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Extract from the Register of European Patents

EP About this file: EP2468741

EP2468741 - Novel quercetin derivatives, their preparation, pharmaceutical compositions containing them and their use [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  07.06.2013
Database last updated on 14.09.2024
Most recent event   Tooltip07.06.2013Application deemed to be withdrawnpublished on 10.07.2013  [2013/28]
Applicant(s)For all designated states
Bel/Novamann International s.r.o.
Továrenská 14
811 09 Bratislava / SK
[2012/26]
Inventor(s)01 / Veverková, Eva
J. Smerka 26
841 08 Bratislava / SK
02 / Veverka, Miroslav
J. Smerka 26
841 08 Bratislava / SK
03 / Svajdlenka, Emil
Okruzni 657
763 21 Slavicin / CZ
04 / Ratkovska, L'ubica
Zeleznicná 368/4
920 01 Hlohovec / SK
05 / Vodny, Stefan
Pod záhradami 62
841 02 Bratislava / SK
 [2012/26]
Representative(s)Zakova, Anna, et al
ROTT, RUZICKA & GUTTMANN, v.o.s.
Patent, Trademark and Law Offices
Pionierska 15
831 02 Bratislava / SK
[2012/26]
Application number, filing date10474003.016.12.2010
[2012/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2468741
Date:27.06.2012
Language:EN
[2012/26]
Search report(s)(Supplementary) European search report - dispatched on:EP27.05.2011
ClassificationIPC:C07D311/62, C07D493/04, A61K31/352, A61K31/357, A61P29/00
[2012/26]
CPC:
C07D493/04 (EP); A61P29/00 (EP); C07D311/62 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/26]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:Neue Quercetin Derivate, ihr Herstellungsverfahren, die pharmazeutischen Zusammensetzungen, die sie enthalten und ihre Verwendung[2012/26]
English:Novel quercetin derivatives, their preparation, pharmaceutical compositions containing them and their use[2012/26]
French:Nouveaux dérivés de quercetin, leur procédé de préparation, les compositions pharmaceutiques qui les contiennent et leur utilisation[2012/26]
Examination procedure03.01.2013Application deemed to be withdrawn, date of legal effect  [2013/28]
12.02.2013Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2013/28]
Fees paidPenalty fee
Additional fee for renewal fee
31.12.201203   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XDI]US6235294  (PERRIER ERIC [FR], et al) [XD] 1 * column 4, line 3 - column 5, line 27 * * column 5, line 63 - column 6, line 21; examples 1-5,30 * [I] 1,11-13;
 [XI]WO9966062  (CONSIGLIO NAZIONALE RICERCHE [IT], et al) [X] 1 * example on pages 8 and 9, table on page 10;; claims 1-3,11,22 * [I] 13;
 [X]WO2004084886  (UNIV DO PORTO [PT], et al) [X] 1,11-13 * pages 9,10; claims 1,2,4,8 *;
 [XDI]US2002106338  (PFLUECKER FRANK [DE], et al) [XD] 1 * Example 4 on page 10 Example 7 on page 12;; claim 1, * [I] 11-13;
 [XI]GB1409149  (CORTIAL) [X] 1,3-6,8 * examples 1,2 * [I] 9;
 [X]US6210701  (DARLAND GARY K [US], et al) [X] 1,11-13 * example 2; claims 1,2,9,14,15; tables 1,8 *;
 [X]FR2088127  (BIOSEDRA LAB) [X] 1,11,12 * the whole document *;
 [XD]US6258840  (GOLDING BERNARD THOMAS [GB], et al) [XD] 1 * Four compounds in the beginning of the reaction scheme in columns 5 and 6.; columns 5,6 *;
 [X]US2892846  (LEONARD JURD, et al) [X] 1 * column 1, line 0 - column 2, line 35; example 1 *;
 [X]WO9813359  (MARIGEN SA [CH], et al) [X] 1 * Compounds on page 19, lines 7 and 8.; pages 18,19 *;
 [X]US6028088  (PERSHADSINGH HARRIHAR A [US], et al) [X] 1 * compound 26 on Figure 6 *;
 [X]  - TAKIZAWA ET AL, "Antioxidative effect and oxidation of quercetin derivatives in lipids", INTERNATIONAL CONGRESS SERIES, EXCERPTA MEDICA, AMSTERDAM, NL, (19920101), vol. 998, ISSN 0531-5131, pages 749 - 752, XP009116598 [X] 1 * the whole document *
 [X]  - SAIJA A ET AL, "'In vitro' antioxidant and photoprotective properties and interaction with model membranes of three new quercetin esters", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, (20030901), vol. 56, no. 2, doi:10.1016/S0939-6411(03)00101-2, ISSN 0939-6411, pages 167 - 174, XP004453349 [X] 1 * page 173, column 2; figure 1 *

DOI:   http://dx.doi.org/10.1016/S0939-6411(03)00101-2
 [XD]  - GULSEN ET AL, "Biomimetic oxidation of quercetin: Isolation of a naturally occurring quercetin heterodimer and evaluation of its in vitro antioxidant properties", FOOD RESEARCH INTERNATIONAL, ELSEVIER APPLIED SCIENCE, BARKING, GB, (20061115), vol. 40, no. 1, doi:10.1016/J.FOODRES.2006.07.009, ISSN 0963-9969, pages 7 - 14, XP005764693 [XD] 1,2,9 * page 8, paragraphs 2.2.,2.7. * * page 12, column 2, paragraph 2; figure 3 *

DOI:   http://dx.doi.org/10.1016/j.foodres.2006.07.009
 [XD]  - KRISHNAMACHARI V ET AL, "Flavonoid oxidation by the radical generator AIBN: a unified mechanism for quercetin radical scavenging", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20020717), vol. 50, no. 15, doi:10.1021/JF020045E, ISSN 0021-8561, pages 4357 - 4363, XP002966878 [XD] 1,2 * compounds (1) and (3) on page 4358;; figure 1 *

DOI:   http://dx.doi.org/10.1021/jf020045e
 [XD]  - BOUKTAIB M ET AL, "Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20021209), vol. 58, no. 50, doi:10.1016/S0040-4020(02)01306-6, ISSN 0040-4020, pages 10001 - 10009, XP004395560 [XD] 1 * compounds 1, 2 and 3 in Scheme 1 on page 10003. *

DOI:   http://dx.doi.org/10.1016/S0040-4020(02)01306-6
 [X]  - LIAN G ET AL, "Synthesis of fructofuranosides: efficient glycosylation with N-phenyltrifluoroacetimidate as the leaving group", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 343, no. 17, doi:10.1016/J.CARRES.2008.09.001, ISSN 0008-6215, (20081124), pages 2992 - 2996, (20080909), XP025561371 [X] 1 * compound 4e on page 2993 *

DOI:   http://dx.doi.org/10.1016/j.carres.2008.09.001
 [X]  - JERZMANOWSKA ZOFIA ET AL, "Polyhydroxyflavone esters. II. Esters of 3',4'-dihydroxyflavone and quercetin", ROCZNIKI CHEMII ANNALES SOCIETATIS CHIMICAE POLONORUM, WARSZAWA : NAKLADEM POLSKIEGO TOWARZYSTWA CHEMICZNEGO, PL, (19690101), vol. 43, no. 6, ISSN 0035-7677, pages 1179 - 1185, XP009147728 [X] 1 * compound 3 in table given on page 1181; page 1179, paragraph 1 * * page 1183, paragraph 4 *
 [X]  - LEVASHOVA I G ET AL, "Reactivity of carbonyl derivatives of phenyl- and diphenylpropane. I. Kinetics of oxime formation from derivatives of furanochromone, dihydroflavanone, and chalcone", HIMIA PRIRODNYH SOEDINENIJ, FAN, TASKENT, UZ, (19870101), no. 1, ISSN 0023-1150, pages 70 - 76, XP009147729 [X] 1 * Quercetin group on page 72 *
 [XD]  - MATTAREI ET ALL, "Regioselective O-Derivatization of Quercetin via Ester Intermediates. An improved Synthesis of Rhamnetin and Development of a New Mitochondriotropic Derivative", MOLECULES, (20100706), vol. 15, ISSN 1420-3049, pages 4722 - 4736, XP002635413 [XD] 1 * compounds 1, 2 a-d, 3 a-d and 4 in Schemes 1 and 2; page 4723, paragraph 4 *

DOI:   http://dx.doi.org/10.3390/MOLECULES15074722
 [XI]  - SUBBAN ET ALL, "Two new flavonoids from Centella asiatica (Linn.)", JOURNAL OF NATURAL MEDICINE, (2008), vol. 62, doi:10.1007/s11418-008-0229-0, pages 369 - 373, XP002635414 [X] 1 * page 371, column 1, paragraph 4; figure 1; table 2 * [I] 1,13

DOI:   http://dx.doi.org/10.1007/S11418-008-0229-0
 [XD]  - JURD LEONARD, "Plant Polyphenols. V. Selective Alkylation of the 7-Hydroxyl Group in Polyhydroxyflavones", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (1958), vol. 80, no. 20, pages 5531 - 5536, XP002635415 [XD] 1 * compound entries 1,3,5,7,10-12 in Table I on page 5532, Experimental section on pages 5535 and 5536 *

DOI:   http://dx.doi.org/10.1021/ja01553a054
by applicantWO0121164
 US3420815
 US4202815
 US5955100
 US6258840
 US6235294
 US2002106338
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    - J. MED. CHEM., (2005), vol. 48, no. 8, pages 2790 - 2804
    - MOLECULES, (2010), vol. 15, page 4722
    - TETRAHEDRON, (2002), vol. 58, page 10001
    - J. AGRIC FOOD CHEM., (2002), vol. 50, page 4357
    - CHEM. NAT. COMPDS., (2008), vol. 44, no. 4, page 427
    - CHEM. NAT. COMPDS., (2007), vol. 43, no. 3
    - FOOD RES. INT., (2007), vol. 40, no. 1, page 7
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    - J. AMER. CHEM. SOC., (1958), vol. 20, page 5531
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    - J. ORG. CHEM., (1962), vol. 27, page 1294
    - J. MED. CHEM., (2007), vol. 50, page 241
    - HOUBEN-WEYL, Methoden der organischen Chemie, GEORG THIEME VERLAG
    - CARBOHYDR. RES., (1992), vol. 229, page 183
    - J AMER. CHEM. SOC., (1958), vol. 20, page 5531
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.