blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2376655

EP2376655 - GENETIC VARIANTS UNDERLYING HUMAN COGNITION AND METHODS OF USE THEREOF AS DIAGNOSTIC AND THERAPEUTIC TARGETS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.08.2020
Database last updated on 11.09.2024
FormerThe patent has been granted
Status updated on  06.09.2019
FormerGrant of patent is intended
Status updated on  14.04.2019
FormerExamination is in progress
Status updated on  27.04.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
The Children's Hospital Of Philadelphia
Research Institute Abramson Research Center Suite 140, Office of Technology Transfer 3615 Civic Center Boulevard
Philadelphia, PA 19104 / US
For all designated states
Trustees of the University of Pennsylvania
3160 Market Street, Suite 200
Philadelphia, PA 19104 / US
For all designated states
The Regents of the University of California
1111 Franklin Street
Oakland, CA 94607-5200 / US
[2019/19]
Former [2011/42]For all designated states
The Children's Hospital Of Philadelphia
Research Institute Abramson Research Center Suite 140, Office of Technology Transfer 3615 Civic Center Boulevard
Philadelphia, PA 19104 / US
For all designated states
The Trustees of The University of Pennsylvania
3160 Market Street, Suite 200
Philadelphia, PA 19104 / US
For all designated states
The Regents Of The University Of California
1111 Franklin Street
Oakland, CA 94607-5200 / US
Inventor(s)01 / HAKONARSON, Hakon
1877 Covered Bridge Road
Malvern, PA 19355 / US
02 / ABRAHAMS, Brett
919 S. Le Doux Road
Los Angeles, CA 90035 / US
03 / BUCAN, Maja
415 Curie Boulevard
Philadelphia, PA 19104 / US
04 / GESCHWIND, Dan
423 Seventh Street
Santa Monica, CA 90402 / US
05 / HERMAN, Edward
111 Park S, Apt 8B
New Haven, CT 06511 / US
06 / WANG, Kai
2351 Crestline Drive
Lansdale, PA 19446 / US
 [2011/50]
Former [2011/42]01 / HAKONARSON, Hakon
1877 Covered Bridge Road
Malvern, PA 19355 / US
02 / ABRAHAMS, Brett
919 S. Le Doux Road
Los Angeles, CA 90035 / US
03 / BUCAN, Maja
415 Curie Boulevard
Philadelphia, PA 19104 / US
04 / GESCHWIND, Dan
423 Seventh Street
Santa Monica, CA 90402 / US
05 / HERMAN, Edward
5369 San Vicente Boulevard, 271
Los Angeles, CA 90019 / US
06 / WANG, Kai
2351 Crestline Drive
Lansdale, PA 19446 / US
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[N/P]
Former [2019/41]Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
Former [2011/42]Cripps, Joanna Elizabeth
Mewburn Ellis LLP 33 Gutter Lane London
EC2V 8AS / GB
Application number, filing date09826923.616.11.2009
[2019/41]
WO2009US64617
Priority number, dateUS20080114921P14.11.2008         Original published format: US 114921 P
[2011/42]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2010057112
Date:20.05.2010
Language:EN
[2010/20]
Type: A2 Application without search report 
No.:EP2376655
Date:19.10.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 20.05.2010 takes the place of the publication of the European patent application.
[2011/42]
Type: B1 Patent specification 
No.:EP2376655
Date:09.10.2019
Language:EN
[2019/41]
Search report(s)International search report - published on:US24.03.2016
(Supplementary) European search report - dispatched on:EP02.06.2017
ClassificationIPC:C12Q1/6883, C07K14/705
[2019/16]
CPC:
C12Q1/6883 (EP,US); A61P21/04 (EP); A61P25/00 (EP);
A61P25/08 (EP); A61P25/14 (EP); A61P25/16 (EP);
A61P25/18 (EP); A61P25/28 (EP); A61P31/00 (EP);
A61P35/00 (EP); A61P9/10 (EP); C07K14/705 (US);
C12Q2600/118 (EP,US); C12Q2600/136 (EP,US); C12Q2600/156 (EP,US) (-)
Former IPC [2011/42]C12Q1/68
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2019/41]
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:GENETISCHE VARIANTEN DER MENSCHLICHEN KOGNITION UND VERFAHREN ZU IHRER VERWENDUNG ALS DIAGNOSTISCHE UND THERAPEUTISCHE ZIELE[2011/42]
English:GENETIC VARIANTS UNDERLYING HUMAN COGNITION AND METHODS OF USE THEREOF AS DIAGNOSTIC AND THERAPEUTIC TARGETS[2011/42]
French:VARIANTS GÉNÉTIQUES INTERVENANT DANS LA COGNITION HUMAINE ET LEURS PROCÉDÉS D'UTILISATION COMME CIBLES DIAGNOSTIQUES ET THÉRAPEUTIQUES[2011/42]
Entry into regional phase26.07.2011National basic fee paid 
26.07.2011Search fee paid 
26.07.2011Designation fee(s) paid 
26.07.2011Examination fee paid 
Examination procedure21.07.2011Despatch of communication that the application is deemed to be withdrawn, reason: filing fee / search fee not paid in time
26.07.2011Examination requested  [2011/42]
21.12.2017Amendment by applicant (claims and/or description)
26.04.2018Despatch of a communication from the examining division (Time limit: M06)
05.11.2018Reply to a communication from the examining division
15.04.2019Communication of intention to grant the patent
16.08.2019Fee for grant paid
16.08.2019Fee for publishing/printing paid
16.08.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.04.2018
Opposition(s)10.07.2020No opposition filed within time limit [2020/38]
Request for further processing for:The application is deemed to be withdrawn due to non-payment of the search fee
26.07.2011Request for further processing filed
26.07.2011Full payment received (date of receipt of payment)
Request granted
17.08.2011Decision despatched
26.07.2011Request for further processing filed
26.07.2011Full payment received (date of receipt of payment)
Request granted
17.08.2011Decision despatched
The application is deemed to be withdrawn due to non-payment of the filing fee
26.07.2011Request for further processing filed
26.07.2011Full payment received (date of receipt of payment)
Request granted
17.08.2011Decision despatched
Fees paidRenewal fee
21.11.2011Renewal fee patent year 03
20.11.2012Renewal fee patent year 04
20.11.2013Renewal fee patent year 05
24.11.2014Renewal fee patent year 06
10.11.2015Renewal fee patent year 07
10.11.2016Renewal fee patent year 08
13.11.2017Renewal fee patent year 09
14.11.2018Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU16.11.2009
AT09.10.2019
CY09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
MK09.10.2019
MT09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SI09.10.2019
SK09.10.2019
SM09.10.2019
TR09.10.2019
IE16.11.2019
LU16.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
FR09.12.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
DE03.06.2020
[2022/31]
Former [2022/26]HU16.11.2009
AT09.10.2019
CY09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
MT09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SI09.10.2019
SK09.10.2019
SM09.10.2019
TR09.10.2019
IE16.11.2019
LU16.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
FR09.12.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
DE03.06.2020
Former [2021/34]HU16.11.2009
AT09.10.2019
CY09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
MT09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SI09.10.2019
SK09.10.2019
SM09.10.2019
IE16.11.2019
LU16.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
FR09.12.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
DE03.06.2020
Former [2021/32]HU16.11.2009
AT09.10.2019
CY09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SI09.10.2019
SK09.10.2019
SM09.10.2019
IE16.11.2019
LU16.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
FR09.12.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
DE03.06.2020
Former [2021/26]AT09.10.2019
CY09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SI09.10.2019
SK09.10.2019
SM09.10.2019
IE16.11.2019
LU16.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
FR09.12.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
DE03.06.2020
Former [2020/51]AT09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SI09.10.2019
SK09.10.2019
SM09.10.2019
IE16.11.2019
LU16.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
FR09.12.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
DE03.06.2020
Former [2020/48]AT09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SK09.10.2019
SM09.10.2019
IE16.11.2019
LU16.11.2019
CH30.11.2019
LI30.11.2019
FR09.12.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
DE03.06.2020
Former [2020/46]AT09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SK09.10.2019
SM09.10.2019
IE16.11.2019
LU16.11.2019
CH30.11.2019
LI30.11.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
Former [2020/38]AT09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
IT09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SK09.10.2019
SM09.10.2019
LU16.11.2019
CH30.11.2019
LI30.11.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
Former [2020/37]AT09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
SK09.10.2019
SM09.10.2019
LU16.11.2019
CH30.11.2019
LI30.11.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
Former [2020/36]AT09.10.2019
CZ09.10.2019
DK09.10.2019
EE09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
LT09.10.2019
LV09.10.2019
MC09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
LU16.11.2019
CH30.11.2019
LI30.11.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
IS09.02.2020
PT10.02.2020
Former [2020/35]AT09.10.2019
CZ09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
LT09.10.2019
LV09.10.2019
NL09.10.2019
PL09.10.2019
RO09.10.2019
SE09.10.2019
LU16.11.2019
CH30.11.2019
LI30.11.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
PT10.02.2020
IS24.02.2020
Former [2020/34]AT09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
LT09.10.2019
LV09.10.2019
NL09.10.2019
PL09.10.2019
SE09.10.2019
CH30.11.2019
LI30.11.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
PT10.02.2020
IS24.02.2020
Former [2020/25]AT09.10.2019
ES09.10.2019
FI09.10.2019
HR09.10.2019
LT09.10.2019
LV09.10.2019
NL09.10.2019
PL09.10.2019
SE09.10.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
PT10.02.2020
IS24.02.2020
Former [2020/24]AT09.10.2019
ES09.10.2019
FI09.10.2019
LT09.10.2019
LV09.10.2019
NL09.10.2019
PL09.10.2019
SE09.10.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
PT10.02.2020
IS24.02.2020
Former [2020/23]AT09.10.2019
ES09.10.2019
FI09.10.2019
LT09.10.2019
LV09.10.2019
NL09.10.2019
PL09.10.2019
SE09.10.2019
BG09.01.2020
NO09.01.2020
GR10.01.2020
PT10.02.2020
Former [2020/22]FI09.10.2019
LT09.10.2019
NL09.10.2019
SE09.10.2019
BG09.01.2020
NO09.01.2020
PT10.02.2020
Former [2020/21]NL09.10.2019
NO09.01.2020
Former [2020/20]NL09.10.2019
Documents cited:Search[I]  - M. Kusenda ET AL, "The role of rare structural variants in the genetics of autism spectrum disorders", Cytogenet Genome Res, doi:10.1159/000184690, (20080910), pages 36 - 43, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920182/pdf/cgr0123-0036.pdf, (20130103), XP055048619 [I] 1-7 * the whole document *

DOI:   http://dx.doi.org/10.1159/000184690
 [I]  - ROPERS ET AL, "Genetics of intellectual disability", CURRENT OPINION IN GENETICS & DEVELOPMENT, CURRENT BIOLOGY LTD, XX, vol. 18, no. 3, doi:10.1016/J.GDE.2008.07.008, ISSN 0959-437X, (20080601), pages 241 - 250, (20080828), XP025472460 [I] 1-7 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.gde.2008.07.008
 [I]  - COSTA E SILVA ET AL, "Autism, a brain developmental disorder: some new pathopysiologic and genetics findings", METABOLISM, CLINICAL AND EXPERIMENTAL, W.B. SAUNDERS CO., PHILADELPHIA, PA, US, vol. 57, ISSN 0026-0495, (20081001), pages S40 - S43, (20080916), XP025412926 [I] 1-7 * the whole document *
 [I]  - ST CLAIR DAVID, "Copy number variation and schizophrenia", SCHIZOPHRENIA BULLETIN, OXFORD UNIVERSITY PRESS, (20081105), vol. 35, no. 1, doi:10.1093/SCHBUL/SBN147, ISSN 0586-7614, pages 9 - 12, XP009123717 [I] 1-7 * the whole document *

DOI:   http://dx.doi.org/10.1093/schbul/sbn147
 [I]  - THE AUTISM GENOME PROJECT CONSORTIUM ET AL, "Genome-wide linkage analyses of quantitative and categorical autism sub-phenotypes", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY; US, vol. 64, no. 7, doi:10.1016/J.BIOPSYCH.2008.05.023, ISSN 0006-3223, (20081001), pages 561 - 570, (20080716), XP026046033 [I] 1-7 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.biopsych.2008.05.023
 [X]  - Samuel Levy ET AL, "The Diploid Genome Sequence of an Individual Human", doi:10.1371/journal.pbio, (20071001), URL: http://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050254&type=printable, (20170127), XP055339811 [X] 10-12 * the whole document *

DOI:   http://dx.doi.org/10.1371/journal.pbio.0050254
 [X]  - Anonymous, "esv1634494 - dbVar Variant - NCBI", (20071001), URL: https://www.ncbi.nlm.nih.gov/dbvar/variants/esv1634494/, (20170127), XP055339813 [X] 10,11 * the whole document *
 [X]  - Agilent, "Open to Anything: The Agilent Genomics Portfolio", (20080601), URL: http://www.agilent.com/cs/library/brochures/IBS-231 genomics catalog mech FINAL.pdf, (20170127), XP055339867 [X] 12 * page 11 *
International search[Y]US2005209181  (AKIL HUDA [US], et al) [Y] 1-8 * para [0043], [0057], [0138], [0151]-[0152], [0276], Table 22, pg 88 *;
 [A]US2006051786  (AKIL HUDA [US], et al) [A] 1-8;
 [Y]  - SEO et al., "An accurate method for quantifying and analyzing copy number variation in porcine KIT by an oligonucleotide ligation assay.", BMC Genet., (20070000), vol. 8, pages 1 - 11, XP021032607 [Y] 1-8 * ; Abstract *
 [A]  - MARSHALL et al., "Structural variation of chromosomes in autism spectrum disorder.", Am. J. Hum. Genet., (20080200), vol. 82, no. 2, doi:doi:10.1016/j.ajhg.2007.12.009, pages 477 - 488, XP 002637348 [A] 1-8
 [A]  - KUOKKANEN et al., "Genomewide scan of multiple sclerosis in Finnish multiplex families.", Am. J. Hum. Genet., (19971200), vol. 61, no. 6, pages 1379 - 1387, XP 055276648 [A] 1-8
 [A]  - CHARDENOT et al., "Expression profile and up-regulation of PRAX-1 mRNA by antidepressant treatment in the rat brain.", Mol. Pharmacol., (20020000), vol. 62, no. 6, pages 1314 - 1320, XP 055276650 [A] 1-8
 [A]  - GALLIEGUE et al., "Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor.", J. Biol. Chem., (19990000), vol. 274, no. 5, pages 2938 - 2952, XP 002122735 [A] 1-8
 [XP]  - BUCAN et al., "Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.", PLoS Genet., (20090600), vol. 5, no. 6, pages 1 - 12, XP 009140103 [XP] 1-8
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.