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Extract from the Register of European Patents

EP About this file: EP2261230

EP2261230 - Protein purification method [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  31.03.2023
Database last updated on 20.12.2024
FormerThe patent has been granted
Status updated on  07.04.2017
FormerGrant of patent is intended
Status updated on  16.11.2016
Most recent event   Tooltip31.03.2023Revocation of patentpublished on 03.05.2023  [2023/18]
Applicant(s)For all designated states
Chugai Seiyaku Kabushiki Kaisha
5-1, Ukima 5-chome Kita-ku
Tokyo 115-8543 / JP
[2010/50]
Inventor(s)01 / Takeda, Kozo
c/o Chugai Seiyaku Kabushiki Kaisha
5-1, Ukima 5-chome
Kita-ku
Tokyo 115-8543 / JP
02 / Ochi, Norimichi
c/o Chugai Seiyaku Kabushiki Kaisha
5-1, Ukima 5-chome
Kita-ku
Tokyo 115-8543 / JP
03 / Ishii, Kimie
c/o Chugai Seiyaku Kabushiki Kaisha
5-1, Ukima 5-chome
Kita-ku
Tokyo 115-8543 / JP
04 / Matsuhashi, Manabu
c/o Chugai Seiyaku Kabushiki Kaisha
5-1, Ukima 5-chome
Kita-ku
Tokyo 115-8543 / JP
05 / Imamura, Akinori
c/o Chugai Seiyaku Kabushiki Kaisha
5-1, Ukima 5-chome
Kita-ku
Tokyo 115-8543 / JP
 [2017/19]
Former [2010/50]01 / Takeda, Kozo
c/o Chugai Seiyaku Kabushiki Kaisha 5-1, Ukima 5-chome Kita-ku
Tokyo 115-8543 / JP
02 / Ochi, Norimichi
c/o Chugai Seiyaku Kabushiki Kaisha 5-1, Ukima 5-chome Kita-ku
Tokyo 115-8543 / JP
03 / Ishii, Kimie
c/o Chugai Seiyaku Kabushiki Kaisha 5-1, Ukima 5-chome Kita-ku
Tokyo 115-8543 / JP
04 / Matsuhashi, Manabu
c/o Chugai Seiyaku Kabushiki Kaisha 5-1, Ukima 5-chome Kita-ku
Tokyo 115-8543 / JP
05 / Imamura, Akinori
c/o Chugai Seiyaku Kabushiki Kaisha 5-1, Ukima 5-chome Kita-ku
Tokyo 115-8543 / JP
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2017/19]
Former [2010/50]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date10180577.811.09.2003
[2010/50]
Priority number, dateJP2002026560911.09.2002         Original published format: JP 2002265609
[2010/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2261230
Date:15.12.2010
Language:EN
[2010/50]
Type: B1 Patent specification 
No.:EP2261230
Date:10.05.2017
Language:EN
[2017/19]
Search report(s)(Supplementary) European search report - dispatched on:EP17.11.2010
ClassificationIPC:C07K1/30, C07K16/06, C07K1/34, C07K16/26, C07K16/28, C07K16/30, C07K1/22
[2015/01]
CPC:
C07K1/30 (EP,US); C07K1/14 (KR); C07K1/22 (US);
C07K1/34 (EP,US); C07K14/535 (US); C07K16/00 (KR);
C07K16/065 (EP,US); C07K16/26 (EP,US); C07K16/2866 (EP,US);
C07K16/2896 (US); C07K16/3061 (EP,US); C07K2317/24 (EP,US) (-)
Former IPC [2013/28]C07K1/30, C07K16/06, C07K1/34, C07K16/26, C07K16/28, C07K16/30
Former IPC [2010/50]C07K1/14, C07K16/00, C07K14/52, C07K1/34
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2017/19]
Former [2010/50]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Verfahren zur Proteinreinigung[2010/50]
English:Protein purification method[2010/50]
French:Méthode de purification d'une protéine[2010/50]
Examination procedure15.06.2011Amendment by applicant (claims and/or description)
15.06.2011Examination requested  [2011/30]
14.03.2012Despatch of a communication from the examining division (Time limit: M06)
12.09.2012Reply to a communication from the examining division
27.06.2013Observations by third parties
09.08.2013Despatch of a communication from the examining division (Time limit: M04)
18.12.2013Reply to a communication from the examining division
04.02.2014Observations by third parties
14.03.2014Despatch of a communication from the examining division (Time limit: M06)
04.08.2014Reply to a communication from the examining division
19.12.2014Communication of intention to grant the patent
13.04.2015Observations by third parties
23.04.2015Fee for grant paid
23.04.2015Fee for publishing/printing paid
29.04.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
28.01.2016Despatch of a communication from the examining division (Time limit: M06)
05.08.2016Reply to a communication from the examining division
17.11.2016Communication of intention to grant the patent
24.03.2017Fee for grant paid
24.03.2017Fee for publishing/printing paid
24.03.2017Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP03795400.5  / EP1561756
Divisional application(s)EP17164053.5  / EP3225625
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20030795400) is  10.11.2006
Opposition(s)Opponent(s)01  07.02.2018  22.02.2018  ADMISSIBLE
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Knight, Lucie Viktoria
GSK
Legal & Compliance - Global Patents
79 New Oxford Street
London WC1A 1DG / GB
 02  08.02.2018  22.02.2018  ADMISSIBLE
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
 03  09.02.2018  22.02.2018  ADMISSIBLE
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 04  09.02.2018  22.02.2018  ADMISSIBLE
Neuefeind, Regina
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
 05  09.02.2018  22.02.2018  ADMISSIBLE
Eder, Michael
Marktstr. 4
80802 Munich / DE
Opponent's representative
Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
 06  12.02.2018  23.02.2018  ADMISSIBLE
Baxalta GmbH
Thurgauerstrasse 130
8152 Glattpark (Opfikon) / CH
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 07  12.02.2018  23.02.2018  ADMISSIBLE
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH
Leonrodstrasse 58
80636 München / DE
Opponent's representative
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
 [N/P]
Former [2023/04]
Opponent(s)01  07.02.2018  22.02.2018  ADMISSIBLE
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Knight, Lucie Viktoria
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
 02  08.02.2018  22.02.2018  ADMISSIBLE
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
 03  09.02.2018  22.02.2018  ADMISSIBLE
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 04  09.02.2018  22.02.2018  ADMISSIBLE
Neuefeind, Regina
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
 05  09.02.2018  22.02.2018  ADMISSIBLE
Eder, Michael
Marktstr. 4
80802 Munich / DE
Opponent's representative
Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
 06  12.02.2018  23.02.2018  ADMISSIBLE
Baxalta GmbH
Thurgauerstrasse 130
8152 Glattpark (Opfikon) / CH
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 07  12.02.2018  23.02.2018  ADMISSIBLE
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH
Leonrodstrasse 58
80636 München / DE
Opponent's representative
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2021/15]
Opponent(s)01  07.02.2018  22.02.2018  ADMISSIBLE
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Knight, Lucie Viktoria
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
 02  08.02.2018  22.02.2018  ADMISSIBLE
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
 03  09.02.2018  22.02.2018  ADMISSIBLE
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 04  09.02.2018  22.02.2018  ADMISSIBLE
Neuefeind, Regina
Maiwald Patentanwalts - und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Neuefeind, Regina
Maiwald Patentanwalts- und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
 05  09.02.2018  22.02.2018  ADMISSIBLE
Eder, Michael
Marktstr. 4
80802 Munich / DE
Opponent's representative
Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
 06  12.02.2018  23.02.2018  ADMISSIBLE
Baxalta GmbH
Thurgauerstrasse 130
8152 Glattpark (Opfikon) / CH
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 07  12.02.2018  23.02.2018  ADMISSIBLE
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH
Leonrodstrasse 58
80636 München / DE
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2021/08]
Opponent(s)01  07.02.2018  22.02.2018  ADMISSIBLE
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Knight, Lucie Viktoria
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
 02  08.02.2018  22.02.2018  ADMISSIBLE
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
 03  09.02.2018  22.02.2018  ADMISSIBLE
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 04  09.02.2018  22.02.2018  ADMISSIBLE
Neuefeind, Regina
Maiwald Patentanwalts - und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Neuefeind, Regina
Maiwald Patentanwalts- und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
 05  09.02.2018  22.02.2018  ADMISSIBLE
Eder, Michael
Marktstr. 4
80802 Munich / DE
Opponent's representative
Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
 06  12.02.2018  23.02.2018  ADMISSIBLE
Baxalta GmbH
Thurgauerstrasse 130
8152 Glattpark (Opfikon) / CH
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 07  12.02.2018  23.02.2018  ADMISSIBLE
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH
Leonrodstrasse 58
80636 München / DE
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2020/18]
Opponent(s)01  07.02.2018  22.02.2018  ADMISSIBLE
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Hillier, Mark
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
 02  08.02.2018  22.02.2018  ADMISSIBLE
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
 03  09.02.2018  22.02.2018  ADMISSIBLE
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 04  09.02.2018  22.02.2018  ADMISSIBLE
Neuefeind, Regina
Maiwald Patentanwalts - und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Neuefeind, Regina
Maiwald Patentanwalts- und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
 05  09.02.2018  22.02.2018  ADMISSIBLE
Eder, Michael
Marktstr. 4
80802 Munich / DE
Opponent's representative
Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
 06  12.02.2018  23.02.2018  ADMISSIBLE
Baxalta GmbH
Thurgauerstrasse 130
8152 Glattpark (Opfikon) / CH
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 07  12.02.2018  23.02.2018  ADMISSIBLE
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH
Leonrodstrasse 58
80636 München / DE
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2019/37]
Opponent(s)01  07.02.2018  22.02.2018  ADMISSIBLE
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Hillier, Mark
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
 02  08.02.2018  22.02.2018  ADMISSIBLE
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
 03  09.02.2018  22.02.2018  ADMISSIBLE
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 04  09.02.2018  22.02.2018  ADMISSIBLE
Neuefeind, Regina
Maiwald Patentanwalts - und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Neuefeind, Regina
Maiwald Patentanwalts- und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
 05  09.02.2018  22.02.2018  ADMISSIBLE
Eder, Michael
Marktstr. 4
80802 Munich / DE
Opponent's representative
Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
 06  12.02.2018  23.02.2018  ADMISSIBLE
Baxalta GmbH
Zählerweg 4
6300 Zug / CH
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 07  12.02.2018  23.02.2018  ADMISSIBLE
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH
Leonrodstrasse 58
80636 München / DE
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2018/12]
Opponent(s)01  07.02.2018    ADMISSIBLE
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Hillier, Mark
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
 02  08.02.2018    ADMISSIBLE
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
 03  09.02.2018    ADMISSIBLE
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 04  09.02.2018    ADMISSIBLE
Neuefeind, Regina
Maiwald Patentanwalts GmbH
Elisenhof
Elisenstrasse 3
80335 München / DE
Opponent's representative
Neuefeind, Regina
Maiwald Patentanwalts GmbH
Elisenhof
Elisenstrasse 3
80335 München / DE
 05  09.02.2018    ADMISSIBLE
Eder, Michael
Marktstr. 4
80802 Munich / DE
Opponent's representative
Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
 06  12.02.2018   
Baxalta GmbH
Zählerweg 4
6300 Zug / CH
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 07  12.02.2018   
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH
Leonrodstrasse 58
80636 München / DE
Opponent's representative
Dilg, Andreas
Dilg, Haeusler, Schindelmann Patentanwaltsgesellschaft mbH Leonrodstrasse 58
80636 München / DE
Former [2018/11]
Opponent(s)01  07.02.2018   
Glaxo Group Limited
980 Great West Road
Brentford Middlesex TW8 9GS / GB
Opponent's representative
Hillier, Mark
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
 02  08.02.2018   
Taormino, Joseph Paul
c/o Hoffmann Eitle Patent - und
Rechtsanwälte PartmbB
Arabellastrasse 30
81925 Munich / DE
19.03.2018Invitation to proprietor to file observations on the notice of opposition
28.09.2018Reply of patent proprietor to notice(s) of opposition
05.11.2019Date of oral proceedings
10.12.2019Despatch of minutes of oral proceedings
10.12.2019Despatch of communication that the patent will be revoked
25.03.2023Legal effect of revocation of patent [2023/18]
Appeal following opposition19.02.2020Appeal received No.  T0436/20
14.04.2020Statement of grounds filed
09.03.2023Result of appeal procedure: appeal of the proprietor was rejected
15.03.2023Despatch of the decision of the Board of Appeal
Fees paidRenewal fee
13.01.2011Renewal fee patent year 03
13.01.2011Renewal fee patent year 04
13.01.2011Renewal fee patent year 05
13.01.2011Renewal fee patent year 06
13.01.2011Renewal fee patent year 07
13.01.2011Renewal fee patent year 08
23.09.2011Renewal fee patent year 09
24.09.2012Renewal fee patent year 10
23.09.2013Renewal fee patent year 11
24.09.2014Renewal fee patent year 12
23.09.2015Renewal fee patent year 13
23.09.2016Renewal fee patent year 14
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.09.2003
CY10.05.2017
CZ10.05.2017
EE10.05.2017
FI10.05.2017
MC10.05.2017
PT10.05.2017
SK10.05.2017
BG10.08.2017
LU11.09.2017
[2020/27]
Former [2019/46]HU11.09.2003
CY10.05.2017
CZ10.05.2017
EE10.05.2017
FI10.05.2017
MC10.05.2017
SK10.05.2017
BG10.08.2017
LU11.09.2017
Former [2019/31]HU11.09.2003
CZ10.05.2017
EE10.05.2017
FI10.05.2017
MC10.05.2017
SK10.05.2017
BG10.08.2017
LU11.09.2017
Former [2018/34]CZ10.05.2017
EE10.05.2017
FI10.05.2017
MC10.05.2017
SK10.05.2017
BG10.08.2017
LU11.09.2017
Former [2018/29]CZ10.05.2017
EE10.05.2017
FI10.05.2017
MC10.05.2017
SK10.05.2017
BG10.08.2017
Former [2018/10]CZ10.05.2017
EE10.05.2017
FI10.05.2017
SK10.05.2017
BG10.08.2017
Former [2018/09]EE10.05.2017
FI10.05.2017
BG10.08.2017
Former [2017/50]FI10.05.2017
BG10.08.2017
Documents cited:Search[X]EP0344796  (CHUGAI PHARMACEUTICAL CO LTD [JP]) [X] 21 * page 5, line 3 - line 4; examples 1-11 *;
 [XD]EP0628639  (CHUGAI PHARMACEUTICAL CO LTD [JP]) [XD] 21 * claim 5 *;
 [XI]WO9522389  (SMITHKLINE BEECHAM CORP [US], et al) [X] 1,3-12,17-21 * page 14 - page 15; table 1 * * page 12, line 21 - line 25 * * page 13, line 1 - line 7 * [I] 2,22;
 [A]EP0893450  (BAYER AG [US]) [A] 1-22 * page 2, lines 5-9 *;
 [XD]EP0960936  (CHUGAI PHARMACEUTICAL CO LTD [JP]) [XD] 21 * claim 7 *;
 [XD]EP0962467  (CHUGAI PHARMACEUTICAL CO LTD [JP]) [XD] 21 * claim 7 *;
 [A]US6096872  (VAN HOLTEN ROBERT WILLIAM [US], et al) [A] 1-22 * column 8, lines 24-39 ** page 2, column 1, lines 52-54 *;
 [X]  - OCTAAF J. M. BOS ET AL., "VIRUS VALIDATION OF pH 4-TREATED HUMAN IMMUNOGLOBULIN PRODUCTS PRODUCED BY THE COHN FRACTIONATION PROCESS", BIOLOGICALS, (199812), vol. 26, no. 4, pages 267 - 276, XP002389916 [X] 1,3-8,10 * page 267, paragraph 1 - page 268, paragraph 6; table 4 * * page 267, paragraph 1 - page 268, paragraph 6 *

DOI:   http://dx.doi.org/10.1006/biol.1998.0148
 [X]  - LYDERSEN B K ET AL, "ACID PRECIPITATION OF MAMMALIAN CELL FERMENTATION BROTH", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, (19941130), vol. 745, ISSN 0077-8923, pages 222 - 231, XP009033271 [X] 1,7,9,10 * page 222 - page 223; figures 1-5 * * page 222, paragraph 3 * * page 226, paragraph 1; figure 4 * * page 222, paragraph 1 - page 223, paragraph 6; figures 1-5 *

DOI:   http://dx.doi.org/10.1111/j.1749-6632.1994.tb44375.x
 [X]  - ARANHA-CREADO H ET AL, "CLEARANCE OF MURINE LEUKAEMIA VIRUS FROM MONOCLONAL ANTIBODY SOLUTIONS BY A HYDROPHILIC PVDF MICROPOROUS MEMBRANE FILTER", BIOLOGICALS, ACADEMIC PRESS LTD., LONDON, GB LNKD- DOI:10.1006/BIOL.1998.0130, (19980101), vol. 26, ISSN 1045-1056, pages 167 - 172, XP001543186 [X] 21 * page 168, column 2, line 8 - page 169, column 1, line 15 *

DOI:   http://dx.doi.org/10.1006/biol.1998.0130
ExaminationWO02072615
 EP1380589
by applicantJPS6112288
 EP0239400
 JPH0159878B
 WO9012874
 WO9201047
 WO9203918
 WO9219759
 WO9220791
 WO9306213
 WO9311236
 WO9312227
 JPH05504579
 WO9319172
 WO9402602
 WO9425585
 WO9501438
 WO9515388
 WO9602576
 JPH0899902
 JPH08151398
 JPH08506023
 WO9634096
 WO9633735
 WO9813388
 WO9814580
 WO9951743
    - SATO, K. ET AL., CANCER RES., (1993), vol. 53, pages 851 - 856
    - "Ion Exchange Chromatography Principles and Methods", PHARMACIA (LATTERLY AMERSHAM BIOSCIENCES, pages 52 - 56
otherWO02072615
 EP1380589
    - USP, "645 WATER CONDUCTIVITY", UNITED STATES PHARMACOPEIA CONVENTION, (2014), pages 1 - 3, URL: HTTPS://HMC.USP.ORG/SITES/DEFAULT/FILES/DOCUMENTS/HMC/GCS-PDFS/C645.PDF, XP055199178
    - ATKINS P.W., PHYSICAL CHEMISTRY, 4TH ED., OXFORD UNIVERSITY PRESS, (1990), pages 23-24,250 - 252, ISBN 9780716720737, XP003035881
OppositionWO9522389
 EP1380589
 WO2004024752
 JP2002265609
 EP1561756
 US5110910
 EP1561756
 EP0166623
 EP0628639
 US5840297
 EP0960936
 EP0962467
 US6127526
 WO02072615
 WO9635710
 EP0893450
    - MERTEN, "Virus contaminations of cell cultures - A biotechnological view", Cytotechnology, (20020600), vol. 39, no. 2, pages 91 - 116, XP019236736

DOI:   http://dx.doi.org/10.1023/A:1022969101804
    - FAHRNER et al., "Industrial Purification of Pharmaceutical Antibodies: Development, Operation, and Validation of Chromatography Processes", Biotechnology and Genetic Engineering Reviews, (20010700), vol. 18, pages 301 - 327, XP003035628

DOI:   http://dx.doi.org/10.1080/02648725.2001.10648017
    - BRORSON et al., "Bracketed Generic Inactivation of Rodent Retroviruses by Low pH Treatmentfor Monoclonal Antibodies and Recombinant Proteins", Biotech. Bioeng, (20030500), vol. 82, no. 3, pages 321 - 329, XP002576451
    - FLOYD et al., "Viral Aggregation: Buffer Effects in the Aggregation of Poliovirus and Reovirus at Low and High pH", Appl. Env. Microb., (19790900), vol. 38, no. 3, pages 395 - 401, XP055307511
    - O.-W. MERTEN, "Virus contaminations of cell cultures - A biotechnological view", Cytotechnology, vol. 39, no. 2, (20020600), pages 91 - 116, (20020700), XP019236736

DOI:   http://dx.doi.org/10.1023/A:1022969101804
    - OZAKI et al., "Humanized Anti-HM1.24 Antibody Mediates Myeloma Cell CytotoxicityThat Is Enhanced by Cytokine Stimulation of Effector Cells", Blood, (19990000), vol. 93, no. 11, pages 3922 - 3930, XP002942079
    - PRIN et al., "Isoelectric restriction of human immunoglobulin isotypes", Biochim. Biophys. Acta, (19950000), vol. 1243, no. 2, pages 287 - 290, XP055307495

DOI:   http://dx.doi.org/10.1016/0304-4165(94)00187-3
    - OMAR et al., "Virus inactivation by pepsin treatment at pH 4 of IgG solutions: factors affecting the rate of virus inactivation", Transfusion, (19960000), vol. 36, no. 10, pages 866 - 872, XP009005370

DOI:   http://dx.doi.org/10.1046/j.1537-2995.1996.361097017171.x
    - NEIL A. CAMPBELL et al., Biology. 5th ed., Addison Wesley Longman, (19990000), pages 319 - 330, XP055315940
    - FAHRNER et al., "Industrial Purification of Pharmaceutical Antibodies: Development, Operation, and Validation of Chromatography Processes", Biotech. and Genetic Engineering Reviews, (20010700), vol. 18, pages 301 - 327, XP008034714

DOI:   http://dx.doi.org/10.1080/02648725.2001.10648017
    - "Scaleup and Virus Clearance Studies on Virus Filtration in Monoclonal Antibody Manufacture", P. U. HUANG et al., Membrane Separations in Biotechnology, Marcel Dekker, (20010000), pages 327 - 350, XP055315868
    - ARANHA-CREADO et al., "Virus retention by a hydrophilic triple-layer PVDF microporous membrane filter", PDA J Pharm Sci Technol, (19970500), vol. 51, no. 3, pages 119 - 124, XP055315717
    - R. FLOYD et al., "Viral Aggregation: Buffer Effects in the Aggregation of Poliovirus and Reovirus at Low and High pH", Appl. Env. Microb., (19790000), vol. 38, no. 3, pages 395 - 401, XP055307511
    - R. FLOYD et al., "Aggregation of Poliovirus and Reovirus by Dilution in Water", Appl. Env. Microb., (19770100), vol. 33, no. 1, pages 159 - 167, XP055315697
    - HERATH et al., "Removal of viruses by microfiltration membranes at different solution environments", Wat Sci. Tech., (19990000), vol. 40, no. 4-5, pages 331 - 338, XP055307422

DOI:   http://dx.doi.org/10.1016/S0273-1223(99)00515-6
    - VALDES et al., "Chromatographic removal combined with heat, acid and chaotropic inactivation of four model viruses", Journal of Biotechnology, (20020000), vol. 96, no. 3, pages 251 - 258, XP002318532

DOI:   http://dx.doi.org/10.1016/S0168-1656(02)00047-0
    - FAHRNER et al., "Industrial Purification of Pharmaceutical Antibodies: Development, Operation, and Validation of Chromatography Processes", Biotech. and Genetic Engineering Reviews, (20010700), vol. 18, no. 12, pages 301 - 327, XP003035628

DOI:   http://dx.doi.org/10.1080/02648725.2001.10648017
    - "Scaleup and Virus Clearance Studies on Virus Filtration in Monoclonal Antibody Manufacture", HUANG et al., Membrane Separations in Biotechnology, NY, Marcel Dekker, (20010000), pages 327 - 350, XP055315868
    - FLOYD, R. et al., "Viral Aggregation: Buffer Effects in the Aggregation of Poliovirus and Reovirus at Low and High pH", Applied and Environmental Microbiology, (19790900), vol. 38, no. 3, pages 395 - 401, XP055307511
    - FLOYD et al., "Viral Aggregation: Buffer Effects in the Aggregation of Poliovirus and Reovirus at Low and High pH", Appl Environ Microbiol, (19790000), vol. 38, no. 3, pages 395 - 401, XP055307511
    - MICHEN et al., "lsoelectric points of viruses", Journal of Applied Microbiology, (20100122), vol. 109, no. 2, pages 388 - 397, XP055314887
    - BEST, "PRECIPITATION OF THE TOBACCO MOSAIC VIRUS COMPLEX AT ITS ISOELECTRIC POINT", Journal of Experimental Biology and Medical Science, (19360300), vol. 14, no. 1, pages 1 - 13, XP055464293

DOI:   http://dx.doi.org/10.1038/icb.1936.1
    - "Citric acid", Wikipedia, the free encyclopedia, (20180102), pages 1 - 10, URL: https://en.wikipedia.org/w/index.php?title=Citric_acid&oldid=818317313, (20180206), XP055464385
    - Rosemount Analytical, "Conductance Data For Commonly Used Chemicals", Emerson, http://www2.emersonprocess.com/siteadmincenter/pm%20Rosemount%20Analytical%20Documents/LIQ_MAN_6039_Conductance_Data_Commonly_Used_Chemicals.pdf, (20101200), XP055464386
    - "Guide to Conductivity and Dissolved Oxygen", Mettler-Toledo, (19990525), pages 1 - 19, XP055464388
    - Mettler-Toledo AG, "A Guide to Conductivity Measurement. Theory and Practice of Conductivity Applications", Conductivity Guide, (20130800), XP055315881
    - CAMPBELL et al., Biology, Addison Wesley Longman, (19990000), pages 319 - 330, XP055315940
    - ARANHA-CREADO et al., "Virus Retention by a Hydrophilic Triple-Layer PVDF Microporous Membrane Filter", PDA J Pharm Sci Technol., (19970600), vol. 51, no. 3, pages 119 - 124, XP055315717
    - FAHRNER et al., "Industrial Purification of Pharmaceutical Antibodies: Development, Operation, and Validation of Chromatography Processes", Biotechnology and Genetic Engineering Reviews, (20010000), vol. 18, pages 301 - 327, XP008034714

DOI:   http://dx.doi.org/10.1080/02648725.2001.10648017
    - GOYON et al., "Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies", J Chromatogr B, (20171015), vol. 1065, pages 119 - 128, XP085233861

DOI:   http://dx.doi.org/10.1016/j.jchromb.2017.09.033
    - OMAR et al., "Virus inactivation by pepsin treatment at pH 4 of IgG solutions: factors affecting the rate of virus inactivation", Transfusion, (19961000), vol. 36, no. 10, pages 866 - 872, XP009005370

DOI:   http://dx.doi.org/10.1046/j.1537-2995.1996.361097017171.x
    - VOET and Voet, Biochemistry. 2nd ed., John Wiley & Sons, (19950000), page 112, XP055464303
    - LIDE D. R., CRC Handbook of Chemistry and Physics, Taylor & Francis Group, (20060000), page 5-72, XP055464300
    - GREBER et al., "Mechanisms of virus uncoating", Trends in Microbiology, (19940000), vol. 2, no. 2, doi:doi:10.1016/0966-842X(94)90126-0, pages 52 - 56, XP025906629

DOI:   http://dx.doi.org/10.1016/0966-842X(94)90126-0
    - FAHRNER et al., "Industrial Purification of Pharmaceutical Antibodies: Development, Operation and Validation of Chromatography Processes", Biotechnology and Genetic Engineering Reviews, (20010700), vol. 18, doi:10.1080/02648725.2001.10648017, pages 301 - 327, XP008034714

DOI:   http://dx.doi.org/10.1080/02648725.2001.10648017
    - "Points to consider in the manufacture and testing of monoclonal antibody products for human use", Food and Drug Administration, Rockville , MD, (19970000), pages 1 - 50, XP055457764
    - MICHEN et al., "Isoelectric points of viruses", Journal of Applied Microbiology, (20100000), vol. 109, no. 2, pages 388 - 397, XP055314887
    - GOYON et al., "Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies", Journal of Chromatography B, (20170000), vol. 1065, pages 119 - 128, XP085233861

DOI:   http://dx.doi.org/10.1016/j.jchromb.2017.09.033
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