blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2385124

EP2385124 - Peptides or peptide analogues for modulating the binding of a PDZ protein and a PL protein [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.07.2014
Database last updated on 24.04.2024
Most recent event   Tooltip23.01.2015Lapse of the patent in a contracting state
New state(s): MC
published on 25.02.2015  [2015/09]
Applicant(s)For all designated states
Arbor Vita Corporation
6611 Dumbarton Circle
Fremont, CA 94555 / US
[2011/45]
Inventor(s)01 / Lu, Peter
c/o Arbor Vita Corporation
6611 Dumbarton Circle
Fremont, CA 94555 / US
 [2013/36]
Former [2011/45]01 / Lu, Peter
c/o Arbor Vita Corporation
6611 Dumbarton Circle
Freemont, CA 94555 / US
Representative(s)Wilkinson, Marc George, et al
Avidity IP
Broers Building
Hauser Forum
21 JJ Thomson Ave
Cambridge CB3 0FA / GB
[N/P]
Former [2013/37]Wilkinson, Marc George, et al
avidity IP
Kestrel House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Former [2013/15]Wilkinson, Marc George, et al
Avidity IP
Kestrel House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Former [2011/45]Broughton, Jon Philip
avidity IP
Merlin House
Falconry Court
Baker's Lane, Epping
Essex CM16 5DQ / GB
Application number, filing date10186068.212.05.2000
[2011/45]
Priority number, dateUS19990134114P14.05.1999         Original published format: US 134114 P
US19990134117P14.05.1999         Original published format: US 134117 P
US19990134118P14.05.1999         Original published format: US 134118 P
US19990160860P21.10.1999         Original published format: US 160860 P
US19990162498P29.10.1999         Original published format: US 162498 P
US19990170453P13.12.1999         Original published format: US 170453 P
US20000176195P14.01.2000         Original published format: US 176195 P
US20000182296P14.02.2000         Original published format: US 182296 P
US2000054727611.04.2000         Original published format: US 547276
US20000196460P11.04.2000         Original published format: US 196460 P
US20000196528P11.04.2000         Original published format: US 196528 P
US20000196527P11.04.2000         Original published format: US 196527 P
US20000196267P11.04.2000         Original published format: US 196267 P
[2011/45]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2385124
Date:09.11.2011
Language:EN
[2011/45]
Type: A3 Search report 
No.:EP2385124
Date:27.06.2012
Language:EN
[2012/26]
Type: B1 Patent specification 
No.:EP2385124
Date:11.09.2013
Language:EN
[2013/37]
Search report(s)(Supplementary) European search report - dispatched on:EP25.05.2012
ClassificationIPC:C07K14/705
[2013/04]
CPC:
C07K14/705 (EP); A61P29/00 (EP); A61P37/02 (EP);
A61P37/06 (EP); A61P43/00 (EP); A61P7/00 (EP);
A01K2217/075 (EP); A61K38/00 (EP); A61K39/00 (EP);
A61K48/00 (EP); C12N2310/315 (EP); Y02A90/10 (EP) (-)
Former IPC [2011/45]C12N15/12, C07K14/705, C07K16/28, C12N15/11, C12N1/21, G01N33/68, C12Q1/68, A61K38/17, A61K39/395
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2011/45]
Extension statesAL30.11.2012
LT30.11.2012
LV30.11.2012
MK30.11.2012
RO30.11.2012
SI30.11.2012
TitleGerman:Peptide oder Peptidanaloga zur Modulation der Bindung zwischen einem PDZ-Protein und einem PL-Protein[2011/45]
English:Peptides or peptide analogues for modulating the binding of a PDZ protein and a PL protein[2011/45]
French:Peptides ou analogues de peptides pour moduler l'interaction entre und protéine PDZ et une protéine PL[2011/45]
Examination procedure30.11.2012Amendment by applicant (claims and/or description)
30.11.2012Examination requested  [2013/02]
22.03.2013Communication of intention to grant the patent
25.07.2013Fee for grant paid
25.07.2013Fee for publishing/printing paid
Parent application(s)   TooltipEP00932386.6  / EP1178817
Opposition(s)12.06.2014No opposition filed within time limit [2014/34]
Fees paidRenewal fee
31.01.2011Renewal fee patent year 03
31.01.2011Renewal fee patent year 04
31.01.2011Renewal fee patent year 05
31.01.2011Renewal fee patent year 06
31.01.2011Renewal fee patent year 07
31.01.2011Renewal fee patent year 08
31.01.2011Renewal fee patent year 09
31.01.2011Renewal fee patent year 10
31.01.2011Renewal fee patent year 11
02.11.2011Renewal fee patent year 12
29.03.2012Renewal fee patent year 13
10.05.2013Renewal fee patent year 14
Penalty fee
Additional fee for renewal fee
31.05.201112   M06   Fee paid on   02.11.2011
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY11.09.2013
FI11.09.2013
MC11.09.2013
GR12.12.2013
PT13.01.2014
[2015/09]
Former [2014/28]CY11.09.2013
FI11.09.2013
GR12.12.2013
PT13.01.2014
Former [2014/18]CY11.09.2013
FI11.09.2013
GR12.12.2013
Former [2014/12]CY31.07.2013
FI11.09.2013
GR12.12.2013
Former [2014/10]CY31.07.2013
Documents cited:Search[A]FR2717081  (CENTRE NAT RECH SCIENT [FR]) [A] 1,5-12 * page 3, line 3 - line 10 * * page 22, line 32 - line 33; sequence 4 *;
 [A]WO9823781  (UNIV JOHNS HOPKINS [US], et al) [A] 1-4,8-12 * abstract *;
 [X]WO9906551  (GENSET SA [FR], et al) [X] 1,5,6,8 * page 116, line 22 - page 117, line 4 * * page 12, line 17 - line 18; sequence 236 *;
 [XI]US5877282  (NADLER STEVEN G [US], et al) [X] 1-3,8-10,12 * page 8, paragraph 2 * * page 8, paragraph 4 * * page 8, paragraph 6; sequence 10 * * page 11, line 49 - page 12, line 52 * [I] 11;
 [XPI]WO9940189  (GENSET SA [FR], et al) [XP] 1-3,8 * page 5, line 3 - line 8; sequences 147, 172 * * page 7, line 24 - page 8, line 6 * [I] 9-12;
 [E]CA2273622  (TYMIANSKI MICHAEL [CA]) [E] 1-4,8-12 * abstract *;
 [T]WO2005068496  (TOOLGEN INC [KR], et al) [T] 11* sequences 7-8 *;
 [XD]  - "Glutamate receptor, ionotropic, N-methyl D-aspartate 2A [Homo sapiens]", PROTEIN, NCBI, (19990319), Database accession no. NP_000824.1, XP002659803 [XD] 1-4,8 * abstract *
 [AD]  - VIVES E ET AL, "A TRUNCATED HIV-1 TAT PROTEIN BASIC DOMAIN RAPIDLY TRANSLOCATES THROUGH THE PLASMA MEMBRANE AND ACCUMULATES IN THE CELL NUCLEUS", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC, US, (19970620), vol. 272, no. 25, doi:10.1074/JBC.272.25.16010, ISSN 0021-9258, pages 16010 - 16017, XP002940007 [AD] 11 * abstract * * page 16016, column 2, paragraph 5 *

DOI:   http://dx.doi.org/10.1074/jbc.272.25.16010
 [T]  - MORRIS M C ET AL, "A peptide carrier for the delivery of biologically active proteins into mammalian cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20011201), vol. 19, doi:10.1038/NBT1201-1173, ISSN 1087-0156, pages 1173 - 1176, XP002559236 [T] 1-4,8-12 * the whole document *

DOI:   http://dx.doi.org/10.1038/nbt1201-1173
Examination   - VIVES E ET AL, "TAT PEPTIDE INTERNALIZATION: SEEKING THE MECHANISM OF ENTRY", CURRENT PROTEIN AND PEPTIDE SCIENCE, BENTHAM SCIENCE PULBISHERS, NL, (20030401), vol. 4, no. 2, doi:10.2174/1389203033487306, ISSN 1389-2037, pages 125 - 132, XP001204952

DOI:   http://dx.doi.org/10.2174/1389203033487306
by applicantUS3817837
 US3850752
 US3939350
 US3996345
 US4108846
 US4215051
 US4235871
 US4275149
 US4277437
 US4318980
 US4366241
 US4501728
 US4603044
 US4837028
 US4925673
 US4946778
 US4957773
 US4980286
 WO9105058
 US5096815
 WO9206180
 WO9220316
 WO9222635
 US5198346
 US5223409
 WO9314188
 WO9320242
 WO9320221
 WO9418318
 US5422426
 US5612895
 WO9840508
 US5907030
 WO0010158
 WO0010156
 US6033884
 WO0020434
    - GOMPERTS ET AL., CELL, (1996), vol. 84, pages 659 - 662
    - SONGYANG ET AL., SCIENCE, (1997), vol. 275, page 73
    - DOYLE ET AL., CELL, (1996), vol. 88, pages 1067 - 1076
    - DOYLE, D. A., CELL, (1996), vol. 85, pages 1067 - 1076
    - "Chemistry and Biochemistry of Amino Acids, Peptides and Proteins", SPATOLA, A Peptide Backbone Modifications, MARCELL DEKKER, (1983), vol. 7, pages 267 - 357
    - NAGAI, TET. LETT., (1985), vol. 26, pages 647 - 650
    - FEIGL, J. AMER. CHEM. SOC., (1986), vol. 108, pages 181 - 182
    - KAHN, J. AMER. CHEM. SOC., (1988), vol. 110, pages 1638 - 1639
    - KEMP, TET. LETT., (1988), vol. 29, pages 5057 - 5060
    - KAHN, J. MOLEC. RECOGNITION, (1988), vol. 1, pages 75 - 79
    - SMITH, J. AMER. CHEM. SOC., (1992), vol. 114, pages 10672 - 10674
    - BEUSEN, BIOPOLYMERS, (1995), vol. 36, pages 181 - 200
    - BANERJEE, BIOPOLYMERS, (1996), vol. 39, pages 769 - 777
    - HIGGINS, J. PEPT. RES., (1997), vol. 50, pages 421 - 435
    - HRUBY, BIOPOLYMERS, (1997), vol. 43, pages 219 - 266
    - PEARSON, W.R.; LIPMAN, D.J., PROC. NATL. ACAD. SCI. U.S.A., (1988), vol. 85, page 2444
    - W. R. PEARSON, METHODS ENZYMOL., (1996), vol. 266, pages 227 - 258
    - SAMBROOK ET AL., MOLECULAR CLONING: A LABORATORY MANUAL, COLD SPRING HARBOR LABORATORY, (1989), vol. 1-3
    - CARUTHERS ET AL., NUCLEIC ACIDS RES. SYMP. SER., (1980), pages 215 - 223
    - HORN ET AL., NUCLEIC ACIDS RES. SYMP. SER., (1980), pages 225 - 232
    - ROBERGE ET AL., SCIENCE, (1995), vol. 269, page 202
    - GUY; FIELDS, METH. ENZ., (1997), vol. 289, pages 67 - 83
    - WELLINGS; ATHERTON, METH. ENZ., (1997), vol. 289, pages 44 - 67
    - DOYLE ET AL., CELL, (1996), vol. 85, page 1067
    - MARFATIA ET AL., J. BIOL. CHEM., (1997), vol. 272, page 24191
    - RABINOWITZ ET AL., IMMUNITY, (1998), vol. 9, page 699
    - PARMLEY; SMITH, ADV. EXP. MED. BIOL., (1989), vol. 251, pages 215 - 218
    - SCOTT; SMITH, SCIENCE, (1990), vol. 249, pages 386 - 390
    - FOWLKES ET AL., BIOTECHNIQUES, (1992), vol. 13, pages 422 - 427
    - OLDENBURG ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 5393 - 5397
    - YU ET AL., CELL, (1994), vol. 76, pages 933 - 945
    - STAUDT ET AL., SCIENCE, (1988), vol. 241, pages 577 - 580
    - BOCK ET AL., NATURE, (1992), vol. 355, pages 564 - 566
    - TUERK ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 6988 - 6992
    - ELLINGTON ET AL., NATURE, (1992), vol. 355, pages 850 - 852
    - REBAR; PABO, SCIENCE, (1993), vol. 263, pages 671 - 673
    - PARMLEY; SMITH, GENE, (1988), vol. 73, pages 305 - 318
    - FIELDS; SONG, NATURE, (1989), vol. 340, pages 245 - 246
    - CHIEN ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 9578 - 9582
    - FODOR ET AL., SCIENCE, (1991), vol. 251, pages 767 - 773
    - HOUGHTEN ET AL., NATURE, (1991), vol. 354, pages 84 - 86
    - LAM ET AL., NATURE, (1991), vol. 354, pages 82 - 84
    - MEDYNSKI, BIOLTECHNOLOGY, (1994), vol. 12, pages 709 - 710
    - GALLOP ET AL., J. MEDICINAL CHEMISTRY, (1994), vol. 37, no. 9, pages 1233 - 1251
    - OHLMEYER ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 1 0922 - 1 0926
    - ERB ET AL., PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 11422 - 11426
    - HOUGHTEN ET AL., BIOTECHRIIQUES, (1992), vol. 13, page 412
    - JAYAWICKREME ET AL., PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 1614 - 1618
    - SALMON ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 11708 - 11712
    - BRENNER; LERNER, PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 5381 - 5383
    - DEVLIN ET AL., SCIENCE, (1990), vol. 249, pages 404 - 406
    - CHRISTIAN, R.B. ET AL., J MOL. BIOL., (1992), vol. 227, pages 711 - 718
    - LENSTRA, J IMMUNOL. METH., (1992), vol. 152, pages 149 - 157
    - KAY ET AL., GENE, (1993), vol. 128, pages 59 - 65
    - MATTHEAKIS ET AL., PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 9022 - 9026
    - BUNIN ET AL., PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 4708 - 4712
    - SIMON ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 9367 - 9371
    - OSTRESH ET AL., PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 11138 - 11142
    - COHEN ET AL., J. CELL. BIOL., (1998), vol. 142, pages 129 - 138
    - GROOTJANS ET AL., PNAS, (1997), vol. 94, pages 13683 - 13688
    - HSUEH ET AL., J. CELL. BIOL., (1998), vol. 142, pages 139 - 151
    - SALOMON ET AL., BLOOD, (1997), vol. 89, pages 2461 - 2471
    - ST-PIERRE ET AL., EUR. J IMMUNOL., (1996), vol. 26, pages 2050 - 2055
    - BELL ET AL., INT. IMMUNOL., (1995), vol. 7, pages 1861 - 1871
    - PASLOSKE ET AL., ANN REV MED, (1994), vol. 45, page 283
    - OCKENHOUSE ET AL., J EXP. MED., (1992), vol. 176, page 1183
    - SOLEZK ET AL., KIDNEY INT., (1997), vol. 51, page 1476
    - TEDLA ET AL., CLIN. EXP. IMMUNOL., (1999), vol. 117, pages 92 - 99
    - KUSTERER ET AL., EXP CLIN ENDOCRINOL DIABETES, (1999), vol. 107, pages 102 - 107
    - BONOMINI ET AL., NEPHRON, (1998), vol. 79, page 399
    - SUASSUNA ET AL., KIDNEY INT., (1994), vol. 46, page 443
    - FERRI ET AL., HYPERTENSION, (1999), vol. 34, page 568
    - LEWIS; CAHALAN, ANN. REV. IMMUNOL., (1995), vol. 13, page 623
    - J. BIOL. CHEM., (1997), vol. 272, page 26899
    - SHIBUYA ET AL., IMMUNITY, (1999), vol. 11, pages 615 - 623
    - SHIBUYA ET AL., J. IMMUN., (1998), vol. 161, pages 1671 - 1676
    - HANADA ET AL., J BIOL CHEM, (1997), vol. 272, page 26899
    - ZHOU; TEDDER, J IMMUNOL., (1995), vol. 154, pages 3821 - 3835
    - ZHOU ET AL., J. IMMUNOL., (1992), vol. 149, pages 735 - 742
    - CZERNIECKI ET AL., J. IMMUNOL., (1997), vol. 159, pages 3823 - 3837
    - BAJORATH, PROTEINS, (2000), vol. 39, pages 103 - 111
    - TAHER ET AL., J BIOL. CHEM., (1996), vol. 271, pages 2863 - 2867
    - ARUFFO, J CLIN. INVEST, (1996), vol. 98, pages 2191 - 2192
    - EICHLER ET AL., SCAND. J IMMUNOL., (1994), vol. 39, pages 111 - 115
    - PICKL ET AL., LEUKOCYTE TYPING, (1995), vol. V, pages 1151 - 1153
    - LE VAN KIM ET AL., J BIOL. CHEM., (1989), vol. 264, pages 20407 - 20414
    - MARFATIA ET AL., J BIOL. CHEM., (1997), vol. 272, pages 24191 - 24197
    - REID ET AL., BLOOD, (1987), vol. 69, pages 1068 - 1072
    - AHUJA, SK; AND MURPHY, J BIOL CHEM, (1996), vol. 271, pages 20545 - 50
    - WEISS; LITTMAN, CELL, (1994), vol. 76, pages 263 - 274
    - LISZEWSKI ET AL., ADV. IMMUNOL., (1999), vol. 61, pages 201 - 283
    - MANCHESTER ET AL., PROC. NATL ACAD. SCI. USA, (1994), vol. 91, page 2161
    - OKADA ET AL., PROC. NATL ACAD. SCI. USA, (1995), vol. 92, pages 2489 - 2493
    - JURIANZ ET AL., MOL IMMUNOL, (1999), vol. 36, pages 929 - 939
    - AHUJA, SK; MURPHY, PM., J BIOL CHEM, (1996), vol. 271, pages 20545 - 50
    - NAGASE, DNA RES, (1996), vol. 3, pages 321 - 329
    - NISHIHARA, H., HOKKAIDO IGAKU ZASSHI, (1999), vol. 74, page 157
    - TURNER, H., NATURE, (1999), vol. 402, page B24
    - TAKATSU ET AL., ADV. IMMUNOL., (1994), vol. 57, pages 145 - 190
    - DOBNER ET AL., EUR J IMMUNOL., (1992), vol. 22, pages 2795 - 2799
    - FLYNN ET AL., J EXP. MED., (1998), vol. 188, pages 297 - 304
    - FORSTER ET AL., CELL, (1996), vol. 87, pages 1037 - 1047
    - GUNN ET AL., NATURE, (1998), vol. 391, pages 799 - 803
    - FORSTER ET AL., CELL MOL BIOL, (1994), vol. 40, pages 381 - 387
    - GEE ET AL., JBIOLOGICAL CHEM., (1998), vol. 273, pages 21980 - 87
    - KOZLOV ET AL., BIOCHEMISTRY, (2000), vol. 39, page 2572
    - YANAGISAWA ET AL., J. BIOL. CHEM., (1997), vol. 272, page 8539
    - VIDAL ET AL., J. IMMUNOL., (1999), vol. 163, page 4811
    - Organic Syntheses Collective, JOHN WILEY & SONS, INC.
    - AL-OBEIDI, MOL. BIOTECHNOL., (1998), vol. 9, pages 205 - 223
    - HRUBY, CURR. OPIN. CHEM. BIOL., (1997), vol. 1, pages 114 - 119
    - OSTERGAARD, MOL. DIVERS., (1997), vol. 3, pages 17 - 27
    - OSTRESH, METHODS ENZYMOL., (1996), vol. 267, pages 220 - 234
    - BRISSON ET AL., NATURE, (1984), vol. 310, pages 511 - 514
    - TAKAMATSU ET AL., EMBO J., (1987), vol. 6, pages 307 - 311
    - CORUZZI ET AL., EMBO J., (1984), vol. 3, pages 1671 - 1680
    - BROGLIE ET AL., SCIENCE, (1984), vol. 224, pages 838 - 843
    - GURLEY, MOL. CELL. BIOL., (1986), vol. 6, pages 559 - 565
    - WEISSBACH; WEISSBACH, Methods for Plant Molecular Biology, ACADEMIC PRESS, (1988), pages 421 - 463
    - SMITH ET AL., J. VIROL., (1983), vol. 46, page 584
    - Current Protocols in Molecular Biology, GREENE PUBLISH. ASSOC. & WILEY INTERSCIENCE, vol. 2
    - LOGAN; SHENK, PROC. NATL. ACAD. SCI. USA, (1984), vol. 81, pages 3655 - 3659
    - MACKETT ET AL., PROC. NATL. ACAD. SCI. USA, (1982), vol. 79, pages 7415 - 7419
    - MACKETT ET AL., J. VIROL., (1984), vol. 49, pages 857 - 864
    - PANICALI ET AL., PROC. NATL. ACAD. SCI. USA, (1982), vol. 79, pages 4927 - 4931
    - KOEHLER; MILSTEIN, NATURE, (1975), vol. 256, pages 495 - 497
    - KOSBOR ET AL., IMMUNOLOGY TODAY, (1983), vol. 4, page 72
    - COTE, PROC. NATL. ACAD. SCI. U.S.A., (1983), vol. 80, pages 2026 - 2030
    - COLE ET AL., Monoclonal Antibodies and Cancer Therapy, ALAN R. LISS, INC., (1985), pages 77 - 96
    - MORRISON ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1984), vol. 81, pages 6851 - 6855
    - NEUBERGER ET AL., NATURE, (1984), vol. 312, pages 604 - 608
    - TAKEDA ET AL., NATURE, (1985), vol. 314, pages 452 - 454
    - HUSE ET AL., SCIENCE, (1989), vol. 246, pages 1275 - 1281
    - METHODS ENZYMOLOGY: IMMUNOAFFINITY CHROMATOGRAPHY OF PROTEINS, vol. 34, pages 723 - 731
    - WINDHAGEN A ET AL., IMMUNITY, (1995), vol. 2, no. 4, pages 373 - 80
    - HARDING ET AL., PROC. NATL. ACAD. SCI., (1989), vol. 86, pages 4230 - 4
    - SIRAGANIAN ET AL., TIPS, (1983), vol. 4, pages 432 - 437
    - PETERS ET AL., BLOOD, (1988), vol. 72, pages 1310 - 5
    - LANZAVECCHIA, A. ET AL., EUR. J. IMMUN., (1983), vol. 13, pages 733 - 738
    - J. BIOL. CHEM., (1997), vol. 272, no. 23, pages 14562 - 14570
    - MCCONNELL, H.M. ET AL., SCIENCE, (1992), vol. 257, pages 1906 - 1912
    - MCCONNELL, H.M., PROC. NATL. ACAD. SCI., (1995), vol. 92, pages 2750 - 2754
    - MISHELL, B. B.; S. M. SHIIGI, Selected Methods in Cellular Immunology, W. H. FREEMAN AND COMPANY, (1980), vol. 194, page 93
    - DUTTON, R. W.; PEARCE, J. D., NATURE, (1962), vol. 194, page 93
    - BARLTROP, J.A. ET AL., BIOORG. & MED. CHEM. LETT., (1991), vol. 1, page 611
    - MOSMANN, T., J. IMMUNOL. METHODS, (1983), vol. 65, page 55
    - GRATZNER, H.G., SCIENCE, (1982), vol. 218, pages 474 - 475
    - VERMES, 1., J. IMMUNOL. METHODS., (1995), vol. 180, pages 39 - 52
    - CELL, (1998), vol. 93, pages 851 - 861
    - MCB, (1996), vol. 12, pages 7151 - 7160
    - FULMER ET AL., AM. J ANAT., (1963), vol. 113, page 273
    - JOCKUSCH ET AL., EXP. NEUROL., (1983), vol. 81, page 749
    - "Measuring Cell Degranulation", BERGER ET AL., Immunology Method Manual, ACADEMIC PRESS, LTD., (1997), pages 1436 - 1440
    - SIRAGANIAN, "Histamine Secretion from Mast Cells and Basophil", TIPS, (1983), vol. 4, pages 432 - 437
    - ROBBINS ET AL., CELL, (1991), vol. 64, page 615
    - BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426
    - HUSTON ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1988), vol. 85, pages 5979 - 5883
    - CHAUDHARY ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1990), vol. 87, pages 1066 - 1070
    - DEROSSI ET AL., TRENDS IN CELL BIOL., (1998), vol. 8, page 84
    - VIVES ET AL., J BIOL. CHEM., (1997), vol. 272, page 16010
    - NAGAHARA ET AL., NAT. MED., (1998), vol. 4, page 1449
    - DEROSSI ET AL., J BIOL. CHEM., (1994), vol. 261, page 10444
    - ELLIOT; D'HARE, CELL, (1997), vol. 88, pages 223 - 233
    - AVRAMEAS ET AL., PROC. NATL ACAD. SCI. U.S.A., (1998), vol. 95, pages 5601 - 5606
    - FUJIHARA, EMBO J, (1999), vol. 18, pages 411 - 419
    - POOGA ET AL., FASEB J., (1998), vol. 12, pages 67 - 77
    - SZOKA ET AL., ANN. REV. BIOPHYS. BIOENG., (1980), vol. 9, page 467
    - GOLDSPIEL ET AL., CLINICAL PHARMACY, (1993), vol. 12, pages 488 - 505
    - WU; WU, BIOTHERAPY, (1991), vol. 3, pages 87 - 95
    - TOLSTOSHEV, ANN. REV. PHARMACOL. TOXICOL., (1993), vol. 32, pages 573 - 596
    - MULLIGAN, SCIENCE, (1993), vol. 260, pages 926 - 932
    - MORGAN; ANDERSON, ANN. REV. BIOCHEM., (1993), vol. 62, pages 191 - 217
    - MAY, TIBTECH, (1993), vol. 11, no. 5, pages 155 - 215
    - KOLLER; SMITHIES, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 8932 - 8935
    - ZIJLSTRA ET AL., NATURE, (1989), vol. 342, pages 435 - 438
    - WU; WU, J. BIOL. CHEM., (1987), vol. 262, pages 4429 - 4432
    - KOZARSKY; WILSON, CURRENT OPINION IN GENETICS AND DEVELOPMENT, (1993), vol. 3, pages 499 - 503
    - ROSENFELD ET AL., SCIENCE, (1991), vol. 252, pages 431 - 434
    - ROSENFELD ET AL., CELL, (1992), vol. 68, pages 143 - 155
    - MASTRANGELI ET AL., J. CLIN. INVEST., (1993), vol. 91, pages 225 - 234
    - WALSH ET AL., PROC. SOC. EXP. BIOL. MED., (1993), vol. 204, pages 289 - 300
    - MILLER ET AL., METH. ENZYMOL., (1993), vol. 217, pages 581 - 599
    - BOESEN ET AL., BIOTHERAPY, (1994), vol. 6, pages 291 - 302
    - CLOWES ET AL., J. CLIN. INVEST., (1994), vol. 93, pages 644 - 651
    - KIEM ET AL., BLOOD, (1994), vol. 83, pages 1467 - 1473
    - SALMONS; GUNZBERG, HUMAN GENE THERAPY, (1993), vol. 4, pages 129 - 141
    - GROSSMAN; WILSON, CURR. OPIN. IN GENETICS AND DEVEL., (1993), vol. 3, pages 110 - 114
    - LOEFFLER; BEHR, METH. ENZYMOL., (1993), vol. 217, pages 599 - 618
    - COHEN ET AL., METH. ENZYMOL., (1993), vol. 217, pages 618 - 644
    - CLINE, PHARMAC. THER., (1985), vol. 29, pages 69 - 92
    - FINGL ET AL., The Pharmacological Basis of Therapeutics, (1975), page 1
    - RABINOWITZ ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1997), vol. 94, pages 8702 - 8707
 WO1999US22996
 US20000547276
 US20000196527
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.