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Extract from the Register of European Patents

EP About this file: EP2379083

EP2379083 - EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.06.2018
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  14.07.2017
FormerGrant of patent is intended
Status updated on  07.07.2017
FormerExamination is in progress
Status updated on  18.05.2017
FormerGrant of patent is intended
Status updated on  16.01.2017
Most recent event   Tooltip19.06.2020Lapse of the patent in a contracting state
New state(s): HR		published on 22.07.2020  [2020/30]
Applicant(s)For all designated states
Dicerna Pharmaceuticals, Inc.
480 Arsenal Street
Watertown, MA 02742 / US
[2011/43]
Inventor(s)01 / BROWN, Bob
54 Leprechaun Drive
Millington NJ 07946 / US
 [2011/43]
Representative(s)Soames, Candida Jane, et al
Maschio & Soames IP Limited
30 Carlton Crescent
Southampton SO15 2EW / GB
[2017/33]
Former [2011/45]Soames, Candida Jane, et al
Edwards Wildman Innovations LLP
10 Carlton Crescent
Southampton SO15 2EZ / GB
Former [2011/43]Soames, Candida Jane
Edwards Angell Palmer & Dodge Innovations LLP 10 Carlton Crescent
Southampton SO15 2EZ / GB
Application number, filing date09837721.118.12.2009
[2017/33]
WO2009US06636
Priority number, dateUS20090173554P28.04.2009         Original published format: US 173554 P
US20090173525P28.04.2009         Original published format: US 173525 P
US20080138946P18.12.2008         Original published format: US 138946 P
US20090173505P28.04.2009         Original published format: US 173505 P
US20090173538P28.04.2009         Original published format: US 173538 P
US20090173544P28.04.2009         Original published format: US 173544 P
US20090173549P28.04.2009         Original published format: US 173549 P
US20090173563P28.04.2009         Original published format: US 173563 P
US20090173558P28.04.2009         Original published format: US 173558 P
US20090173521P28.04.2009         Original published format: US 173521 P
US20090173532P28.04.2009         Original published format: US 173532 P
US20090166227P02.04.2009         Original published format: US 166227 P
US20090173556P28.04.2009         Original published format: US 173556 P
US20090173514P28.04.2009         Original published format: US 173514 P
[2011/43]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2010080129
Date:15.07.2010
Language:EN
[2010/28]
Type: A2 Application without search report 
No.:EP2379083
Date:26.10.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 15.07.2010 takes the place of the publication of the European patent application.
[2011/43]
Type: B1 Patent specification 
No.:EP2379083
Date:16.08.2017
Language:EN
[2017/33]
Search report(s)International search report - published on:US16.09.2010
(Supplementary) European search report - dispatched on:EP21.02.2013
ClassificationIPC:A61K31/70, C07H21/04
[2011/43]
CPC:
C12N15/1135 (EP,CN,KR,US); C12N15/113 (EP,CN,KR,US); A61K31/713 (EP,CN,US);
A61P43/00 (EP); C12N15/111 (EP,US); C12N15/1131 (CN);
C12N15/1138 (KR); C12N2310/122 (CN); C12N2310/14 (EP,US);
C12N2310/141 (CN); C12N2310/321 (EP,US); C12N2310/322 (EP,CN,US);
C12N2310/342 (EP,US); C12N2310/344 (EP,US); C12N2310/533 (EP,US);
C12N2320/52 (EP,US) (-)
C-Set:
C12N2310/321, C12N2310/3521 (US,EP);
C12N2310/322, C12N2310/3531 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2017/33]
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:VERLÄNGERTE DICER-SUBSTRATSTOFFE UND VERFAHREN FÜR SPEZIFISCHE GENEXPRESSIONSHEMMUNG[2011/43]
English:EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION[2011/43]
French:AGENTS ALLONGÉS SERVANT DE SUBSTRATS DE DICER ET PROCÉDÉS D'INHIBITION SPÉCIFIQUE DE L'EXPRESSION D'UN GÈNE[2011/43]
Entry into regional phase16.07.2011National basic fee paid 
16.07.2011Search fee paid 
16.07.2011Designation fee(s) paid 
16.07.2011Examination fee paid 
Examination procedure16.07.2011Examination requested  [2011/43]
29.10.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
08.01.2014Amendment by applicant (claims and/or description)
28.02.2014Despatch of a communication from the examining division (Time limit: M04)
24.06.2014Reply to a communication from the examining division
19.06.2015Cancellation of oral proceeding that was planned for 02.09.2015
17.07.2015Despatch of a communication from the examining division (Time limit: M04)
02.09.2015Date of oral proceedings (cancelled)
05.11.2015Reply to a communication from the examining division
17.01.2017Communication of intention to grant the patent
12.05.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
12.05.2017Fee for grant paid
12.05.2017Fee for publishing/printing paid
06.07.2017Information about intention to grant a patent
06.07.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.02.2014
Opposition(s)17.05.2018No opposition filed within time limit [2018/30]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
08.01.2014Request for further processing filed
08.01.2014Full payment received (date of receipt of payment)
Request granted
30.01.2014Decision despatched
Fees paidRenewal fee
27.12.2011Renewal fee patent year 03
26.12.2012Renewal fee patent year 04
27.12.2013Renewal fee patent year 05
29.12.2014Renewal fee patent year 06
28.12.2015Renewal fee patent year 07
27.12.2016Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.12.2009
AT16.08.2017
CY16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
HR16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
NL16.08.2017
PL16.08.2017
PT16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
TR16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
[2020/30]
Former [2020/27]HU18.12.2009
AT16.08.2017
CY16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
NL16.08.2017
PL16.08.2017
PT16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
TR16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2020/16]HU18.12.2009
AT16.08.2017
CY16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
TR16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/51]HU18.12.2009
AT16.08.2017
CY16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/46]HU18.12.2009
AT16.08.2017
CY16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/31]HU18.12.2009
AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/30]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2018/52]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2018/50]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
Former [2018/45]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
IE18.12.2017
LU18.12.2017
MT18.12.2017
Former [2018/43]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
LU18.12.2017
MT18.12.2017
Former [2018/39]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/24]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
IT16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/23]AT16.08.2017
CZ16.08.2017
DK16.08.2017
EE16.08.2017
ES16.08.2017
FI16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
RO16.08.2017
SE16.08.2017
SK16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/21]AT16.08.2017
CZ16.08.2017
DK16.08.2017
ES16.08.2017
FI16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
SE16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/12]AT16.08.2017
ES16.08.2017
FI16.08.2017
LT16.08.2017
LV16.08.2017
NL16.08.2017
PL16.08.2017
SE16.08.2017
BG16.11.2017
NO16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/10]AT16.08.2017
FI16.08.2017
LT16.08.2017
NL16.08.2017
SE16.08.2017
NO16.11.2017
Former [2018/09]FI16.08.2017
LT16.08.2017
NL16.08.2017
SE16.08.2017
NO16.11.2017
Former [2018/08]FI16.08.2017
LT16.08.2017
NL16.08.2017
NO16.11.2017
Former [2018/07]LT16.08.2017
NO16.11.2017
Documents cited:Search[A]WO2007038788  (CLEVELAND CLINIC FOUNDATION [US], et al)[A] 1-15;
 [A]  - HEFNER ET AL, "Increased potency and longevity of gene silencing using validated Dicer substrates.", JOURNAL OF BIOMOLECULAR TECHNIQUES, (20080901), vol. 19, no. 4, ISSN 1524-0215, pages 231 - 237, XP055050408 [A] 1-15
 [A]  - UI-TEI KUMIKO ET AL, "Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 36, no. 7, doi:10.1093/NAR/GKN042, ISSN 0305-1048, (20080401), pages 2136 - 2151, (20080211), XP002598044 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/gkn042
 [A]  - UI-TEI K ET AL, "DNA-modified siRNA-dependent gene silencing with reduced off-target effect is induced through a pathway parallel to that for siRNA-mediated RNA interference", MICRO-NANOMECHATRONICS AND HUMAN SCIENCE, 2008. MHS 2008. INTERNATIONAL SYMPOSIUM ON, IEEE, PISCATAWAY, NJ, USA, (20081106), ISBN 978-1-4244-2918-9, pages 339 - 345, XP031407702 [A] 1-15
International search[X]US2005282188  (HAEBERLI PETER [US], et al);
 [X]US2007265220  (ROSSI JOHN J [US], et al)
by applicantWO2007038788
    - HEFNER ET AL., JOURNAL OF BIOMOLECULAR TECHNIQUES, (2008), vol. 19, no. 4, pages 231 - 237
    - KUMIKO ET AL., NUCLEIC ACIDS RESEARCH, (2008), vol. 36, no. 7, pages 2136 - 2151
    - "Micro-Nano mechatronic and Human Science", INTERNATIONAL SYMPOSIUM ON IEEE, PISCATAWAY, NJ, USA, (2008), pages 339 - 345
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.