Deutsch English Français

Contact

EP2471909

European procedure

Quick help

Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...

News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...

Extract from the Register of European Patents

EP About this file: EP2471909

EP2471909 - Nucleic acid molecules for generating adenoviral vectors [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 31.05.2013 Database last updated on 07.06.2024
Most recent event Tooltip	31.05.2013	Application deemed to be withdrawn	published on 03.07.2013 [2013/27]
Applicant(s)	For all designated states SIRION BIOTECH GmbH Am Klopferspitz 19 82152 Planegg/Martinsried / DE
	[2012/27]
Inventor(s)	01 / Thirion, Christian Maistrasse 63 80337 Munich / DE
	[2012/27]
Representative(s)	Bohmann, Armin K. Bohmann Anwaltssozietät Nymphenburger Strasse 1 80335 München / DE
	[N/P]
Former [2012/27]	Bohmann, Armin K. bohmann Anwaltssozietät Nymphenburger Strasse 1 80335 München / DE
Application number, filing date	10016217.1	30.12.2010
	[2012/27]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP2471909
	Date:	04.07.2012
	Language:	EN
	[2012/27]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	01.06.2011
Classification	IPC:	C12N7/02, C12N15/861	[2012/27]
	CPC:	C12N15/63 (EP,US); C12N15/86 (EP,US); C12N7/00 (EP,US); C12N2710/10343 (EP,US); C12N2710/10351 (EP,US); C12N2800/204 (EP,US); (+) C12N2800/30 (EP,US); C12N2800/50 (EP,US); C12N2820/002 (EP,US); C12N2820/60 (EP,US); C12N2830/55 (EP,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/27]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	Nukleinsäuremoleküle zur Herstellung adenoviraler Vektoren	[2012/27]
	English:	Nucleic acid molecules for generating adenoviral vectors	[2012/27]
	French:	Molécules d'acide nucléique pour generer des vecteurs d'adenovirus	[2012/27]
Biological material	This application mentions deposited biological material, check the file for details
Examination procedure	05.01.2013	Application deemed to be withdrawn, date of legal effect [2013/27]
	12.02.2013	Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time [2013/27]
Fees paid	Renewal fee
	11.10.2012	Renewal fee patent year 03
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[AD]US6379943 (GRAHAM FRANK L [CA], et al) [AD] 1-15 * abstract * * figure 1 *;
		[X]US2003054555 (FARMER ANDREW ALAN [US], et al) [X] 1-15 * abstract * * paragraph [0069] * * paragraph [0072] * * paragraph [0087] * * paragraph [0091] * * paragraph [0093] * * paragraph [0095] * * paragraph [0097] * * paragraph [0098] * * paragraph [0100] * * paragraph [0104] * * paragraph [0115] * * paragraph [0131] * * paragraph [0145] * * paragraph [0147] - paragraph [0149] *;
		[A] - NG P ET AL, "YEAST RECOMBINASE FLP FUNCTIONS EFFECTIVELY IN HUMAN CELLS FOR CONSTRUCTION OF ADENOVIRUS VECTORS", 20000901, (20000901), vol. 29, no. 3, ISSN 0736-6205, pages 524 - 528, XP009026455 [A] 1-15 * the whole document *
		[A] - NG P ET AL, "A HIGH-EFFICIENCY CRE/LOXP-BASED SYSTEM FOR CONSTRUCTION OF ADENOVIRAL VECTORS", HUMAN GENE THERAPY, MARY ANN LIEBERT, NEW YORK ,NY, US, (19991101), vol. 10, no. 16, doi:10.1089/10430349950016708, ISSN 1043-0342, pages 2667 - 2672, XP000864495 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1089/10430349950016708
	by applicant	US5888732
		WO9925854
		US6379943
		US2006210965
		US7132290
		US7282326
		- BETT ET AL., "Packaging capacity and stability of human adenovirus type 5 vectors", J. VIROL., (1993), vol. 67, pages 5921 - 5921
		- LANDY A., "Mechanistic and structural complexity in the site-specific recombination pathways of Int and Flp", CURR OPIN GENET DEV., (1993), vol. 3, pages 699 - 707
		- HOESS RH. ET AL., "P1 site-specific recombination: Nucleotide sequence of the recombining sites", PROC. NATL. ACAD. SCI. USA, (1982), vol. 79, pages 3398 - 3402
		- ABREMSKI ET AL., "Bacteriophage P1 Cre-loxP Site-specific Recombination: Site-specific DNA Topoisomerase Activity of the Cre Recombination Protein", J BIOL CHEM, (1986), vol. 261, pages 391 - 396
		- CAMPBELL, AM., "Chromosomal Insertion Sites for Phages and Plasmids", J BACTERIOL, (1992), vol. 174, pages 7495 - 7499
		- QIAN XH. ET AL., "Reactions between Half- and Full-Flp Recombination Target Sites: A Model System for Analyzing Early Steps in Flp Protein-Mediated Site-Specific Recombination", J. BIOL. CHEM., (1992), vol. 267, pages 7794 - 7805
		- ARAKI H. ET AL., "Site-specific Recombinase, R, Encoded by Yeast Plasmid pSRI", J. MOL. BIOL., (1992), vol. 225, pages 25 - 37
		- MAESER S; KAHNMANN R., "The Gin recombinase of phage Mu can catalyse site-specific recombination in plant protoplasts", MOL. GEN: GENET., (1991), vol. 230, pages 170 - 176
		- ESPOSITO D; SCOCCA JJ, "The integrase family of tyrosine recombinases: evolution of a conserved active site domain", NUCL ACIDS RES, (1997), vol. 25, pages 3605 - 3614
		- LANDY A., "Mechanistic and structural complexity in the site-specific recombination pathways of Int and Flp", CURRENT OPINIONS IN GENETICS AND DEVEL., (1993), vol. 3, pages 699 - 707
		- "The Cre-lox Recombination System", HOESS RH; ABREMSKI K, Nucleic Acids and Molecular Biology, SPRINGER-VERLAG, (1990), vol. 4, pages 90 - 109
		- BROACH JR. ET AL., "Recombination within the Yeast Plasmid 2.mu. Circle is Site-Specific", CELL, (1982), vol. 29, pages 227 - 234
		- CHEN L; ANTON M; GRAHAM FL., "Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre", SOMAT. CELL AND MOLEC. GENET., (1996), vol. 22, pages 477 - 488
		- HOESS; ABREMSKI, Nucleic Acids and Molecular Biology, SPRINGER VERLAG, (1990), vol. 4, pages 90 - 109
		- HARDY ET AL., "Construction of adenovirus vectors through Cre-lox recombination", J. VIROL., (1997), vol. 71, pages 1842 - 1849
		- PARKS ET AL., "A new helper dependent adenovirus vector system: removal of helper virus by cre-mediated excision of the viral packaging system", PROC. NATL. ACAD. SCI. U.S.A., (1996), vol. 93, pages 13565 - 13570
		- ANTON M.; GRAHAM F.L., "Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression", J.VIROL., (1995), vol. 69, pages 4600 - 4606
		- HARDY S.; KITAMURA M.; HARRIS-STANSIL T.; DAI Y.; PHIPPS M.L., "Construction of adenovirus vectors through Cre-lox recombination", J. VIROL., (1997), vol. 71, pages 1842 - 1849
		- SEMPRINI S; TROUP TJ; KOTELEVTSEVA N; KING K; DAVIS JR; MULLINS LJ; CHAPMAN KE; DUNBAR DR; MULLINS JJ, "Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques", NUCLEIC ACIDS RES., (1997), vol. 35, pages 1402 - 1410
		- SCHMIDT EE; TAYLOR DS; PRIGGE JR; BARNETT S; CAPECCHI MR, "Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids", PROC. NATL. ACAD. SCI. U. S. A., (2000), vol. 97, pages 13702 - 13707
		- SAUER B, "Identification of cryptic lox sites in the yeast genome by selection for Cre-mediated chromosome translocations that confer multiple drug resistance", J. MOL. BIOL., (1992), vol. 223, pages 911 - 928
		- SHARP PA; MOORE C; HAVERTY J L, "The infectivity of adenovirus 5 DNA-protein complex", VIROLOGY, (1976), vol. 75, pages 442 - 456
		- CHINNADURAI G; CHINNADURAI S; GREEN M, "Enhanced infectivity of adenovirus type 2 DNA and a DNA-protein Complex", J. VIROL., (1978), vol. 26, pages 195 - 199
		- ELAHI SM; OUALIKENE W; NAGHDI L; O'CONNOR-MCCOURT M; MASSIE B., "Adenovirus-based libraries: efficient generation of recombinant adenoviruses by positive selection with the adenovirus protease", GENE THER., (2002), vol. 9, pages 1238 - 1246
		- BALLAY A; LEVRERO M; BUENDIA MA; TIOLLAIS P; PERRICAUDET M, "In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses", EMBO J., (1985), vol. 30, pages 3861 - 5
		- ROSENFELD MA; SIEGFRIED W; YOSHIMURA K; YONEYAMA K; FUKAYAMA M; STIER LE; PAAKKO PK; GILARDI P; STRATFORD-PERRICAUDET LD; PERRICAU, "Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo", SCIENCE, (1991), vol. 252, pages 431 - 4
		- BETT AJ; HIDAKA W; PREVEC L; GRAHAM FL, "An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3", PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 8801 - 8806
		- MIZUGUCHI H; KAY MA, "Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method", HUM. GENE THER., (1998), vol. 9, pages 2577 - 2583
		- HE T-C; ZHOU S; YU J; KINZLER KW; VOGELSTEIN B, "A simplified system for generating recombinant adenoviruses", PROC. NATL. ACAD. SCI. U.S., (1998), vol. 95, pages 2509 - 2514
		- CHARTIER C; DEGRYSE E; GANTZER M; DIETERLE A; PAVIRANI A; MEHTALI M, "Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli", J. VIROL., (1996), vol. 70, pages 4805 - 4810
		- CROUZET J; NAUDIN L; ORSINI C; VIGNE E; FERRERO L; LE ROUX A; BENOIT P; LATTA M; TORRENT C; BRANELLEC D, "Recombinational construction in Escherichia coli of infectious adenoviral genomes", PROC. NATL. ACAD. SCI USA, (1997), vol. 94, pages 1414 - 1419
		- KETNER G; SPENCER F; TUGENDREICH S; CONNELLY C; HIETER P, "Efficient manipulation of the human adenovirus genome as an infectious yeast artificial chromosome clone", PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 6186 - 6190
		- KATZEN, F, "Gatewayo recombinational cloning: a biological operating system", EXPERT OPINION DRUG DISCOVERY, (2007), vol. 2, pages 571 - 589
		- SHENG Y; MANCINO V; BIRREN B., "Transformation of Escherichia coli with large DNA molecules by electroporation", NUCLEIC ACIDS RES., (1995), vol. 23, pages 1990 - 1996
		- BZYMEK M; LOVETT ST, "Instability of repetitive DNA sequences: the role of replication in multiple mechanisms", PROC NATL ACAD SCI U S A., (2001), vol. 98, pages 8319 - 8325
		- FAN ZC; BIRD RC, "An improved reverse genetics system for generation of bovine viral diarrhea virus as a BAC cDNA", J. VIROL. METHODS, (2008), vol. 149, pages 309 - 315
		- RUZSICS Z; WAGNER M; OSTERLEHNER A; COOK J; KOSZINOWSKI U; BURGERT HG, "Transposon-assisted cloning and traceless mutagenesis of adenoviruses: Development of a novel vector based on species D", J. VIROL., (2006), vol. 80, pages 8100 - 8113
		- KIM UJ; SHIZUYA H; DE JONG PJ; BIRREN B; SIMON MI, "Stable propagation of cosmid sized human DNA inserts in an F factor based vector", NUCLEIC ACIDS RES., (1992), vol. 20, pages 1083 - 1085
		- SHIZUYA H; KOUROS-MEHR H., "The development and applications of the bacterial artificial chromosome cloning system", KEIO J. MED., (2001), vol. 50, pages 26 - 30
		- GRABLE M.; HEARING P., J. VIROL., (1992), vol. 66, pages 723 - 731
		- OSTAPCHUK P; HEARING P, CURR. TOP. MICROBIOL. IMMUNOL., (2003), vol. 272, pages 165 - 85
		- YAMAMOTO M. ET AL., J. VIROL., (2003), vol. 77, pages 1633 - 1637
		- HEARING; SHENK, CELL, (1983), vol. 33, pages 695 - 703
		- LIU H; NAISMITH JH; HAY RT, CURR. TOP. MICROBIOL. IMMUNOL., (2003), vol. 272, pages 131 - 64
		- GONCALVES MA, VIROL J., (2005), vol. 2, page 43
		- SPATE R; MOCARSKI E, J. VIROL., (1985), vol. 54, pages 817 - 24
		- JUVEN-GERSHON T; HSU JY; THEISEN JW; KADONAGA JT., CURR. OPIN. CELL BIOL., (2008), vol. 20, pages 253 - 259
		- GEIDUSCHEK EP; GP TOCCHINI-VALENTINI, ANNU. REV. BIOCHEM., (1988), vol. 57, pages 873 - 914
		- BROACH JR; GUARASCIO VR; JAYARAM M, CELL, (1982), vol. 29, pages 227 - 234
		- SCHLAKE T.; BODE J., BIOCHEMISTRY, (1994), vol. 33, pages 12746 - 12751
		- CHEREPANOV PP; WACKERNAGEL W, GENE, (1995), vol. 158, pages 9 - 14
		- SHAFFERMAN A; KOLTER R; STALKER D; HELINSKI DR, J. MOL. BIOL., (1982), vol. 161, pages 57 - 76
		- MARCAIDA MJ ET AL., "Homing endonucleases: from basics to therapeutic applications", CELL MOL LIFE SCI., (2010), vol. 67, no. 5, pages 727 - 48
		- KLUG A, "The discovery of zinc fingers and their applications in gene regulation and genome manipulation", ANNU REV BIOCHEM., (2010), vol. 79, pages 213 - 31
		- SCOTT JR, "Regulation of plasmid replication", MICROBIOL. REV., (1984), vol. 48, pages 1 - 23
		- RUZSICS Z; WAGNER M; OSTERLEHNER A; COOK J; KOSZINOWSKI U; BURGERT HG, "Transposon assisted cloning and traceless mutagenesis of adenoviruses: Development of a novel vector based on species D", J. VIROL., (2006), vol. 80, pages 8100 - 8113
		- SCHAACK J, FRONT. BIOSCI., (2005), vol. 10, pages 1146 - 1155
		- GORZIGLIA MI; LAPCEVICH C; ROY S; KANG Q; KADAN M; WU V; PECHAN P; KALEKO M, J VIROL., (1999), vol. 73, pages 6048 - 6055
	- KOCHANEK S; SCHIEDNER G; VOLPERS C, CURR. OPIN. MOL. THER, (2001), vol. 3, pages 454 - 463
	- TENORIO C; ZARAZAGA M; MARTINEZ C; TORRES C, J. CLIN. MICROBIOL., (2001), vol. 39, pages 824 - 825
	- SHAFFERMAN A; KOLTER R; STALKER D; HELINSKI DR, "Plasmid R6K DNA replication. III. Regulatory properties of the pi initiation protein", J. MOL. BIOL., (1982), vol. 161, pages 57 - 76
	- SEMPRINI S ET AL., "Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques", NUCLEIC ACIDS RES., (1997), vol. 35, pages 1402 - 1410
	- LEE EC. ET AL., "A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA", GENOMICS, (2001), vol. 73, pages 56 - 65
	- CHEREPANOV PP; WACKERNAGEL W, "Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant", GENE, (1995), vol. 158, pages 9 - 14
	- GOSSEN M; BUJARD H, "Tight control of gene expression in mammalian cells by tetracycline-responsive promoters", PROC NATL ACAD SCI U S A, (1992), vol. 89, pages 5547 - 51
	- JUVEN-GERSHON T; HSU JY; THEISEN JW; KADONAGA JT, CURR. OPIN. CELL BIOL., (2008), pages 253 - 259
	- GEIDUSCHEK EP; GP TOCCHINI- VALENTINI, "Transcription by RNA polymerase III", ANNU. REV. BIOCHEM., (1988), vol. 57, pages 873 - 914
	- KüES U; STAHL U, "Microbial reviews", MICROBIAL REVIEWS, vol. 53, pages 491 - 516
	- BUSBY S; EBRIGHT RH, CELL, (1994), vol. 79, pages 743 - 746
	- MAO FD; DAM P; CHOU J; OLMAN V; XU Y, NUCLEIC ACIDS RES., (2009), vol. 37, pages D459 - 463
	- ZHANG X; PAN Z; FANG Q; ZHENG J; HU M; JIAO X, J MICROBIOL METHODS, (2009), vol. 79, pages 199 - 204
	- BUKRINSKY ET AL., AN AUTO-INDUCIBLE ESCHERICHIA COLI LYSIS SYSTEM CONTROLLED BY MAGNESIUM GENE, (1988), vol. 70, pages 415 - 417
	- REYRAT JM; PELICIC V; GICQUEL B; RAPPUOLI R, INFECT IMMUN., (1998), vol. 6, pages 4011 - 4017
	- DEAN D, "A plasmid cloning vector for the direct selection of strains carrying recombinant plasmids", GENE, (1981), vol. 15, pages 99 - 102
	- LEE EC. ET AL., GENOMICS, (2001), vol. 73, pages 56 - 65
	- MESSERLE ET AL., PROC. NATL. ACAD. SCI. U. S. A., (1997), vol. 94, pages 14759 - 14763
	- BUBECK A. ET AL., J. VIROL., (2004), vol. 78, pages 8026 - 8035
	- WARMING, S.; N. COSTANTINO; COURT DL; N. A. JENKINS; N. G. COPELAND, "Simple and highly efficient BAC recombineering using galK selection", NUCLEIC ACIDS RES, (2005), vol. 33, page E36
	- REYRAT JM; PELICIC V; GICQUEL B; RAPPUOLI R, "Counterselectable markers: untapped tools for bacterial genetics and pathogenesis", INFECT. IMMUN., (1998), vol. 66, pages 4011 - 4017
	- SHIZUYA H; KOUROS-MEHR H, "The development and applications of the bacterial artificial chromosome cloning system", KEIO J. MED., (2001), vol. 50, pages 26 - 30
	- CURR OPIN GENET DEV., (1993), vol. 3, pages 699 - 707
	- HOESS RH; ZIESE M; STEMBERG N, "P site-specific recombination: Nucleotide sequence of the recombining sites", PROC. NATL. ACAD. SCI. USA, (1982), vol. 79, pages 3398 - 3402
	- ABREMSKI K; WIERZBICKI A; FROMMER B; HOESS RH, "Bacteriophage P1 Cre-loxP Sitespecific Recombination: Site-specific DNA Topoisomerase Activity of the Cre Recombination Protein", J. BIOL. CHEM., (1986), vol. 261, pages 391 - 396
	- CAMPBELL, AM, "Chromosomal Insertion Sites for Phages and Plasmids", J. BACTERIOL., (1992), vol. 174, pages 7495 - 7499
	- QIAN XH; INMAN RB; COX MM, "Reactions between Half- and Full-Flp Recombination Target Sites: A Model System for Analyzing Early Steps in Flp Protein-Mediated Site- Specific Recombination", J. BIOL. CHEM., (1992), vol. 267, pages 7794 - 7805
	- ARAKI H; NAKANISHI N; EVANS BR; MATSUZAKI H; JAYARAM M; OSHIMA Y, "Site-specific Recombinase, R, Encoded by Yeast Plasmid pSR1", J. MOL. BIOL., (1992), vol. 225, pages 25 - 37
	- MAESER S; KAHNMANN R, "The Gin recombinase of phage Mu can catalyse site-specific recombination in plant protoplasts", MOL. GEN. GENET., (1991), vol. 230, pages 170 - 176
	- ESPOSITO D; SCOCCA JJ, "The integrase family of tyrosine recombinases: evolution of a conserved active site domain", NUCL. ACIDS RES., (1997), vol. 25, pages 3605 - 3614
	- BROACH JR; GUARASCIO VR; JAYARAM M, "Recombination within the Yeast Plasmid 2.mu. Circle is Site-Specific", CELL, (1982), vol. 29, pages 227 - 234
	- CHEN L; ANTON M; GRAHAM FL, "Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre", SOMAT. CELL AND MOLEC. GENET., (1996), vol. 22, pages 477 - 488
	- HARDY S; KITAMURA M; HARRIS-STANSIL T; DAI Y; PHIPPS ML, "Construction of adenovirus vectors through Cre-lox recombination", J. VIROL., (1997), vol. 71, pages 1842 - 1849
	- PARKS RJ; CHEN L; ANTON M; SANKAR U; RUDNICKI MA; GRAHAM FL, "A new helper-dependent adenovirus vector system: removal of helper virus by cre-mediated excision of the viral packaging system", PROC. NATL. ACAD. SCI. U.S.A., (1996), vol. 93, pages 13565 - 13570
	- ANTON M.; GRAHAM FL, "Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression", J.VIROL., (1995), vol. 69, pages 4600 - 4606
	- SAUER B, "Identification of cryptic lox sites in the yeast genome by selection for Cremediated chromosome translocations that confer multiple drug resistance", J. MOL. BIOL., (1992), vol. 223, pages 911 - 928
	- ELAHI SM; OUALIKENE W; NAGHDI L; O'CONNOR-MCCOURT M; MASSIE B, "Adenovirus-based libraries: efficient generation of recombinant adenoviruses by positive selection with the adenovirus protease", GENE THER., (2002), vol. 9, pages 1238 - 1246
	- BALLAY A; LEVRERO M; BUENDIA MA; TIOLLAIS P; PERRICAUDET M, "vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses", EMBO J., (1985), vol. 30, pages 3861 - 5
	- BETT AJ; HIDAKA W; PREVEC L; GRAHAM FL, "An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3", PROC. NATL. ACAD. SCI. U.S.A., (1994), vol. 91, pages 8801 - 8806
	- HE T-C; ZHOU S; YU J; KINZLER KW; VOGELSTEIN B, "A simplified system for generating recombinant adenoviruses", PROC. NATL. ACAD. SCI. U.S.A., (1998), vol. 95, pages 2509 - 2514
	- CROUZET J; NAUDIN L; ORSINI C; VIGNE E; FERRERO L; LE ROUX A; BENOIT P; LATTA M; TORRENT C; BRANELLEC D, "Recombinational construction in Escherichia coli of infectious adenoviral genomes", PROC. NATL. ACAD. SCI. U.S.A., (1997), vol. 94, pages 1414 - 1419
	- KETNER G; SPENCER F; TUGENDREICH S; CONNELLY C; HIETER P, "Efficient manipulation of the human adenovirus genome as an infectious yeast artificial chromosome clone", PROC. NATL. ACAD. SCI. U.S.A., (1994), vol. 91, pages 6186 - 6190
	- SHENG Y; MANCINO V; BIRREN B, "Transformation of Escherichia coli with large DNA molecules by electroporation", NUCLEIC ACIDS RES., (1995), vol. 23, pages 1990 - 1996
	- BZYMEK M; LOVETT ST, "Instability of repetitive DNA sequences: the role of replication in multiple mechanisms", PROC. NATL. ACAD. SCI. U. S. A., (2001), vol. 98, pages 8319 - 8325
	- YAMAMOTO M; DAVYDOVA J; TAKAYAMA K; ALEMANY R; CURIEL DT, "Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with el deleted", J. VIROL., (2003), vol. 77, pages 1633 - 1637
	- HEARING P; SHENK T, "The adenovirus type 5 EIA transcriptional control region contains a duplicated enhancer element", CELL, vol. 33, pages 695 - 703
	- LIU H; NAISMITH JH; HAY RT, "Adenovirus DNA replication", CURR. TOP. MICROBIOL. IMMUNOL., (2003), vol. 272, pages 131 - 64
	- GONCALVES MA, "Adeno-associated virus: from defective virus to effective vector", VIROL J., (2005), vol. 6, no. 2, page 43
	- SPATE R; MOCARSKI E, "The alpha sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes", J. VIROL., (1985), vol. 54, pages 817 - 24
	- GARBLE M.; HEARING P., "cis and trans requirements for the selective packaging of adenovirus type 5 DNA", J. VIROL., (1992), vol. 66, pages 723 - 731
	- OSTAPCHUK P; HEARING P, "Regulation of adenovirus packaging", CURR. TOP. MICROBIOL. IMMUNOL., (2003), vol. 272, pages 165 - 85
	- JUVEN-GERSHON T; HSU JY; THEISEN JW; KADONAGA JT, "The RNA polymerase II core promoter - the gateway to transcription", CURR. OPIN. CELL BIOL., (2008), vol. 20, pages 253 - 259
	- GEIDUSCHEK EP; TOCCHINI-VALENTINI GP, "Transcription by RNA polymerase III", ANNU. REV. BIOCHEM., (1988), vol. 57, pages 873 - 914
	- BROACH JR; GUARASCIO VR; JAYARAM M, "Recombination within the yeast plasmid 2mu circle is site-specific", CELL, (1982), vol. 29, pages 227 - 234
	- SCHLAKE T.; BODE J, "Use of mutated Flp recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal", LOCI BIOCHEMISTRY, (1994), vol. 33, pages 12746 - 12751
	- KIIES U; STAHL U, "replication of plasmids in gram-negative bacteria", MICROBIOLOGICAL. REV., (1989), vol. 53, pages 491 - 516
	- BUSBY S; EBRIGHT RH, "Promoter structure, promoter recognition, anated by d transcription activation in prokaryotes", CELL, (1994), vol. 79, pages 743 - 46
	- MAO F; DAM P; CHOU J; OLMAN V; XU Y, "DOOR: a database for prokaryotic operons", NUCLEIC ACIDS RES., (2009), vol. 37, pages D459 - 63
	- ZHANG X; PAN Z; FANG Q; ZHENG J; HU M; JIAO X, "An auto-inducible Escherichia coli lysis system controlled by magnesium", J MICROBIOL METHODS, (2009), vol. 79, pages 199 - 204
	- BUKRINSKY ET AL., "Multicopy expression vector based on temperature-regulated lac repressor: expression of human immunodeficiency virus env gene in Escherichia coli", GENE, (1988), vol. 70, pages 415 - 417
	- REYRAT JM; PELICIC V; GICQUEL B; RAPPUOLI R, "Counterselectable markers: untapped tools for bacterial genetics and pathogenesis", INFECT IMMUN., (1998), vol. 6, pages 4011 - 4017
	- SCHAACK J, "Adenovirus vectors deleted for genes essential for viral DNA replication", FRONT. BIOSCI., (2005), vol. 10, pages 1146 - 1155
	- GORZIGLIA MI; LAPCEVICH C; ROY S; KANG Q; KADAN M; WU V; PECHAN P; KALEKO M, "Generation of an adenovirus vector lacking El, e2a, E3, and all of E4 except open reading frame 3", J VIROL., (1999), vol. 73, pages 6048 - 6055
	- KOCHANEK S; SCHIEDNER G; VOLPERS C, "High-capacity 'gutless' adenoviral vectors", CURR. OPIN. MOL. THER, (2001), vol. 3, pages 454 - 463
	- TENORIO C; ZARAZAGA M ET AL., "Bifunctional Enzyme 6'-N-Aminoglycoside Acetyltransferase-2"-O- Aminoglycoside Phosphotransferase in Lactobacillus and Pediococcus Isolates of Animal Origin", J. CLIN .MICROBIOL., (2001), vol. 39, pages 824 - 825
	- MESSERLE M; CRNKOVIC I; HAMMERSCHMIDT W; ZIEGLER H; KOSZINOWSKI UH, "Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome", PROC. NATL. ACAD. SCI. U. S. A., (1997), vol. 94, pages 14759 - 14763
	- BUBECK A; WAGNER M; RUZSICS Z; LOTZERICH M; IGLESIAS M; SINGH IR; KOSZINOWSKI UH, "Comprehensive mutational analysis of a herpesvirus gene in the viral genome context reveals a region essential for virus replication", J. VIROL., (2004), vol. 78, pages 8026 - 8035
	- WARMING S; COSTANTINO N; COURT DL; JENKINS NA; COPELAND NG, "Simple and highly efficient BAC recombineering using galK selection", NUCLEIC ACIDS RES, (2005), vol. 33, page E36
	- LEDERBERG J, "Streptomycin resistance: a genetically recessive mutation", J. BACTERIOL., (1951), vol. 61, pages 549 - 550
	- GOSSEN M; BUJARD H, "Tight control of gene expression in mammalian cells by tetracycline-responsive promoters", PROC NATL ACAD SCI U S A., (1992), vol. 89, pages 5547 - 51

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

Legal notice
Terms of use
24.1.24; 34p