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Extract from the Register of European Patents

EP About this file: EP2459555

EP2459555 - PROCESSES FOR CRYSTALLIZATION OF RIVAROXABAN [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  01.10.2021
Database last updated on 07.10.2024
FormerGrant of patent is intended
Status updated on  18.05.2021
FormerExamination is in progress
Status updated on  10.05.2019
Most recent event   Tooltip07.10.2024Change: Date of oral proceedings 
07.10.2024Deletion: Despatch of minutes of oral proceedings 
Applicant(s)For all designated states
KRKA, D.D., Novo Mesto
Smarjeska cesta 6
8501 Novo mesto / SI
[2012/23]
Inventor(s)01 / ZUPANCIC, Silvo
Zupnca 4b
SI-8000 NOVO MESTO / SI
02 / PECAVAR, Anica
Gotna vas 18
SI-8000 NOVO MESTO / SI
 [2012/23]
Representative(s)Hoefer & Partner Patentanwälte mbB
Pilgersheimer Straße 20
81543 München / DE
[2021/44]
Former [2012/23]Westendorp | Sommer
Uhlandstrasse 2
80336 München / DE
Application number, filing date10740170.530.07.2010
[2021/44]
WO2010EP04688
Priority number, dateSI2009000021831.07.2009         Original published format: SI 200900218
[2012/23]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011012321
Date:03.02.2011
Language:EN
[2011/05]
Type: A1 Application with search report 
No.:EP2459555
Date:06.06.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 03.02.2011 takes the place of the publication of the European patent application.
[2012/23]
Type: B1 Patent specification 
No.:EP2459555
Date:03.11.2021
Language:EN
[2021/44]
Search report(s)International search report - published on:EP03.02.2011
ClassificationIPC:C07D413/14, A61K31/42, A61P7/00
[2012/23]
CPC:
C07D413/14 (EP,EA); A61K31/42 (EP,EA); A61P7/00 (EP,EA)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/23]
Extension statesBA22.02.2012
ME22.02.2012
RS22.02.2012
TitleGerman:VERFAHREN ZUR KRISTALLISIERUNG VON RIVAROXABAN[2012/23]
English:PROCESSES FOR CRYSTALLIZATION OF RIVAROXABAN[2012/23]
French:MÉTHODES DE CRISTALLISATION DE RIVAROXABAN[2012/23]
Entry into regional phase22.02.2012National basic fee paid 
22.02.2012Designation fee(s) paid 
22.02.2012Examination fee paid 
Examination procedure22.02.2012Examination requested  [2012/23]
07.11.2012Request for decision received: Application is deemed to be withdrawn
03.12.2012Result of request for decision (Application is deemed to be withdrawn): Request accepted
05.02.2013Observations by third parties
13.06.2013Amendment by applicant (claims and/or description)
05.10.2015Despatch of a communication from the examining division (Time limit: M06)
15.04.2016Reply to a communication from the examining division
22.03.2019Observations by third parties
14.05.2019Despatch of a communication from the examining division (Time limit: M06)
03.01.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
13.03.2020Reply to a communication from the examining division
15.10.2020Despatch of a communication from the examining division (Time limit: M04)
29.10.2020Observations by third parties
25.01.2021Observations by third parties
24.02.2021Reply to a communication from the examining division
19.05.2021Communication of intention to grant the patent
22.09.2021Fee for grant paid
22.09.2021Fee for publishing/printing paid
22.09.2021Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  05.10.2015
Opposition(s)Opponent(s)01  02.08.2022  03.08.2022  ADMISSIBLE
Dr. Schön, Neymeyr & Partner Patentanwälte mbB
Bavariaring 26
80336 München / DE
 [2022/36]
deletedDeletion: Legal effect of rejection of opposition [ N /P ]
18.08.2022Invitation to proprietor to file observations on the notice of opposition
28.12.2022Reply of patent proprietor to notice(s) of opposition
25.10.2023Date of oral proceedings
17.11.2023Despatch of minutes of oral proceedings
17.11.2023Date of despatch of rejection of opposition
Appeal following opposition05.01.2024Appeal received No.  T0074/24
05.01.2024Payment of appeal fee
26.02.2024Statement of grounds filed
18.12.2025Date of oral proceedings
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
13.03.2020Request for further processing filed
13.03.2020Full payment received (date of receipt of payment)
Request granted
20.03.2020Decision despatched
Fees paidRenewal fee
11.04.2012Renewal fee patent year 03
22.07.2013Renewal fee patent year 04
12.06.2014Renewal fee patent year 05
13.07.2015Renewal fee patent year 06
15.07.2016Renewal fee patent year 07
27.07.2017Renewal fee patent year 08
30.07.2018Renewal fee patent year 09
31.07.2019Renewal fee patent year 10
31.07.2020Renewal fee patent year 11
31.07.2021Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL03.11.2021
AT03.11.2021
CY03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
MK03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
TR03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB30.07.2022
IE30.07.2022
LU30.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
[2024/29]
Former [2024/22]AL03.11.2021
AT03.11.2021
CY03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
MK03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB30.07.2022
IE30.07.2022
LU30.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
Former [2024/20]AL03.11.2021
AT03.11.2021
CY03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB30.07.2022
IE30.07.2022
LU30.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
Former [2023/33]AL03.11.2021
AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB30.07.2022
IE30.07.2022
LU30.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
Former [2023/27]AL03.11.2021
AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
GB30.07.2022
LU30.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
Former [2023/25]AL03.11.2021
AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
IT03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
LU30.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
Former [2023/22]AL03.11.2021
AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
LU30.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
Former [2023/21]AL03.11.2021
AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
LU30.07.2022
CH31.07.2022
LI31.07.2022
Former [2023/11]AL03.11.2021
AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
MC03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/49]AL03.11.2021
AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/35]AT03.11.2021
DK03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SK03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/34]AT03.11.2021
EE03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
RO03.11.2021
SE03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/33]AT03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
SE03.11.2021
SM03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/25]AT03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
SE03.11.2021
BG03.02.2022
NO03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/24]AT03.11.2021
FI03.11.2021
HR03.11.2021
LT03.11.2021
LV03.11.2021
NL03.11.2021
SE03.11.2021
BG03.02.2022
GR04.02.2022
IS03.03.2022
PT03.03.2022
Former [2022/22]AT03.11.2021
FI03.11.2021
LT03.11.2021
BG03.02.2022
Former [2022/21]AT03.11.2021
BG03.02.2022
Former [2022/19]BG03.02.2022
Cited inInternational search[XDI]WO0147919  (BAYER AG [DE], et al) [XD] 1 * example 44 * [I] 13;
 [ID]WO2004060887  (BAYER HEALTHCARE AG [DE], et al) [ID] 13 * the whole document *;
 [XD]WO2007039132  (BAYER HEALTHCARE AG [DE], et al) [XD] 1-5,14 * page 6, line 21 - page 7, line 11 * * page 2, line 26 - line 33 *;
 [X]WO2009074249  (BAYER SCHERING PHARMA AG [DE], et al) [X] 13 * page 6, line 19 - page 9, line 16; example 1 *;
 [XD]  - ROEHRIG S ET AL, "Discovery of the Novel Antithrombotic Agent 5-Chloro-N-(((5S)-2-oxo-3 [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl)methyl)thiophene 2-carboxamide (BAY 59-7939): An Oral, Direct Factor Xa Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM050101D, (20050922), vol. 48, ISSN 0022-2623, pages 5900 - 5908, XP002418821 [XD] 1 * page 5903, paragraph 2 *

DOI:   http://dx.doi.org/10.1021/jm050101d
by applicantWO0147919
 DE10129725
 WO2004060887
 WO2005068456
 WO2007039132
    - JOURNAL OF MEDICINAL CHEMISTRY, (2005), vol. 48, pages 5900 - 5908
otherUS2005182055
 WO2007039132
 US7351823
 WO2010075631
 US8188270
 WO0147919
 US7157456
    - "RECRYSTALLISATION TECHNIOUES", Brian S. Furniss et al, Vogel's Textbook of Practical Organic Chemistry. 5th ed., Longman Scientific & Technical, (19890000), pages 135 - 153, XP055580749
    - SHERRY L. MORISSETTEA, "High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids", Advanced Drug Delivery Reviews, (20040000), vol. 56, pages 275 - 300, XP009072233

DOI:   http://dx.doi.org/10.1016/j.addr.2003.10.020
    - BRIAN S. FURNISS et al., Vogel's Textbook of Practical Organic Chemistry, (19890000), pages 135 - 153, XP055580749
    - M.GIULIETTI, "INDUSTRIAL CRYSTALLIZATION AND PRECIPITATION FROM SOLUTIONS: STATE OF THE TECHNIQUE", Braz. J. Chem. Eng., (20011200), vol. 18, no. 4, XP002563840
    - Morissette S, "High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids", Advanced Drug Delivery Reviews, (20040000), vol. 56, pages 275 - 300, XP055531004

DOI:   http://dx.doi.org/10.1016/j.addr.2003.10.020
    - Brian S Furniss; Et Al, Vogel's Textbook of Practical Organic Chemistry. 5th ed,, Longman Scientific & Technical, (19890000), pages 135 - 142, XP055580749
    - GIULIETTI M; SECKLER M M; DERENZO S; RÉ M I; CEKINSKI E, "INDUSTRIAL CRYSTALLIZATION AND PRECIPITATION FROM SOLUTIONS: STATE OF THE TECHNIQUE", BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING,, (20011200), vol. 18, no. 4, pages 423 - 440, XP002563840
OppositionWO0147919
 US2005182055
 WO2007039132
 WO2010075631
 US7351823
 WO2014020458
    - Furniss Brian, Et Al, Furniss Brian, Et Al, Vogel A. I.; Furniss B.S.; Hannaford A.J.; Smith P.W.G.; Tatchell A.R., Vogel's Textbook of Practical Organic Chemistry, Harlow , Addison Wesley Longman Limited , (19890101), pages 135 - 153, ISBN 978-0-582-46236-6, XP055950142
    - Falbe Jürgen, Manfred Regitz, "Waschen", RÖMPP CHEMIELEXIKON, T-Z, Thieme Verlag, (19920101), page 4990, XP093108201
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.