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Extract from the Register of European Patents

EP About this file: EP2464668

EP2464668 - PROCESS FOR PREPARING FONDAPARINUX SODIUM AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.10.2023
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  04.11.2022
FormerGrant of patent is intended
Status updated on  18.07.2022
FormerExamination is in progress
Status updated on  02.08.2017
Most recent event   Tooltip10.05.2024Lapse of the patent in a contracting state
New state(s): BE, CH		published on 12.06.2024  [2024/24]
Applicant(s)For all designated states
Reliable Biopharmaceutical, LLC
Radnor Corporate Center, 100
Matsonford Road, Building 1, Suite 200
Radnor, PA 19087 / US
[2023/20]
Former [2012/25]For all designated states
Reliable Biopharmaceutical Corporation
1945 Walton Road
St. Louis, MO 63114 / US
Inventor(s)01 / SOURENA, Nadji
3 Bon Aire Drive
Olivette, MO 63132 / US
02 / SMOOT, James, T.
35 Sundance Drive
Mt. Zion, IL 62549 / US
03 / VANARTSDALEN, Joseph, A.
4161 Mcclay Road
Saint Charles, MO 63304 / US
 [2012/25]
Representative(s)Pons
Glorieta Rubén Darío 4
28010 Madrid / ES
[2022/49]
Former [2012/25]Pons Ariño, Angel
Glorieta Ruben Dario 4
28010 Madrid / ES
Application number, filing date10740809.830.07.2010
[2022/49]
WO2010US43946
Priority number, dateUS20090230557P31.07.2009         Original published format: US 230557 P
[2012/25]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011014793
Date:03.02.2011
Language:EN
[2011/05]
Type: A2 Application without search report 
No.:EP2464668
Date:20.06.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 03.02.2011 takes the place of the publication of the European patent application.
[2012/25]
Type: B1 Patent specification 
No.:EP2464668
Date:07.12.2022
Language:EN
[2022/49]
Search report(s)International search report - published on:EP07.02.2013
ClassificationIPC:C08B37/10, A61K31/737
[2012/25]
CPC:
A61K31/737 (EP,US); C07H1/00 (EP,US); A61P7/02 (EP);
C07H13/04 (EP,US); C07H19/01 (US); C07H5/04 (US);
C07H5/06 (US); C07H5/08 (US); C07H5/10 (US);
C08B37/0063 (EP,US); Y02P20/55 (EP) (-)
C-Set:
A61K31/737, A61K2300/00 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/25]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON FONDAPARINUXNATRIUM UND NÜTZLICHE ZWISCHENPRODUKTE FÜR SEINE SYNTHESE[2012/25]
English:PROCESS FOR PREPARING FONDAPARINUX SODIUM AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF[2012/25]
French:PROCÉDÉ DE PRÉPARATION DE FONDAPARINUX SODIQUE ET INTERMÉDIAIRES UTILES POUR SA SYNTHÈSE[2012/25]
Entry into regional phase30.01.2012National basic fee paid 
30.01.2012Designation fee(s) paid 
30.01.2012Examination fee paid 
Examination procedure30.01.2012Examination requested  [2012/25]
13.08.2012Amendment by applicant (claims and/or description)
11.02.2016Despatch of a communication from the examining division (Time limit: M06)
10.08.2016Reply to a communication from the examining division
21.07.2017Despatch of a communication from the examining division (Time limit: M04)
23.11.2017Reply to a communication from the examining division
27.03.2019Despatch of a communication from the examining division (Time limit: M04)
15.07.2019Reply to a communication from the examining division
20.11.2019Despatch of a communication from the examining division (Time limit: M04)
20.03.2020Reply to a communication from the examining division
12.06.2020Despatch of a communication from the examining division (Time limit: M03)
26.08.2020Reply to a communication from the examining division
19.07.2022Communication of intention to grant the patent
02.11.2022Fee for grant paid
02.11.2022Fee for publishing/printing paid
02.11.2022Receipt of the translation of the claim(s)
Divisional application(s)EP20153568.9  / EP3666786
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  11.02.2016
Opposition(s)08.09.2023No opposition filed within time limit [2023/46]
Fees paidRenewal fee
25.06.2012Renewal fee patent year 03
08.07.2013Renewal fee patent year 04
08.07.2014Renewal fee patent year 05
09.07.2015Renewal fee patent year 06
11.07.2016Renewal fee patent year 07
10.07.2017Renewal fee patent year 08
27.07.2018Renewal fee patent year 09
29.07.2019Renewal fee patent year 10
27.07.2020Renewal fee patent year 11
15.07.2021Renewal fee patent year 12
26.07.2022Renewal fee patent year 13
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL07.12.2022
AT07.12.2022
CZ07.12.2022
DK07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
MC07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SI07.12.2022
SK07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
IS07.04.2023
PT10.04.2023
LU30.07.2023
BE31.07.2023
CH31.07.2023
[2024/24]
Former [2024/18]AL07.12.2022
AT07.12.2022
CZ07.12.2022
DK07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
MC07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SI07.12.2022
SK07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
IS07.04.2023
PT10.04.2023
LU30.07.2023
Former [2024/14]AL07.12.2022
AT07.12.2022
CZ07.12.2022
DK07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
MC07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SI07.12.2022
SK07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
IS07.04.2023
PT10.04.2023
Former [2023/51]AL07.12.2022
AT07.12.2022
CZ07.12.2022
DK07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SI07.12.2022
SK07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
IS07.04.2023
PT10.04.2023
Former [2023/46]AL07.12.2022
AT07.12.2022
CZ07.12.2022
DK07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SK07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
IS07.04.2023
PT10.04.2023
Former [2023/39]AL07.12.2022
AT07.12.2022
CZ07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SK07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
IS07.04.2023
PT10.04.2023
Former [2023/38]AL07.12.2022
AT07.12.2022
CZ07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SK07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
PT10.04.2023
Former [2023/37]AL07.12.2022
AT07.12.2022
CZ07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
PT10.04.2023
Former [2023/35]AT07.12.2022
CZ07.12.2022
EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
RO07.12.2022
SE07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
PT10.04.2023
Former [2023/34]EE07.12.2022
FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
SE07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
PT10.04.2023
Former [2023/33]FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
SE07.12.2022
SM07.12.2022
NO07.03.2023
GR08.03.2023
Former [2023/29]FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
NL07.12.2022
PL07.12.2022
SE07.12.2022
NO07.03.2023
GR08.03.2023
Former [2023/26]FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
PL07.12.2022
SE07.12.2022
NO07.03.2023
GR08.03.2023
Former [2023/24]FI07.12.2022
HR07.12.2022
LT07.12.2022
LV07.12.2022
SE07.12.2022
NO07.03.2023
GR08.03.2023
Former [2023/23]FI07.12.2022
LT07.12.2022
LV07.12.2022
SE07.12.2022
NO07.03.2023
GR08.03.2023
Former [2023/22]FI07.12.2022
LT07.12.2022
SE07.12.2022
NO07.03.2023
Former [2023/20]LT07.12.2022
NO07.03.2023
Cited inInternational search[A]WO02058633  (MASSACHUSETTS INST TECHNOLOGY [US]) [A] 1-49 * the whole document *;
 [AD]WO03022860  (ALCHEMIA PTY LTD [AU], et al) [AD] 1-49 * the whole document *;
 [Y]  - LOHMAN ET AL, "A Stereochemical Surprise at the Late Stage of the Synthesis of Fully N-Differentiated Heparin Oligosaccharides Containing Amino, Acetamido, and N-Sulfonate Groups", JOURNAL OF ORGANIC CHEMISTRY, ACS, US, (20040101), ISSN 0022-3263, XP002404119 [Y] 44 * figure 2 *

DOI:   http://dx.doi.org/10.1021/jo035732z
 [Y]  - ORGUEIRA H A ET AL, "Modular synthesis of Heparin oligosaccharides", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, WEINHEIM, DE, (20030101), vol. 9, no. 1, ISSN 0947-6539, pages 140 - 169, XP002682960 [Y] 44 * page 148; compound 66+7 *

DOI:   http://dx.doi.org/10.1002/chem.200390009
 [YD]  - SINAY P. , JACQUINET J.C., "Total synthesis of a heparin pentasaccharide fragment having high affinity for antithrombin III", CARBOHYDRATE RESEARCH, (19840901), vol. 132, no. 2, doi:10.1016/0008-6215(84)85236-2, ISSN 0008-6215, pages C5 - C9, XP055046153 [YD] 44 * the whole document *

DOI:   http://dx.doi.org/10.1016/0008-6215(84)85236-2
by applicantUS4818816
 US7468358
 US7541445
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.