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Extract from the Register of European Patents

EP About this file: EP2398791

EP2398791 - INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  06.03.2015
Database last updated on 12.07.2024
Most recent event   Tooltip06.03.2015Application deemed to be withdrawnpublished on 08.04.2015  [2015/15]
Applicant(s)For all designated states
Amgen, Inc
One Amgen Center Drive
Thousand Oaks, CA 91320-1799 / US
[2011/52]
Inventor(s)01 / BOEZIO, Alessandro
54 Myrtle Street
Unit 1
Somerville, MA 02145 / US
02 / CHENG, Alan, C.
122 Stillings Avenue
San Francisco, CA 94131 / US
03 / COATS, James, R.
418 Oak Street
Somerville Massachusetts 02143 / US
04 / COPELAND, Katrina, W.
17 Oakridge Road
Sudbury Massachusetts 01776 / US
05 / GRACEFFA, Russell
2 Wingate Street
Hampton New Hampshire 03842 / US
06 / HARMANGE, Jean-Christophe
57 William Street
Andover Massachusetts 01810 / US
07 / HUANG, Hongbing
11 Rockville Avenue
Lexington Massachusetts 02421 / US
08 / LA, Daniel
124 Park Street
3
Brookline Massachusetts 02446 / US
09 / OLIVIERI, Philip, R.
27 Parker St. Unit 1
Charlestown Massachusetts 02129 / US
10 / PETERSON, Emily, A.
60 Fairfield Street Apt. 3
Cambridge Massachusetts 02140 / US
11 / SCHENKEL, Laurie
10 Bowdoin Street
508
Boston
Massachusetts 02114 / US
 [2012/12]
Former [2011/52]01 / BOEZIO, Alessandro
54 Myrtle Street
Unit 1
Somerville, MA 02145 / US
02 / CHENG, Alan, C.
334 Harvard Street, A6
Cambridge, Massachusetts 02139 / US
03 / COATS, James, R.
418 Oak Street
Somerville Massachusetts 02143 / US
04 / COPELAND, Katrina, W.
17 Oakridge Road
Sudbury Massachusetts 01776 / US
05 / GRACEFFA, Russell
2 Wingate Street
Hampton New Hampshire 03842 / US
06 / HARMANGE, Jean-Christophe
57 William Street
Andover Massachusetts 01810 / US
07 / HUANG, Hongbing
11 Rockville Avenue
Lexington Massachusetts 02421 / US
08 / LA, Daniel
124 Park Street
3
Brookline Massachusetts 02446 / US
09 / OLIVIERI, Philip, R.
27 Parker St. Unit 1
Charlestown Massachusetts 02129 / US
10 / PETERSON, Emily, A.
60 Fairfield Street Apt. 3
Cambridge Massachusetts 02140 / US
11 / SCHENKEL, Laurie
10 Bowdoin Street
508
Boston
Massachusetts 02114 / US
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
[N/P]
Former [2012/24]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Former [2011/52]Wiedemann, Peter
Hoffmann - Eitle Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
Application number, filing date10704074.310.02.2010
WO2010US23764
Priority number, dateUS20090153580P18.02.2009         Original published format: US 153580 P
[2011/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010096314
Date:26.08.2010
Language:EN
[2010/34]
Type: A1 Application with search report 
No.:EP2398791
Date:28.12.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 26.08.2010 takes the place of the publication of the European patent application.
[2011/52]
Search report(s)International search report - published on:EP26.08.2010
ClassificationIPC:C07D401/14, C07D403/04, C07D403/14, C07D405/14, C07D409/14, C07D413/14, C07D417/14, A61K31/53, A61K31/506, A61K31/5355, A61P35/00
[2011/52]
CPC:
C07D403/14 (EP,US); A61P35/00 (EP); A61P43/00 (EP);
C07D401/14 (EP,US); C07D403/04 (EP,US); C07D405/14 (EP,US);
C07D409/14 (EP,US); C07D413/14 (EP,US); C07D417/14 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2011/52]
Extension statesAL09.09.2011
BA09.09.2011
RS09.09.2011
TitleGerman:INDOL/BENZIMIDAZOLVERBINDUNGEN ALS MTOR-KINASE-INHIBITOREN[2011/52]
English:INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS[2011/52]
French:COMPOSÉS D'INDOLE OU BENZIMIDAZOLE CONVENANT COMME INHIBITEURS DE LA KINASE MTOR[2011/52]
Entry into regional phase09.09.2011National basic fee paid 
09.09.2011Designation fee(s) paid 
09.09.2011Examination fee paid 
Examination procedure09.09.2011Examination requested  [2011/52]
27.04.2012Amendment by applicant (claims and/or description)
11.10.2012Despatch of a communication from the examining division (Time limit: M06)
11.04.2013Reply to a communication from the examining division
20.08.2014Despatch of a communication from the examining division (Time limit: M02)
31.10.2014Application deemed to be withdrawn, date of legal effect  [2015/15]
01.12.2014Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2015/15]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  11.10.2012
Fees paidRenewal fee
15.02.2012Renewal fee patent year 03
12.02.2013Renewal fee patent year 04
12.02.2014Renewal fee patent year 05
11.02.2015Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[XAI]WO2007005673  (IRM LLC [US], et al) [X] 1-3,5,8,18-20 * claim 1 * * claim 5 and examples * * pages 4 and 20 * [A] 4 [I] 6,7,9-17;
 [XI]US2004116388  (ARMISTEAD DAVID M [US], et al) [X] 1-3,5-11,18-20 * claims 1, 17 * * pages 2 and 14 * * page 55 - page 214; compounds 336, 375-377, 381-388, 390, 397-402, 404, 406, 415 * [I] 4,12-17;
 [XAI]WO02083654  (AMGEN INC [US]) [X] 1-3,5,8,18-20 * page 7 * * page 108; example 1 * * page 119 - page 120; table 2; compounds 84-102, 105-109, 112-114, 116 * [A] 4 [I] 6,7,9-17;
 [XAI]WO2005042518  (AMGEN INC [US], et al) [X] 1,4,5,8,18-20 * Claim 9 and examples 1-3 and 5-12 * * page 3 - page 4 * * claim 1 * [A] 2,3 [I] 6,7,9-17;
 [XA]EP1418175  (JANSSEN PHARMACEUTICA NV [BE]) [X] 1-3,18,19 * page 61; compound 42 * [A] 4-17,20;
 [XA]JPS6233158  (SHIONOGI & CO) [X] 1-3,5,18,19 * page 479 * [A] 4,6-17,20;
 [Y]WO2008032036  (ASTRAZENECA AB [SE], et al) [Y] 1-20 * the whole document *;
 [A]US2005065179  (POITOUT LYDIE [FR], et al) [A] 1-20 * page 88 - page 112; compounds 163, 164, 184, 235-238 *;
 [A]US2005049290  (POITOUT LYDIE [FR], et al) [A] 1-20 * page 142; compounds 408-409 *;
 [XAI]  - MARTIN ET AL., "Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity", JOURNAL OF MEDICINAL CHEMISTRY, (20080216), vol. 51, pages 1637 - 1648, XP002585275 [X] 1-3,5,18,19 * figure 1 * [A] 4,6-17 [I] 20

DOI:   http://dx.doi.org/10.1021/JM701095M
 [XA]  - ZHANG G ET AL, "Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2008.08.104, vol. 18, no. 20, ISSN 0960-894X, (20081015), pages 5618 - 5621, (20080831), XP025519200 [X] 1-3,5,18,19 * schemes 1 and 2 * [A] 4,6-17,20

DOI:   http://dx.doi.org/10.1016/j.bmcl.2008.08.104
 [Y]  - DING H ET AL, "Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2005.07.050, vol. 15, no. 21, ISSN 0960-894X, (20051101), pages 4799 - 4802, (20051101), XP025313930 [Y] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2005.07.050
 [A]  - POITOUT ET AL, "Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2007.06.010, (20070717), vol. 17, no. 16, ISSN 0960-894X, pages 4464 - 4470, XP022181848 [A] 1-20 * page 4467; compound (5m) *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2007.06.010
 [A]  - YAPING H ET AL, "Remarkably Selective Palladium-Catalyzed Amination Process: Rapid Assembly of Multiamino Based Structures", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/S0040-4039(98)00517-6, (19980514), vol. 39, no. 20, ISSN 0040-4039, pages 3121 - 3124, XP004116209 [A] 1-20 * page 3123; compound 17 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(98)00517-6
 [XPA]  - ZHANG G ET AL, "Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2009.09.123, vol. 19, no. 23, ISSN 0960-894X, (20091201), pages 6691 - 6695, (20091012), XP026736085 [XP] 1-3,5,18-20 * the whole document * [A] 4,6-17

DOI:   http://dx.doi.org/10.1016/j.bmcl.2009.09.123
by applicantUS4107288
 US5145684
    - FIESER; FIESER'S, Reagents for Organic Synthesis, JOHN WILEY AND SONS, (1991), vol. 1-17
    - Rodd's Chemistry of Carbon Compounds, ELSEVIER SCIENCE PUBLISHERS, (1989), vol. 1-5
    - Organic Reactions, JOHN WILEY AND SONS, (1991), vol. 1-40
    - March's Advanced Organic Chemistry, JOHN WILEY AND SONS
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.