EP2334800 - MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 01.11.2019 Database last updated on 03.09.2024 | |
Former | The patent has been granted Status updated on 23.11.2018 | ||
Former | Grant of patent is intended Status updated on 24.07.2018 | ||
Former | Examination is in progress Status updated on 13.06.2018 | ||
Former | Grant of patent is intended Status updated on 21.02.2018 | ||
Former | Examination is in progress Status updated on 07.11.2016 | Most recent event Tooltip | 01.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 03.08.2022 [2022/31] | Applicant(s) | For all designated states Genomatica, Inc. 4757 Nexus Center Drive San Diego, CA 92121 / US | [2014/52] |
Former [2011/25] | For all designated states Genomatica, Inc. 10520 Wateridge Circle San Diego, CA 92121 / US | Inventor(s) | 01 /
BURK, Mark, J. 12634 Intermezzo Way San Diego, CA 92130 / US | 02 /
BURGARD, Anthony, P. 237 Walker Crossing Bellefonte, PA 16823 / US | 03 /
OSTERHOUT, Robin, E. 4910 Orchard Avenue San Diego, CA 92107 / US | 04 /
SUN, Jun 8274 Bryn Glen Way San Diego, CA 92129 / US | [2011/25] | Representative(s) | Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | [2018/52] |
Former [2013/33] | HOFFMANN EITLE Patent- und Rechtsanwälte Arabellastrasse 4 81925 München / DE | ||
Former [2011/25] | Jones Day Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München / DE | Application number, filing date | 09813563.5 | 09.09.2009 | [2011/25] | WO2009US56415 | Priority number, date | US20080191710P | 10.09.2008 Original published format: US 191710 P | US20080192511P | 17.09.2008 Original published format: US 192511 P | [2011/25] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2010030711 | Date: | 18.03.2010 | Language: | EN | [2010/11] | Type: | A2 Application without search report | No.: | EP2334800 | Date: | 22.06.2011 | Language: | EN | The application published by WIPO in one of the EPO official languages on 18.03.2010 takes the place of the publication of the European patent application. | [2011/25] | Type: | B1 Patent specification | No.: | EP2334800 | Date: | 26.12.2018 | Language: | EN | [2018/52] | Search report(s) | International search report - published on: | US | 07.10.2010 | (Supplementary) European search report - dispatched on: | EP | 23.07.2012 | Classification | IPC: | C12N9/00, C12N9/02, C12N9/04, C12N9/10, C12N9/12, C12N9/16, C12N9/88, C12N9/90, C12N15/52, C12N15/70, C12N15/81, C12P7/18 | [2018/08] | CPC: |
C12P7/18 (EP,US);
B01D3/002 (EP,US);
C12N15/52 (EP,US);
C12N15/70 (EP,US);
C12N15/81 (EP,US);
C12N9/0006 (EP,US);
C12N9/0008 (EP,US);
C12N9/001 (EP,US);
C12N9/1029 (EP,US);
C12N9/1096 (EP,US);
C12N9/12 (EP,US);
C12N9/13 (EP,US);
C12N9/16 (EP,US);
C12N9/88 (EP,US);
C12N9/90 (EP,US);
C12N9/93 (EP,US);
C12Y101/01157 (EP,US);
C12Y402/01055 (EP,US);
Y02E50/10 (EP)
(-)
|
Former IPC [2011/25] | C12P7/16, C12P1/04 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2018/52] |
Former [2011/25] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR | Extension states | AL | Not yet paid | BA | Not yet paid | RS | Not yet paid | Title | German: | MIKROORGANISMEN ZUR HERSTELLUNG VON 1,4-BUTANDIOL | [2011/25] | English: | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL | [2011/25] | French: | MICROORGANISMES POUR LA PRODUCTION DE 1,4-BUTANEDIOL | [2011/25] | Entry into regional phase | 08.04.2011 | National basic fee paid | 08.04.2011 | Search fee paid | 08.04.2011 | Designation fee(s) paid | 08.04.2011 | Examination fee paid | Examination procedure | 08.04.2011 | Examination requested [2011/25] | 19.02.2013 | Amendment by applicant (claims and/or description) | 03.07.2013 | Despatch of a communication from the examining division (Time limit: M06) | 13.01.2014 | Reply to a communication from the examining division | 28.04.2016 | Despatch of a communication from the examining division (Time limit: M06) | 07.11.2016 | Reply to a communication from the examining division | 05.07.2017 | Despatch of a communication from the examining division (Time limit: M06) | 11.01.2018 | Reply to a communication from the examining division | 22.02.2018 | Communication of intention to grant the patent | 11.06.2018 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 25.07.2018 | Communication of intention to grant the patent | 13.11.2018 | Fee for grant paid | 13.11.2018 | Fee for publishing/printing paid | 13.11.2018 | Receipt of the translation of the claim(s) | Divisional application(s) | EP18214553.2 / EP3514242 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 03.07.2013 | Opposition(s) | 27.09.2019 | No opposition filed within time limit [2019/49] | Fees paid | Renewal fee | 29.09.2011 | Renewal fee patent year 03 | 12.09.2012 | Renewal fee patent year 04 | 12.09.2013 | Renewal fee patent year 05 | 12.09.2014 | Renewal fee patent year 06 | 11.09.2015 | Renewal fee patent year 07 | 13.09.2016 | Renewal fee patent year 08 | 12.09.2017 | Renewal fee patent year 09 | 11.09.2018 | Renewal fee patent year 10 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 09.09.2009 | AT | 26.12.2018 | CY | 26.12.2018 | CZ | 26.12.2018 | DK | 26.12.2018 | EE | 26.12.2018 | ES | 26.12.2018 | FI | 26.12.2018 | HR | 26.12.2018 | LT | 26.12.2018 | LV | 26.12.2018 | MC | 26.12.2018 | MK | 26.12.2018 | MT | 26.12.2018 | PL | 26.12.2018 | RO | 26.12.2018 | SE | 26.12.2018 | SI | 26.12.2018 | SK | 26.12.2018 | SM | 26.12.2018 | TR | 26.12.2018 | BG | 26.03.2019 | NO | 26.03.2019 | GR | 27.03.2019 | IS | 26.04.2019 | PT | 26.04.2019 | IE | 09.09.2019 | IT | 09.09.2019 | LU | 09.09.2019 | [2022/31] |
Former [2021/34] | HU | 09.09.2009 | |
AT | 26.12.2018 | ||
CY | 26.12.2018 | ||
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
MC | 26.12.2018 | ||
MT | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
IE | 09.09.2019 | ||
IT | 09.09.2019 | ||
LU | 09.09.2019 | ||
Former [2021/32] | HU | 09.09.2009 | |
AT | 26.12.2018 | ||
CY | 26.12.2018 | ||
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
MC | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
IE | 09.09.2019 | ||
IT | 09.09.2019 | ||
LU | 09.09.2019 | ||
Former [2021/26] | AT | 26.12.2018 | |
CY | 26.12.2018 | ||
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
MC | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
IE | 09.09.2019 | ||
IT | 09.09.2019 | ||
LU | 09.09.2019 | ||
Former [2020/39] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
MC | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
IE | 09.09.2019 | ||
IT | 09.09.2019 | ||
LU | 09.09.2019 | ||
Former [2020/36] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
MC | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
IE | 09.09.2019 | ||
LU | 09.09.2019 | ||
Former [2020/35] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
MC | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
LU | 09.09.2019 | ||
Former [2020/25] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
MC | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
Former [2020/17] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
TR | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
Former [2020/13] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SI | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
Former [2019/48] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
DK | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
Former [2019/46] | AT | 26.12.2018 | |
CZ | 26.12.2018 | ||
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
Former [2019/39] | CZ | 26.12.2018 | |
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SK | 26.12.2018 | ||
SM | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
IS | 26.04.2019 | ||
PT | 26.04.2019 | ||
Former [2019/37] | CZ | 26.12.2018 | |
EE | 26.12.2018 | ||
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
PL | 26.12.2018 | ||
RO | 26.12.2018 | ||
SE | 26.12.2018 | ||
SM | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
PT | 26.04.2019 | ||
Former [2019/35] | CZ | 26.12.2018 | |
ES | 26.12.2018 | ||
FI | 26.12.2018 | ||
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
PL | 26.12.2018 | ||
SE | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
PT | 26.04.2019 | ||
Former [2019/33] | FI | 26.12.2018 | |
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
SE | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
PT | 26.04.2019 | ||
Former [2019/24] | FI | 26.12.2018 | |
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
SE | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
GR | 27.03.2019 | ||
Former [2019/23] | FI | 26.12.2018 | |
HR | 26.12.2018 | ||
LT | 26.12.2018 | ||
LV | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
Former [2019/22] | FI | 26.12.2018 | |
LT | 26.12.2018 | ||
BG | 26.03.2019 | ||
NO | 26.03.2019 | ||
Former [2019/21] | FI | 26.12.2018 | |
LT | 26.12.2018 | ||
NO | 26.03.2019 | ||
Former [2019/20] | LT | 26.12.2018 | |
NO | 26.03.2019 | Documents cited: | Search | [A]KR20070096348 (LG CHEMICAL LTD [KR], et al) [A] 1,2,10,12-16* claims 1-30 *; | [E]WO2010006076 (OPX BIOTECHNOLOGIES INC [US], et al) [E] 1 * paragraph [00169]; claims 1,4,6,11 * | International search | [A]JPS62285779 (CHIYODA CHEM ENG CONSTRUCT CO); | [A]WO0061763 (UNIV GUELPH [CA], et al); | [X]US2007190605 (BESSLER CORNELIUS [DE], et al); | [A]US2008138870 (BRAMUCCI MICHAEL G [US], et al); | [A]US2008182308 (DONALDSON GAIL K [US], et al); | [XE]US2009047719 (BURGARD ANTHONY P [US], et al); | [XE]WO2009094485 (GENOMATICA INC [US], et al); | [X] - GERHARDT ET AL., "Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA.", ARCH. MICROBIOL., (2000), vol. 174, no. 3, pages 189 - 199, XP008109904 DOI: http://dx.doi.org/10.1007/s002030000195 | [A] - CKINLAY ET AL., "Prospects for a bio-based succinate industry.", APPL. MICROBIOL. BIOTECHNOL., (2007), vol. 76, no. 4, pages 727 - 740, XP019538718 DOI: http://dx.doi.org/10.1007/s00253-007-1057-y | [A] - TAKIGAWA ET AL., "Probabilistic path ranking based on adjacent pairwise coexpression for metabolic transcripts analysis.", BIOINFORMATICS., (20080115), vol. 24, no. 2, pages 250 - 257, XP008131673 DOI: http://dx.doi.org/10.1093/bioinformatics/btm575 | [A] - JEWELL ET AL., "Bioconversion of Propionic, Valeric, and 4-Hydroxybutyric Acids into the Corresponding Alcohols by Clostridium acetobutylicum NRRL 537.", CURR. MICROBIOL., (1986), vol. 13, pages 215 - 219, XP008139685 | [AP] - CUKALOVIC ET AL., "Feasibility of production method for succinic acid derivatives: a marriage of renewable resources and chemical technology.", BIOFUELS BIOPROD. BIOREF., (20081013), vol. 2, pages 505 - 529, XP008139686 DOI: http://dx.doi.org/10.1002/bbb.105 | [A] - FEIST ET AL., "The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli.", NAT. BIOTECHNOL., (200806), vol. 26, no. 6, pages 659 - 667, XP008139687 DOI: http://dx.doi.org/10.1038/nbt1401 | [A] - WANG ET AL., "Screening microorganisms for utilization of furfural and possible intermediates in its degradative pathway.", BIOTECHNOL. LETT., (1994), vol. 16, no. 9, pages 977 - 982, XP008139688 | [A] - OKINO ET AL., "An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain.", APPL. MICROBIOL. BIOTECHNOL., (20080906), vol. 81, no. 3, pages 459 - 464, XP019654155 DOI: http://dx.doi.org/10.1007/s00253-008-1668-y | by applicant | GB1230276 | GB1314126 | GB1344557 | US4048196 | GB1512751 | US4301077 | WO8203854 | US4652685 | US2003233218 | US6686310 | US2005221466 | - HENNESSY ET AL., J. FORENSIC SCI., (2004), vol. 46, no. 6, pages 1 - 9 | - GONZALEZ-PAJUELO ET AL., MET. ENG., (2005), vol. 7, pages 329 - 336 | - HOFFMEISTER ET AL., J. BIOL. CHEM., (2005), vol. 280, pages 4329 - 4338 | - WILKS ET AL., BIOCHEMISTRY, (1992), vol. 31, pages 7802 - 7806 | - LIN ET AL., BIOTECHNOL. BIOENG., (2005), vol. 90, pages 775 - 779 | - POSTON, J. M., METHODS ENZYMOL., (1988), vol. 166, pages 130 - 135 | - BUCK ET AL., BIOCHEMISTRY, (1985), vol. 24, no. 22, pages 6245 - 6252 | - VAMECQ ET AL., BIOCHEM J., (1985), vol. 230, no. 3, pages 683 - 693 | - LAMAS-MACEIRAS ET AL., BIOCHEM J, (2006), vol. 395, no. 1, pages 147 - 155 | - WANG ET AL., BIOCHEM BIOPHYS RES COMMUN, (2007), vol. 360, no. 2, pages 453 - 458 | - MARTINEZ-BLANCO ET AL., JBIOL CHEM., (1990), vol. 265, no. 12, pages 7084 - 7090 | - BOWER ET AL., J BCTCTERIOL, (1996), vol. 178, no. 14, pages 4122 - 4130 | WO2003US18838 |