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Extract from the Register of European Patents

EP About this file: EP2348843

EP2348843 - SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.09.2016
Database last updated on 24.08.2024
Most recent event   Tooltip17.08.2018Lapse of the patent in a contracting state
New state(s): BG		published on 19.09.2018  [2018/38]
Applicant(s)For all designated states
Duquesne University of The Holy Spirit
600 Forbes Avenue
Pittsburgh, PA 15282 / US
For all designated states
WAYNE STATE UNIVERSITY
5057 Woodward Avenue Suite 6306
Detroit, MI 48202 / US
[2011/32]
Former [2011/31]For all designated states
Duquesne University of the Holy Ghost
600 Forbes Avenue
Pittsburgh, PA 15282 / US
For all designated states
WAYNE STATE UNIVERSITY
5057 Woodward Avenue Suite 6306
Detroit, MI 48202 / US
Inventor(s)01 / GANGJEE, Aleem
3855 Oakbrook Court
Allison Park Pennsylvania 15101 / US
02 / MATHERLY, Larry H.
25127 Lyncastle Street
Farmington Hills Michigan 48336 / US
 [2011/31]
Representative(s)Grünecker Patent- und Rechtsanwälte PartG mbB
Leopoldstraße 4
80802 München / DE
[2015/46]
Former [2011/31]Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
Leopoldstrasse 4
80802 München / DE
Application number, filing date09818418.730.09.2009
[2011/31]
WO2009US58968
Priority number, dateUS2008024298801.10.2008         Original published format: US 242988
[2011/31]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010039792
Date:08.04.2010
Language:EN
[2010/14]
Type: A1 Application with search report 
No.:EP2348843
Date:03.08.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 08.04.2010 takes the place of the publication of the European patent application.
[2011/31]
Type: B1 Patent specification 
No.:EP2348843
Date:11.11.2015
Language:EN
[2015/46]
Search report(s)International search report - published on:US08.04.2010
(Supplementary) European search report - dispatched on:EP05.07.2012
ClassificationIPC:A01N43/00, C07D487/04, A61K31/519, A61P35/00
[2012/32]
CPC:
C07D487/04 (EP,US); A61K31/519 (EP,US); A61P19/02 (EP);
A61P29/00 (EP); A61P35/00 (EP); A61P35/04 (US);
A61P37/00 (EP); A61P37/06 (EP); A61P43/00 (EP);
C07D239/70 (US); C07D495/04 (US) (-)
Former IPC [2011/31]A01N43/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2015/46]
Former [2011/31]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:PROTONENGEKOPPELTER SELEKTIVER FOLATTRANSPORTER UND FOLATREZEPTOR, GARFTASE-HEMMERVERBINDUNGEN UND ANWENDUNGSVERFAHREN DAFÜR[2011/31]
English:SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME[2011/31]
French:RÉCEPTEUR DU FOLATE ET TRANSPORTEUR DU FOLATE SÉLECTIFS COUPLÉS AUX PROTONS, ET COMPOSÉS INHIBITEURS DE LA GARFTASE ET MÉTHODES D'UTILISATION ASSOCIÉES[2011/31]
Entry into regional phase02.05.2011National basic fee paid 
02.05.2011Search fee paid 
02.05.2011Designation fee(s) paid 
02.05.2011Examination fee paid 
Examination procedure06.07.2010Request for preliminary examination filed
International Preliminary Examining Authority: US
02.05.2011Examination requested  [2011/31]
04.02.2013Amendment by applicant (claims and/or description)
13.05.2013Despatch of a communication from the examining division (Time limit: M04)
14.05.2013Reply to a communication from the examining division
22.07.2013Despatch of a communication from the examining division (Time limit: M04)
02.12.2013Reply to a communication from the examining division
03.07.2014Despatch of a communication from the examining division (Time limit: M04)
13.11.2014Reply to a communication from the examining division
13.03.2015Communication of intention to grant the patent
01.04.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
22.05.2015Communication of intention to grant the patent
14.09.2015Fee for grant paid
14.09.2015Fee for publishing/printing paid
14.09.2015Receipt of the translation of the claim(s)
Divisional application(s)EP15187759.4  / EP2995199
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  13.05.2013
Opposition(s)12.08.2016No opposition filed within time limit [2016/42]
Fees paidRenewal fee
28.09.2011Renewal fee patent year 03
25.09.2012Renewal fee patent year 04
27.09.2013Renewal fee patent year 05
29.09.2014Renewal fee patent year 06
28.09.2015Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.09.2009
AT11.11.2015
BE11.11.2015
BG11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
[2018/38]
Former [2018/33]HU30.09.2009
AT11.11.2015
BE11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2018/29]HU30.09.2009
AT11.11.2015
BE11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2018/28]HU30.09.2009
AT11.11.2015
BE11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2017/31]AT11.11.2015
BE11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2017/03]AT11.11.2015
BE11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/49]AT11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/39]AT11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/38]AT11.11.2015
CZ11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/36]AT11.11.2015
CZ11.11.2015
EE11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
SE11.11.2015
SK11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/34]AT11.11.2015
CZ11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/25]AT11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/24]AT11.11.2015
ES11.11.2015
FI11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
NL11.11.2015
PL11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/23]ES11.11.2015
HR11.11.2015
IT11.11.2015
LT11.11.2015
NL11.11.2015
SE11.11.2015
NO11.02.2016
IS11.03.2016
Former [2016/22]ES11.11.2015
IT11.11.2015
LT11.11.2015
NL11.11.2015
NO11.02.2016
IS11.03.2016
Former [2016/21]ES11.11.2015
IT11.11.2015
LT11.11.2015
NO11.02.2016
Former [2016/20]ES11.11.2015
LT11.11.2015
Documents cited:Search[AD]US2008045710  (GANGJEE ALEEM [US]) [AD] 1-11,14-17 * page 1, paragraph [0004],;; figures 1,2 *
International search[Y]WO2008027949  (DUQUESNE UNIVERSITY OF THIE HO [US], et al);
 [Y]EP0438261  (TAKEDA CHEMICAL INDUSTRIES LTD [JP]);
 [Y]US2005032786  (KAJINO MASAHIRO [JP], et al);
 [A]US2004096436  (CARSON DENNIS A [US], et al);
 [A]US6525050  (ROMINES III WILLIAM H [US], et al);
 [A]US6518426  (GANGJEE ALEEM [US]);
 [A]US5317019  (BENDER PAUL E [US], et al)
ExaminationEP0418924
    - Y. KOTAKE ET AL, "Novel 6-5 Fused Rgin Heterocycle Antifolates with Potent Antitumor Activity: Bridge Modifications and Heterocyclic Benzoyl Isosters of 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine Antifolate", CHEM. PHARM. BULL., (199505), vol. 43, no. 5, pages 829 - 841
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.