EP2348843 - SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 16.09.2016 Database last updated on 24.08.2024 | Most recent event Tooltip | 17.08.2018 | Lapse of the patent in a contracting state New state(s): BG | published on 19.09.2018 [2018/38] | Applicant(s) | For all designated states Duquesne University of The Holy Spirit 600 Forbes Avenue Pittsburgh, PA 15282 / US | For all designated states WAYNE STATE UNIVERSITY 5057 Woodward Avenue Suite 6306 Detroit, MI 48202 / US | [2011/32] |
Former [2011/31] | For all designated states Duquesne University of the Holy Ghost 600 Forbes Avenue Pittsburgh, PA 15282 / US | ||
For all designated states WAYNE STATE UNIVERSITY 5057 Woodward Avenue Suite 6306 Detroit, MI 48202 / US | Inventor(s) | 01 /
GANGJEE, Aleem 3855 Oakbrook Court Allison Park Pennsylvania 15101 / US | 02 /
MATHERLY, Larry H. 25127 Lyncastle Street Farmington Hills Michigan 48336 / US | [2011/31] | Representative(s) | Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstraße 4 80802 München / DE | [2015/46] |
Former [2011/31] | Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Leopoldstrasse 4 80802 München / DE | Application number, filing date | 09818418.7 | 30.09.2009 | [2011/31] | WO2009US58968 | Priority number, date | US20080242988 | 01.10.2008 Original published format: US 242988 | [2011/31] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2010039792 | Date: | 08.04.2010 | Language: | EN | [2010/14] | Type: | A1 Application with search report | No.: | EP2348843 | Date: | 03.08.2011 | Language: | EN | The application published by WIPO in one of the EPO official languages on 08.04.2010 takes the place of the publication of the European patent application. | [2011/31] | Type: | B1 Patent specification | No.: | EP2348843 | Date: | 11.11.2015 | Language: | EN | [2015/46] | Search report(s) | International search report - published on: | US | 08.04.2010 | (Supplementary) European search report - dispatched on: | EP | 05.07.2012 | Classification | IPC: | A01N43/00, C07D487/04, A61K31/519, A61P35/00 | [2012/32] | CPC: |
C07D487/04 (EP,US);
A61K31/519 (EP,US);
A61P19/02 (EP);
A61P29/00 (EP);
A61P35/00 (EP);
A61P35/04 (US);
A61P37/00 (EP);
A61P37/06 (EP);
A61P43/00 (EP);
|
Former IPC [2011/31] | A01N43/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2015/46] |
Former [2011/31] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR | Extension states | AL | Not yet paid | BA | Not yet paid | RS | Not yet paid | Title | German: | PROTONENGEKOPPELTER SELEKTIVER FOLATTRANSPORTER UND FOLATREZEPTOR, GARFTASE-HEMMERVERBINDUNGEN UND ANWENDUNGSVERFAHREN DAFÜR | [2011/31] | English: | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | [2011/31] | French: | RÉCEPTEUR DU FOLATE ET TRANSPORTEUR DU FOLATE SÉLECTIFS COUPLÉS AUX PROTONS, ET COMPOSÉS INHIBITEURS DE LA GARFTASE ET MÉTHODES D'UTILISATION ASSOCIÉES | [2011/31] | Entry into regional phase | 02.05.2011 | National basic fee paid | 02.05.2011 | Search fee paid | 02.05.2011 | Designation fee(s) paid | 02.05.2011 | Examination fee paid | Examination procedure | 06.07.2010 | Request for preliminary examination filed International Preliminary Examining Authority: US | 02.05.2011 | Examination requested [2011/31] | 04.02.2013 | Amendment by applicant (claims and/or description) | 13.05.2013 | Despatch of a communication from the examining division (Time limit: M04) | 14.05.2013 | Reply to a communication from the examining division | 22.07.2013 | Despatch of a communication from the examining division (Time limit: M04) | 02.12.2013 | Reply to a communication from the examining division | 03.07.2014 | Despatch of a communication from the examining division (Time limit: M04) | 13.11.2014 | Reply to a communication from the examining division | 13.03.2015 | Communication of intention to grant the patent | 01.04.2015 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 22.05.2015 | Communication of intention to grant the patent | 14.09.2015 | Fee for grant paid | 14.09.2015 | Fee for publishing/printing paid | 14.09.2015 | Receipt of the translation of the claim(s) | Divisional application(s) | EP15187759.4 / EP2995199 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 13.05.2013 | Opposition(s) | 12.08.2016 | No opposition filed within time limit [2016/42] | Fees paid | Renewal fee | 28.09.2011 | Renewal fee patent year 03 | 25.09.2012 | Renewal fee patent year 04 | 27.09.2013 | Renewal fee patent year 05 | 29.09.2014 | Renewal fee patent year 06 | 28.09.2015 | Renewal fee patent year 07 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 30.09.2009 | AT | 11.11.2015 | BE | 11.11.2015 | BG | 11.11.2015 | CY | 11.11.2015 | CZ | 11.11.2015 | DK | 11.11.2015 | EE | 11.11.2015 | ES | 11.11.2015 | FI | 11.11.2015 | HR | 11.11.2015 | IT | 11.11.2015 | LT | 11.11.2015 | LV | 11.11.2015 | MC | 11.11.2015 | MK | 11.11.2015 | NL | 11.11.2015 | PL | 11.11.2015 | RO | 11.11.2015 | SE | 11.11.2015 | SI | 11.11.2015 | SK | 11.11.2015 | SM | 11.11.2015 | TR | 11.11.2015 | NO | 11.02.2016 | GR | 12.02.2016 | IS | 11.03.2016 | PT | 11.03.2016 | [2018/38] |
Former [2018/33] | HU | 30.09.2009 | |
AT | 11.11.2015 | ||
BE | 11.11.2015 | ||
CY | 11.11.2015 | ||
CZ | 11.11.2015 | ||
DK | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
MC | 11.11.2015 | ||
MK | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SI | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
TR | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2018/29] | HU | 30.09.2009 | |
AT | 11.11.2015 | ||
BE | 11.11.2015 | ||
CY | 11.11.2015 | ||
CZ | 11.11.2015 | ||
DK | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
MC | 11.11.2015 | ||
MK | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SI | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
TR | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2018/28] | HU | 30.09.2009 | |
AT | 11.11.2015 | ||
BE | 11.11.2015 | ||
CY | 11.11.2015 | ||
CZ | 11.11.2015 | ||
DK | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
MC | 11.11.2015 | ||
MK | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SI | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2017/31] | AT | 11.11.2015 | |
BE | 11.11.2015 | ||
CZ | 11.11.2015 | ||
DK | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
MC | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SI | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2017/03] | AT | 11.11.2015 | |
BE | 11.11.2015 | ||
CZ | 11.11.2015 | ||
DK | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SI | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/49] | AT | 11.11.2015 | |
CZ | 11.11.2015 | ||
DK | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SI | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/39] | AT | 11.11.2015 | |
CZ | 11.11.2015 | ||
DK | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/38] | AT | 11.11.2015 | |
CZ | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SK | 11.11.2015 | ||
SM | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/36] | AT | 11.11.2015 | |
CZ | 11.11.2015 | ||
EE | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
RO | 11.11.2015 | ||
SE | 11.11.2015 | ||
SK | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/34] | AT | 11.11.2015 | |
CZ | 11.11.2015 | ||
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
SE | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/25] | AT | 11.11.2015 | |
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
LV | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
SE | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/24] | AT | 11.11.2015 | |
ES | 11.11.2015 | ||
FI | 11.11.2015 | ||
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
NL | 11.11.2015 | ||
PL | 11.11.2015 | ||
SE | 11.11.2015 | ||
NO | 11.02.2016 | ||
GR | 12.02.2016 | ||
IS | 11.03.2016 | ||
PT | 11.03.2016 | ||
Former [2016/23] | ES | 11.11.2015 | |
HR | 11.11.2015 | ||
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
NL | 11.11.2015 | ||
SE | 11.11.2015 | ||
NO | 11.02.2016 | ||
IS | 11.03.2016 | ||
Former [2016/22] | ES | 11.11.2015 | |
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
NL | 11.11.2015 | ||
NO | 11.02.2016 | ||
IS | 11.03.2016 | ||
Former [2016/21] | ES | 11.11.2015 | |
IT | 11.11.2015 | ||
LT | 11.11.2015 | ||
NO | 11.02.2016 | ||
Former [2016/20] | ES | 11.11.2015 | |
LT | 11.11.2015 | Documents cited: | Search | [AD]US2008045710 (GANGJEE ALEEM [US]) [AD] 1-11,14-17 * page 1, paragraph [0004],;; figures 1,2 * | International search | [Y]WO2008027949 (DUQUESNE UNIVERSITY OF THIE HO [US], et al); | [Y]EP0438261 (TAKEDA CHEMICAL INDUSTRIES LTD [JP]); | [Y]US2005032786 (KAJINO MASAHIRO [JP], et al); | [A]US2004096436 (CARSON DENNIS A [US], et al); | [A]US6525050 (ROMINES III WILLIAM H [US], et al); | [A]US6518426 (GANGJEE ALEEM [US]); | [A]US5317019 (BENDER PAUL E [US], et al) | Examination | EP0418924 | - Y. KOTAKE ET AL, "Novel 6-5 Fused Rgin Heterocycle Antifolates with Potent Antitumor Activity: Bridge Modifications and Heterocyclic Benzoyl Isosters of 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine Antifolate", CHEM. PHARM. BULL., (199505), vol. 43, no. 5, pages 829 - 841 |