EP2598876 - NOVEL ULTRASENSITIVE CELL BASED SENSORS AND USES THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 03.02.2017 Database last updated on 03.09.2024 | Most recent event Tooltip | 12.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 14.11.2018 [2018/46] | Applicant(s) | For all designated states Canvax Biotech SL Poligono Tecnocordoba Calle Estocolmo 47 14014 Cordoba / ES | [2013/23] | Inventor(s) | 01 /
PAZ ROJAS, Elier c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 02 /
MONTERO PEÑALVO, Maria de Gracia c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 03 /
LUNA GUERRERO, Verónica lnmaculada c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 04 /
GARCIA MACEIRA, Fe Isabel c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 05 /
MORALES-MARTÍNEZ, José Andrés c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 06 /
GARCIA MACEIRA, Tania c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 07 /
ARAGÓN GÓMEZ, Ana Belén c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 08 /
QUESADA MOLINA, Ana c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | 09 /
MARQUEZ MORALES, Aurora María c/o Canvax Biotech SL Parque Científico Tecnológico Rabanales 21 Calle Astrónoma Cecilia Payne - Edificio Orión 14014 Cordoba / ES | [2013/27] |
Former [2013/23] | 01 /
PAZ-ROJAS, Elier Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | ||
02 /
MONTERO-PEÑALVO, Maria de Gracia Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | |||
03 /
LUNA-GUERRERO, Veronica lnmaculada Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | |||
04 /
GARCIA MACEIRA, Fe Isabel Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | |||
05 /
MORALES-MARTÍNEZ, Jose Andres Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | |||
06 /
GARCIA MACEIRA, Tania Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | |||
07 /
ARAGÓN-GÓMEZ, Ana Belén Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | |||
08 /
QUESADA-MOLINA, Ana Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | |||
09 /
MARQUEZ-MORALES, Aurora Maria Poligono Tecnocordoba calle Estocolmo 47 14014 Cordoba / ES | Representative(s) | Illescas, Manuel, et al Manuel Illescas y Asociados, S.L. (MIA) Principe de Vergara n° 197 Oficina 1°A 28002 Madrid / ES | [2014/04] |
Former [2014/02] | Illescas, Manuel, et al Manuel Illescas y Asocioados, S.L. (MIA) Principe de Vergara n° 197 Ofucina 1°A 28002 Madrid / ES | ||
Former [2013/23] | Illescas, Manuel González-Bueno & Illescas C/ Recoletos, 13 - 5º Izda 28001 Madrid / ES | Application number, filing date | 10744506.6 | 28.07.2010 | [2016/13] | WO2010EP04619 | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2012013204 | Date: | 02.02.2012 | Language: | EN | [2012/05] | Type: | A1 Application with search report | No.: | EP2598876 | Date: | 05.06.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.02.2012 takes the place of the publication of the European patent application. | [2013/23] | Type: | B1 Patent specification | No.: | EP2598876 | Date: | 30.03.2016 | Language: | EN | [2016/13] | Search report(s) | International search report - published on: | EP | 02.02.2012 | Classification | IPC: | G01N33/50 | [2013/23] | CPC: |
G01N33/5044 (EP,US);
G01N33/566 (US);
C12N15/85 (US);
C12Q1/37 (US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2013/23] | Extension states | BA | Not yet paid | ME | Not yet paid | RS | Not yet paid | Title | German: | NEUE HOCHEMPFINDLICHE ZELLBASIERTE SENSOREN UND IHRE VERWENDUNG | [2013/23] | English: | NOVEL ULTRASENSITIVE CELL BASED SENSORS AND USES THEREOF | [2013/23] | French: | NOUVEAUX CAPTEURS ULTRASENSIBLES À BASE DE CELLULES ET LEURS UTILISATIONS | [2013/23] | Entry into regional phase | 13.02.2013 | National basic fee paid | 13.02.2013 | Designation fee(s) paid | 13.02.2013 | Examination fee paid | Examination procedure | 28.05.2012 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 13.02.2013 | Examination requested [2013/23] | 05.09.2013 | Amendment by applicant (claims and/or description) | 05.11.2013 | Despatch of a communication from the examining division (Time limit: M04) | 30.01.2014 | Reply to a communication from the examining division | 22.05.2014 | Despatch of a communication from the examining division (Time limit: M04) | 31.07.2014 | Reply to a communication from the examining division | 06.08.2015 | Despatch of a communication from the examining division (Time limit: M01) | 04.09.2015 | Reply to a communication from the examining division | 26.11.2015 | Communication of intention to grant the patent | 25.01.2016 | Fee for grant paid | 25.01.2016 | Fee for publishing/printing paid | 25.01.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 05.11.2013 | Opposition(s) | 03.01.2017 | No opposition filed within time limit [2017/10] | Fees paid | Renewal fee | 13.02.2013 | Renewal fee patent year 03 | 01.07.2013 | Renewal fee patent year 04 | 30.06.2014 | Renewal fee patent year 05 | 15.07.2015 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 28.07.2010 | AL | 30.03.2016 | AT | 30.03.2016 | BE | 30.03.2016 | BG | 30.03.2016 | CY | 30.03.2016 | CZ | 30.03.2016 | DK | 30.03.2016 | EE | 30.03.2016 | FI | 30.03.2016 | HR | 30.03.2016 | LT | 30.03.2016 | LV | 30.03.2016 | MC | 30.03.2016 | MK | 30.03.2016 | NL | 30.03.2016 | PL | 30.03.2016 | RO | 30.03.2016 | SE | 30.03.2016 | SI | 30.03.2016 | SK | 30.03.2016 | SM | 30.03.2016 | TR | 30.03.2016 | NO | 30.06.2016 | GR | 01.07.2016 | IE | 28.07.2016 | LU | 28.07.2016 | IS | 30.07.2016 | CH | 31.07.2016 | LI | 31.07.2016 | MT | 31.07.2016 | PT | 01.08.2016 | [2018/46] |
Former [2018/38] | HU | 28.07.2010 | |
AT | 30.03.2016 | ||
BE | 30.03.2016 | ||
BG | 30.03.2016 | ||
CY | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
MC | 30.03.2016 | ||
MK | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SI | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
TR | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IE | 28.07.2016 | ||
LU | 28.07.2016 | ||
IS | 30.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
MT | 31.07.2016 | ||
PT | 01.08.2016 | ||
Former [2018/33] | HU | 28.07.2010 | |
AT | 30.03.2016 | ||
BE | 30.03.2016 | ||
CY | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
MC | 30.03.2016 | ||
MK | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SI | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
TR | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IE | 28.07.2016 | ||
LU | 28.07.2016 | ||
IS | 30.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
MT | 31.07.2016 | ||
PT | 01.08.2016 | ||
Former [2018/29] | HU | 28.07.2010 | |
AT | 30.03.2016 | ||
BE | 30.03.2016 | ||
CY | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
MC | 30.03.2016 | ||
MK | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SI | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
TR | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IE | 28.07.2016 | ||
LU | 28.07.2016 | ||
IS | 30.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
PT | 01.08.2016 | ||
Former [2018/28] | HU | 28.07.2010 | |
AT | 30.03.2016 | ||
BE | 30.03.2016 | ||
CY | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
MC | 30.03.2016 | ||
MK | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SI | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IE | 28.07.2016 | ||
LU | 28.07.2016 | ||
IS | 30.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
PT | 01.08.2016 | ||
Former [2017/37] | AT | 30.03.2016 | |
BE | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
MC | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SI | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IE | 28.07.2016 | ||
LU | 28.07.2016 | ||
IS | 30.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
PT | 01.08.2016 | ||
Former [2017/25] | AT | 30.03.2016 | |
BE | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
MC | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SI | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
PT | 01.08.2016 | ||
Former [2017/22] | AT | 30.03.2016 | |
BE | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
MC | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
PT | 01.08.2016 | ||
Former [2017/07] | AT | 30.03.2016 | |
BE | 30.03.2016 | ||
CZ | 30.03.2016 | ||
DK | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
PT | 01.08.2016 | ||
Former [2017/03] | AT | 30.03.2016 | |
BE | 30.03.2016 | ||
CZ | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
PT | 01.08.2016 | ||
Former [2016/51] | AT | 30.03.2016 | |
CZ | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
PT | 01.08.2016 | ||
Former [2016/50] | AT | 30.03.2016 | |
CZ | 30.03.2016 | ||
EE | 30.03.2016 | ||
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
RO | 30.03.2016 | ||
SE | 30.03.2016 | ||
SK | 30.03.2016 | ||
SM | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
Former [2016/49] | EE | 30.03.2016 | |
FI | 30.03.2016 | ||
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
NL | 30.03.2016 | ||
PL | 30.03.2016 | ||
SE | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
Former [2016/48] | FI | 30.03.2016 | |
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
NL | 30.03.2016 | ||
SE | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
IS | 30.07.2016 | ||
Former [2016/44] | FI | 30.03.2016 | |
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
NL | 30.03.2016 | ||
SE | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
Former [2016/39] | FI | 30.03.2016 | |
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
LV | 30.03.2016 | ||
SE | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
Former [2016/36] | FI | 30.03.2016 | |
HR | 30.03.2016 | ||
LT | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | ||
Former [2016/35] | FI | 30.03.2016 | |
HR | 30.03.2016 | ||
NO | 30.06.2016 | ||
GR | 01.07.2016 | Cited in | International search | [I]US2003190684 (FISHER JOSEPH [US], et al) [I] 1-50* par.0010-0011, 0026; example 12; claims 3, 5 *; | [XI] - SHIVER J W ET AL, "Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 71, no. 2, doi:DOI:10.1016/0092-8674(92)90359-K, ISSN 0092-8674, (19921016), pages 315 - 322, (19921016), XP024245467 [X] 1-11,20,34,36,44-46,48-50 * abstract; p.316, col.2, par.2; p.319, col.1, par.2; p.321, col.1, par.2 and col.2, par.2; Table 2 * [I] 12-19,21-33,35,37-43,47 DOI: http://dx.doi.org/10.1016/0092-8674(92)90359-K | by applicant | US4463090 | US4557862 | US5035999 | US5811252 | WO2004016212 | - TIBERGHIEN ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, (1999), vol. 223, pages 63 - 75 | - NAAL RM ET AL., BIOSENS BIOELECTRON, (20041101), vol. 20, no. 4, pages 791 - 6 | - GRAMINSKI GF ET AL., J. BIOL. CHEM., (1993), vol. 268, no. 8, pages 5957 - 5964 | - SCHWARTZ ET AL., J. IMMUNOL., (1979), vol. 123, pages 1445 - 1450 | - DRAGONETTI ET AL., J. CELL SCI., (2000), vol. 113, pages 3289 - 3298 | - SCHECHTER I; BERGER A., BIOCHEM. BIOPHYS. RES. COMMUN., (1968), vol. 32, pages 898 - 902 | - SMITH MJ ET AL., J. LEUKOC. BIOL., (1996), vol. 60, pages 555 - 562 | - TURK V; TURK B; TURK D., EMBO J, (2001), vol. 20, pages 4629 - 33 | - GROSSMAN, WJ. ET AL., CURR. OPIN. IMMUNOL., (2003), vol. 15, pages 544 - 552 | - CABRERA-VERA TM ET AL., ENDOCR REV., (200312), vol. 24, no. 6, pages 765 - 81 | - STENNICKE HR; SALVESEN GS, CELL DEATH AND DIFFERENTIATION, (1999), vol. 6, pages 1054 - 1059 | - BURGOYNE RD; MORGAN A, PHYSIOL REV, (2003), vol. 83, pages 581 - 632 | - ARVAN P; CASTLE D., BIOCHEM J, (1998), vol. 332, pages 593 - 610 | - BURGOYNE RD; DUNCAN JS, J MAMM GLAND BIOL NEOPLASIA, (1998), vol. 3, pages 275 - 286 | - BURGOYNE, RD; MORGAN, A., PHYSIOLOGICAL REVIEWS, (200304), vol. 83, no. 2, pages 581 - 632 | - ANDERSSON ET AL., MOL PHARMACOL, (2003), vol. 64, pages 570 - 577 | - EI MESKINI, R ET AL., ENDOCRINOLOGY, (2001), vol. 142, no. 2, pages 864 - 873 | - TAM WWH ET AL., EUR J CELL BIOL, (1993), vol. 62, pages 294 - 306 | - ROY P ET AL., MOL CELL ENDOCRINOL, (1991), vol. 82, pages 237 - 250 | - COOL DR ET AL., J BIOL CHEM, (1995), vol. 270, pages 8723 - 8729 | - HUANG ET AL., J CLIN IMMUNOL., (1998), vol. 18, pages 169 - 183 | - KAUR, J; CUTLER DF, J. BIOL. CHEM., (2002), vol. 277, no. 12, pages 10498 - 10505 | - TURK V; TURK B; TURK D, EMBO J, (2001), vol. 20, pages 4629 - 33 | - OWEN CA; CAMPBELL EJ, J. LEUKOC. BIOL., (1999), vol. 65, pages 137 - 150 | - ISAAZ ET AL., EUR J IMMUNOL, (1995), vol. 25, no. 4, pages 1071 - 9 | - PHAM W ET AL., BIOCONJ. CHEM., (2004), vol. 15, pages 1403 - 1407 | - MUZIO M. ET AL., J. BIOL. CHEM., (1998), vol. 273, pages 2926 - 2930 | - MAHRUS S; CRAIK CS, CHEMISTRY & BIOLOGY, (2005), vol. 12, pages 567 - 577 | - VERHEIJEN JH ET AL., BIOCHEM. J., (1997), vol. 323, pages 603 - 609 | - LI Y, MOLECULAR BIOTECHNOLOGY, (2001), vol. 18, no. 1, pages 1 - 10 | - VOCERO-AKBANI AM ET AL., NAT MED., (1999), vol. 5, no. 1, pages 29 - 33 | - PLAINKUM P ET AL., NAT STRUCT BIOL., (200302), vol. 10, no. 2, pages 115 - 9 | - JOHNSON RJ ET AL., FEBS JOURNAL, (2006), vol. 273, no. 23, pages 5457 - 5465 | - JUCOVIC M ET AL., PROTEIN ENGINEERING DESIGN AND SELECTION, (2008), vol. 21, no. 10, pages 631 - 638 |