blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2467480

EP2467480 - TREATMENT OF PATIENTS AFTER STENT IMPLANTATION OR BALLOON DILATATION AND DRUG ELUTING STENTS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  08.03.2013
Database last updated on 12.08.2024
Most recent event   Tooltip08.03.2013Application deemed to be withdrawnpublished on 10.04.2013  [2013/15]
Applicant(s)For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Hofgartenstrasse 8
80539 München / DE
[N/P]
Former [2012/26]For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Hofgartenstrasse 8
80539 München / DE
Inventor(s)01 / BRAUN, Thomas
Höhenweg 20
61231 Bad Nauheim / DE
02 / BOETTGER, Thomas
Merlinweg 1
61231 Bad Nauheim / DE
 [2012/26]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[N/P]
Former [2012/26]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date10742003.613.08.2010
WO2010EP61828
Priority number, dateEP2009001057217.08.2009         Original published format: EP 09010572
[2012/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011020790
Date:24.02.2011
Language:EN
[2011/08]
Type: A1 Application with search report 
No.:EP2467480
Date:27.06.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 24.02.2011 takes the place of the publication of the European patent application.
[2012/26]
Search report(s)International search report - published on:EP24.02.2011
ClassificationIPC:C12N15/113, A61K31/713
[2012/26]
CPC:
C12N15/113 (EP,US); A61K48/00 (EP,US); C12N2310/141 (EP,US);
C12N2310/3515 (EP,US); Y10T436/143333 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/26]
TitleGerman:BEHANDLUNG VON PATIENTEN NACH EINER STENTIMPLANTATION ODER BALLONDILATATION UND MEDIKAMENTENBESCHICHTETE STENTS[2012/26]
English:TREATMENT OF PATIENTS AFTER STENT IMPLANTATION OR BALLOON DILATATION AND DRUG ELUTING STENTS[2012/26]
French:TRAITEMENT DE PATIENTS APRÈS IMPLANTATION DE STENT OU DILATATION AU BALLONNET ET STENTS D ÉLUTION DE MÉDICAMENT[2012/26]
Entry into regional phase14.03.2012National basic fee paid 
14.03.2012Designation fee(s) paid 
14.03.2012Examination fee paid 
Examination procedure14.03.2012Examination requested  [2012/26]
16.10.2012Application deemed to be withdrawn, date of legal effect  [2013/15]
20.11.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time  [2013/15]
Fees paidRenewal fee
24.08.2012Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[XP]WO2009105759  (UNIV TEXAS [US], et al) [XP] 1-8 * page 2, line 11 * * page 22 - page 23 * * page 31 * * page 37 - page 38 * * the whole document *;
 [A]WO2008122666  (INST NAT SANTE RECH MED [FR], et al) [A] 1-8 * the whole document *;
 [A]WO2009075787  (UNIV JOHNS HOPKINS [US], et al) [A] 1 * the whole document *
 [X]  - CHENG Y. ET AL., "MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 105, no. 2, ISSN 0009-7330, (20090717), pages 158 - 166, (20090618), XP008116950 [X] 1-7 * the whole document *

DOI:   http://dx.doi.org/10.1161/CIRCRESAHA.109.197517
 [X]  - CORDES K.R. ET AL., "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity", NATURE, (20090806), vol. 460, pages 705 - 711, XP002562556 [X] 8 * page 706 * * the whole document *

DOI:   http://dx.doi.org/10.1038/nature08195
 [A]  - NEPPL R.L. AND WANG D.-Z., "Smooth(ing) muscle differentiation by MicroRNAs", CELL STEM CELL, (20090807), vol. 5, pages 130 - 132, XP002562557 [A] 1-8 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.stem.2009.07.004
 [T]  - BOETTGER T. ET AL., "Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster", THE JOURNAL OF CLINICAL INVESTIGATION, (200909), vol. 119, no. 9, pages 2634 - 2647, XP002562558 [T] * the whole document *

DOI:   http://dx.doi.org/10.1172/JCI38864
 [T]  - PARMACEK M.S., "MicroRNA-modulated targeting of vascular smooth muscle cells", THE JOURNAL OF CLINICAL INVESTIGATION, (200909), vol. 119, no. 9, pages 2526 - 2528, XP002562559 [T] * the whole document *

DOI:   http://dx.doi.org/10.1172/JCI40503
 [T]  - ELIA L. ET AL., "The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human diseases", CELL DEATH AND DIFFERENTIATION, (20091009), vol. 16, pages 1590 - 1598, XP002562560

DOI:   http://dx.doi.org/10.1038/cdd.2009.153
by applicantUS5075109
 US4452775
 US4675189
 US5736152
 US4667013
 US4748034
 US5239660
 US3832253
 US3854480
 US5133974
 US5407686
    - ELBASHIR ET AL., NATURE, (20010524), vol. 411, no. 6836, pages 494 - 8
    - THOMPSON NUD. ACIDS RES., (1994), vol. 2, pages 4673 - 4680
    - PEARSON; LIPMAN, PROC. NATL. ACAD. SCI., (1988), vol. 85, page 2444
    - ALTSCHUL, NUCL. ACIDS RES., (1977), vol. 25, page 3389
    - HENIKOFF, PROC. NATL. ACAD. SCI., (1989), vol. 89, page 10915
    - SOUTSCHEK ET AL., NATURE, (2005), vol. 432, pages 173 - 178
    - KRüTZFELDT ET AL., NATURE, (2005), vol. 438, pages 685 - 689
    - DE FOUGEROLLES ET AL., CURRENT OPINION IN PHARMACOLOGY, (2008), vol. 8, pages 280 - 285
    - UDIPI, JOURNAL OF BIOCHEMICAL MATERIALS RESEARCH PART A, (2007), pages 1065 - 1071
    - H. S. SAWHNEY; C. P. PATHAK; J. A. HUBELL, MACROMOLECULES, (1993), vol. 26, pages 581 - 587
    - OWENS, G.K.; KUMAR, M.S.; WAMHOFF, B.R., "Molecular regulation of vascular smooth muscle cell differentiation in development and disease", PHYSIOL REV, (2004), vol. 84, pages 767 - 801
    - RENSEN, S.S.; DOEVENDANS, P.A.; VAN EYS, G.J., "Regulation and characteristics of vascular smooth muscle cell phenotypic diversity", NETH HEART J, (2007), vol. 15, pages 100 - 108
    - DORAN, A.C.; MELLER, N.; MCNAMARA, C.A., "Role of smooth muscle cells in the initiation and early progression of atherosclerosis", ARTERIOSCLER THROMB VASC BIOL, (2008), vol. 28, pages 812 - 819
    - ROSS, R., "Cell biology of atherosclerosis", ANNU REV PHYSIOL, (1995), vol. 57, pages 791 - 804
    - BARTEL, D.P., "MicroRNAs: genomics, biogenesis, mechanism, and function", CELL, (2004), vol. 116, pages 281 - 297
    - LANDGRAF, P.; RUSU, M.; SHERIDAN, R.; SEWER, A.; LOVINO, N.; ARAVIN, A.; PFEFFER, S.; RICE, A.; KAMPHORST, A.O.; LANDTHALER, M. ET, "A mammalian microRNA expression atlas based on small RNA library sequencing", CELL, (2007), vol. 129, pages 1401 - 1414
    - ZHAO, Y.; RANSOM, J.F.; LI, A.; VEDANTHAM, V.; VON DREHLE, M.; MUTH, A.N.; TSUCHIHASHI, T.; MCMANUS, M.T.; SCHWARTZ, R.J.; SRIVAST, "Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1 -2", CELL, (2007), vol. 129, pages 303 - 317
    - MAKEYEV, E.V.; ZHANG, J.; CARRASCO, M.A.; MANIATIS, T., "The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative premRNA splicing", MOL CELL, (2007), vol. 27, pages 435 - 448
    - LEUCHT, C.; STIGLOHER, C.; WIZENMANN, A.; KLAFKE, R.; FOLCHERT, A.; BALLY-CUIF, L.; 2008, "MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary", NAT NEUROSCI, vol. 11, pages 641 - 648
    - RUZICKA, D.L.; SCHWARTZ, R.J., "Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alpha-actin gene transcripts mark the onset of cardiomyocyte differentiation", J CELL 8IOL, (1988), vol. 107, pages 2575 - 2586
    - LI, L.; MIANO, J.M; CSERJESI, P.; OLSON, E.N., "SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis", CIRC RES, (1996), vol. 78, pages 188 - 195
    - RISHNIW, M.; XIN, H.B.; DENG, K.Y.; KOTLIKOFF, M.I., "Skeletal myogenesis in the mouse esophagus does not occur through transdifferentiation", GENESIS, (2003), vol. 36, pages 81 - 82
    - PFITZER, G.; BOELS, P.J., "Differential skinning of smooth muscle: a new approach to excitation-contraction coupling", BLOOD VESSELS, (1991), vol. 28, pages 262 - 267
    - KHROMOV, A.S.; WANG, H.; CHOUDHURY, N.; MCDUFFIE, M.; HERRING, B.P.; NAKAMOTO, R.; OWENS, G.K.; SOMLYO, A.P.; SOMLYO, A.V., "Smooth muscle of telokindeficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP induced relaxation", PROC NATL ACAD SCI USA, (2006), vol. 103, pages 2440 - 2445
    - KRUGER, M.; MOSER, M.; USSAR, S.; THIEVESSEN, I.; LUBER, C.A.; FORNER, F.; SCHMIDT, S.; ZANIVAN, S.; FASSLER, R.; MANN, M., "SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function", CELL, (2008), vol. 134, pages 353 - 364
    - JOHN, B.; ENRIGHT, A.J.; ARAVIN, A.; TUSCHL, T.; SANDER, C.; MARKS, D.S., "Human MicroRNA targets", PLOS BIOL, (2004), vol. 2, page E363
    - BETEL, D.; WILSON, M.; GABOW, A.; MARKS, D.S.; SANDER, C., "The microRNA.org resource: targets and expression", NUCLEIC ACIDS RES, (2008), vol. 36, pages 149 - 153
    - GRIFFITHS-JONES, S.; SAINI, H.K.; VAN DONGEN, S.; ENRIGHT, A.J., "miRBase: tools for microRNA genomics", NUCLEIC ACIDS RES, (2008), vol. 36, pages 154 - 158
    - GRIMSON, A.; FARH, K.K.; JOHNSTON, W.K.; GARRETT-ENGELE, P.; LIM, L.P.; BARTEL, D.P., "MicroRNA targeting specificity in mammals: determinants beyond seed pairing", MOL CELL, (2007), vol. 27, pages 91 - 105
    - BUSSEY, K.J.; KANE, D.; SUNSHINE, M.; NARASIMHAN, S.; NISHIZUKA, S.; REINHOLD, W.C.; ZEEBERG, B.; AJAY, W.; WEINSTEIN, J.N., "MatchMiner: a tool for batch navigation among gene and gene product identifiers", GENOME BIO, (2003), vol. 4, page R27
    - ABOUHAMED, M.; REICHENBERG, S.; ROBENEK, H.; PLENZ, G., "Tropomyosin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis", EUR J CELL BIOL, (2003), vol. 82, pages 473 - 482
    - POTAPOVA, I.A.; COHEN, I.S.; DORONIN, S.V., "Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap", FEBS J, (2007), vol. 274, pages 4375 - 4384
    - MIRALLES, F.; POSERN, G.; ZAROMYTIDOU, A.I.; TREISMAN, R., "Actin dynamics control SRF activity by regulation of its coactivator MAL", CELL, (2003), vol. 113, pages 329 - 342
    - JI, R.; CHENG, Y.; YUE, J.; YANG, J.; LIU, X.; CHEN, H.; DEAN, D.B.; ZHANG, C., "MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointima lesion formation", CIRC RES, (2007), vol. 100, pages 1579 - 1588
    - XU, Q., "Mouse models of arteriosclerosis: from arterial injuries to vascular grafts", AM J PATHOL, (2004), vol. 165, pages 1 - 10
    - FARH, K.K.; GRIMSON, A.; JAN, C.; LEWIS, B.P.; JOHNSTON, W.K.; LIM, L.P.; BURGE, C.B.; BARTEL, D.P., "The widespread impact of mammalian MicroRNAs on mRNA repression and evolution", SCIENCE, (2005), vol. 310, pages 1817 - 1821
    - WANG, D.; CHANG, P.S.; WANG, Z.; SUTHERLAND, L.; RICHARDSON, J.A.; SMALL, E.; KRIEG, P.A.; OLSON, E.N., "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor", CELL, (2001), vol. 105, pages 851 - 862
    - XU, N.; PAPAGIANNAKOPOULOS, T.; PAN, G.; THOMSON, J.A.; KOSIK, K.S., "MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells", CELL, (2009), vol. 137, pages 647 - 658
    - DZAU, V.J., "Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis", HYPERTENSION, (2001), vol. 37, pages 1047 - 1052
    - TOUYZ, RM., "Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin", EXP PHYSIOL, (2005), vol. 90, pages 449 - 455
    - SCHIEFFER, B.; SCHIEFFER, E.; HILFIKER-KLEINER, D.; HILFIKER, A.; KOVANEN, P.T.; KAARTINEN, M.; NUSSBERGER, J.; HARRINGER, W.; DRE, "Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability", CIRCULATION, (2000), vol. 101, pages 1372 - 1378
    - GRIENDLING, K.K.; DELAFONTAINE, P.; RITTENHOUSE, S.E.; GIMBRONE, M.A., JR.; ALEXANDER, R.W., "Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells", J BIOL CHEM, (1987), vol. 262, pages 14555 - 14562
    - LASSEGUE, B.; ALEXANDER, R.W.; NICKENIG, G.; CLARK, M.; MURPHY, T.J.; GRIENDLING, K.K., "Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms: evidence for homologous and heterologous regulation", MOL PHARMACO, (1995), vol. 148, pages 601 - 609
    - WANG, X.; ADAMS, L.D.; PABON, L.M.; BEAUDRY, D.; GUNAJE, J.; GEARY, RL.; DEBLOIS, D.; SCHWARTZ, S.M., "RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy", J MOL CELL CARDIOL., (2007), vol. 33
    - HERCULE, H.C.; TANK, J.; PLEHM, R.; WELLNER, M.; DA COSTA GONCALVES, A.C.; GOLLASCH, M.; DIEDRICH, A.; JORDAN, J.; LUFT, F.C.; GRO, "Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice", EXP PHYSIOL, (2007), vol. 92, pages 1014 - 1022
    - LYSSAND, J.S.; DEFINO, M.C.; TANG, X.B.; HERTZ, A.L.; FELLER, D.B.; WACKER, J.L.; ADAMS, M.E.; HAGUE, C., "Blood pressure is regulated by an aiphalDadrenergic receptor/dystrophin signalosome", J BIOL CHEM, (2008), vol. 283, pages 18792 - 18800
    - KREGE, J.H.; KIM, H.S.; MOYER, J.S.; JENNETTE, J.C.; PENG, L.; HILLER, S.K.; SMITHIES, O., "Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis", HYPERTENSION, (1997), vol. 29, pages 150 - 157
    - SEITZ, H., "Redefining microRNA targets", CURR BIOL, (2009), vol. 19, pages 870 - 873
    - PENN, B.H.; BERGSTROM, D.A.; DILWORTH, F.J.; BENGAL, E.; TAPSCOTT, S.J., "A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation", GENES DEV, (2004), vol. 18, pages 2348 - 2353
    - IP, J.H.; FUSTER, V.; BADIMON, L.; BADIMON, J.; TAUBMAN, M.B.; CHESEBRO, J.H., "Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation", J AM CALL CARDIOL, (1990), vol. 15, pages 1667 - 1687
    - ROSS, R.; GLOMSET, J.A., "Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis", SCIENCE, (1973), vol. 180, pages 1332 - 1339
    - DAUGHERTY, A.; MANNING, M.W.; CASSIS, L.A., "Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice", J CLIN INVEST, (2000), vol. 105, pages 1605 - 1612
    - HALKIN, A.; KEREN, G., "Potential indications for angiotensin-converting enzyme inhibitors in atherosclerotic vascular disease", AM J MED, (2002), vol. 112, pages 126 - 134
    - WARMING, S.; COSTANTINO, N.; COURT, D.L.; JENKINS, N.A.; COPELAND, N.G., "Simple and highly efficient BAC recombineering using galK selection", NUCLEIC ACIDS RES, (2005), vol. 33, page E36
    - VOSS, A.K.; THOMAS, T.; GRUSS, P., "Germ line chimeras from female ES cells", EXP CELL RES, (1997), vol. 230, pages 45 - 49
    - SCHOLZ, D.; ITO, W.; FLEMING, I.; DEINDL, E.; SAUER, A.; WIESNET, M.; BUSSE, R.; SCHAPER, J.; SCHAPER, W., "Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis)", VIRCHOWS ARCH, (2000), vol. 436, pages 257 - 270
    - COX, J.; MANN, M., "Is proteomics the new genomics?", CELL, (2007), vol. 130, pages 395 - 398
    - GRAUMANN, J.; HUBNER, N.C.; KIM, J.B.; KO, K.; MOSER, M.; KUMAR, C.; COX, J.; SCHOLER, H.; MANN, M., "Stable isotope labeling by amino acids in cell culture (SILAC) and proteome quantitation of mouse embryonic stem cells to a depth of 5,111 proteins", MOL CELL PROTEOMICS, (2008), vol. 7, pages 672 - 683
    - KERSEY, P.J.; DUARTE, J.; WILLIAMS, A.; KARAVIDOPOULOU, Y.; BIRNEY, E.; APWEILER, R., "The International Protein Index: an integrated database for proteomics experiments", PROTEOMICS, (2004), vol. 4, pages 1985 - 1988
    - BREDE, M.; WIESMANN, F.; JAHNS, R.; HADAMEK, K.; ARNOLT, C.; NEUBAUER, S.; LOHSE, M.J.; HEIN, L., "Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure", CIRCULATION, (2002), vol. 106, pages 2491 - 2496
    - BREDE, M.; HADAMEK, K.; MEINEL, L.; WIESMANN, F.; PETERS, J.; ENGELHARDT, S.; SIMM, A.; HAASE, A.; LOHSE, M.J.; HEIN, L., "Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor", CIRCULATION, (2001), vol. 104, pages 2602 - 2607
    - FABIATO, A.; FABIATO, F., "Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells", J PHYSIOL (PARIS), (1979), vol. 75, pages 463 - 505
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.