| EP2332575 - Treatment of cancer with novel anti-IL 13 monoclonal antibodies [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 18.09.2015 Database last updated on 28.03.2026 | Most recent event Tooltip | 15.07.2016 | Lapse of the patent in a contracting state New state(s): LU | published on 17.08.2016 [2016/33] | Applicant(s) | For all designated states Genentech, Inc. 1 DNA Way South San Francisco, CA 94080 / US | [2011/24] | Inventor(s) | 01 /
Fung, Sek Chung 922 Beacon Square Court, No. 425 Gaithersburg, MD 20878 / US | 02 /
Moyle, Matthew 15737 NE 134th Street Redmond, WA 98052 / US | [2011/24] | Representative(s) | Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE | [N/P] |
| Former [2014/46] | Vossius & Partner Siebertstrasse 4 81675 München / DE | ||
| Former [2011/24] | Vossius & Partner Siebertstrasse 4 81675 München / DE | Application number, filing date | 10179775.1 | 23.12.2004 | [2011/24] | Priority number, date | US20030532130P | 23.12.2003 Original published format: US 532130 P | [2011/24] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP2332575 | Date: | 15.06.2011 | Language: | EN | [2011/24] | Type: | B1 Patent specification | No.: | EP2332575 | Date: | 12.11.2014 | Language: | EN | [2014/46] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 12.04.2011 | Classification | IPC: | A61K39/395, A61P35/00, G01N33/53, C07K16/24 | [2014/24] | CPC: |
C07K16/244 (EP,US);
C07K16/00 (KR);
A61K39/395 (KR,RU);
A61P1/04 (EP);
A61P11/00 (EP);
A61P11/02 (EP);
A61P11/06 (EP);
A61P17/00 (EP);
A61P17/02 (EP);
A61P17/04 (EP);
A61P19/10 (EP);
A61P27/02 (EP);
A61P29/00 (EP);
A61P31/12 (EP);
A61P35/00 (EP);
A61P35/04 (EP);
A61P37/00 (EP);
A61P37/08 (EP);
A61P43/00 (EP);
C07K7/06 (RU);
C07K7/08 (RU);
A61K2039/505 (EP,US);
A61K2039/55522 (US);
C07K2317/24 (EP,US);
C07K2317/34 (EP,US);
C07K2317/56 (EP,US);
C07K2317/565 (EP,US);
C07K2317/567 (EP,US);
C07K2317/73 (EP,US);
C07K2317/76 (EP,US);
C07K2317/92 (EP,US)
(-)
|
| Former IPC [2011/24] | A61K39/395, A61P35/00, G01N33/53, // C07K16/24 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2011/24] | Title | German: | Behandlung von Krebs mit neuen monoklonalen anti-IL-13-Antikörpern | [2011/24] | English: | Treatment of cancer with novel anti-IL 13 monoclonal antibodies | [2011/24] | French: | Traitement du cancer au moyen de nouveaux anticorps monoclonaux anti-IL 13 | [2011/24] | Biological material | This application mentions deposited biological material, check the file for details | Examination procedure | 15.12.2011 | Amendment by applicant (claims and/or description) | 15.12.2011 | Examination requested [2012/04] | 13.02.2012 | Despatch of a communication from the examining division (Time limit: M06) | 01.10.2012 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 10.12.2012 | Reply to a communication from the examining division | 09.01.2013 | Despatch of a communication from the examining division (Time limit: M06) | 18.07.2013 | Reply to a communication from the examining division | 20.05.2014 | Communication of intention to grant the patent | 26.09.2014 | Fee for grant paid | 26.09.2014 | Fee for publishing/printing paid | 26.09.2014 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP04815598.0 / EP1711528 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20040815598) is 19.11.2007 | Opposition(s) | 13.08.2015 | No opposition filed within time limit [2015/43] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 10.12.2012 | Request for further processing filed | 10.12.2012 | Full payment received (date of receipt of payment) Request granted | 02.01.2013 | Decision despatched | Fees paid | Renewal fee | 13.01.2011 | Renewal fee patent year 03 | 13.01.2011 | Renewal fee patent year 04 | 13.01.2011 | Renewal fee patent year 05 | 13.01.2011 | Renewal fee patent year 06 | 15.12.2010 | Renewal fee patent year 07 | 12.12.2011 | Renewal fee patent year 08 | 11.12.2012 | Renewal fee patent year 09 | 06.12.2013 | Renewal fee patent year 10 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 23.12.2004 | AT | 12.11.2014 | BG | 12.11.2014 | CY | 12.11.2014 | CZ | 12.11.2014 | DK | 12.11.2014 | EE | 12.11.2014 | FI | 12.11.2014 | LT | 12.11.2014 | MC | 12.11.2014 | NL | 12.11.2014 | PL | 12.11.2014 | RO | 12.11.2014 | SE | 12.11.2014 | SI | 12.11.2014 | SK | 12.11.2014 | IE | 23.12.2014 | LU | 23.12.2014 | BE | 31.12.2014 | GR | 13.02.2015 | IS | 12.03.2015 | PT | 12.03.2015 | [2016/33] |
| Former [2016/32] | HU | 23.12.2004 | |
| AT | 12.11.2014 | ||
| BG | 12.11.2014 | ||
| CY | 12.11.2014 | ||
| CZ | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| MC | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| RO | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| SI | 12.11.2014 | ||
| SK | 12.11.2014 | ||
| IE | 23.12.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2016/25] | AT | 12.11.2014 | |
| BG | 12.11.2014 | ||
| CY | 12.11.2014 | ||
| CZ | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| MC | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| RO | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| SI | 12.11.2014 | ||
| SK | 12.11.2014 | ||
| IE | 23.12.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2016/12] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| CZ | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| MC | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| RO | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| SI | 12.11.2014 | ||
| SK | 12.11.2014 | ||
| IE | 23.12.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/46] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| CZ | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| MC | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| RO | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| SK | 12.11.2014 | ||
| IE | 23.12.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/39] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| CZ | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| MC | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| RO | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| SK | 12.11.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/37] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| CZ | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| RO | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| SK | 12.11.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/36] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| CZ | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| RO | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/35] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| DK | 12.11.2014 | ||
| EE | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/30] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| BE | 31.12.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/26] | AT | 12.11.2014 | |
| CY | 12.11.2014 | ||
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/25] | AT | 12.11.2014 | |
| FI | 12.11.2014 | ||
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/24] | FI | 12.11.2014 | |
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| PL | 12.11.2014 | ||
| SE | 12.11.2014 | ||
| GR | 13.02.2015 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/23] | FI | 12.11.2014 | |
| LT | 12.11.2014 | ||
| NL | 12.11.2014 | ||
| IS | 12.03.2015 | ||
| PT | 12.03.2015 | ||
| Former [2015/22] | LT | 12.11.2014 | |
| PT | 12.03.2015 | ||
| Former [2015/20] | LT | 12.11.2014 | Documents cited: | Search | [I] US2003049257 (MAK TAK W et al.) | [A] WO02055100 (INST GENETICS LLC et al.) | [I] SKINNIDER BRIAN F ET AL: "The role of interleukin 13 in classical Hodgkin lymphoma.", LEUKEMIA & LYMPHOMA JUN 2002, vol. 43, no. 6, June 2002 (2002-06-01), pages 1203 - 1210, XP008078949, ISSN: 1042-8194 DOI: http://dx.doi.org/10.1080/10428190290026259 | [I] SKINNIDER BRIAN F ET AL: "Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.", BLOOD 15 JAN 2002, vol. 99, no. 2, 15 January 2002 (2002-01-15), pages 618 - 626, XP008079082, ISSN: 0006-4971 DOI: http://dx.doi.org/10.1182/blood.V99.2.618 | [I] KAPP U ET AL: "INTERLEUKIN 13 IS SECRETED BY AND STIMULATES THE GROWTH OF HODGKIN AND REED-STERNBERG CELLS", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 189, no. 12, 1999, pages 1939 - 1945, XP000914767, ISSN: 0022-1007 DOI: http://dx.doi.org/10.1084/jem.189.12.1939 | [AP] WYNN THOMAS A: "IL-13 effector functions.", ANNUAL REVIEW OF IMMUNOLOGY. VOLUME 21 ANNUAL REVIEWS, 4139 EL CAMINO WAY, P. O. BOX 10139, PALO ALTO, CA, 94303-0139, USA SERIES : ANNUAL REVIEW OF IMMUNOLOGY (ISSN 0732-0582 (ISSN PRINT)), 2003, pages 425 - 456, XP008079048 DOI: http://dx.doi.org/10.1146/annurev.immunol.21.120601.141142 | [A] TRIEU YOUNG ET AL: "Inhibition of Hodgkin Lymphoma Cell Line Growth Using an Adenovirus Expressing the Soluble IL-13 Decoy Receptor (sIL-13Ralpha2).", BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), & 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002, XP008078909, ISSN: 0006-4971 | [A] OSHIMA Y ET AL: "Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 276, no. 18, 4 May 2001 (2001-05-04), pages 15185 - 15191, XP002239705, ISSN: 0021-9258 DOI: http://dx.doi.org/10.1074/jbc.M010159200 | [A] MCKENZIE A N ET AL: "Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 15 APR 1993, vol. 90, no. 8, 15 April 1993 (1993-04-15), pages 3735 - 3739, XP002948382, ISSN: 0027-8424 DOI: http://dx.doi.org/10.1073/pnas.90.8.3735 | by applicant | US5939598 | US5652123 | US4376110 | US4816567 | US5807715 | US4816397 | US5585089 | EP0239400 | WO9109967 | US5225539 | US5530101 | EP0592106 | EP0519596 | US5565332 | US4444887 | US4716111 | WO9846645 | WO9850433 | WO9824893 | WO9816654 | WO9634096 | WO9633735 | WO9110741 | WO9201047 | EP0598877 | US5413923 | US5625126 | US5633425 | US5569825 | US5661016 | US5545806 | US5814318 | US5885793 | US5916771 | WO9308829 | US4676980 | WO9425591 | US2003130496 | WO9317715 | WO9208802 | WO9100360 | WO9205793 | US4474893 | US4714681 | US4925648 | US5573920 | US5601819 | US5698435 | WO8605807 | WO8901036 | US5122464 | US4946778 | WO9321232 | EP0439095 | US5474981 | US4741900 | US5441050 | US6514496 | WO9208495 | WO9114438 | WO8912624 | US5314995 | EP0396387 | WO9733899 | WO9734911 | WO9923105 | HERSHEY, GKK, J ALLERGY CFIN LMMUNOL., vol. 111, 2003, pages 677 - 90 | WYNN, TA, ANNU REV IMMUNOL., vol. 21, 2003, pages 425 - 56 | WYNN TA., NAT REV IMMUNOL., vol. 4, 2004, pages 583 - 94 | HELLER F ET AL., IMMUNITY, vol. 17, 2002, pages 629 - 38 | KAPP U ET AL., J EXP MED., vol. 189, 1999, pages 1939 - 4 | TRIEU Y ET AL., CANCER RES., vol. 64, 2004, pages 3271 - 5 | TERABE M ET AL., CANCER IMMUNOL IMMUNOTHER., vol. 53, 2004, pages 79 - 85 | TERABE M ET AL., NAT IMMUNOL., vol. 1, 2000, pages 515 - 20 | DEBINSKI W ET AL., J BIOL CHEM., vol. 270, 1995, pages 16775 - 80 | PURI RK ET AL., BLOOD, vol. 87, 1996, pages 4333 - 9 | MAINI A ET AL., J UROL., vol. 158, 1997, pages 948 - 53 | DEBINSKI W ET AL., CLIN CANCER RES., vol. 1, 1995, pages 1253 - 8 | KOMMANN M ET AL., ANTICANCER RES., vol. 19, 1999, pages 125 - 31 | HUSAIN SR ET AL., BLOOD, vol. 95, 2000, pages 3506 - 13 | KAWAKAMI K ET AL., CANCER RES., vol. 61, 2001, pages 6194 - 6200 | WAHL ET AL., J. NUD. MED., vol. 24, 1983, pages 316 - 325 | CLYNES ET AL., PNAS, vol. 95, 1998, pages 652 - 656 | THOMPSON ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 2994 | HARLOW ET AL.: "Antibodies: a Laboratory Manual, 2nd ed.", 1988, COLD SPRING HARBOR LABORATORY PRESS | KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 | HARLOW ET AL.: "Antibodies: A Laboratory Manual, 2.sup.nd ed.", 1988, COLD SPRING HARBOR LABORATORY PRESS | HAMMERLING ET AL.: "Monoclonal Antibodies and T-Cell Hybridomas", 1981, ELSEVIER | KOSBOR ET AL., IMMUNOLOGY TODAY, vol. 4, 1983, pages 72 | COLE ET AL., PROC. NATI. ACAD. SCI. USA, vol. 80, 1983, pages 2026 - 2030 | COLE ET AL.: "Monoclonal Antibodies And Cancer Therapy", 1985, ALAN R. LISS, INC., pages: 77 - 96 | GODING: "Monoclonal Antibodies: Principles and Practice", 1986, ACADEMIC PRESS, pages: 59 - 103 | KOZBOR, J. IMMUNOL., vol. 133, 1984, pages 3001 | BRODEUR ET AL.: "Monoclonal Antibody Production Techniques and Applications", 1987, MARCEL DEKKER, INC., pages: 51 - 63 | MUNSON ET AL., ANAL BIOCHEM., vol. 107, 1980, pages 220 | MORRISON, SCIENCE, vol. 229, 1985, pages 1202 | OI, BIOTECHNIQUES, vol. 4, 1986, pages 214 | GILLIES ET AL., J. IMMUNOL. METHODS, vol. 125, 1989, pages 191 - 202 | RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 | PADLAN, MOLECULAR IMMUNOLOGY, vol. 28, no. 4/5, 1991, pages 489 - 498 | STUDNICKA ET AL., PROTEIN ENGINEERING, vol. 7, no. 6, 1994, pages 805 - 814 | ROGUSKA. ET AL., PNAS, vol. 91, 1994, pages 969 - 973 | JONES, NATURE, vol. 321, 1986, pages 522 - 525 | REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327 | VERHOEYEN ET AL., SCIENCE, vol. 239, 1988, pages 1534,1536 | COLE ET AL.: "Monoclonal Antibodies and Cancer Therapy", 1985, ALAN R. RISS | BOERNER ET AL., J. IMMUNOL., vol. 147, no. 1, 1991, pages 86 - 95 | LONBERG; HUSZAR, LNT, REV. LMMUNOL., vol. 13, 1995, pages 65 - 93 | JESPERS ET AL., BIOLTECHNOLOGY, vol. 12, 1988, pages 899 - 903 | GREENSPAN; BONA, FASEB J., vol. 7, no. 5, 1989, pages 437 - 444 | NISSINOFF, J. LMMUNOL., vol. 147, no. 8, 1991, pages 2429 - 2438 | MILSTEIN; CUELLO, NATURE, vol. 305, 1983, pages 537 - 539 | TRAUNECKER ET AL., EMBO J., vol. 1, no. 0, 1991, pages 3655 - 3659 | SURESH ET AL., METH. IN ENZYM., vol. 121, 1986, pages 210 | TUTT ET AL., J. IMMUNOL., vol. 147, 1991, pages 60 - 69 | KOSTEINY ET AL., J. IMMUNOL., vol. 148, 1992, pages 1547 - 1553 | STUDIER, F.W., J. MOL. BIOL., vol. 219, 1991, pages 37 | SCHOEPFER, R., GENE, vol. 124, 1993, pages 83 | ROSENBERG ET AL., GENE, vol. 56, 1987, pages 125 - 135 | CHANG ET AL., NATURE, vol. 275, 1978, pages 615 | GOEDDEL ET AL., NATURE, vol. 281, 1979, pages 544 | GOEDDEL ET AL., NUCL. ACIDS RES., vol. 8, 1980, pages 4057 | SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual, 2d Ed.,", 1990, COLD SPRING HARBOR LABORATORY | HITZEMAN ET AL., J. BIOL. CHEM., vol. 255, 1980, pages 2073 | HOLLAND ET AL., BIOCHEM., vol. 17, 1978, pages 4900 | FLEER ET AL., GENE, vol. 107, 1991, pages 285 - 195 | HINNEN, PROC. NATL. ACAD. SCI., vol. 75, 1978, pages 1929 | KUTMEIER ET AL., BIOTECHNIQUES, vol. 17, 1994, pages 242 | "Current Protocols in Molecular Biology", 1998, JOHN WILEY & SONS | CHOTHIA ET AL., J. MOL. BIOL., vol. 278, 1998, pages 457 - 479 | MORRISON ET AL., PROC. NATI. ACAD. SCI., vol. 81, 1984, pages 851 - 855 | NEUBERGER ET AL., NATURE, vol. 312, 1984, pages 604 - 608 | TAKEDA ET AL., NATURE, vol. 314, 1985, pages 452 - 454 | BIRD, SCIENCE, vol. 242, 1988, pages 423 - 42 | HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883 | WARD ET AL., NATURE, vol. 334, 1989, pages 544 - 54 | SKERRA ET AL., SCIENCE, vol. 242, 1988, pages 1038 - 1041 | FOECKING ET AL., GENE, vol. 45, 1986, pages 101 | COCKETT, BIO/TECHNOLOGY, vol. 8, 1990, pages 2 | WIGLER ET AL., CELL, vol. 11, 1977, pages 223 | SZYBALSKA; SZYBALSKI, PROC. NATL. ACAD. SCI. USA, vol. 48, 1992, pages 202 | LOWY ET AL., CELL, vol. 22, 1980, pages 817 | WIGLER, PROC. NATL. ACAD. SCI._ USA, vol. 77, 1980, pages 357 | O'HARE ET AL., PROC, NAT). ACAD. SCI. USA, vol. 78, 1981, pages 1527 | MULLIGAN; BERG, PROC. NATL. ACAD. SCI, USA, vol. 78, 1981, pages 2072 | WU; WU, BIOTHERAPY, vol. 3, 1991, pages 87 - 95 | SANTERRE ET AL., GENE, vol. 30, 1984, pages 147 | "Current Protocols in Molecular Biology", 1993, JOHN WILEY & SONS | KRIEGIER: "Gene Transfer and Expression, A Laboratory Manual", 1990, STOCKTON PRESS | "Current Protocols in Human Genetics", 1994, JOHN WILEY & SONS | COLBERRE-GARAPIN, J. MOL, BIOL., vol. 150, 1981, pages 1 | "DNA Cloning", vol. 3, 1987, ACADEMIC PRESS | CROUSE ET AL., MOL. CELL. BIOL., vol. 3, 1983, pages 257 | PROUDFOOT, NATURE, vol. 322, 1986, pages 52 | KOHLER, PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 2197 | NARAMURA ET AL., IMMUNOL. LETT., vol. 39, 1994, pages 91 - 99 | GILLIES ET AL., PROC. NATL. ACAD. SCI., vol. 89, 1992, pages 1428 - 1432 | FELL ET AL., J. IMMUNOL., vol. 146, 1991, pages 2446 - 2452 | GENTZ ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 821 - 824 | WILSON ET AL., CELL, vol. 37, 1984, pages 767 | HARLOW ET AL.: "Antibodies: A Laboratory Manual,2nd ed.", 1988, COLD SPRING HARBOR LABORATORY PRESS | JALKANEN ET AL., J. CELL. BIOL., vol. 101, 1985, pages 976 - 985 | JALKANEN ET AL., J. CELL. BIOL., vol. 105, 1987, pages 3087 - 3096 | S. W. BURCHIEL ET AL.: "Tumor imaging: The Radiochemical Detection of Cancer", 1982, MASSON PUBLISHING INC., article "Immunopharmacokineties of Radiolabeled Antibodies and Their Fragments" | LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533 | TREAT ET AL.: "Liposomes in the Therapy of Infectious Disease and Cancer", 1989, LISS, pages: 353 - 365 | SEFTON, CRC CRIT. REF. BIOMED. ENG., vol. 14, 1987, pages 201 | BUCHWALD ET AL., SURGERY, vol. 88, 1980, pages 507 | SAUDEK ET AL., N. ENGL. J. MED., vol. 321, 1989, pages 574 | "Medical Applications of Controlled Release", 1974, CRC PRES. | "Controlled Drug Bioavailability, Drug Product Design and Performance", 1984, WILEY | RANGER; PEPPAS, J., MACROMOL. SCI. REV. MACROMOL CHEM., vol. 23, 1983, pages 61 | LEVY ET AL., SCIENCE, vol. 228, 1985, pages 190 | DURING ET AL., ANN, NEURO!, vol. 25, 1989, pages 351 | HOWARD ET AL., J. NEUROSURG., vol. 71, 1989, pages 105 | ARNON ET AL.: "Monoclonal Antibodies And Cancer Therapy", 1985, ALAN R. LISS, INC., article "Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy", pages: 243 - 56 | HELISTROM ET AL.: "Controlled Drug Delivery(2nd Ed.)", 1987, MARCEL DEKKER, INC., article "Antibodies For Drug Delivery", pages: 623 - 53 | THORPE ET AL.: "Monoclonal Antibodies '84: Biological And Clinical Applications", 1985, article "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review", pages: 475 - 506 | "Monoclonal Antibodies For Cancer Detection And Therapy", 1985, ACADEMIC PRESS, article "Analysis, Results, And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy", pages: 303 - 16 | THORPE ET AL.: "The Preparation And Cytotoxic Properties Of Antibody-Toxin Conjugates", LMMUNOL. REV., vol. 62, 1982, pages 119 - 58 | TAKAHASHI ET AL., INT. IMMUNOL., vol. 6, 1994, pages 1567 - 1574 | THOMPSON ET AL., J. BIOL, CHEM., vol. 274, 1999, pages 29944 | KAPP U, J. EXP. MED., vol. 189, 1999, pages 1939 | DE WAAL MALEFYT ET AL., J. IMMUNOL., vol. 151, 1993, pages 6370 | CHOMARAT ET AL., LNT. REV. LMMUNOI., vol. 17, 1998, pages 1 | MURATA T ET AL., INT. IMMUNOL., vol. 10, 1998, pages 1103 - 1110 | O'BRIEN S.; JONES T.: "Antibody Engineering", 2001, SPRINGER LAB MANUAL, article "Humanizing antibodies by CDR grafting" | GLASER S. ET AL.: "Antibody Engineering", 1995, OXFORD UNIVERSITY PRESS | NEAR RI, BIOTECHNIQUES, vol. 12, 1992, pages 88 | L. M. WEINER ET AL., CANCER RES., vol. 48, 1988, pages 2568 - 2573 | P. HERSEY ET AL., CANCER RES., vol. 46, 1988, pages 6083 - 6090 | C. J. HANSIK ET AL., PROC. NATL, ACAD. SCI., vol. 83, 1986, pages 7893 - 97 |