Extract from the Register of European Patents

EP About this file: EP2401364

EP2401364 - DIFFERENTIATION OF PLURIPOTENT CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.02.2016
Database last updated on 11.04.2026
Most recent event   Tooltip17.08.2018Lapse of the patent in a contracting state
New state(s): BG
published on 19.09.2018  [2018/38]
Applicant(s)For all designated states
Cellular Dynamics International, Inc.
University Research Park 525 Science Drive, Suite 200
Madison, WI 53711 / US
[2012/01]
Inventor(s)01 / RAJESH, Deepika
c/o Cellular Dynamics International Inc.
University Research Park
525 Science Drive
Suite 200
Madison, WI 53711 / US
02 / LEWIS, Rachel
c/o CellularDynamics International Inc.
University Research Park
525 Science Drive
Suite 200
Madison, WI 53711 / US
 [2012/01]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2015/17]
Former [2012/01]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date10707179.701.03.2010
WO2010US25776
Priority number, dateUS20090156304P27.02.2009         Original published format: US 156304 P
[2012/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010099539
Date:02.09.2010
Language:EN
[2010/35]
Type: A1 Application with search report 
No.:EP2401364
Date:04.01.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 02.09.2010 takes the place of the publication of the European patent application.
[2012/01]
Type: B1 Patent specification 
No.:EP2401364
Date:22.04.2015
Language:EN
[2015/17]
Search report(s)International search report - published on:EP02.09.2010
ClassificationIPC:C12N5/0781, C12N5/071
[2012/01]
CPC:
C12N5/0647 (EP,US); A61P25/00 (EP); A61P37/02 (EP);
A61P7/00 (EP); A61P9/00 (EP); C12N5/0692 (EP,US);
C12N2500/02 (EP,US); C12N2501/115 (EP,US); C12N2501/125 (EP,US);
C12N2501/14 (EP,US); C12N2501/145 (EP,US); C12N2501/155 (EP,US);
C12N2501/165 (EP,US); C12N2501/22 (EP,US); C12N2501/23 (EP,US);
C12N2501/26 (EP,US); C12N2506/03 (EP,US); C12N2506/45 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/01]
Extension statesALNot yet paid
BANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:DIFFERENZIERUNG PLURIPOTENTER ZELLEN[2012/01]
English:DIFFERENTIATION OF PLURIPOTENT CELLS[2012/01]
French:DIFFÉRENCIATION DE CELLULES PLURIPOTENTES[2012/01]
Entry into regional phase27.09.2011National basic fee paid 
27.09.2011Designation fee(s) paid 
27.09.2011Examination fee paid 
Examination procedure27.09.2011Examination requested  [2012/01]
27.03.2012Amendment by applicant (claims and/or description)
24.01.2013Despatch of a communication from the examining division (Time limit: M06)
02.08.2013Reply to a communication from the examining division
10.10.2014Communication of intention to grant the patent
18.02.2015Fee for grant paid
18.02.2015Fee for publishing/printing paid
18.02.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.01.2013
Opposition(s)25.01.2016No opposition filed within time limit [2016/13]
Fees paidRenewal fee
14.03.2012Renewal fee patent year 03
11.03.2013Renewal fee patent year 04
12.03.2014Renewal fee patent year 05
10.03.2015Renewal fee patent year 06
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Lapses during opposition  TooltipHU01.03.2010
AT22.04.2015
BE22.04.2015
BG22.04.2015
CY22.04.2015
CZ22.04.2015
DK22.04.2015
EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
IT22.04.2015
LT22.04.2015
LV22.04.2015
MC22.04.2015
MK22.04.2015
PL22.04.2015
RO22.04.2015
SE22.04.2015
SI22.04.2015
SK22.04.2015
SM22.04.2015
TR22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
[2018/38]
Former [2018/31]HU01.03.2010
AT22.04.2015
BE22.04.2015
CY22.04.2015
CZ22.04.2015
DK22.04.2015
EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
IT22.04.2015
LT22.04.2015
LV22.04.2015
MC22.04.2015
MK22.04.2015
PL22.04.2015
RO22.04.2015
SE22.04.2015
SI22.04.2015
SK22.04.2015
SM22.04.2015
TR22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2018/29]HU01.03.2010
AT22.04.2015
BE22.04.2015
CY22.04.2015
CZ22.04.2015
DK22.04.2015
EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
IT22.04.2015
LT22.04.2015
LV22.04.2015
MC22.04.2015
MK22.04.2015
MT22.04.2015
PL22.04.2015
RO22.04.2015
SE22.04.2015
SI22.04.2015
SK22.04.2015
SM22.04.2015
TR22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2018/28]HU01.03.2010
AT22.04.2015
BE22.04.2015
CY22.04.2015
CZ22.04.2015
DK22.04.2015
EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
IT22.04.2015
LT22.04.2015
LV22.04.2015
MC22.04.2015
MK22.04.2015
MT22.04.2015
PL22.04.2015
RO22.04.2015
SE22.04.2015
SI22.04.2015
SK22.04.2015
SM22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2017/40]AT22.04.2015
BE22.04.2015
CZ22.04.2015
DK22.04.2015
EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
IT22.04.2015
LT22.04.2015
LV22.04.2015
MC22.04.2015
MT22.04.2015
PL22.04.2015
RO22.04.2015
SE22.04.2015
SI22.04.2015
SK22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2016/49]AT22.04.2015
BE22.04.2015
CZ22.04.2015
DK22.04.2015
EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
IT22.04.2015
LT22.04.2015
LV22.04.2015
MC22.04.2015
PL22.04.2015
RO22.04.2015
SI22.04.2015
SK22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2016/37]AT22.04.2015
BE22.04.2015
CZ22.04.2015
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EE22.04.2015
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SI22.04.2015
SK22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2016/24]AT22.04.2015
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DK22.04.2015
EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
IT22.04.2015
LT22.04.2015
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PL22.04.2015
RO22.04.2015
SI22.04.2015
SK22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2016/21]AT22.04.2015
CZ22.04.2015
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EE22.04.2015
ES22.04.2015
FI22.04.2015
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IT22.04.2015
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PL22.04.2015
RO22.04.2015
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GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2016/10]AT22.04.2015
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EE22.04.2015
ES22.04.2015
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NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2016/09]AT22.04.2015
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EE22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
LT22.04.2015
LV22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2016/07]AT22.04.2015
DK22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
LT22.04.2015
LV22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2015/51]AT22.04.2015
ES22.04.2015
FI22.04.2015
HR22.04.2015
LT22.04.2015
LV22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2015/50]ES22.04.2015
FI22.04.2015
HR22.04.2015
LT22.04.2015
LV22.04.2015
NO22.07.2015
GR23.07.2015
IS22.08.2015
PT24.08.2015
Former [2015/49]ES22.04.2015
FI22.04.2015
HR22.04.2015
LT22.04.2015
LV22.04.2015
NO22.07.2015
GR23.07.2015
PT24.08.2015
Cited inInternational search[Y]   PARK CHANGWON ET AL: "A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells", DEVELOPMENT (CAMBRIDGE), vol. 131, no. 11, June 2004 (2004-06-01), pages 2749 - 2762, XP002511712, ISSN: 0950-1991 [Y] 1-54 * the whole document *

DOI:   http://dx.doi.org/10.1242/DEV.01130
 [Y]   WANG LISHENG ET AL: "Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties", IMMUNITY, CELL PRESS, US LNKD- DOI:10.1016/J.IMMUNI.2004.06.006, vol. 21, no. 1, 1 July 2004 (2004-07-01), pages 31 - 41, XP002484358, ISSN: 1074-7613 [Y] 1-54 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.immuni.2004.06.006
 [Y]   BHATIA MICKIE: "Hematopoiesis from human embryonic stem cells.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES JUN 2007 LNKD- PUBMED:17332088, vol. 1106, June 2007 (2007-06-01), pages 219 - 222, XP007912752, ISSN: 0077-8923 [Y] 1-54 * figure 1 *

DOI:   http://dx.doi.org/10.1196/annals.1392.007
 [Y]   KENNEDY MARION ET AL: "Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 109, no. 7, 1 April 2007 (2007-04-01), pages 2679 - 2687, XP002483687, ISSN: 0006-4971 [Y] 1-54 * the whole document *
 [Y]   PEARSON STELLA ET AL: "The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF", DEVELOPMENT, COMPANY OF BIOLOGISTS, CAMBRIDGE, GB LNKD- DOI:10.1242/DEV.011767, vol. 135, no. 8, 1 April 2008 (2008-04-01), pages 1525 - 1535, XP008092701, ISSN: 0950-1991 [Y] 1-54 * the whole document *

DOI:   http://dx.doi.org/10.1242/dev.011767
 [Y]   PICK MARJORIE ET AL: "Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis", STEM CELLS, ALPHAMED PRESS LNKD- DOI:10.1634/STEMCELLS.2006-0713, vol. 25, no. 9, 1 September 2007 (2007-09-01), pages 2206 - 2214, XP008092704, ISSN: 1549-4918, [retrieved on 20070607] [Y] 1-54 * the whole document *

DOI:   http://dx.doi.org/10.1634/stemcells.2006-0713
 [Y]   NAKAYAMA NAOKI ET AL: "Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro", BLOOD, vol. 95, no. 7, 1 April 2000 (2000-04-01), pages 2275 - 2283, XP002221609, ISSN: 0006-4971 [Y] 1-54 * the whole document *
 [Y]   WANG ZACK Z ET AL: "BMP4 and TGFbeta Differentially Regulate CD34+Progenitor Development in Human Embryonic Stem Cells through SMAD-Dependent Pathway", BLOOD, vol. 112, no. 11, November 2008 (2008-11-01), & 50TH ANNUAL MEETING OF THE AMERICAN- SOCIETY-OF-HEMATOLOGY; SAN FRANCISCO, CA, USA; DECEMBER 06 -09, 2008, pages 328, XP007912753, ISSN: 0006-4971 [Y] 1-54 * the whole document *
 [Y]   TIAN XINGHUI ET AL: "Differentiation of embryonic stem cells towards hematopoietic cells: progress and pitfalls", CURRENT OPINION IN HEMATOLOGY, RAPID SCIENCE PUBLISHERS, PHILADELPHIA, PA, US, vol. 15, no. 4, 1 July 2008 (2008-07-01), pages 312 - 318, XP009132345, ISSN: 1065-6251 [Y] 1-54 * the whole document *
 [Y]   NOROL F ET AL: "Ex vivo expanded mobilized peripheral blood CD34+ cells accelerate haematological recovery in a baboon model of autologous transplantation", BRITISH JOURNAL OF HAEMATOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB LNKD- DOI:10.1046/J.1365-2141.2000.01995.X, vol. 109, 1 January 2000 (2000-01-01), pages 162 - 172, XP003013492, ISSN: 0007-1048 [Y] 1,4-54 * the whole document *

DOI:   http://dx.doi.org/10.1046/j.1365-2141.2000.01995.x
 [Y]   YANG SHI ET AL: "[Hematopoietic reconstitution of fresh and cultured cord blood CD34+ cells in NOD/SCID mice]", XI BAO YU FEN ZI MIAN YI XUE ZA ZHI = CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY OCT 2008 LNKD- PUBMED:18845075, vol. 24, no. 10, October 2008 (2008-10-01), pages 947 - 949, XP007912757, ISSN: 1007-8738 [Y] 1,4-54 * the whole document *
 [Y]   FADILAH S A W ET AL: "Cord blood CD34+ cells cultured with FLT3L, stem cell factor, interleukin-6, and IL-3 produce CD11c+CD1a-/c- myeloid dendritic cells.", STEM CELLS AND DEVELOPMENT OCT 2007 LNKD- PUBMED:17999605, vol. 16, no. 5, October 2007 (2007-10-01), pages 849 - 855, XP007912758, ISSN: 1547-3287 [Y] 1,4-54 * the whole document *

DOI:   http://dx.doi.org/10.1089/scd.2007.0003
 [Y]   SHIOZAWA YUSUKE ET AL: "Human Osteoblasts Support Hematopoietic Cell Development in vitro", ACTA HAEMATOLOGICA, S. KARGER, BASEL, CH, vol. 120, no. 3, 28 November 2008 (2008-11-28), pages 134 - 145, XP009132445, ISSN: 0001-5792 [Y] 1,4-54 * the whole document *
 [Y]   WU M H ET AL: "Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation", BONE MARROW TRANSPLANTATION, vol. 27, no. 11, 1 June 2001 (2001-06-01), pages 1201 - 1209, XP007913656, ISSN: 0268-3369 [Y] 1,3-54 * the whole document *

DOI:   http://dx.doi.org/10.1038/sj.bmt.1703054
 [Y]   CHUTE J P ET AL: "A comparative study of the cell cycle status and primitive cell adhesion molecule profile of human CD34+ cells cultured in stroma-free versus porcine microvascular endothelial cell cultures.", EXPERIMENTAL HEMATOLOGY FEB 1999 LNKD- PUBMED:10029177, vol. 27, no. 2, February 1999 (1999-02-01), pages 370 - 379, XP000929912, ISSN: 0301-472X [Y] 1-54 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0301-472X(98)00004-6
 [Y]   HUBER TARA L ET AL: "Cooperative effects of growth factors involved in the induction of hematopoietic mesoderm", BLOOD, vol. 92, no. 11, 1 December 1998 (1998-12-01), pages 4128 - 4137, XP007913633, ISSN: 0006-4971 [Y] 2,7-54 * the whole document *
 [Y]   SLACK J M W ET AL: "MESODERM INDUCTION BY FIBROBLAST GROWTH FACTOR IN EARLY XENOPUS DEVELOPMENT", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON B BIOLOGICAL SCIENCES, vol. 327, no. 1239, 1990, pages 75 - 84, XP007913634, ISSN: 0962-8436 [Y] 2,7-54 * the whole document *

DOI:   http://dx.doi.org/10.1098/rstb.1990.0044
 [Y]   ZHANG PENGBO ET AL: "Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells", BLOOD, vol. 111, no. 4, February 2008 (2008-02-01), pages 1933 - 1941, XP007913635, ISSN: 0006-4971 [Y] 2,7-54 * Mesoderm induction in human ES cells by BMP-4 and FGF results in cells capable of hematopoietic differentiation.; page 1935, column 1, paragraph 3 * * page 1937, column 1, paragraph 4 - page 1938, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1182/blood-2007-02-074120
 [Y]   PURPURA K A ET AL: "Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC, US LNKD- DOI:10.1016/J.EXPHEM.2008.04.003, vol. 36, no. 9, 1 September 2008 (2008-09-01), pages 1186 - 1198, XP023976901, ISSN: 0301-472X, [retrieved on 20080611] [Y] 1,4-54 * Effect of TPO on BMP-4/VEGF mouse ES cell cultures.; page 1195; figures 5, 6 * * page 1938, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/j.exphem.2008.04.003
 [X]   YAMASHITA ET AL: "Differentiation of Arterial, Venous, and Lymphatic Endothelial Cells From Vascular Progenitors", TRENDS IN CARDIOVASCULAR MEDICINE, ELSEVIER SCIENCE, NEW YORK, NY, US LNKD- DOI:10.1016/J.TCM.2007.01.001, vol. 17, no. 2, 7 February 2007 (2007-02-07), pages 59 - 63, XP005878224, ISSN: 1050-1738 [X] 65,66 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.tcm.2007.01.001
 [Y]   MOHAMED AZZA A ET AL: "Ex vivo expansion of stem cells: defining optimum conditions using various cytokines.", LABORATORY HEMATOLOGY : OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY FOR LABORATORY HEMATOLOGY 2006 LNKD- PUBMED:16751136, vol. 12, no. 2, 2006, pages 86 - 93, XP009135584, ISSN: 1080-2924 [Y] 1-54 * the whole document *
by applicant  BASHCY ET AL., TRANSFUSION, vol. 47, no. 11, 2007, pages 2153 - 2160 [Y] 1,4-54 * the whole document *
   BHARDWAJ ET AL., NAT. IMMUNOL., vol. 2, 2001, pages 172 - 180 [Y] 1,4-54 * the whole document *
   BHATIA ET AL., J. EXP. MED., vol. 189, 1999, pages 1139 - 1148 [Y] 1,4-54 * the whole document *
   CHADWICK ET AL., BLOOD, vol. 102, no. 3, 2003, pages 906 - 915
   DAVIDSON; ZON, CURR. TOP DEV. BIOL., vol. 50, 2000, pages 45 - 60 [Y] 1,3-54 * the whole document *
   DAVIES ET AL., STRUCTURE, vol. 8, no. 2, 2000, pages 185 - 195 [Y] 1-54 * the whole document *
   DREXLER ET AL., GROWTH FACTORS, vol. 22, no. 2, 2004, pages 71 - 3 [Y] 2,7-54 * the whole document *
   FADILAH ET AL., STEM CELLS DEV., vol. 16, no. 5, 2007, pages 849 - 856 [Y] 2,7-54 * the whole document *
   GAUR ET AL., J. THROMB. HAEMOST., vol. 4, no. 2, 2006, pages 436 - 42 [Y] 2,7-54 * Mesoderm induction in human ES cells by BMP-4 and FGF results in cells capable of hematopoietic differentiation.; page 1935, column 1, paragraph 3 * * page 1937, column 1, paragraph 4 - page 1938, column 1, paragraph 2 *
   HANNA ET AL., SCIENCE, vol. 318, no. 5858, 2007, pages 1920 - 1923 [Y] 1,4-54 * Effect of TPO on BMP-4/VEGF mouse ES cell cultures.; page 1195; figures 5, 6 * * page 1938, column 1, paragraph 2 *
   HUBER ET AL., BLOOD, vol. 92, 1998, pages 4128 - 4137 [X] 65,66 * the whole document *
   IKENOYA ET AL., J. NEUROCHEM, vol. 81, 2002, pages 9 [Y] 1-54 * the whole document *
   KAUFMAN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 98, 2001, pages 19
   KISELYOV ET AL., STRUCTURE, vol. 11, no. 6, 2003, pages 691 - 701
   LAPPALAINEN ET AL., CLIN. EXPERIM. ALLERGY, vol. 37, 2007, pages 1404 - 1414
   LIN ET AL., INT. J. MOL. MED., vol. 17, 2006, pages 833 - 839
   LUDWIG ET AL., NATURE BIOTECH., 2006, pages 185 - 187
   LUDWIG ET AL., NATURE METHODS, vol. 3, no. 8, 2006, pages 637 - 646
   MAEKAWA ET AL., SCIENCE, vol. 285, no. 5429, 1999, pages 895 - 8
   MARSHALL ET AL., BLOOD, vol. 96, 2000, pages 1591 - 1593
   NAKAGAWA ET AL., NAT. BIOTECHNOL., vol. 26, no. 1, 2007, pages 101 - 106
   PENG ET AL., CELL BIOLOGY INTERNATIONAL, vol. 32, no. 10, 2008, pages 1265 - 1271
   RATAJCZAK ET AL., BR. J. HAEMATOL., vol. 93, no. 4, 1996, pages 772 - 782
   GENNARO: "Remington: The Science and Practice of Pharmacy, 21st Ed.,", UNIVERSITY OF THE SCIENCES
   SASAKI ET AL., PHARMACOL. THER., vol. 93, 2002, pages 225
   SCHERNTHANER ET AL., BLOOD, vol. 98, 2001, pages 3784 - 3792
   SLUKVIN ET AL.: "Directed Production of Specific Blood Lineages from Human Embryonic Stem Cells", ASCI/AAP JOINT MEET. POSTERS, vol. #33, 2007
   TAKAHASHI ET AL., CELL, vol. 131, no. 5, 2007, pages 861 - 872
   TAKAHASHI ET AL., NAT. PROTOC., vol. 2, no. 12, 2007, pages 3081 - 3089
   VODYANIK ET AL., BLOOD, vol. 108, no. 6, 2006, pages 2095 - 105
   WAGEMAKER ET AL., BIOTHERAPY, vol. 2, no. 4, 1990, pages 337 - 345
   WANG ET AL., NATURE BIOTECH., vol. 25, no. 3, 2007, pages 317 - 318
   YAMAMURA ET AL., STEM CELLS, vol. 26, no. 2, 2008, pages 543 - 9
   YU ET AL., SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.