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Extract from the Register of European Patents

EP About this file: EP2314686

EP2314686 - Cells producing antibody compositions [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  19.05.2023
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  02.06.2017
FormerGrant of patent is intended
Status updated on  30.05.2017
FormerExamination is in progress
Status updated on  19.05.2017
FormerGrant of patent is intended
Status updated on  04.03.2017
Most recent event   Tooltip19.05.2023Patent maintained (B2 publication)published on 21.06.2023  [2023/25]
Applicant(s)For all designated states
Kyowa Kirin Co., Ltd.
1-9-2, Otemachi
Chiyoda-ku
Tokyo / JP
[2019/47]
Former [2011/17]For all designated states
Kyowa Hakko Kirin Co., Ltd.
1-6-1, Ohtemachi Chiyoda-ku
Tokyo 100-8185 / JP
Inventor(s)01 / Kanda, Yutaka
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
02 / Satoh, Mitsuo
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
03 / Nakamura, Kazuyasu
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
04 / Uchida, Kazuhisa
c/o Head Office
Kyowa Kirin Co., Ltd.
1-9-2 Otemachi
Chiyoda-ku
Tokyo / JP
05 / Shinkawa, Toyohide
c/o Bio Process Research and Development
Laboratories
Kyowa Hakko Kirin Co., Ltd.
100-1, Hagiwara-machi, Takasaki-shi
Gunma 370-0013 / JP
06 / Yamane, Naoko
c/o Head Office
Kyowa Kirin Co., Ltd.
1-9-2 Otemachi
Chiyoda-ku
Tokyo / JP
07 / Hosaka, Emi
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
08 / Yamano, Kazuya
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
09 / Yamasaki, Motoo
c/o Innovative Drug Research Laboratories
Kyowa Hakko Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
10 / Hanai, Nobuo
c/o Head Office
Kyowa Kirin Co., Ltd.
1-9-2 Otemachi
Chiyoda-ku
Tokyo / JP
 [2019/48]
Former [2017/27]01 / Kanda, Yutaka
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
02 / Satoh, Mitsuo
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
03 / Nakamura, Kazuyasu
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
04 / Uchida, Kazuhisa
c/o Head Office, Kyowa Hakko Kirin Co., Ltd.
1-6-1, Ohtemachi
Chiyoda-ku
Tokyo 100-8185 / JP
05 / Shinkawa, Toyohide
c/o Bio Process Research and Development
Laboratories
Kyowa Hakko Kirin Co., Ltd.
100-1, Hagiwara-machi, Takasaki-shi
Gunma 370-0013 / JP
06 / Yamane, Naoko
c/o Head Office, Kyowa Hakko Kirin Co., Ltd.
1-6-1, Ohtemachi
Chiyoda-ku
Tokyo 100-8185 / JP
07 / Hosaka, Emi
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
08 / Yamano, Kazuya
c/o Antibody Research Laboratories, Kyowa Hakko
Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
09 / Yamasaki, Motoo
c/o Innovative Drug Research Laboratories
Kyowa Hakko Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi
Tokyo 194-8533 / JP
10 / Hanai, Nobuo
c/o Head Office, Kyowa Hakko Kirin Co., Ltd.
1-6-1, Ohtemachi
Chiyoda-ku
Tokyo 100-8185 / JP
Former [2011/17]01 / Kanda, Yutaka
c/o Antibody Research Laboratories, Kyowa Hakko Kirin Co., Ltd. 6-6, Asahi-machi 3-chome Machida-shi
Tokyo 194-8533 / JP
02 / Satoh, Mitsuo
c/o Antibody Research Laboratories, Kyowa Hakko Kirin Co., Ltd. 6-6, Asahi-machi 3-chome Machida-shi
Tokyo 194-8533 / JP
03 / Nakamura, Kazuyasu
c/o Antibody Research Laboratories, Kyowa Hakko Kirin Co., Ltd. 6-6, Asahi-machi 3-chome Machida-shi
Tokyo 194-8533 / JP
04 / Uchida, Kazuhisa
c/o Head Office, Kyowa Hakko Kirin Co., Ltd. 1-6-1, Ohtemachi Chiyoda-ku
Tokyo 100-8185 / JP
05 / Shinkawa, Toyohide
c/o Bio Process Research and Development Laboratories Kyowa Hakko Kirin Co., Ltd. 100-1, Hagiwara-machi Takasaki-shi
Gunma 370-0013 / JP
06 / Yamane, Naoko
c/o Head Office, Kyowa Hakko Kirin Co., Ltd. 1-6-1, Ohtemachi Chiyoda-ku
Tokyo 100-8185 / JP
07 / Hosaka, Emi
c/o Antibody Research Laboratories, Kyowa Hakko Kirin Co., Ltd. 6-6, Asahi-machi 3-chome Machida-shi
Tokyo 194-8533 / JP
08 / Yamano, Kazuya
c/o Antibody Research Laboratories, Kyowa Hakko Kirin Co., Ltd. 6-6, Asahi-machi 3-chome Machida-shi
Tokyo 194-8533 / JP
09 / Yamasaki, Motoo
c/o Innovative Drug Research Laboratories Kyowa Hakko Kirin Co., Ltd. 6-6, Asahi-machi 3-chome Machida-shi
Tokyo 194-8533 / JP
10 / Hanai, Nobuo
c/o Head Office, Kyowa Hakko Kirin Co., Ltd. 1-6-1, Ohtemachi Chiyoda-ku
Tokyo 100-8185 / JP
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2017/27]
Former [2011/17]HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastraße 4
81925 München / DE
Application number, filing date10180018.305.10.2001
[2011/17]
Priority number, dateJP2000030852606.10.2000         Original published format: JP 2000308526
[2011/17]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2314686
Date:27.04.2011
Language:EN
[2011/17]
Type: B1 Patent specification 
No.:EP2314686
Date:05.07.2017
Language:EN
[2017/27]
Type: B2 New European patent specification 
No.:EP2314686
Date:21.06.2023
Language:EN
[2023/25]
Search report(s)(Supplementary) European search report - dispatched on:EP16.03.2011
ClassificationIPC:C12N15/10, C12P21/08, C07K16/00, A01K67/00, A61K39/395, C12N9/00, C12N15/52, G01N33/53
[2011/17]
CPC:
C07K16/3084 (EP); C12N5/16 (KR); A61P29/00 (EP);
A61P31/00 (EP); A61P31/04 (EP); A61P31/12 (EP);
A61P35/00 (EP); A61P37/00 (EP); A61P37/02 (EP);
A61P37/06 (EP); A61P37/08 (EP); A61P9/00 (EP);
A61P9/12 (EP); C07K16/00 (EP); C07K16/065 (EP);
C07K16/18 (EP); C07K16/2866 (EP); C07K16/32 (EP);
C12N9/0006 (EP); C12N9/1051 (EP); C12N9/1241 (EP);
C12N9/90 (EP); C12P21/005 (EP); A61K2039/505 (EP);
C07K2317/24 (EP); C07K2317/41 (EP); C07K2317/732 (EP);
C07K2319/30 (EP) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2017/27]
Former [2011/17]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE,  TR 
Extension statesAL27.09.2010
LT27.09.2010
LV27.09.2010
MK27.09.2010
RO27.09.2010
SI27.09.2010
TitleGerman:Zellen die eine Antikörperzusammensetzung produzieren[2011/17]
English:Cells producing antibody compositions[2011/17]
French:Cellules produisant une composition d'anticorps[2011/17]
Biological materialThis application mentions deposited biological material, check the file for details
Examination procedure27.09.2010Examination requested  [2011/17]
27.12.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
27.02.2012Amendment by applicant (claims and/or description)
08.04.2013Despatch of a communication from the examining division (Time limit: M04)
05.08.2013Reply to a communication from the examining division
30.05.2014Despatch of a communication from the examining division (Time limit: M04)
22.09.2014Reply to a communication from the examining division
29.09.2016Cancellation of oral proceeding that was planned for 05.10.2016
05.10.2016Date of oral proceedings (cancelled)
21.10.2016Communication of intention to grant the patent
27.02.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
27.02.2017Fee for grant paid
27.02.2017Fee for publishing/printing paid
29.05.2017Information about intention to grant a patent
29.05.2017Receipt of the translation of the claim(s)
02.06.2017Request for correction of the decision to grant filed
Parent application(s)   TooltipEP01974718.7  / EP1331266
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20010974718) is  06.06.2008
Opposition(s)Opponent(s)01  05.04.2018  12.04.2018  ADMISSIBLE
LC Patents
Kempische Steenweg 542A
3500 Hasselt / BE
Opponent's representative
Arnold & Siedsma
Bezuidenhoutseweg 57
2594 AC The Hague / NL
 [2021/17]
Former [2018/20]
Opponent(s)01  05.04.2018  12.04.2018  ADMISSIBLE
LC Patents
Kempische Steenweg 542A
3500 Hasselt / BE
Opponent's representative
LC Patents, et al, et al
Kempische Steenweg 542A
3500 Hasselt / BE
19.04.2018Invitation to proprietor to file observations on the notice of opposition
27.08.2018Reply of patent proprietor to notice(s) of opposition
27.03.2020Despatch of a communication from the opposition division (Time limit: M04)
12.11.2021Cancellation of oral proceeding that was planned for 15.12.2021
09.12.2021Despatch of a communication from the opposition division (Time limit: M02)
15.12.2021Date of oral proceedings
07.02.2022Reply to a communication from the opposition division
04.05.2022Despatch of a communication from the opposition division (Time limit: M02)
04.11.2022Despatch of interlocutory decision in opposition
14.11.2022Legal effect of interlocutory decision in opposition
22.02.2023Despatch of communication that the patent will be maintained as amended
16.05.2023Fee for printing new specification paid
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
27.02.2012Request for further processing filed
27.02.2012Full payment received (date of receipt of payment)
Request granted
12.03.2012Decision despatched
Fees paidRenewal fee
27.09.2010Renewal fee patent year 03
27.09.2010Renewal fee patent year 04
27.09.2010Renewal fee patent year 05
27.09.2010Renewal fee patent year 06
27.09.2010Renewal fee patent year 07
27.09.2010Renewal fee patent year 08
27.09.2010Renewal fee patent year 09
27.09.2010Renewal fee patent year 10
25.10.2011Renewal fee patent year 11
18.10.2012Renewal fee patent year 12
24.10.2013Renewal fee patent year 13
28.10.2014Renewal fee patent year 14
26.10.2015Renewal fee patent year 15
27.10.2016Renewal fee patent year 16
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY05.07.2017
FI05.07.2017
MC05.07.2017
PT05.07.2017
TR05.07.2017
IE05.10.2017
LU05.10.2017
GR06.10.2017
GB04.10.2021
ES06.10.2021
[2022/23]
Former [2022/09]CY05.07.2017
FI05.07.2017
MC05.07.2017
PT05.07.2017
TR05.07.2017
IE05.10.2017
LU05.10.2017
GR06.10.2017
GB04.10.2021
Former [2020/27]CY05.07.2017
FI05.07.2017
MC05.07.2017
PT05.07.2017
TR05.07.2017
IE05.10.2017
LU05.10.2017
GR06.10.2017
Former [2020/15]CY05.07.2017
FI05.07.2017
MC05.07.2017
TR05.07.2017
IE05.10.2017
LU05.10.2017
GR06.10.2017
Former [2019/46]CY05.07.2017
FI05.07.2017
MC05.07.2017
IE05.10.2017
LU05.10.2017
GR06.10.2017
Former [2018/45]FI05.07.2017
MC05.07.2017
IE05.10.2017
LU05.10.2017
GR06.10.2017
Former [2018/36]FI05.07.2017
MC05.07.2017
LU05.10.2017
GR06.10.2017
Former [2018/29]FI05.07.2017
MC05.07.2017
GR06.10.2017
Former [2018/12]FI05.07.2017
GR06.10.2017
Former [2018/08]FI05.07.2017
Documents cited:Search[XY]  - OHYAMA C ET AL, "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 5 JUN 1998, (19980605), vol. 273, no. 23, ISSN 0021-9258, pages 14582 - 14587, XP002328593 [X] 1-3 * abstract * [Y] 4

DOI:   http://dx.doi.org/10.1074/jbc.273.23.14582
 [XY]  - RIPKA J ET AL, "Two Chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, NEW YORK, US, US, (198609), vol. 249, no. 2, ISSN 0003-9861, pages 533 - 545, XP002971006 [X] 1-3 * abstract * [Y] 4

DOI:   http://dx.doi.org/10.1016/0003-9861(86)90031-7
 [XY]  - RIPKA J ET AL, "LECTIN-RESISTANT CHO CELLS: SELECTION OF FOUR NEW PEA LECTIN-RESISTANT PHENOTYPES", SOMATIC CELL AND MOLECULAR GENETICS, NEW YORK, NY, US, (19860101), vol. 12, no. 1, pages 51 - 62, XP009073686 [X] 1-3,5,6 * abstract * [Y] 4
 [X]  - PATNAIK S K ET AL, "alpha(1,3)fucosyltransferases expressed by the gain-of-function Chinese hamster ovary glycosylation mutants LEC12, LEC29, and LEC30.", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 15 MAR 2000 LNKD- PUBMED:10700388, (20000315), vol. 375, no. 2, ISSN 0003-9861, pages 322 - 332, XP002626008 [X] 1-3 * the whole document *

DOI:   http://dx.doi.org/10.1006/ABBI.1999.1693
 [XY]  - STANLEY P ET AL, "Selection and characterization of eight phenotypically distinct lines of lectin-resistant chinese hamster ovary cells", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 6, no. 2, doi:10.1016/0092-8674(75)90002-1, ISSN 0092-8674, (19751001), pages 121 - 128, (19751001), XP023873877 [X] 1-3,5,6 * the whole document * [Y] 4

DOI:   http://dx.doi.org/10.1016/0092-8674(75)90002-1
 [XY]  - STANLEY P ET AL, "LECTIN-RESISTANT CHO CELLS SELECTION OF SEVEN NEW MUTANTS RESISTANT TO RICIN", SOMATIC CELL AND MOLECULAR GENETICS, (1990), vol. 16, no. 3, ISSN 0740-7750, pages 211 - 224, XP009145287 [X] 1-3,5,6 * abstract * [Y] 4
 [Y]  - UMANA P ET AL, "ENGINEERED GLYCOFORMS OF AN ANTINEUROBLASTOMA IGG1 WITH OPTIMIZED ANTIBODY-DEPENDENT CELLULAR CYTOTOXIC ACTIVITY", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, (199902), vol. 17, ISSN 1087-0156, pages 176 - 180, XP002921620 [Y] 4 * the whole document *

DOI:   http://dx.doi.org/10.1038/6179
 [A]  - WRIGHT A ET AL, "Effect of glycosylation on antibody function: implications for genetic engineering", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, (1997), vol. 15, no. 1, ISSN 0167-7799, pages 26 - 32, XP004016809 [A] 1-6 * page 30 *

DOI:   http://dx.doi.org/10.1016/S0167-7799(96)10062-7
ExaminationEP1176195
    - WRIGHT A ET AL, "EFFECT OF ALTERED CH2-ASSOCIATED CARBOHYDRATE STRUCTURE ON THE FUNCTIONAL PROPERTIES AND IN VIVO FATE OF CHIMERIC MOUSE-HUMAN IMMUNOGLOBULIN G1", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, (19940901), vol. 180, no. 3, doi:10.1084/JEM.180.3.1087, ISSN 0022-1007, pages 1087 - 1096, XP000676306

DOI:   http://dx.doi.org/10.1084/jem.180.3.1087
    - LI ET AL, "Structure of the altered oligosaccharide present in glycoproteins from a clone of Chinese hamster ovary cells deficient in N-acetylglucosaminyltransferase activity.", JOURNAL OF BIOLOGICAL CHEMISTRY, (19780901), vol. 253, no. 18, ISSN 0021-9258, pages 6426 - 6431, XP055119436
    - KANDA ET AL, "Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20070619), vol. 130, no. 3, doi:10.1016/J.JBIOTEC.2007.04.025, ISSN 0168-1656, pages 300 - 310, XP022119693

DOI:   http://dx.doi.org/10.1016/j.jbiotec.2007.04.025
    - Maureen Spearman ET AL, "Chapter 12 : The role of glycosylation in therapeutic antibodies", Antibody expression and production, Springer, (20110516), pages 251 - 292, XP055240498
by applicantJPS59140885
 JPS6070080
 JPS60251887
 JPS63299
 JPS63309192
 JPH02227075
 JPH02257891
 JPH0322979B
 EP0533199
 JPH05304989
 JPH05336963
 WO9400977
 JP2517813B
 WO9710354
 JP2606856B
 WO9954342
 JPH11314512
 WO0164754
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