Shiseido Research Center (Shin-Yokohama)
2-2-1, Hayabuchi
Tsuzuki-ku
Yokohama-shi Kanagawa 224-8558 / JP
 [2015/38]
Former [2011/26]01 / HAMASE, Kenji
c/o Kyusyu University National University Corporation 10-1, Hakozaki 6-chome Higashi-ku
Fukuoka-shi Fukuoka 812-8581 / JP
02 / ZAITSU, Kiyoshi
c/o Kyusyu University National University Corporation 10-1, Hakozaki 6-chome Higashi-ku
Fukuoka-shi Fukuoka 812-8581 / JP
03 / MITA, Masashi
c/o Shiseido Company LTD. 5-5, Ginza 7-chome Chuo-ku
Tokyo 104-8010 / JP
04 / ASHIDA, Yutaka
c/o Shiseido Research Center (Kanazawa Hakkei) 2-12-1, Fukuura Kanazawa-ku
Yokohama-shi Kanagawa 236-0004 / JP
05 / TOUJO, Yousuke
c/o Shiseido Research Center (Shin-Yokohama) 2-2-1, Hayabuchi Tsuzuki-ku
Yokohama-shi Kanagawa 224-8558 / JP
Representative(s)Scholz, Volker, et al
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[N/P]
Former [2015/38]Scholz, Volker, et al
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Patentanwälte Rechtsanwälte
Pettenkoferstrasse 20-22
80336 München / DE
Former [2013/24]Scholz, Volker, et al
Boehmert & Boehmert
Pettenkoferstrasse 20-22
80336 München / DE
Former [2011/26]Winkler, Andreas Fritz Ernst
Forrester & Boehmert Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date09809745.431.07.2009
[2011/26]
WO2009JP63696
Priority number, dateJP2008021723926.08.2008         Original published format: JP 2008217239
[2011/26]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010024091
Date:04.03.2010
Language:JA
[2010/09]
Type: A1 Application with search report 
No.:EP2338988
Date:29.06.2011
Language:EN
[2011/26]
Type: B1 Patent specification 
No.:EP2338988
Date:16.09.2015
Language:EN
[2015/38]
Search report(s)International search report - published on:JP04.03.2010
(Supplementary) European search report - dispatched on:EP02.03.2012
ClassificationIPC:C12N15/00, C12N15/09, C12Q1/02, C12Q1/68, G01N30/88, G01N33/15, G01N33/50, G01N33/53, G01N33/577
[2011/26]
CPC:
G01N33/5088 (EP,US); A01K67/0276 (EP,US); C07K14/4702 (EP,US);
C12N15/8509 (EP,US); C12N9/0024 (EP,US); C12Q1/26 (EP,US);
A01K2217/03 (EP,US); A01K2217/075 (EP,US); A01K2217/15 (EP,US);
A01K2227/105 (EP,US); A01K2267/0331 (EP,US); A01K2267/0356 (EP,US);
G01N2333/90644 (EP,US); G01N2500/10 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2015/38]
Former [2011/26]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:BEURTEILUNGS-/SCREENINGVERFAHREN FÜR ERKRANKUNGEN IN ZUSAMMENHANG MIT D-AMINOSÄURE MITTELS DAO1-/-MAUS[2011/26]
English:EVALUATION/SCREENING METHOD FOR DISEASES ASSOCIATED WITH D-AMINO ACID UTILIZING DAO1-/- MOUSE[2011/26]
French:PROCÉDÉ D'ÉVALUATION/CRIBLAGE POUR DES MALADIES ASSOCIÉES À UN ACIDE AMINÉ D UTILISANT UNE SOURIS DAO1-/-[2011/26]
Entry into regional phase01.03.2011Translation filed 
01.03.2011National basic fee paid 
01.03.2011Search fee paid 
01.03.2011Designation fee(s) paid 
01.03.2011Examination fee paid 
Examination procedure01.03.2011Examination requested  [2011/26]
05.09.2012Amendment by applicant (claims and/or description)
08.10.2012Despatch of a communication from the examining division (Time limit: M04)
11.01.2013Reply to a communication from the examining division
25.07.2013Despatch of a communication from the examining division (Time limit: M02)
11.09.2013Reply to a communication from the examining division
01.04.2014Despatch of a communication from the examining division (Time limit: M06)
01.10.2014Reply to a communication from the examining division
16.04.2015Communication of intention to grant the patent
06.08.2015Fee for grant paid
06.08.2015Fee for publishing/printing paid
06.08.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.10.2012
Opposition(s)17.06.2016No opposition filed within time limit [2016/34]
Fees paidRenewal fee
12.07.2011Renewal fee patent year 03
13.07.2012Renewal fee patent year 04
10.07.2013Renewal fee patent year 05
14.07.2014Renewal fee patent year 06
10.07.2015Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU31.07.2009
AT16.09.2015
BE16.09.2015
BG16.09.2015
CY16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
MC16.09.2015
MK16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SI16.09.2015
SK16.09.2015
SM16.09.2015
TR16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
[2018/38]
Former [2018/33]HU31.07.2009
AT16.09.2015
BE16.09.2015
CY16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
MC16.09.2015
MK16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SI16.09.2015
SK16.09.2015
SM16.09.2015
TR16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2018/29]HU31.07.2009
AT16.09.2015
BE16.09.2015
CY16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
MC16.09.2015
MK16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SI16.09.2015
SK16.09.2015
SM16.09.2015
TR16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2018/28]HU31.07.2009
AT16.09.2015
BE16.09.2015
CY16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
MC16.09.2015
MK16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SI16.09.2015
SK16.09.2015
SM16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2017/22]AT16.09.2015
BE16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
MC16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SI16.09.2015
SK16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2017/03]AT16.09.2015
BE16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SI16.09.2015
SK16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2016/49]AT16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SI16.09.2015
SK16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2016/39]AT16.09.2015
CZ16.09.2015
DK16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SK16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2016/24]AT16.09.2015
CZ16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
PL16.09.2015
RO16.09.2015
SE16.09.2015
SK16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
PT18.01.2016
Former [2016/23]CZ16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
RO16.09.2015
SE16.09.2015
SK16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
Former [2016/22]CZ16.09.2015
EE16.09.2015
ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
SE16.09.2015
NO16.12.2015
GR17.12.2015
IS16.01.2016
Former [2016/21]ES16.09.2015
FI16.09.2015
HR16.09.2015
IT16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
SE16.09.2015
NO16.12.2015
GR17.12.2015
Former [2016/20]ES16.09.2015
FI16.09.2015
HR16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
SE16.09.2015
NO16.12.2015
GR17.12.2015
Former [2016/14]FI16.09.2015
HR16.09.2015
LT16.09.2015
LV16.09.2015
NL16.09.2015
SE16.09.2015
NO16.12.2015
GR17.12.2015
Former [2016/11]FI16.09.2015
HR16.09.2015
LT16.09.2015
LV16.09.2015
SE16.09.2015
NO16.12.2015
GR17.12.2015
Former [2016/09]FI16.09.2015
LT16.09.2015
LV16.09.2015
NO16.12.2015
GR17.12.2015
Former [2016/08]LT16.09.2015
NO16.12.2015
Former [2016/07]LT16.09.2015
Documents cited:Search[XYI]  - MORIKAWA A ET AL, "Alterations in D-amino acid levels in the brains of mice and rats after the administration of D-amino acids", AMINO ACIDS ; THE FORUM FOR AMINO ACID AND PROTEIN RESEARCH, SPRINGER-VERLAG, VI, (20060607), vol. 32, no. 1, ISSN 1438-2199, pages 13 - 20, XP019461853 [X] 1,4 * page 14, column r; figures 1-5 * [Y] 2,3,11,12 [I] 6-10
 [Y]  - TOJO Y ET AL, "Simple and rapid genotyping of D-amino acid oxidase gene using microchip electrophoresis", AMINO ACIDS (VIENNA), & 10TH INTERNATIONAL CONGRESS ON AMINO ACIDS AND PROTEINS; KALLITHEA, GREECE; AUGUST 20 -25, 2007, (200709), vol. 33, no. 3, ISSN 0939-4451, pages VII - VIII, XP002670046 [Y] 2,3,12 * the whole document *
 [Y]  - TOJO Y ET AL, "Automated and simultaneous two-dimensional micro-high-performance liquid chromatographic determination of proline and hydroxyproline enantiomers in mammals", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 875, no. 1, doi:10.1016/J.JCHROMB.2008.06.025, ISSN 1570-0232, (20080620), pages 174 - 179, (20080620), XP025572307 [Y] 11 * page 174, column r; table 3 * * page 179, column r, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/j.jchromb.2008.06.025
International search[X]  - HASHIMOTO A. ET AL., "Mice lacking D-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy", EUR. J. PHARMACOL., (200805), vol. 586, pages 221 - 225, XP022671785

DOI:   http://dx.doi.org/10.1016/j.ejphar.2008.03.031
 [X]  - HAMASE K., "Sensitive two-dimensional determination of small amounts of D-amino acids in mammals and the study on their functions", CHEM PHARM BULL (TOKYO)., (2007), vol. 55, pages 503 - 510, XP008136569
 [Y]  - SASAKI M. ET AL., "A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse", BIOCHIM. BIOPHYS. ACTA, (1992), vol. 1139, pages 315 - 318, XP023554746

DOI:   http://dx.doi.org/10.1016/0925-4439(92)90107-X
 [Y]  - OHGUSU T. ET AL., "High-throughput determination of free D-aspartic acid in mammals by enzyme immunoassay using specific monoclonal antibody", ANAL BIOCHEM., (2006), vol. 357, pages 15 - 20, XP024942353

DOI:   http://dx.doi.org/10.1016/j.ab.2006.06.039
 [XP]  - TOJO Y. ET AL., "Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis", J. SEP. SCI., (200901), vol. 32, pages 430 - 436, XP008136374

DOI:   http://dx.doi.org/10.1002/jssc.200800587
by applicantJP2008027650
    - HAMASE K; MORIKAWA A; ZAITSU K., J CHROMATOGR B, (2002), vol. 781, pages 73 - 91
    - D'ANIELLO A ET AL., FASEB J, (2000), vol. 14, pages 699 - 714
    - NISHIKAWA T, BIOL. PHARM. BULL., (2005), vol. 28, pages 1561 - 1565
    - FUJII N ET AL., BIOL. PHARM. BULL., (2005), vol. 28, pages 1585 - 1589
    - FUJII N. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2002), vol. 294, pages 1047 - 1051
    - HAMASE K.; KONNO R.; MORIKAWA A.; ZAITSU K., BIOL. PHARM. BULL., (2005), vol. 28, pages 1578 - 1584
    - KONNO R.; YASUMURA Y., GENETICS, (1983), vol. 103, pages 277 - 285
    - HASHIMOTO A.; YOSHIKAWA M.; NIWA A.; KONNO R., BRAIN RES., (2005), vol. 1033, pages 210 - 21
    - KENJI HAMASE; KIYOSHI ZAITSU, BUNSEKI KAGAKU, (2004), vol. 53, pages 677 - 690
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.