EP2393420 - CHARGE-BALANCED IMAGING AGENTS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 05.04.2019 Database last updated on 02.09.2024 | |
Former | The patent has been granted Status updated on 27.04.2018 | ||
Former | Grant of patent is intended Status updated on 07.12.2017 | ||
Former | Examination is in progress Status updated on 06.06.2017 | Most recent event Tooltip | 01.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 03.08.2022 [2022/31] | Applicant(s) | For all designated states Beth Israel Deaconess Medical Center, Inc. 330 Brookline Avenue Boston, MA 02215 / US | For all designated states Georgia State University Research Foundation, Inc. 30 Courtland Street Suite 326 Atlanta, GA 30303 / US | [2018/22] |
Former [2011/50] | For all designated states Beth Israel Deaconess Medical Center, Inc. 330 Brookline Avenue Boston, MA 02215 / US | ||
For all designated states Georgia State University Research Foundation, Inc. 30 Courtland Street Suite 326 Atlanta, GA 30303 / US | Inventor(s) | 01 /
FRANGIONI, John, V. 34 Wayland Hills Road Wayland MA 01778 / US | 02 /
HENARY, Maged M. 1549 Hampton Hollow Drive Lawrenceville, GA 30043 / US | [2011/50] |
Former [N/P] | 01 /
FRANGIONI, John, V. 34 Wayland Hills Road Wayland MA 01778 / US | Representative(s) | Adam, Holger, et al Kraus & Weisert Patentanwälte PartGmbB Thomas-Wimmer-Ring 15 80539 München / DE | [2018/22] |
Former [2012/12] | Adam, Holger, et al Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15 80539 München / DE | ||
Former [2011/50] | Peterreins, Frank, et al Fish & Richardson P.C. Highlight Business Towers Mies-van-der-Rohe-Strasse 8 80807 München / DE | Application number, filing date | 10739160.9 | 05.02.2010 | [2018/22] | WO2010US23305 | Priority number, date | US20090150522P | 06.02.2009 Original published format: US 150522 P | [2011/50] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2010091243 | Date: | 12.08.2010 | Language: | EN | [2010/32] | Type: | A1 Application with search report | No.: | EP2393420 | Date: | 14.12.2011 | Language: | EN | The application published by WIPO in one of the EPO official languages on 12.08.2010 takes the place of the publication of the European patent application. | [2011/50] | Type: | B1 Patent specification | No.: | EP2393420 | Date: | 30.05.2018 | Language: | EN | [2018/22] | Search report(s) | International search report - published on: | US | 12.08.2010 | (Supplementary) European search report - dispatched on: | EP | 21.09.2015 | Classification | IPC: | A61B5/00, A61B6/00, A61K49/00, C07D209/02, C07D209/42, C07D255/02, C09B23/01, C12Q1/02, G01N33/58, C09B23/08 | [2017/51] | CPC: |
A61K49/0032 (EP,US);
A61B6/00 (US);
C07D209/02 (EP,US);
C07D209/42 (EP,US);
C07D255/02 (EP,US);
C09B23/0066 (EP,US);
|
Former IPC [2015/43] | A61B5/00, A61K49/00, C07D209/02, C07D209/42, C07D255/02, C09B23/01, C12Q1/02, G01N33/58, C09B23/08 | ||
Former IPC [2011/50] | A61B5/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2011/50] | Extension states | AL | Not yet paid | BA | Not yet paid | RS | Not yet paid | Title | German: | LADUNGSAUSGEGLICHENE KONTRASTMITTEL | [2011/50] | English: | CHARGE-BALANCED IMAGING AGENTS | [2011/50] | French: | AGENTS D'IMAGERIE ÉQUILIBRÉS EN CHARGE | [2011/50] | Entry into regional phase | 05.09.2011 | National basic fee paid | 05.09.2011 | Search fee paid | 05.09.2011 | Designation fee(s) paid | 05.09.2011 | Examination fee paid | Examination procedure | 05.09.2011 | Amendment by applicant (claims and/or description) | 05.09.2011 | Examination requested [2011/50] | 21.10.2015 | Despatch of a communication from the examining division (Time limit: M06) | 15.04.2016 | Reply to a communication from the examining division | 26.05.2017 | Despatch of a communication from the examining division (Time limit: M04) | 05.10.2017 | Reply to a communication from the examining division | 08.12.2017 | Communication of intention to grant the patent | 17.04.2018 | Fee for grant paid | 17.04.2018 | Fee for publishing/printing paid | 17.04.2018 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 21.10.2015 | Opposition(s) | 01.03.2019 | No opposition filed within time limit [2019/19] | Fees paid | Renewal fee | 24.02.2012 | Renewal fee patent year 03 | 27.02.2013 | Renewal fee patent year 04 | 27.02.2014 | Renewal fee patent year 05 | 26.02.2015 | Renewal fee patent year 06 | 27.04.2016 | Renewal fee patent year 07 | 27.02.2017 | Renewal fee patent year 08 | 27.02.2018 | Renewal fee patent year 09 | Penalty fee | Additional fee for renewal fee | 29.02.2016 | 07   M06   Fee paid on   27.04.2016 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 05.02.2010 | AT | 30.05.2018 | CY | 30.05.2018 | CZ | 30.05.2018 | DK | 30.05.2018 | EE | 30.05.2018 | FI | 30.05.2018 | HR | 30.05.2018 | LT | 30.05.2018 | LV | 30.05.2018 | MC | 30.05.2018 | MK | 30.05.2018 | PL | 30.05.2018 | RO | 30.05.2018 | SE | 30.05.2018 | SI | 30.05.2018 | SK | 30.05.2018 | SM | 30.05.2018 | TR | 30.05.2018 | BG | 30.08.2018 | NO | 30.08.2018 | GR | 31.08.2018 | IS | 30.09.2018 | PT | 01.10.2018 | LU | 05.02.2019 | MT | 05.02.2019 | [2022/31] |
Former [2021/32] | HU | 05.02.2010 | |
AT | 30.05.2018 | ||
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
MC | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SI | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
TR | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
IS | 30.09.2018 | ||
PT | 01.10.2018 | ||
LU | 05.02.2019 | ||
MT | 05.02.2019 | ||
Former [2021/31] | AT | 30.05.2018 | |
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
MC | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SI | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
TR | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
IS | 30.09.2018 | ||
PT | 01.10.2018 | ||
LU | 05.02.2019 | ||
MT | 05.02.2019 | ||
Former [2020/29] | AT | 30.05.2018 | |
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
MC | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SI | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
TR | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
PT | 01.10.2018 | ||
LU | 05.02.2019 | ||
MT | 05.02.2019 | ||
Former [2020/16] | AT | 30.05.2018 | |
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
MC | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SI | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
TR | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
LU | 05.02.2019 | ||
Former [2019/47] | AT | 30.05.2018 | |
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
MC | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SI | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
LU | 05.02.2019 | ||
Former [2019/45] | AT | 30.05.2018 | |
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
MC | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SI | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
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CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SI | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
Former [2019/11] | AT | 30.05.2018 | |
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SK | 30.05.2018 | ||
SM | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
Former [2019/10] | AT | 30.05.2018 | |
CY | 30.05.2018 | ||
CZ | 30.05.2018 | ||
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
PL | 30.05.2018 | ||
RO | 30.05.2018 | ||
SE | 30.05.2018 | ||
SK | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
Former [2019/09] | CY | 30.05.2018 | |
DK | 30.05.2018 | ||
EE | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
SE | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
Former [2019/08] | CY | 30.05.2018 | |
DK | 30.05.2018 | ||
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
SE | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
Former [2018/52] | CY | 30.05.2018 | |
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
SE | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
GR | 31.08.2018 | ||
Former [2018/51] | CY | 30.05.2018 | |
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
LV | 30.05.2018 | ||
SE | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
Former [2018/50] | CY | 30.05.2018 | |
FI | 30.05.2018 | ||
HR | 30.05.2018 | ||
LT | 30.05.2018 | ||
SE | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
Former [2018/49] | CY | 30.05.2018 | |
FI | 30.05.2018 | ||
LT | 30.05.2018 | ||
SE | 30.05.2018 | ||
BG | 30.08.2018 | ||
NO | 30.08.2018 | ||
Former [2018/47] | FI | 30.05.2018 | |
LT | 30.05.2018 | ||
NO | 30.08.2018 | Documents cited: | Search | [X]WO0224815 (LI COR INC [US], et al) [X] 2-5,12-14 * the whole document * * page 2, line 16 - page 4, line 15 * * page 5, line 28 - page 6, line 19 * * page 9, line 8 - line 23 * * page 12, line 2 - page 16, line 15 ** examples 3,5-9 *; | [X]WO2007005222 (LI COR INC [US], et al) [X] 2-5,12-14 * the whole document * * abstract * * paragraph [0003] * * paragraph [0005] * * paragraph [0085] - paragraph [0086] * * paragraph [0092] - paragraph [0093] * * paragraph [0112] - paragraph [0132] * * paragraph [0148] - paragraph [0163] * * claims 18-24,26-54 *; | [X]WO2007136996 (LI COR INC [US], et al) [X] 2-5,12-14 * abstract * * paragraph [0002] - paragraph [0003] * * paragraph [0009] - paragraph [0015] * * paragraph [0069] * * paragraph [0097] - paragraph [0112] * * paragraph [0116] - paragraph [0138] * * paragraph [0139] - paragraph [0144] * * paragraph [0153] - paragraph [0170] * * example 12 * * claims 14-35 *; | [X]WO2008017074 (BETH ISRAEL HOSPITAL [US], et al) [X] 2-5,12-14 * the whole document * * page 2, paragraph 2 - page 7, line 14 * * page 9, paragraph l - page 19 *; | [X]WO2009014513 (ENZO LIFE SCIENCES INC [US], et al) [X] 2-5,12-14 * the whole document * * abstract * * page 7, line 2 - page 9, line 15 * * page 10 - page 29 * * page 31, paragraph l - page 35 * * page 37 - page 52 * * page 37; compounds NIRD-101-NHS Ester * * claims 5-40 * | International search | [A]WO2006020947 (EPOCH BIOSCIENCES INC [US], et al); | [Y]WO2007136996 (LI COR INC [US], et al); | [Y]WO2008017074 (BETH ISRAEL HOSPITAL [US], et al); | [Y]US2008044811 (HAUGLAND RICHARD P [US], et al) | by applicant | WO0190253 | WO0224815 | WO02098885 | WO03082988 | US6875886 | US2006063834 | WO2007005222 | WO2007136996 | WO2008017074 | WO2008015415 | WO2009006443 | WO2009014513 | - MOJZYCH, M. et al., "Synthesis of Cyanine Dyes", Top. Heterocycl. Chem., (20080000), vol. 14, pages 1 - 9 | - Sysmex Journal International, (19990000), vol. 9, no. 2, page 185 | - STREKOWSKI, L. et al., Synthetic Communications, (19920000), vol. 22, no. 17, pages 2593 - 2598 | - STREKOWSKI, L. et al., J. Org. Chem., (19920000), vol. 57, pages 4578 - 4580 | - NARAYANAN, N. et al., J. Org. Chem., (19950000), vol. 60, no. 8, pages 2391 - 2395 | - MAKIN, S.M. et al., Journal of Organic Chemistry of the USSR, (19770000), vol. 13, no. 6, pages 1093 - 1096 | - LEE, H. et al., J. Org. Chem., (20060000), vol. 71, pages 7862 - 7865 | - HUMBLET, V. et al., Mol. Imaging, (20050000), vol. 4, pages 448 - 62 | - MISRA P. et al., J Nucl. Med., (20070000), vol. 48, pages 1379 - 89 | - CHEN, Y. et al., J. Med. Chem, (20080000), vol. 51, pages 7933 - 43 | - CHANDRAN, S.S. et al., Cancer Biol. Ther., (20080000), vol. 7, pages 974 - 82 | - BANERJEE, S.R., J. Med. Chem., (20080000), vol. 51, pages 4504 - 17 | - MEASE, R.C. et al., Clin. Cancer Res., (20080000), vol. 14, pages 3036 - 43 | - FOSS, C.A. et al., Clin. Cancer. Res., (20050000), vol. 11, pages 4022 - 8 | - LEE, H. et al., J. Org. Chem., (20060000), vol. 71, no. 20, pages 7862 - 7865 | - STREKOWSKI, L. et al., Communications, (19920000), vol. 22, no. 17, pages 2593 - 2598 | - MAISON, W.; J.V. FRANGIONI; N. PANNIER, "Synthesis of rigid multivalent scaffolds based on adamantane", Org Lett, (20040000), vol. 6, pages 4567 - 9 | - TANAKA, E.; H.S. CHOI; H. FUJII; M.G. BAWENDI; J.V. FRANGIONI, "Image-guided oncologic surgery using invisible light: completed pre-clinical development for sentinel lymph node mapping", Ann Surg Oncol, (20060000), vol. 13, doi:doi:10.1245/s10434-006-9194-6, pages 1671 - 81, XP019446446 DOI: http://dx.doi.org/10.1245/s10434-006-9194-6 | - DE GRAND, A.M.; J.V. FRANGIONI, "An operational near-infrared fluorescence imaging system prototype for large animal surgery", Technol Cancer Res Treat, (20030000), vol. 2, pages 553 - 562, XP008077536 | - NAKAYAMA, A.; F. DEL MONTE; R.J. HAJJAR; J.V. FRANGIONI, "Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy", Molecular Imaging, (20020000), vol. 1, pages 365 - 377 | US20090376243 | US20090376225 |