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EP About this file: EP2411408

EP2411408 - SOLUBLE "HEAVY-CHAIN ONLY" ANTIBODIES [Right-click to bookmark this link]
Status	Patent maintained as amended Status updated on 17.02.2023 Database last updated on 11.04.2026
Most recent event Tooltip	17.02.2023	Patent maintained (B2 publication)	published on 22.03.2023 [2023/12]
Applicant(s)	For all designated states Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O.Box 1738 3000 DR Rotterdam / NL
	For all designated states Craig, Roger Kingdon Jubilee House Farm, Spen Moss, Smallwood Sandbach, Cheshire CW11 2XB / GB
	[2023/12]
Former [2015/48]	For all designated states Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O.Box 1738 3000 DR Rotterdam / NL
	For all designated states Craig, Roger Kingdon Jubilee House Farm, Spen Moss, Smallwood Sandbach, Cheshire CW11 2XB / GB
Former [2012/05]	For all designated states Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O.Box 1738 3000 DR Rotterdam / NL
	For all designated states Craig, Roger Kingdon Jubilee House Farm, Spen Moss, Smallwood Sandbach, Cheshire CW11 2XB / GB
Inventor(s)	01 / GROSVELD, Franklin, Gerardus Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	02 / JANSSENS, Richard, Wilhelm Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	03 / DRABEK, Dubravka Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	04 / CHEN, Tao Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	05 / DE BOER, Ernie Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	06 / CRAIG, Roger, Kingdon Jubilee House Farm, Spen Moss Smallwood, Sandbach Cheshire CW11 2XB / GB
	[2015/48]
Former [2012/05]	01 / JANSSENS, Richard, Wilhelm Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	02 / DRABEK, Dubravka Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	03 / CHEN, Tao Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	04 / DE BOER, Ernie Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
Former [N/P]	01 / JANSSENS, Richard, Wilhelm Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	02 / DRABEK, Dubravka Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
	03 / CHEN, Tao Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics P.O. Box 1738 NL-3000 DR Rotterdam / NL
Representative(s)	Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	[2023/12]
Former [2015/48]	Chapman, Desmond Mark Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
Former [2012/05]	Bullett, Rachel Margaret Carpmaels & Ransford One Southampton Row London WC1B 5HA / GB
Application number, filing date	10711069.4	19.03.2010
	[2015/48]
	WO2010GB00500
Priority number, date	GB20090005023	24.03.2009 Original published format: GB 0905023
	[2012/05]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2010109165
	Date:	30.09.2010
	Language:	EN
	[2010/39]
	Type:	A2 Application without search report
	No.:	EP2411408
	Date:	01.02.2012
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 30.09.2010 takes the place of the publication of the European patent application.
	[2012/05]
	Type:	B1 Patent specification
	No.:	EP2411408
	Date:	25.11.2015
	Language:	EN
	[2015/48]
	Type:	B2 New European patent specification
	No.:	EP2411408
	Date:	22.03.2023
	Language:	EN
	[2023/12]
Search report(s)	International search report - published on:	EP	24.02.2011
Classification	IPC:	C07K16/00, C07K16/10, C07K16/12, C07K16/28	[2012/05]
	CPC:	A61P9/00 (EP); C07K16/28 (KR); C07K16/46 (US); A01K67/027 (KR); A61P31/00 (EP); A61P35/00 (EP); (+) C07K16/00 (EP,US); C07K16/108 (EP,US); C07K16/1271 (EP,US); C07K16/2896 (EP,US); C12N15/11 (KR); C12N15/8509 (US); A01K2267/01 (EP,US); C07K2317/21 (EP,US); C07K2317/22 (EP,US); C07K2317/24 (EP,US); C07K2317/565 (EP,US); C07K2317/567 (EP,US); C07K2317/569 (EP,US); C07K2317/92 (EP,US) (-)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2012/05]
Title	German:	LÖSLICHE ANTIKÖRPER, DIE NUR SCHWERE KETTEN ENTHALTEN	[2012/05]
	English:	SOLUBLE "HEAVY-CHAIN ONLY" ANTIBODIES	[2012/05]
	French:	ANTICORPS SOLUBLES NE CONTENANT QUE DES CHAÎNES LOURDES	[2015/29]
	Former [2012/05]	MOLÉCULES DE LIAISON
Entry into regional phase	24.10.2011	National basic fee paid
	24.10.2011	Designation fee(s) paid
	24.10.2011	Examination fee paid
Examination procedure	24.10.2011	Examination requested [2012/05]
	14.05.2012	Amendment by applicant (claims and/or description)
	23.07.2012	Despatch of a communication from the examining division (Time limit: M06)
	24.01.2013	Reply to a communication from the examining division
	22.03.2013	Despatch of a communication from the examining division (Time limit: M04)
	01.08.2013	Reply to a communication from the examining division
	25.10.2013	Despatch of a communication from the examining division (Time limit: M02)
	06.01.2014	Reply to a communication from the examining division
	09.07.2014	Despatch of a communication from the examining division (Time limit: M04)
	18.11.2014	Reply to a communication from the examining division
	17.06.2015	Communication of intention to grant the patent
	01.07.2015	Observations by third parties
	13.07.2015	Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
	17.07.2015	Despatch of a communication from the examining division (Time limit: M04)
	07.08.2015	Reply to a communication from the examining division
	08.10.2015	Communication of intention to grant the patent
	09.10.2015	Fee for grant paid
	09.10.2015	Fee for publishing/printing paid
	09.10.2015	Receipt of the translation of the claim(s)
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 23.07.2012
Opposition(s)	Opponent(s)	01 23.08.2016 29.08.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB
		02 25.08.2016 30.08.2016 ADMISSIBLE Ablynx N.V. Technologiepark 21 9052 Ghent-Zwijnaarde / BE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		03 24.08.2016 01.09.2016 ADMISSIBLE Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte, Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE Opponent's representative Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE
		[N/P]
	Former [2020/10]
	Opponent(s)	01 23.08.2016 29.08.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative J A Kemp LLP 14 South Square Gray's Inn London WC1R 5JJ / GB
		02 25.08.2016 30.08.2016 ADMISSIBLE Ablynx N.V. Technologiepark 21 9052 Ghent-Zwijnaarde / BE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		03 24.08.2016 01.09.2016 ADMISSIBLE Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte, Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE Opponent's representative Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE
	Former [2020/03]
	Opponent(s)	01 23.08.2016 29.08.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative J A Kemp LLP 14 South Square Gray's Inn London WC1R 5JJ / GB
		02 25.08.2016 30.08.2016 ADMISSIBLE Ablynx N.V. Technologiepark 21 9052 Ghent-Zwijnaarde / BE Opponent's representative Sanofi 54, rue La Boétie 75008 Paris / FR
		03 24.08.2016 01.09.2016 ADMISSIBLE Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte, Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE Opponent's representative Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE
	Former [2019/14]
	Opponent(s)	01 23.08.2016 29.08.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB
		02 25.08.2016 30.08.2016 ADMISSIBLE Ablynx N.V. Technologiepark 21 9052 Ghent-Zwijnaarde / BE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		03 24.08.2016 01.09.2016 ADMISSIBLE Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte, Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE Opponent's representative Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE
	Former [2017/32]
	Opponent(s)	01 23.08.2016 29.08.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB
		02 25.08.2016 30.08.2016 ADMISSIBLE Ablynx N.V. Technologiepark 21 9052 Ghent-Zwijnaarde / BE Opponent's representative Vlassak, Katrien, et al, et al Ablynx NV Technologiepark 21 9052 Zwijnaarde / BE
		03 24.08.2016 01.09.2016 ADMISSIBLE Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte, Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE Opponent's representative Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE
	Former [2016/40]
	Opponent(s)	01 23.08.2016 29.08.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative Nicholls, James Ronald J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB
		02 25.08.2016 30.08.2016 ADMISSIBLE Ablynx N.V. Technologiepark 21 9052 Ghent-Zwijnaarde / BE Opponent's representative Vlassak, Katrien, et al, et al Ablynx NV Technologiepark 21 9052 Zwijnaarde / BE
		03 24.08.2016 01.09.2016 ADMISSIBLE Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte, Partnerschaft mbB Zweibrückenstrasse 5-7 80331 München / DE Opponent's representative Virnekäs, Bernhard Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte Zweibrückenstrasse 5-7 80331 München / DE
	Former [2016/39]
	Opponent(s)	01 23.08.2016 Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative Nicholls, James Ronald J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB
	07.10.2016	Invitation to proprietor to file observations on the notice of opposition
	17.02.2017	Reply of patent proprietor to notice(s) of opposition
	26.03.2019	Date of oral proceedings
	09.08.2019	Despatch of interlocutory decision in opposition
	09.08.2019	Despatch of minutes of oral proceedings
	07.07.2022	Legal effect of interlocutory decision in opposition
	02.11.2022	Despatch of communication that the patent will be maintained as amended
	10.02.2023	Fee for printing new specification paid
Appeal following opposition	09.10.2019	Appeal received No. T2775/19
	18.12.2019	Statement of grounds filed
	07.07.2022	Result of appeal procedure: appeal of the opponent was rejected
	18.10.2022	Despatch of the decision of the Board of Appeal
	07.07.2022	Date of oral proceedings
Fees paid	Renewal fee
	14.03.2012	Renewal fee patent year 03
	11.03.2013	Renewal fee patent year 04
	12.03.2014	Renewal fee patent year 05
	28.04.2015	Renewal fee patent year 06
	Penalty fee
	Additional fee for renewal fee
	31.03.2015	06 M06 Fee paid on 28.04.2015
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	deleted
	[2016/27]
Former [2016/25]	LV	25.11.2015
Cited in	International search	[IY] WO2008035216 (UNIV ERASMUS MEDICAL CT et al.) [I] 1-24,43-46 * page 17, paragraph 3 * * examples 1-3; claims 1-23 *[Y] 25-42
		[YA] WO2006008548 (UNIV ERASMUS MEDICAL CT et al.) [Y] 25-42 * figures 14,25,26; example 1 *[A] 1-24,43-46
		[Y] WO2008151081 (OMT INC et al.) [Y] 25-42 * paragraphs [0084] , [0106] , [0107] , [0200] - [0204]; claim 27 *
		[A] WO03035694 (VLAAMS INTERUNIV INST BIOTECH et al.) [A] 1-24,43-46 * examples 1-6 *
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		[YA] JANSSENS RICK ET AL: "Generation of heavy-chain-only antibodies in mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.0601108103, vol. 103, no. 41, 10 October 2006 (2006-10-10), pages 15130 - 15135, XP002494537, ISSN: 0027-8424 [Y] 25-42 * page 15133, column r, paragraphs 4,5 [A] 1-24,43-46 DOI:* http://dx.doi.org/10.1073/pnas.0601108103
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		[A] NGUYEN VIET KHONG ET AL: "Heavy-chain only antibodies derived from dromedary are secreted and displayed by mouse B cells", IMMUNOLOGY, BLACKWELL PUBLISHING, OXFORD, GB LNKD- DOI:10.1046/J.1365-2567.2003.01633.X, vol. 109, no. 1, 1 May 2003 (2003-05-01), pages 93 - 101, XP002293545, ISSN: 0019-2805 [A] 25-42 * page 99, column r, paragraph 2 * DOI: http://dx.doi.org/10.1046/j.1365-2567.2003.01633.x
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		WRAMMERT ET AL.: "Rapid cloning of high-affinity human monoclonal antibodies against influenza virus", NATURE, vol. 453, no. 7195, 29 May 2008 (2008-05-29), pages 667 - 671
		MARK K. SLIFKA ET AL.: "Humoral immunity due to long-lived plasma cells", IMMUNITY, vol. 8, no. 3, March 1998 (1998-03-01), pages 363 - 372
		JANEWAY C.A. ET AL.: "IMMUNOBIOLOGY: THE IMMUNE SYSTEM IN HEALTH AND DISEASE, 1st edition", 1994, article "The Humoral Immune Response", pages: 8.10 - 8.19
		HEATHER A. MINGES WOLS: "PLASMA CELLS", ENCYCLOPEDIA OF LIFE SCIENCES, 2005, pages 1 - 8
		BABCOOK J.S. ET AL.: "A NOVEL STRATEGY FOR GENERATING MONOCLONAL ANTIBODIES FROM SINGLE, ISOLATED LYMPHOCYTES PRODUCING ANTIBODIES OF DEFINED SPECIFICITIES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 93, no. 15, 23 July 1996 (1996-07-23), pages 7843 - 7848
	CORONELLA J.A ET AL.: "AMPLIFICATION OF IGG VH AND VL (FAB) FROM SINGLE HUMAN PLASMA CELLS AND B CELLS", NUCLEIC ACIDS RESEARCH, vol. 28, no. 20, 15 October 2000 (2000-10-15), pages E85 - 1- E85-7
	SCHEID ET AL.: "Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.", NATURE, vol. 458, no. 7238, 15 March 2009 (2009-03-15), pages 636 - 640
	MANZ: "MAINTENANCE OF SERUM ANTIBODY LEVELS", ANNU. REV. IMMUNOL., vol. 23, 2005, pages 367 - 386
	MCHEYZER-WILLIAMS ET AL.: "B cell memory and the long-lived plasma cell", CURRENT OPINION IN IMMUNOLOGY, vol. 11, no. 2, 1999, pages 172 - 179
	YEFENOF: "Preparation and analysis of antigen-specific memory B cells.", J IMMUNOL, vol. 135, no. 6, 1985, pages 3777 - 3784
	HOOGENBOOM: "Selecting and screening recombinant antibody libraries", NATURE BIOTECHNOLOGY, vol. 23, no. 9, September 2005 (2005-09-01), pages 1105 - 1116
	PASQUOLINI ET AL.: "Hybridoma-free generation of monoclonal antibodies", PNAS, vol. 101, no. 1, 2004, pages 257 - 259
	SANDERSON: "B lymphocytes express and lose syndecan at specific stages of differentiation.", CELL REGULATION, vol. 1, no. 1, November 1989 (1989-11-01), pages 27 - 35
	ANDERSON: "New markers for murine memory B cells that define mutated and unmutated subsets", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 204, no. 9, 3 September 2007 (2007-09-03), pages 2103 - 2114
	STEINITZ: "EB virus-induced B lymphocyte cell lines producing specific antibody", NATURE, vol. 269, no. 5627, 29 September 1977 (1977-09-29), pages 420 - 422
	MATHESON: "Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching", INTERNATIONAL IMMUNOLOGY, vol. 21, no. 8, 2009, pages 957 - 966
	LIAO ET AL.: "High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies", J. VIROL METHODS, vol. 158, no. 1-2, 2009, pages 171 - 179
	LANZAVECCHIA ET AL.: "Human monoclonal antibodies by immortalization of memory B cells", CURR OPIN BIOTECHNOL, vol. 18, no. 6, 2007, pages 523 - 528
	STUART G. TANGYE ET AL.: "Memory B cells: Effectors of long-lived immune responses", EUR J IMMUNOL, vol. 39, no. 8, August 2009 (2009-08-01), pages 2065 - 2075
	THOMAS DRNER ET AL.: "Antibodies and B cell memory in viral immunity", IMMUNITY, vol. 27, no. 3, September 2007 (2007-09-01), pages 384 - 392
	KARIN TARTE ET AL.: "Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B- cell differentiation", BLOOD, vol. 102, no. 2, 15 July 2003 (2003-07-15), pages 592 - 600
	BRGGEMANN MARIANNE ET AL.: "Heavy-chain-only antibody expression and B- cell development in the mouse", CRITICAL REVIEWS IN IMMUNOLOGY, vol. 26, no. 5, 2006, pages 377 - 390 , 25-42
	RADBRUCH ET AL.: "Competence and competition: the challenge of becoming a long- lived plasma cell", NATURE REVIEWS IMMUNOLOGY, vol. 6, no. 10, 2006, pages 741 - 750
	WILLIAM E PAUL: "Fundamental Immunology", 2008, ISBN: 978-0-7817-6519-0, article "Chapter 9 & 36", pages: 300-305, - 1148
	KODITUWAKKU ET AL.: "Isolation of antigen-specific B cells.", IMMUNOLOGY AND CELL BIOLOGY, vol. 81, no. 3, 2003, pages 163 - 170

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