EP2411411 - NOVEL ANTI-ALPHA5BETA1 ANTIBODIES AND USES THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 07.07.2017 Database last updated on 04.06.2024 | Most recent event Tooltip | 10.07.2020 | Lapse of the patent in a contracting state New state(s): IS | published on 12.08.2020 [2020/33] | Applicant(s) | For all designated states F. Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel / CH | [N/P] |
Former [2012/05] | For all designated states F.Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel / CH | Inventor(s) | 01 /
LIANG, Wei-Ching 342 Menhaden Court Foster City CA 94404 / US | 02 /
PLOWMAN, Gregory, D. 1386 Chestnut Street San Carlos CA 94070 / US | 03 /
WU, Yan 1160 Blythe Street Foster City CA 94404 / US | 04 /
YE, Weilan 119 Barkentine Street Foster City CA 94404 / US | [2016/35] |
Former [2012/05] | 01 /
LIANG, Wei-Ching 342 Menhaden Court Foster City CA 94044 / US | ||
02 /
PLOWMAN, Gregory, D. 1386 Chestnut Street San Carlos CA 94070 / US | |||
03 /
WU, Yan 1160 Blythe Street Foster City CA 94404 / US | |||
04 /
YE, Weilan 119 Barkentine Street Foster City CA 94404 / US | Representative(s) | Brodbeck, Michel F. Hoffmann-La Roche AG Patent Department CLP Grenzacherstrasse 124 4070 Basel / CH | [2016/35] |
Former [2012/05] | Brodbeck, Michel F. Hoffmann-La Roche AG Patent Department CLP Grenzacherstrasse 124 4070 Basel / CH | Application number, filing date | 10710524.9 | 23.03.2010 | [2016/35] | WO2010US28291 | Priority number, date | US20090163241P | 25.03.2009 Original published format: US 163241 P | [2012/05] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2010111254 | Date: | 30.09.2010 | Language: | EN | [2010/39] | Type: | A1 Application with search report | No.: | EP2411411 | Date: | 01.02.2012 | Language: | EN | The application published by WIPO in one of the EPO official languages on 30.09.2010 takes the place of the publication of the European patent application. | [2012/05] | Type: | B1 Patent specification | No.: | EP2411411 | Date: | 31.08.2016 | Language: | EN | [2016/35] | Search report(s) | International search report - published on: | EP | 30.09.2010 | Classification | IPC: | C07K16/28, C12N15/13, A61K39/395, A61P35/00 | [2012/05] | CPC: |
C07K16/2842 (EP,US);
C07K16/28 (KR);
A61K39/395 (KR);
A61K47/6835 (EP,US);
A61P1/00 (EP);
A61P13/12 (EP);
A61P17/06 (EP);
A61P19/02 (EP);
A61P27/00 (EP);
A61P27/02 (EP);
A61P35/00 (EP);
A61P37/00 (EP);
A61P37/02 (EP);
A61P37/06 (EP);
A61P9/00 (EP);
C07K16/22 (EP,US);
C12N15/11 (KR);
A61K2039/505 (EP,US);
A61K2039/507 (EP,US);
C07K2317/24 (EP,US);
C07K2317/31 (US);
C07K2317/56 (EP,US);
C07K2317/565 (EP,US);
C07K2317/92 (EP,US);
Y02A50/30 (EP,US)
(-)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2012/05] | Extension states | RS | 18.10.2011 | Title | German: | NEUE ANTI-ALPHA5BETA1-ANTIKÖRPER UND ANWENDUNGEN DAVON | [2012/05] | English: | NOVEL ANTI-ALPHA5BETA1 ANTIBODIES AND USES THEREOF | [2012/05] | French: | NOUVEAUX ANTICORPS ANTI-ALPHA5BETA1 ET LEURS UTILISATIONS | [2012/09] |
Former [2012/05] | NOUVEAUX ANTICORPS ANTI- 5 1 ET LEURS UTILISATIONS | Entry into regional phase | 25.10.2011 | National basic fee paid | 25.10.2011 | Designation fee(s) paid | 25.10.2011 | Examination fee paid | Examination procedure | 25.10.2011 | Examination requested [2012/05] | 15.05.2012 | Amendment by applicant (claims and/or description) | 28.06.2013 | Despatch of a communication from the examining division (Time limit: M06) | 31.01.2014 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 28.03.2014 | Reply to a communication from the examining division | 04.05.2015 | Despatch of a communication from the examining division (Time limit: M04) | 14.09.2015 | Reply to a communication from the examining division | 06.04.2016 | Communication of intention to grant the patent | 20.07.2016 | Fee for grant paid | 20.07.2016 | Fee for publishing/printing paid | 20.07.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 28.06.2013 | Opposition(s) | 01.06.2017 | No opposition filed within time limit [2017/32] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 28.03.2014 | Request for further processing filed | 28.03.2014 | Full payment received (date of receipt of payment) Request granted | 09.04.2014 | Decision despatched | Fees paid | Renewal fee | 07.03.2012 | Renewal fee patent year 03 | 08.03.2013 | Renewal fee patent year 04 | 10.03.2014 | Renewal fee patent year 05 | 06.03.2015 | Renewal fee patent year 06 | 08.03.2016 | Renewal fee patent year 07 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 23.03.2010 | AT | 31.08.2016 | BE | 31.08.2016 | CY | 31.08.2016 | CZ | 31.08.2016 | EE | 31.08.2016 | ES | 31.08.2016 | FI | 31.08.2016 | HR | 31.08.2016 | IT | 31.08.2016 | LT | 31.08.2016 | LV | 31.08.2016 | MC | 31.08.2016 | MK | 31.08.2016 | PL | 31.08.2016 | RO | 31.08.2016 | SI | 31.08.2016 | SK | 31.08.2016 | SM | 31.08.2016 | TR | 31.08.2016 | BG | 30.11.2016 | NO | 30.11.2016 | GR | 01.12.2016 | IS | 31.12.2016 | PT | 02.01.2017 | LU | 23.03.2017 | MT | 23.03.2017 | [2020/33] |
Former [2020/15] | HU | 23.03.2010 | |
AT | 31.08.2016 | ||
BE | 31.08.2016 | ||
CY | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
MC | 31.08.2016 | ||
MK | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
TR | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
LU | 23.03.2017 | ||
MT | 23.03.2017 | ||
Former [2019/51] | HU | 23.03.2010 | |
AT | 31.08.2016 | ||
BE | 31.08.2016 | ||
CY | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
MC | 31.08.2016 | ||
MK | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
LU | 23.03.2017 | ||
MT | 23.03.2017 | ||
Former [2019/46] | HU | 23.03.2010 | |
AT | 31.08.2016 | ||
BE | 31.08.2016 | ||
CY | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
MC | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
LU | 23.03.2017 | ||
MT | 23.03.2017 | ||
Former [2019/31] | HU | 23.03.2010 | |
AT | 31.08.2016 | ||
BE | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
MC | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
LU | 23.03.2017 | ||
MT | 23.03.2017 | ||
Former [2018/43] | AT | 31.08.2016 | |
BE | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
MC | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
LU | 23.03.2017 | ||
MT | 23.03.2017 | ||
Former [2018/10] | AT | 31.08.2016 | |
BE | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
MC | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
LU | 23.03.2017 | ||
Former [2018/01] | AT | 31.08.2016 | |
BE | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
MC | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
Former [2017/37] | AT | 31.08.2016 | |
BE | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SI | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
Former [2017/32] | AT | 31.08.2016 | |
BE | 31.08.2016 | ||
CZ | 31.08.2016 | ||
EE | 31.08.2016 | ||
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
IT | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
PL | 31.08.2016 | ||
RO | 31.08.2016 | ||
SK | 31.08.2016 | ||
SM | 31.08.2016 | ||
BG | 30.11.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
PT | 02.01.2017 | ||
Former [2017/13] | AT | 31.08.2016 | |
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
LT | 31.08.2016 | ||
LV | 31.08.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
Former [2017/11] | AT | 31.08.2016 | |
ES | 31.08.2016 | ||
FI | 31.08.2016 | ||
HR | 31.08.2016 | ||
LT | 31.08.2016 | ||
NO | 30.11.2016 | ||
GR | 01.12.2016 | ||
Former [2017/10] | FI | 31.08.2016 | |
HR | 31.08.2016 | ||
LT | 31.08.2016 | ||
NO | 30.11.2016 | ||
Former [2017/09] | FI | 31.08.2016 | |
LT | 31.08.2016 | ||
NO | 30.11.2016 | ||
Former [2017/07] | LT | 31.08.2016 | Cited in | International search | [Y]WO2004056308 (PROTEIN DESIGN LABS INC [US], et al) [Y] 1-36 * the whole document *; | [Y]WO2004089988 (PROTEIN DESIGN LABS INC [US], et al) [Y] 1-36 * the whole document *; | [Y]WO2005092073 (PROTEIN DESIGN LABS INC [US], et al) [Y] 1-36 * the whole document *; | [Y]WO2007134876 (BAYER SCHERING PHARMA AG [DE], et al) [Y] 1-36 * the whole document *; | [Y]WO2008060645 (GENENTECH INC [US], et al) [Y] 1-36 * the whole document *; | [YP]WO2009042746 (GENENTECH INC [US], et al) [YP] 1-36 * the whole document *; | [YP]WO2009100110 (MEDAREX INC [US], et al) [YP] 1-36* the whole document *; | [A] - HOLT L J ET AL, "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB LNKD- DOI:10.1016/J.TIBTECH.2003.08.007, (20031101), vol. 21, no. 11, ISSN 0167-7799, pages 484 - 490, XP004467495 [A] 1-36 * the whole document * DOI: http://dx.doi.org/10.1016/j.tibtech.2003.08.007 | [A] - DAVIES J ET AL, "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL LNKD- DOI:10.1016/S1380-2933(96)00045-0, (19960901), vol. 2, no. 3, ISSN 1380-2933, pages 169 - 179, XP004070292 [A] 1-36 * the whole document * DOI: http://dx.doi.org/10.1016/S1380-2933(96)00045-0 | [A] - MOULD A P ET AL, "Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD- DOI:10.1074/JBC.272.28.17283, (19970711), vol. 272, no. 28, ISSN 0021-9258, pages 17283 - 17292, XP002485038 [A] 1-36 * the whole document * DOI: http://dx.doi.org/10.1074/jbc.272.28.17283 | [A] - BURROWS L ET AL, "Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB LNKD- DOI:10.1042/0264-6021:3440527, (19991201), vol. 344, no. Pt 2, ISSN 0264-6021, pages 527 - 533, XP002485037 [A] 1-36 * the whole document * DOI: http://dx.doi.org/10.1042/0264-6021:3440527 | [A] - ORECCHIA ANGELA ET AL, "Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha5beta1 integrin", JOURNAL OF CELL SCIENCE, CAMBRIDGE UNIVERSITY PRESS, LONDON, GB LNKD- DOI:10.1242/JCS.00673, (20030901), vol. 116, no. 17, ISSN 0021-9533, pages 3479 - 3489, XP002468572 [A] 1-36 * the whole document * DOI: http://dx.doi.org/10.1242/jcs.00673 | [A] - RAMAKRISHNAN V ET AL, "Preclinical evaluation of an anti-ÄalphaÜ5ÄbetaÜ1 integrin antibody as a novel anti-angiogenic agent", JOURNAL OF EXPERIMENTAL THERAPEUTICS AND ONCOLOGY, RAPID SCIENCE PUBLISHERS, LONDON, GB, (20060504), vol. 5, no. 4, ISSN 1359-4117, pages 273 - 286, XP008081487 [A] 1-36 * the whole document * | [A] - ECONOMOPOULOU MATINA ET AL, "Inhibition of pathologic retinal neovascularization by alpha-defensins", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US LNKD- DOI:10.1182/BLOOD-2005-03-0889, (20051201), vol. 106, no. 12, ISSN 0006-4971, pages 3831 - 3838, XP002495156 [A] 1-36 * the whole document * DOI: http://dx.doi.org/10.1182/blood-2005-03-0889 | Examination | - WARK K L ET AL, "Latest technologies for the enhancement of antibody affinity", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL, vol. 58, no. 5-6, doi:10.1016/J.ADDR.2006.01.025, ISSN 0169-409X, (20060807), pages 657 - 670, (20060807), XP024892147 DOI: http://dx.doi.org/10.1016/j.addr.2006.01.025 | - CARTER P J, "POTENT ANTIBODY THERAPEUTICS BY DESIGN", THE JOURNAL OF IMMUNOLOGY, NATURE PUB. GROUP, (20060407), vol. 6, doi:10.1038/NRI1837, ISSN 1474-1733, pages 343 - 357, XP007901440 DOI: http://dx.doi.org/10.1038/nri1837 | by applicant | US3773919 | US4179337 | US4301144 | US4485045 | US4496689 | US4544545 | US4640835 | US4670417 | US4675187 | US4676980 | US4791192 | US4816567 | US4933294 | EP0404097 | US4994560 | WO9105264 | US5013556 | US5208020 | WO9308829 | WO9311161 | US5274119 | WO9411026 | US5342604 | WO9429351 | US5401638 | US5416064 | US5428130 | US5428139 | US5435990 | US5489425 | US5500362 | US5505931 | EP0425235 | WO9704801 | US5624821 | US5635483 | US5641870 | US5648260 | US5652361 | WO9730087 | US5696239 | US5712374 | US5714586 | US5714631 | US5731168 | US5739116 | US5750373 | US5756065 | US5767285 | US5770429 | US5770701 | US5770710 | US5773001 | US5780588 | US5808003 | US5821337 | WO9845331 | WO9845479 | WO9856418 | WO9858964 | US5877296 | WO9922764 | WO9951642 | US6075181 | WO0042072 | WO0061739 | US6150584 | US6194551 | WO0129246 | US6235764 | WO0231140 | US2002164328 | WO03011878 | US6534524 | US2003115614 | US6602684 | US2003157108 | US6630579 | US2003190317 | WO03085119 | WO03084570 | WO03085107 | US2004093621 | US6737056 | US2004110704 | US2004110282 | US2004109865 | US2004132140 | WO2004056312 | WO2004113304 | US2005014934 | WO2005012359 | US2005079574 | WO2005035586 | WO2005035778 | US6884879 | WO2005044853 | US2005119455 | US2005123546 | WO2005053742 | WO2005100402 | US2005260186 | US2005266000 | US6982321 | US2006025576 | WO2006029879 | US7041870 | US2006104968 | US7087409 | US7189826 | US2007061900 | US2007117126 | US2007160598 | US2007237764 | US2007292936 | US7332581 | US2008069820 | US7371826 | WO2008077546 | US2009002360 | US7498298 | US7521541 | US7527791 | WO2009089004 | - LEUNG ET AL., SCIENCE, (1989), vol. 246, page 1306 | - HOUCK ET AL., MOL. ENDOCRIN., (1991), vol. 5, page 1806 | - PRESTA ET AL., CANCER RES., (1997), vol. 57, pages 4593 - 4599 | - KLAGSBRUN; D'AMORE, ANNU. REV. PHYSIOL., (1991), vol. 53, pages 217 - 239 | - DETMAR, ONCOGENE, (2003), vol. 22, pages 3172 - 3179 | - FERRARA; ALITALO, NATURE MEDICINE, (1999), vol. 5, no. 12, pages 1359 - 1364 | - TONINI ET AL., ONCOGENE, (2003), vol. 22, pages 6549 - 6556 | - SATO, INT. J. CLIN. ONCOL., (2003), vol. 8, pages 200 - 206 | - KLAGSBRUN; D'AMORE, ANNU. REV. PHYSIOL, (1991), vol. 53, pages 217 - 239 | - STREIT; DETMAR, ONCOGENE, (2003), vol. 22, pages 3172 - 3179 | - CHEN ET AL., J. MOL BIOL, (1999), vol. 293, pages 865 - 881 | - CHEN, Y. ET AL., J. MOL BIOL, (1999), vol. 293, pages 865 - 881 | - "Cell cycle regulation, oncogenes, and antineoplastic drugs", MURAKAMI ET AL., The Molecular Basis of Cancer, WB SAUNDERS, (1995), page 13 | - AGNCW, CHCM INTL. ED. ENGL., (1994), vol. 33, pages 183 - 186 | - WILMAN, "Prodrugs in Cancer Chemotherapy", BIOCHEMICAL SOCIETY TRANSACTIONS, (1986), vol. 14, pages 375 - 382 | - "Prodrugs: A Chemical Approach to Targeted Drug Delivery", STELLA ET AL., Directed Drug Delivery, HUMANA PRESS, (1985), pages 247 - 267 | - BASIC AND CLINICAL IMMUNOLOGY, APPLETON & LANGE, (1994), page 71 | - CHOTHIA; LESK, J. MOL. BIOL., (1987), vol. 196, pages 901 - 917 | - KOHLER ET AL., NATURE, (1975), vol. 256, page 495 | - CLACKSON, NATURE, (1991), vol. 352, pages 624 - 628 | - MARKS ET AL., J. MOL. BIOL., (1991), vol. 222, pages 581 - 597 | - MORRISON ET AL., PNAS USA, (1984), vol. 81, pages 6851 - 6855 | - MARKS ET AL., BIOLTECHNOLOGY, (1992), vol. 10, pages 779 - 783 | - BARBAS ET AL., PNAS USA, (1994), vol. 91, pages 3809 - 3813 | - SCHIER ET AL., GENE, (1995), vol. 169, pages 147 - 155 | - YELTON ET AL., J. IMMUNOL., (1995), vol. 155, pages 1994 - 2004 | - JACKSON ET AL., J. IMMUNOL., (1995), vol. 154, no. 7, pages 3310 - 3319 | - HAWKINS ET AL., J. MOL. BIOL., (1992), vol. 226, pages 889 - 896 | - ZAPATA ET AL., PROTEIN ENG., (1995), vol. 8, no. 10, pages 1057 - 1062 | - Pluckthun in The Pharmacology of Monoclonal Antibodies, SPRINGER-VERLAG, (1994), vol. 113, pages 269 - 315 | - HOLLINGER ET AL., PNAS USA, (1993), vol. 90, pages 6444 - 6448 | - JONES ET AL., NATURE, (1986), vol. 321, pages 522 - 525 | - RIECHMANN ET AL., NATURE, (1988), vol. 332, pages 323 - 329 | - PRESTA, CURR. OP. STRUCT. BIOL., (1992), vol. 2, pages 593 - 596 | - DACRON, ANNU. REV. IMMUNOL., (1997), vol. 15, pages 203 - 234 | - RAVETCH; KINET, ANNU. REV. IMMUNOL, (1991), vol. 9, pages 457 - 492 | - CAPEL ET AL., IMMUNOMETHODS, (1994), vol. 4, pages 25 - 34 | - DE HAAS ET AL., J. LAB. CLIN. MED., (1995), vol. 126, pages 330 - 341 | - GUYER ET AL., J. IMMUNOL., (1976), vol. 117, page 587 | - KIM ET AL., J. IMMUNOL, (1994), vol. 24, page 249 | - GHETIE; WARD, ANNU. REV. IMMUNOL., (2000), vol. 18, pages 739 - 766 | - SHIELDS ET AL., J. BIOL. CHEM., (2001), vol. 9, no. 2, pages 6591 - 6604 | - BURTON, MOLEC. IMMUNOL., (1985), vol. 22, pages 161 - 206 | - RAVETCH; KINET, ANNU. REV. LMMUNOL, (1991), vol. 9, pages 457 - 92 | - CLYNES ET AL., PNAS (USA), (1998), vol. 95, pages 652 - 656 | - GAZZANO-SANTORO ET AL., J. IMMUNOL. METHODS, (1996), vol. 202, page 163 | - IDUSOGIE ET AL., J. IMMUNOL., (2000), vol. 164, pages 4178 - 4184 | - WELLS; LOWMAN, CURR. OPIN. STRUCT. BIOL., (1992), vol. 3, pages 355 - 362 | - LOWMAN; WELLS, METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, (1991), vol. 3, pages 205 - 0216 | - T.E. CREIGHTON, Proteins: Structure and Molecular Properties, W.H. FREEMAN & CO., (1983), pages 79 - 86 | - SCHWARZE ET AL., SCIENCE, (1999), vol. 285, pages 1569 - 72 | - FIELD ET AL., MOL. CELL. BIOL., (1988), vol. 8, pages 2159 - 2165 | - EVAN ET AL., MOLECULAR AND CELLULAR BIOLOGY, (1985), vol. 5, pages 3610 - 3616 | - PABORSKY ET AL., PROTEIN ENGINEERING, (1990), vol. 3, no. 6, pages 547 - 553 | - HOPP ET AL., BIOTECHNOLOGY, (1988), vol. 6, pages 1204 - 1210 | - MARTIN ET AL., SCIENCE, (1992), vol. 255, pages 192 - 194 | - SKINNER ET AL., J. BIOL. CHEM., (1991), vol. 266, pages 15163 - 15166 | - LUTZ-FREYERMUTH ET AL., PNAS USA, (1990), vol. 87, pages 6393 - 6397 | - LAZARUS ET AL., "Definitions and guidelines for assessment of wounds and evaluation of healing", ARCH. DERMATOL., (1994), vol. 130, pages 489 - 93 | - KOHLER; MILSTEIN, NATURE, (1975), vol. 256, page 495 | - GODING, MONOCLONAL ANTIBODIES: PRINCIPLES AND PRACTICE, ACADEMIC PRESS, (1986), pages 59 - 103 | - KOZBOR, J. Immunol., (1984), vol. 133, page 3001 | - BRODEUR ET AL., MONOCLONAL ANTIBODY PRODUCTION TECHNIQUES AND APPLICATIONS, MARCEL DEKKER, INC., (1987), pages 51 - 63 | - MUNSON; POLLARD, ANAL. BIOCHEM., (1980), vol. 107, page 220 | - VAN DIJK; VAN DE WINKEL, CURR. OPIN. PHARMACOL., (2001), vol. 5, pages 368 - 74 | - LONBERG, CURR. OPIN. IMMUNOL., (2008), vol. 20, pages 450 - 459 | - LONBERG, NAT. BIOTECH., (2005), vol. 23, pages 1117 - 1125 | - KOZBORJ., IMMUNOL., (1984), vol. 133, page 3001 | - BRODEUR ET AL., Monoclonal Antibody Production Techniques and Applications, MARCEL DEKKER, INC., (1987), pages 51 - 63 | - BOERNER ET AL., J. IMMUNOL., (1991), vol. 147, page 86 | - LI ET AL., PNAS, USA, (2006), vol. 103, pages 3557 - 3562 | - NI, XIANDAI MIANYIXUE, (2006), vol. 26, no. 4, pages 265 - 268 | - VOLLMERS; BRANDLEIN, HISTOLOGY AND HISTOPATHOLOGY, (2005), vol. 20, no. 3, pages 927 - 937 | - VOLLMERS; BRANDLEIN, METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, (2005), vol. 27, no. 3, pages 185 - 191 | - HOOGENBOOM ET AL., Methods in Molecular Biology, HUMAN PRESS, (2001), vol. 178, pages 1 - 37 | - THE MCCAFFERTY ET AL., NATURE, vol. 348, pages 552 - 554 | - MARKS ET AL., J. MOL. BIOL., (1992), vol. 222, pages 581 - 597 | - MARKS; BRADBURY, Methods in Molecular Biology, HUMAN PRESS, (2003), vol. 248, pages 161 - 175 | - SIDHU ET AL., J. MOL. BIOL., (2004), vol. 338, no. 2, pages 299 - 310 | - LEE ET AL., J MOL. BIOL., (2004), vol. 340, no. 5, pages 1073 - 1093 | - FELLOUSE, PNAS USA, (2004), vol. 101, no. 34, pages 12467 - 12472 | - LEE ET AL., J. IMMUNOL. METHODS, (2004), vol. 284, no. 1-2, pages 119 - 132 | - WINTER ET AL., ANN. REV. IMMUNOL., (1994), vol. 12, pages 433 - 455 | - GRIFFITHS ET AL., EMBO.L, (1993), vol. 12, pages 725 - 734 | - HOOGENBOOM; WINTER, J. MOL. RIOL., (1992), vol. 227, pages 381 - 388 | - ALMAGRO; FRANSSON, FRONT. BIOSCI., (2008), vol. 13, pages 1619 - 1633 | - QUEEN ET AL., PNAS USA, (1989), vol. 86, pages 10029 - 10033 | - KASHMIRI ET AL., METHODS, (2005), vol. 36, pages 25 - 34 | - PADLAN, MOL. IMMUNOL., (1991), vol. 28, pages 489 - 498 | - DALL'ACQUA ET AL., METHODS, (2005), vol. 36, pages 43 - 60 | - OSBOURN ET AL., METHODS, (2005), vol. 36, pages 61 - 68 | - KLIMKA ET AL., BR. J. CANCER, (2000), vol. 83, pages 252 - 260 | - SIMS ET AL., J. IMMUNOL., (1993), vol. 151, page 2296 | - CARTER ET AL., PNAS USA, (1992), vol. 89, page 4285 | - PRESTA ET AL., J. IMMUNOL., (1993), vol. 151, page 2623 | - BACA ET AL., J. BIOL. CHEM., (1997), vol. 272, pages 10678 - 10684 | - ROSOK ET AL., J. BIOL. CHEM., (1996), vol. 271, pages 22611 - 22618 | - MILSTEIN; CUELLO, NATURE, (1983), vol. 305, page 537 | - TRAUNECKER ET AL., EMBOJ., (1991), vol. 10, page 3655 | - BRENNAN ET AL., SCIENCE, (1985), vol. 229, page 81 | - KOSTELNY ET AL., J. IMMUNOL., (1992), vol. 148, no. 5, pages 1547 - 1553 | - GRUBER ET AL., J. IMMUNOL., (1994), vol. 152, page 5368 | - TUTT ET AL., J. IMMUNOL., (1991), vol. 147, page 60 | - CHOWDHURY, METHODS MOL. BIOL., (2008), vol. 207, pages 179 - 196 | - CUNNINGHAM; WELLS, SCIENCE, (1989), vol. 244, pages 1081 - 1085 | - WRIGHT ET AL., TIBTECH, (1997), vol. 15, pages 26 - 32 | - OKAZAKI ET AL., J. MOL. BIOL., (2004), vol. 336, pages 1239 - 1249 | - YAMANE-OHNUKI ET AL., BIOTECH. BIOENG., (2004), vol. 87, page 614 | - RIPKA ET AL., ARCH. BIOCHEM. BIOPHYS., (1986), vol. 249, pages 533 - 545 | - KANDA, Y. ET AL., BIOTECHNOL. BIOENG., (2006), vol. 94, no. 4, pages 680 - 688 | - RAVETCH; KINET, ANNU. REV. IMMUNOL., (1991), vol. 9, pages 457 - 492 | - HELLSTROM, 1. ET AL., PNAS USA, (1986), vol. 83, pages 7059 - 7063 | - HELLSTROM, I ET AL., PNAS USA, (1985), vol. 82, pages 1499 - 1502 | - BRUGGEMANN, M. ET AL., J. EXP. MED., (1987), vol. 166, pages 1351 - 1361 | - CLYNES ET AL., PNAS USA, (1998), vol. 95, pages 652 - 656 | - CRAGG, M.S. ET AL., BLOOD, (2003), vol. 101, pages 1045 - 1052 | - CRAGG, M.S.; M.J. GLENNIE, BLOOD, (2004), vol. 103, pages 2738 - 2743 | - PETKOVA, S.B. ET AL., INT'L. IMMUNOL., (2006), vol. 18, no. 12, pages 1759 - 1769 | - SHIELDS, RL ET AL., JBC, (2001), vol. 276, no. 6, pages 6591 - 6604 | - PRESTA, L.G., BIOCHEMICAL SOCIETY TRANSACTIONS, (2002), vol. 30, no. 4, pages 487 - 490 | - KIM ET AL., J. IMMUNOL., (1994), vol. 24, page 249 | - DUNCAN; WINTER, NATURE, (1988), vol. 322, pages 738 - 40 | - CARON ET AL., J. EXP. MED., (1992), vol. 176, pages 1191 - 1195 | - SHOPES, J. IMMUNOL., (1992), vol. 148, pages 2918 - 2922 | - WOLFF ET AL., CANCER RESEARCH, (1993), vol. 53, pages 2560 - 2565 | - STEVENSON ET AL., ANTI-CANCER DRUG DESIGN, (1989), vol. 3, pages 219 - 230 | - KAM ET AL., PROC. NATL. ACAD. SCI. USA, (2005), vol. 102, pages 11600 - 11605 | - HINMAN ET AL., CANCER RES., (1993), vol. 53, pages 3336 - 3342 | - LODE ET AL., CANCER RES., (1998), vol. 58, pages 2925 - 2928 | - KRATZ ET AL., CURRENT MED. CHEM., (2006), vol. 13, pages 477 - 523 | - JEFFREY ET AL., BIOORGANIC & MED. CHEM. LETTERS, (2006), vol. 16, pages 358 - 362 | - TORGOV ET AL., BIOCONJ. CHEM., (2005), vol. 16, pages 717 - 721 | - NAGY ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 829 - 834 | - DUBOWCHIK ET AL., BIOORG. & MED. CHEM. LETTERS, (2002), vol. 12, pages 1529 - 1532 | - KING ET AL., J. MED. CHEM., (2002), vol. 45, pages 4336 - 4343 | - VITETTA ET AL., SCIENCE, (1987), vol. 238, page 1098 | - CHARI ET AL., CANCER RES., (1992), vol. 52, pages 127 - 131 | - EPSTEIN ET AL., PNAS USA, (1985), vol. 82, page 3688 | - HWANG ET AL., PNAS USA, (1980), vol. 77, page 4030 | - MARTIN ET AL., J. BIOL. CHEM., (1982), vol. 257, pages 286 - 288 | - GABIZON ET AL., J. NATIONAL CANCER INST., (1989), vol. 81, no. 19, page 1484 | - MARASCO ET AL., PNAS USA, (1993), vol. 90, pages 7889 - 7893 | - JALKANEN ET AL., J. CELL. BIOL., (1985), vol. 101, pages 976 - 985 | - JALKANEN ET AL., J CELL. BIOL., (1987), vol. 105, pages 3087 - 3096 | - SIAS ET AL., J. IMMUNOL. METHODS, (1990), vol. 132, pages 73 - 80 |