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Extract from the Register of European Patents

EP About this file: EP2228383

EP2228383 - Library of toxin mutants, and methods of using same [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.03.2013
Database last updated on 29.06.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Molecular Templates, Inc.
111 W. Cooperative Way, Suite 201
Georgetown, TX 78626 / US
[2010/37]
Inventor(s)01 / Gariepy, Jean
29 Elmsthorpe Avenue
Toronto, Ontario M5P 2 L5 / CA
02 / Wei, Xin
222 Williamson Road
Markham, Ontario L6E 1R9 / CA
 [2010/37]
Representative(s)Griffin, Philippa Jane
Mathys & Squire The Shard
32 London Bridge Street
London SE1 9SG / GB
[N/P]
Former [2012/48]Griffin, Philippa Jane
Mathys & Squire LLP 120 Holborn
London EC1N 2SQ / GB
Former [2012/21]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Former [2010/37]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date10159280.626.03.2004
[2010/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2228383
Date:15.09.2010
Language:EN
[2010/37]
Type: B1 Patent specification 
No.:EP2228383
Date:23.05.2012
Language:EN
[2012/21]
Search report(s)(Supplementary) European search report - dispatched on:EP03.08.2010
ClassificationIPC:C07K14/245
[2010/37]
CPC:
C07K14/25 (EP,US); C07K14/245 (US); C07K2319/55 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/37]
TitleGerman:Bibliothek von Toxin Mutanten und deren Verwendung[2012/19]
English:Library of toxin mutants, and methods of using same[2010/37]
French:Bibliothèque de mutants de toxines et procédés pour leur utilisation[2010/37]
Former [2010/37]Library von Toxin Mutanten und deren Verwendung
Examination procedure15.03.2011Amendment by applicant (claims and/or description)
15.03.2011Examination requested  [2011/17]
22.07.2011Communication of intention to grant the patent
29.11.2011Fee for grant paid
29.11.2011Fee for publishing/printing paid
Parent application(s)   TooltipEP04785852.7  / EP1727827
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20040785852) is  24.01.2007
Opposition(s)26.02.2013No opposition filed within time limit [2013/18]
Fees paidRenewal fee
07.04.2010Renewal fee patent year 03
07.04.2010Renewal fee patent year 04
07.04.2010Renewal fee patent year 05
07.04.2010Renewal fee patent year 06
07.04.2010Renewal fee patent year 07
29.03.2011Renewal fee patent year 08
26.03.2012Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.03.2004
AT23.05.2012
BE23.05.2012
CY23.05.2012
CZ23.05.2012
DK23.05.2012
EE23.05.2012
FI23.05.2012
NL23.05.2012
PL23.05.2012
RO23.05.2012
SE23.05.2012
SI23.05.2012
SK23.05.2012
TR23.05.2012
BG23.08.2012
GR24.08.2012
PT24.09.2012
[2015/34]
Former [2015/32]AT23.05.2012
BE23.05.2012
CY23.05.2012
CZ23.05.2012
DK23.05.2012
EE23.05.2012
FI23.05.2012
NL23.05.2012
PL23.05.2012
RO23.05.2012
SE23.05.2012
SI23.05.2012
SK23.05.2012
TR23.05.2012
BG23.08.2012
GR24.08.2012
PT24.09.2012
Former [2013/34]AT23.05.2012
BE23.05.2012
CY23.05.2012
CZ23.05.2012
DK23.05.2012
EE23.05.2012
FI23.05.2012
NL23.05.2012
PL23.05.2012
RO23.05.2012
SE23.05.2012
SI23.05.2012
SK23.05.2012
BG23.08.2012
GR24.08.2012
PT24.09.2012
Former [2013/11]AT23.05.2012
BE23.05.2012
CY23.05.2012
CZ23.05.2012
DK23.05.2012
EE23.05.2012
FI23.05.2012
NL23.05.2012
PL23.05.2012
RO23.05.2012
SE23.05.2012
SI23.05.2012
SK23.05.2012
GR24.08.2012
PT24.09.2012
Former [2013/10]AT23.05.2012
BE23.05.2012
CY23.05.2012
CZ23.05.2012
DK23.05.2012
EE23.05.2012
FI23.05.2012
NL23.05.2012
RO23.05.2012
SE23.05.2012
SI23.05.2012
SK23.05.2012
GR24.08.2012
PT24.09.2012
Former [2013/09]AT23.05.2012
BE23.05.2012
CY23.05.2012
DK23.05.2012
EE23.05.2012
FI23.05.2012
NL23.05.2012
SE23.05.2012
SI23.05.2012
GR24.08.2012
PT24.09.2012
Former [2013/08]AT23.05.2012
BE23.05.2012
CY23.05.2012
DK23.05.2012
FI23.05.2012
NL23.05.2012
SE23.05.2012
SI23.05.2012
GR24.08.2012
PT24.09.2012
Former [2013/07]AT23.05.2012
BE23.05.2012
CY23.05.2012
FI23.05.2012
SE23.05.2012
SI23.05.2012
GR24.08.2012
PT24.09.2012
Former [2013/04]BE23.05.2012
CY23.05.2012
FI23.05.2012
SE23.05.2012
SI23.05.2012
GR24.08.2012
PT24.09.2012
Former [2013/01]CY23.05.2012
FI23.05.2012
SE23.05.2012
SI23.05.2012
GR24.08.2012
PT24.09.2012
Former [2012/51]CY23.05.2012
FI23.05.2012
SE23.05.2012
SI23.05.2012
GR24.08.2012
Former [2012/50]CY23.05.2012
FI23.05.2012
SE23.05.2012
GR24.08.2012
Former [2012/49]CY23.05.2012
FI23.05.2012
SE23.05.2012
Former [2012/48]FI23.05.2012
SE23.05.2012
Documents cited:Search[A]US5552144  (SAMUEL JAMES E [US], et al) [A] 1-23* the whole document *;
 [X]WO9940185  (ONTARIO CANCER INST [CA], et al) [X] 1-23 * the whole document *;
 [X]  - BRAY MARK R ET AL, "Probing the surface of eukaryotic cells using combinatorial toxin libraries", CURRENT BIOLOGY, (20010501), vol. 11, no. 9, ISSN 0960-9822, pages 697 - 701, XP002303223 [X] 1-23 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-9822(01)00207-X
 [X]  - BRAY ET AL, "Shiga-like toxin as a template for the development of anti-breast cancer agents", PROCEEDINGS OF THE 89TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. NEW ORLEANS, LA, MARCH 28 - APRIL 1, 1998, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA : AACR, US, (19980301), VOL. 39, page 62, XP002096335 [X] 1-23 * the whole document *
 [X]  - BRAY ET AL, "Expression of the Shiga-like toxin I receptor CD77 on human breast carcinomas, follicular lymphomas and multiple myelomas and absence of expression on CD34+ human hematopoietic cells: Implications for tumor cell purging", PROCEEDINGS OF THE 89TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. NEW ORLEANS, LA, MARCH 28 - APRIL 1, 1998, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA : AACR, US, (19980301), VOL. 39, page 63, XP002096336 [X] 1-23 * the whole document *
by applicantUS5552144
 WO9940185
 US6593132
 US6649742
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    - HOVDE ET AL., "Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I", PROC NATL ACAD SCI USA., (1988), vol. 85, pages 2568 - 2572
    - YAMASAKI ET AL., "Importance of arginine at position 170 of the A submit ofVero toxin 1 produced by enterohemomhagic Escherichia coli for toxin activity", MICROB PATHOG, (1991), vol. 11, pages 1 - 9
    - LINSLEY ET AL., "Monoclonal antibodies reactive with mucin glycoproteins found in sera from breast cancer patients", CANCER RES, (1988), vol. 48, pages 2138 - 2148
    - GENDLER ET AL., "A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats", J BIOL CHEM, (1989), vol. 263, no. 12, pages 20 - 12823
    - GIRLING ET AL., "A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas", INT J CANCER, (1989), vol. 43, pages 1072 - 1077
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    - BRAY ET AL., "Probing the surface of eukaryotic cells using combinatorial toxin libraries", CURRENT BIOLOGY, (2001), vol. 11, pages 697 - 701
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.