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EP About this file: EP2468269

EP2468269 - Nitric oxide donors in therapy of nitric oxide deficiency-induced disturbances of cerebral microcirculation [Right-click to bookmark this link]
Status	The application has been refused Status updated on 19.10.2012 Database last updated on 24.04.2024
Most recent event Tooltip	19.10.2012	Refusal of application	published on 21.11.2012 [2012/47]
Applicant(s)	For all designated states Universitätsklinikum Münster Domagkstrasse 5 48149 Münster / DE
	[2012/26]
Representative(s)	Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB Ganghoferstraße 68 B 80339 München / DE
	[N/P]
Former [2012/26]	Schiweck, Weinzierl & Koch European Patent Attorneys Landsberger Straße 98 80339 München / DE
Application number, filing date	10192669.9	26.11.2010
	[2012/26]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP2468269
	Date:	27.06.2012
	Language:	EN
	[2012/26]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	28.04.2011
Classification	IPC:	A61K31/00, A61K31/4245, A61K31/454, A61K31/5377, A61K31/541, A61P9/10	[2012/26]
	CPC:	A61K31/4245 (EP,US); C07D271/04 (EP,US); A61K31/454 (EP,US); A61K31/5377 (EP,US); A61K31/541 (EP,US); A61P9/10 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/26]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	Nitridoxidspender bei der Behandlung von Nitridoxidmangel-induzierten Störungen der Hirnmikrozirkulation	[2012/26]
	English:	Nitric oxide donors in therapy of nitric oxide deficiency-induced disturbances of cerebral microcirculation	[2012/26]
	French:	Donneurs d'oxyde nitrique pour la thérapie des perturbations induites par une déficience d'oxyde nitrique de la microcirculation cérébrale	[2012/26]
Examination procedure	04.07.2012	Despatch of communication that the application is refused, reason: Examination on filing A.90(5) [2012/47]
	14.07.2012	Application refused, date of legal effect [2012/47]
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XI]WO9918949 (UNIV JEFFERSON [US], et al) [X] 1,10-14 * page 4, line 17 - page 5, line 2 * * page 11, line 23 - page 12, line 2 * * examples 2-3 * * claims 1-3,8-11 * [I] 15;
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		[XI] - YAMAMOTO S ET AL, "Subarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries.", BRAIN RESEARCH 16 MAY 1997 LNKD- PUBMED:9200492, (19970516), vol. 757, no. 1, ISSN 0006-8993, pages 1 - 9, XP002632927 [X] 1-14 * abstract * * page 5 * * figure 3 * [I] 15
		[A] - MEGSON I L, "NITRIC OXIDE DONOR DRUGS", DRUGS OF THE FUTURE, PROUS SCIENCE, ES, (20000101), vol. 25, no. 7, doi:10.1358/DOF.2000.025.07.858691, ISSN 0377-8282, pages 701 - 715, XP008018362 [A] 1-15 * page 703, column r, paragraph l - page 704, column l, paragraph 1; figure 3 * DOI: http://dx.doi.org/10.1358/dof.2000.025.07.858691
		[XI] - VAJKOCZY P ET AL, "Intrathecal sodium nitroprusside improves cerebral blood flow and oxygenation in refractory cerebral vasospasm and ischemia in humans", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, (20000501), vol. 31, no. 5, ISSN 0039-2499, pages 1195 - 1197, XP008135441 [X] 1,10-14 * the whole document * [I] 15
		[XI] - RAABE ANDREAS ET AL, "Effect of intraventricular sodium nitroprusside on cerebral hemodynamics and oxygenation in poor-grade aneurysm patients with severe, medically refractory vasospasm", NEUROSURGERY, WILLIAMS & WILKINS, BALTIMORE, MD, US, (20020501), vol. 50, no. 5, ISSN 0148-396X, pages 1006 - 1014, XP008135440 [X] 1,10-14 * the whole document * [I] 15
		[XI] - HÄNGGI D ET AL, "Nitric oxide in subarachnoid haemorrhage and its therapeutics implications", ACTA NEUROCHIRURGICA ; THE EUROPEAN JOURNAL OF NEUROSURGERY, SPRINGER-VERLAG, VI, (20060315), vol. 148, no. 6, doi:10.1007/S00701-005-0721-1, ISSN 0942-0940, pages 605 - 613, XP019430322 [X] 1,10-14 * abstract * * page 609, column l, paragraph 2 - page 611, column l, paragraph l * [I] 15 DOI: http://dx.doi.org/10.1007/s00701-005-0721-1
		[XI] - PLUTA R M ET AL, "Analysis of nitric oxide (NO) in cerebral vasospasm after aneursymal bleeding", REVIEWS ON RECENT CLINICAL TRIALS, BENTHAM SCIENCE PUBLISHERS, NL, vol. 2, no. 1, ISSN 1574-8871, (20070101), pages 59 - 67, XP008135437 [X] 1,10-14 * the whole document * [I] 15
		[A] - OHKUMA H ET AL, "Impact of cerebral microcirculatory changes on cerebral blood flow during cerebral vasospasm after aneurysmal subarachnoid hemorrhage.", STROKE; A JOURNAL OF CEREBRAL CIRCULATION JUL 2000 LNKD- PUBMED:10884463, (200007), vol. 31, no. 7, ISSN 0039-2499, pages 1621 - 1627, XP002632928 [A] 1-15 * abstract *
	by applicant	US4962091
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		US6359182
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