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Extract from the Register of European Patents

EP About this file: EP2213291

EP2213291 - Antisense inhibition of PTP1B expression [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  24.04.2015
Database last updated on 23.09.2024
Most recent event   Tooltip24.04.2015Application deemed to be withdrawnpublished on 27.05.2015  [2015/22]
Applicant(s)For all designated states
Isis Pharmaceuticals, Inc.
2855 Gazelle Court
Carlsbad, CA 92010 / US
[2011/39]
Former [2010/31]For all designated states
Isis Pharmaceuticals, Inc.
1896 Rutherford Road
Carlsbad, CA 92008 / US
Inventor(s)01 / Cowsert, Lex M.
1570 Dustin Cade Drive
New Braunfels, TX 78130 / US
02 / Wyatt, Jacqueline R.
809 Canyon Road
Sundance, WY 82729 / US
 [2010/31]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2010/31]Carpmaels & Ransford
One Southampton Row London
WC1B 5HA / GB
Application number, filing date10004747.104.01.2001
[2010/31]
Priority number, dateUS2000048736818.01.2000         Original published format: US 487368
[2010/31]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2213291
Date:04.08.2010
Language:EN
[2010/31]
Search report(s)(Supplementary) European search report - dispatched on:EP29.06.2010
ClassificationIPC:A61K31/713, C12N15/88, C12N15/11, C12Q1/68, C07H21/04
[2010/31]
CPC:
C12N15/1137 (EP,US); A61K48/00 (EP,US); A61P3/04 (EP);
A61P3/10 (EP); A61P35/00 (EP); C12Y301/03048 (EP,US);
A61K38/00 (EP,US); C12N2310/315 (EP,US); C12N2310/321 (EP,US);
C12N2310/3341 (EP,US); C12N2310/341 (EP,US); C12N2310/346 (EP,US);
Y02P20/582 (EP,US) (-)
C-Set:
C12N2310/321, C12N2310/3525 (EP,US)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2010/31]
TitleGerman:Antisense-Hemmung der PTP1B-Expression[2010/31]
English:Antisense inhibition of PTP1B expression[2010/31]
French:Inhibition anti-sens d'expression PTP1B[2010/31]
Examination procedure01.02.2011Amendment by applicant (claims and/or description)
03.02.2011Examination requested  [2011/11]
25.04.2012Despatch of a communication from the examining division (Time limit: M04)
05.09.2012Reply to a communication from the examining division
23.09.2014Cancellation of oral proceeding that was planned for 24.09.2014
24.09.2014Date of oral proceedings (cancelled)
01.10.2014Despatch of a communication from the examining division (Time limit: M02)
12.12.2014Application deemed to be withdrawn, date of legal effect  [2015/22]
13.01.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2015/22]
Parent application(s)   TooltipEP01900829.1  / EP1250455
EP08008871.9  / EP2003207
Divisional application(s)EP10176460.3  / EP2329830
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20010900829) is  10.11.2004
Fees paidRenewal fee
05.05.2010Renewal fee patent year 03
05.05.2010Renewal fee patent year 04
05.05.2010Renewal fee patent year 05
05.05.2010Renewal fee patent year 06
05.05.2010Renewal fee patent year 07
05.05.2010Renewal fee patent year 08
05.05.2010Renewal fee patent year 09
05.05.2010Renewal fee patent year 10
06.01.2011Renewal fee patent year 11
09.01.2012Renewal fee patent year 12
30.01.2013Renewal fee patent year 13
30.01.2014Renewal fee patent year 14
Penalty fee
Additional fee for renewal fee
31.01.201515   M06   Not yet paid
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Documents cited:Search[XDYI]WO9732595  (UNIV CALIFORNIA [US]) [XD] 1-4,6,7 * page 9 - page 10 * [Y] 4,5 [I] 8-15;
 [YD]  - LEE S-R ET AL, "Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD- DOI:10.1074/JBC.273.25.15366, (19980619), vol. 273, no. 25, ISSN 0021-9258, pages 15366 - 15372, XP002308665 [YD] 4,5 * abstract *

DOI:   http://dx.doi.org/10.1074/jbc.273.25.15366
 [Y]  - HENRY S P ET AL, "TOXICOLOGICAL AND PHARMACOKINETIC PROPERTIES OF CHEMICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDE INHIBITORS OF PKC-ALPHA AND C-RAF KINASE", ANTI-CANCER DRUG DESIGN, BASINGSTOKE, GB, (199707), vol. 12, no. 5, ISSN 0266-9536, pages 409 - 420, XP009008948 [Y] 7-15 * the whole document *
 [IDY]  - ELCHEBLY MOUNIB ET AL, "Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene", SCIENCE (WASHINGTON D C), (19990305), vol. 283, no. 5407, ISSN 0036-8075, pages 1544 - 1548, XP002119313 [ID] 1-3,6 * abstract * * page 1547 * [Y] 7-15

DOI:   http://dx.doi.org/10.1126/science.283.5407.1544
 [A]  - CROOKE S T, "BASIC PRINCIPLES OF ANTISENSE THERAPEUTICS", ANTISENSE RESEARCH AND APPLICATIONS, CRC PRESS, GB, (19980101), pages 1 - 50, XP000900999 [A] 1-15 * page 9 - page 12 *
 [A]  - HASSID A ET AL, "Role of PTP-1B in aortic smooth muscle cell motility and tyrosine phosphorylation of focal adhesion proteins", AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY, THE AMERICAN PHYSIOLOGICAL SOCIETY, XX, (199907), vol. 277, no. 1 part 2, ISSN 0363-6135, pages H192 - H198, XP002218828 [A] 1-15 * abstract * * page H193, column L * * page H197; figures 2-4 *
by applicantUS3687808
 US4426330
 US4469863
 US4476301
 US4534899
 US4587044
 US4605735
 US4667025
 WO8804924
 US4762779
 US4789737
 US4824941
 US4828979
 US4835263
 US4837028
 US4845205
 US4876335
 US4904582
 WO9004384
 US4948882
 US4958013
 US4981957
 WO9105545
 US5013830
 US5013556
 US5023243
 US5034506
 US5082830
 US5109124
 US5108921
 US5112963
 US5118800
 US5118802
 US5130302
 US5134066
 US5138045
 US5149797
 US5166315
 US5175273
 US5177196
 US5177198
 US5185444
 US5188897
 US5214134
 US5214136
 US5213804
 US5216141
 US5218105
 US5220007
 US5223618
 US5225212
 US5227170
 US5235033
 US5245022
 US5254469
 US5256775
 US5258506
 US5262536
 US5264423
 US5264562
 US5264564
 US5264221
 WO9324510
 US5272250
 US5276019
 US5278302
 WO9402501
 WO9402499
 US5286717
 US5292873
 EP0445131
 US5317098
 US5319080
 US5321131
 WO9417093
 WO9420073
 US5354844
 US5356633
 US5359044
 US5367066
 US5366878
 WO9426764
 US5371241
 EP0496813
 US5378825
 US5386023
 US5391723
 US5393878
 US5395619
 US5399676
 US5403711
 US5405939
 US5405938
 US5414077
 US5416203
 US5416016
 US5417978
 US5432272
 US5434257
 US5446137
 US5451463
 US5453496
 US5455233
 US5457187
 US5459255
 US5459127
 US5462854
 US5466677
 US5466786
 US5470967
 US5469854
 US5476925
 US5484908
 US5486603
 US5489677
 US5491133
 US5502177
 US5506351
 WO9610391
 US5508270
 US5510475
 US5512439
 US5512667
 US5512295
 US5514785
 US5519126
 US5519134
 US5521291
 US5525711
 US5525465
 US5527528
 US5534259
 US5536821
 US5539082
 US5541306
 US5541307
 US5541313
 US5540935
 US5543158
 US5543152
 US5545730
 US5547932
 US5550111
 US5552540
 US5552538
 US5556948
 US5561225
 US5563253
 US5565552
 US5565350
 US5567811
 US5567810
 US5571799
 US5574142
 US5576427
 US5578717
 US5578718
 US5580731
 US5580575
 US5583020
 US5585481
 WO9640062
 US5587361
 US5587469
 US5587371
 US5591722
 US5591584
 US5591721
 US5594121
 US5596086
 US5596091
 US5595726
 US5595756
 US5597909
 US5597696
 US5599923
 US5599928
 US5602240
 WO9704787
 US5608046
 US5610289
 US5610300
 US5614617
 US5618704
 WO9713499
 US5623070
 US5623065
 US5625050
 US5627053
 US5633360
 US5639873
 US5646265
 US5652355
 US5652356
 US5658873
 WO9730731
 US5663312
 US5665710
 WO9732595
 US5670633
 US5677437
 US5677439
 US5681941
 US5688941
 US5700920
 US5700922
 US5705188
 US5714331
 US5719262
 US5750692
    - ZHANG, CRIT. REV. BIOCHEM. MOL. BIOL., (1998), vol. 33, pages 1 - 52
    - TONKS ET AL., J. BIOL. CHEM., (1988), vol. 263, pages 6731 - 6737
    - TONKS ET AL., J. BIOL. CHEM., (1988), vol. 263, pages 6722 - 6730
    - GOLDSTEIN ET AL., MOL. CELL. BIOCHEM., (1998), vol. 182, pages 91 - 99
    - SEELY ET AL., DIABETES, (1996), vol. 45, pages 1379 - 1385
    - CHEN ET AL., J. BIOL. CHEM., (1997), vol. 272, pages 8026 - 8031
    - ELCHEBLY ET AL., SCIENCE, (1999), vol. 283, pages 1544 - 1548
    - SCHIEVELLA ET AL., CELL. GROWTH DIFFER., (1993), vol. 4, pages 239 - 246
    - SHIFRIN; NEEL, J. BIOL. CHEM., (1993), vol. 268, pages 25376 - 25384
    - SELL; REESE, MOL. GENET. METAB., (1999), vol. 66, pages 189 - 192
    - LIU; CHERNOFF, BIOCHEM. J., (1997), vol. 327, pages 139 - 145
    - LEE ET AL., J. BIOL.. CHEM., (1998), vol. 273, pages 15366 - 15372
    - WIENER ET AL., AM. J. OBSTET. GYNECOL., (1994), vol. 170, pages 1177 - 1183
    - BROWN-SHIMER ET AL., CANCER RES., (1992), vol. 52, pages 478 - 482
    - LIU ET AL., MOL. CELL. BIOL., (1998), vol. 18, pages 250 - 259
    - LAMONTAGNE ET AL., PROC. NATL. ACAD. SCI. U. S. A., (1998), vol. 95, pages 14094 - 14099
    - LIU ET AL., CURR. BIOL., (1998), vol. 8, pages 173 - 176
    - BALSAMO ET AL., J. CELL. BIOL., (1998), vol. 143, pages 523 - 532
    - ARREGUI ET AL., J. CELL. BIOL., (1998), vol. 143, pages 861 - 873
    - HAM ET AL., BIOORG. MED. CHEM. LETT., (1999), vol. 9, pages 185 - 186
    - SKOREY ET AL., J. BIOL. CHEM., (1997), vol. 272, pages 22472 - 22480
    - TAING ET AL., BIOCHEMISTRY, (1999), vol. 38, pages 3793 - 3803
    - TAYLOR ET AL., BIOORG. MED. CHEM., (1998), vol. 6, pages 1457 - 1468
    - WANG ET AL., BIOORG. MED. CHEM. LETT., (1998), vol. 8, pages 345 - 350
    - WANG ET AL., BIOCHEM. PHARMACOL., (1997), vol. 54, pages 703 - 711
    - YAO ET AL., BIOORG. MED. CHEM., (1998), vol. 6, pages 1799 - 1810
    - CHEN ET AL., BIOCHEMISTRY, (1999), vol. 38, pages 384 - 389
    - DESMARAIS ET AL., ARCH. BIOCHEM. BIOPHYS., (1998), vol. 354, pages 225 - 231
    - ROLLER ET AL., BIOORG. MED. CHEM. LETT., (1998), vol. 8, pages 2149 - 2150
    - NIELSEN ET AL., SCIENCE, (1991), vol. 254, pages 1497 - 1500
    - MARTIN ET AL., HELV. CHIM. ACTA, (1995), vol. 78, pages 486 - 504
    - LETSINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 6553 - 6556
    - MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1994), vol. 4, pages 1053 - 1060
    - MANOHARAN ET AL., ANN. N.Y. ACAD. SCI., (1992), vol. 660, pages 306 - 309
    - MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1993), vol. 3, pages 2765 - 2770
    - OBERHAUSER ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 533 - 538
    - SAISON-BEHMOARAS ET AL., EMBO J., (1991), vol. 10, pages 1111 - 1118
    - KABANOV ET AL., FEBS LETT., (1990), vol. 259, pages 327 - 330
    - SVINARCHUK ET AL., 5 BIOCHIMIE, (1993), vol. 75, pages 49 - 54
    - MANOHARAN ET AL., TETRAHEDRON LETT., (1995), vol. 36, pages 3651 - 3654
    - SHEA ET AL., NUCL. ACIDS RES., (1990), vol. 18, pages 3777 - 3783
    - MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, (1995), vol. 14, pages 969 - 973
    - MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, (1995), vol. 1264, pages 229 - 237
    - CROOKE ET AL., J. PHARMACOL. EXP. THER., (1996), vol. 277, pages 923 - 937
    - BERGE ET AL., "Pharmaceutical Salts", J. OF PHARMA SCI., (1977), vol. 66, doi:doi:10.1002/jps.2600660104, pages 1 - 19, XP002675560

DOI:   http://dx.doi.org/10.1002/jps.2600660104
    - CONSTANTINIDES ET AL., PHARMACEUTICAL RESEARCH, (1994), vol. 11, pages 1385 - 1390
    - RITSCHEL, METH. FIND. EXP. CLIN. PHARMACOL., (1993), vol. 13, page 205
    - CONSTANTINIDES ET AL., PHARMACEUTICAL RESEARCH, (1994), vol. 11, page 1385
    - HO ET AL., J. PHARM. SCI., (1996), vol. 85, pages 138 - 143
    - LEE ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, (1991), page 92
    - WANG ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1987), vol. 147, pages 980 - 985
    - ZHOU ET AL., JOURNAL OF CONTROLLED RELEASE, (1992), vol. 19, pages 269 - 274
    - WEINER ET AL., JOURNAL OF DRUG TARGETING, (1992), vol. 2, pages 405 - 410
    - PLESSIS ET AL., ANTIVIRAL RESEARCH, (1992), vol. 18, pages 259 - 265
    - HU ET AL., S.T.P.PHARMA. SCI., (1994), vol. 4, no. 6, page 466
    - ALLEN ET AL., FEBS LETTERS, (1987), vol. 223, page 42
    - WU ET AL., CANCER RESEARCH, (1993), vol. 53, page 3765
    - PAPAHADJOPOULOS ET AL., ANN. N.Y. ACAD. SCI., (1987), vol. 507, page 64
    - GABIZON ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1988), vol. 85, page 6949
    - SUNAMOTO ET AL., BULL. CHEM. SOC. JPN., (1980), vol. 53, page 2778
    - ILLUM ET AL., FEBS LETT., (1984), vol. 167, page 79
    - KLIBANOV ET AL., FEBS LETT., (1990), vol. 268, page 235
    - BLUME ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, (1990), vol. 1029, page 91
    - TAKAHASHI ET AL., J. PHARM. PHARMACOL., (1988), vol. 40, page 252
    - MURANISHI, CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, (1990), vol. 7, pages 1 - 33
    - EL HARIRI ET AL., J. PHARM. PHARMACOL., (1992), vol. 44, pages 651 - 654
    - YAMAMOTO ET AL., J. PHARM. EXP. THER., (1992), vol. 263, page 25
    - YAMASHITA ET AL., J. PHARM. SCI., (1990), vol. 79, pages 579 - 583
    - JARRETT, J. CHROMATOGR., (1993), vol. 618, pages 315 - 339
    - BUUR ET AL., J. CONTROL REL., (1990), vol. 14, pages 43 - 51
    - YAMASHITA ET AL., J. PHARM. PHARMACOL., (1987), vol. 39, pages 621 - 626
    - MIYAO ET AL., ANTISENSE RES. DEV., (1995), vol. 5, pages 115 - 121
    - TAKAKURA ET AL., ANTISENSE & NUCL. ACID DRUG DEV., (1996), vol. 6, pages 177 - 183
    - SANGHVI, NUCLEIC ACIDS RESEARCH, (1993), vol. 21, pages 3197 - 3203
    - KAWASAKI, J. MED. CHEM., (1993), vol. 36, pages 831 - 841
    - MARTIN, P., HELVETICA CHIMICA ACTA, (1995), vol. 78, pages 486 - 504
    - "Peptide Nucleic Acids (PNA): Synthesis, Properties and Potential Applications", BIOORGANIC & MEDICINAL CHEMISTRY, (1996), vol. 4, pages 5 - 23
    - CHIANG ET AL., J. BIOL. CHEM., (1991), vol. 266, pages 18162 - 18171
    - MIURA ET AL., CLIN. CHEM., (1996), vol. 42, pages 1758 - 1764
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.