blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2486047

EP2486047 - EXPRESSION SYSTEM [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.08.2017
Database last updated on 15.06.2024
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
GlaxoSmithKline Biologicals S.A.
Rue de l'Institut, 89
1330 Rixensart / BE
[2016/40]
Former [2012/33]For all designated states
GlaxoSmithKline Biologicals S.A.
rue de l'Institut, 89
1330 Rixensart / BE
Inventor(s)01 / BLAIS, Normand
GlaxoSmithKline Biologicals Canada
525 Cartier Boulevard West
Laval, Québec H7V 3S8 / CA
02 / DEHOTTAY, Philippe Marc Helene
GlaxoSmithKline Biologicals s.a.
Rue de l'Institut 89
B-1330 Rixensart / BE
03 / DEWERCHIN, Marianne
GlaxoSmithKline Biologicals s.a.
Rue de l'Institut 89
B-1330 Rixensart / BE
04 / GOFFIN, Philippe
GlaxoSmithKline Biologicals s.a.
Rue de l'Institut 89
B-1330 Rixensart / BE
05 / MARTIN, Denis
GlaxoSmithKline Biologicals Canada
525 Cartier Boulevard West
Laval, Québec H7V 3S8 / CA
 [2012/33]
Representative(s)Bhogal, Jasber Kaur
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
[2014/38]
Former [2012/33]Johnston, Caroline Louise
GlaxoSmithKline 980 Great West Road
GB-Brentford, Middlesex TW8 9GS / GB
Application number, filing date10762693.907.10.2010
[2016/40]
WO2010EP65047
Priority number, dateGB2009001764708.10.2009         Original published format: GB 0917647
[2012/33]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011042516
Date:14.04.2011
Language:EN
[2011/15]
Type: A2 Application without search report 
No.:EP2486047
Date:15.08.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 14.04.2011 takes the place of the publication of the European patent application.
[2012/33]
Type: B1 Patent specification 
No.:EP2486047
Date:05.10.2016
Language:EN
[2016/40]
Search report(s)International search report - published on:EP16.06.2011
ClassificationIPC:C07K14/34
[2012/33]
CPC:
C07K14/34 (EP,US); C12N15/62 (KR); A61K39/02 (KR);
A61P31/04 (EP); C07K1/00 (US); C07K14/195 (KR);
C12N15/63 (KR); C12N9/1077 (EP,US); C12Y204/02036 (EP,US);
C07K2319/034 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/33]
Extension statesBA04.05.2012
ME04.05.2012
TitleGerman:EXPRESSIONSSYSTEM[2012/33]
English:EXPRESSION SYSTEM[2012/33]
French:SYSTÈME D'EXPRESSION[2012/33]
Entry into regional phase04.05.2012National basic fee paid 
04.05.2012Designation fee(s) paid 
04.05.2012Examination fee paid 
Examination procedure05.08.2011Request for preliminary examination filed
International Preliminary Examining Authority: EP
04.05.2012Examination requested  [2012/33]
23.11.2012Amendment by applicant (claims and/or description)
15.04.2014Despatch of a communication from the examining division (Time limit: M06)
14.10.2014Reply to a communication from the examining division
25.11.2014Despatch of a communication from the examining division (Time limit: M06)
22.05.2015Reply to a communication from the examining division
29.07.2015Despatch of a communication from the examining division (Time limit: M06)
04.02.2016Reply to a communication from the examining division
10.05.2016Communication of intention to grant the patent
23.08.2016Fee for grant paid
23.08.2016Fee for publishing/printing paid
23.08.2016Receipt of the translation of the claim(s)
Divisional application(s)EP16192258.8  / EP3170837
EP18167370.8  / EP3480209
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.04.2014
Opposition(s)06.07.2017No opposition filed within time limit [2017/37]
Fees paidRenewal fee
05.10.2012Renewal fee patent year 03
07.10.2013Renewal fee patent year 04
07.10.2014Renewal fee patent year 05
07.10.2015Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.10.2010
AL05.10.2016
AT05.10.2016
CY05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
MK05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SI05.10.2016
SK05.10.2016
SM05.10.2016
LU07.10.2016
CH31.10.2016
LI31.10.2016
MT31.10.2016
BG05.01.2017
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
[2020/33]
Former [2018/34]HU07.10.2010
AT05.10.2016
CY05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
MK05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SI05.10.2016
SK05.10.2016
SM05.10.2016
LU07.10.2016
CH31.10.2016
LI31.10.2016
MT31.10.2016
BG05.01.2017
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2018/28]HU07.10.2010
AT05.10.2016
CY05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
MK05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SI05.10.2016
SK05.10.2016
SM05.10.2016
LU07.10.2016
CH31.10.2016
LI31.10.2016
BG05.01.2017
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/52]AT05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SI05.10.2016
SK05.10.2016
SM05.10.2016
LU07.10.2016
CH31.10.2016
LI31.10.2016
BG05.01.2017
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/41]AT05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SK05.10.2016
SM05.10.2016
LU07.10.2016
CH31.10.2016
LI31.10.2016
BG05.01.2017
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/38]AT05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SK05.10.2016
SM05.10.2016
CH31.10.2016
LI31.10.2016
BG05.01.2017
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/37]AT05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SK05.10.2016
SM05.10.2016
CH31.10.2016
LI31.10.2016
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/36]AT05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
SK05.10.2016
CH31.10.2016
LI31.10.2016
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/35]AT05.10.2016
CZ05.10.2016
DK05.10.2016
EE05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RO05.10.2016
RS05.10.2016
SE05.10.2016
CH31.10.2016
LI31.10.2016
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/34]AT05.10.2016
CZ05.10.2016
DK05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RS05.10.2016
SE05.10.2016
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/33]AT05.10.2016
DK05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
MC05.10.2016
PL05.10.2016
RS05.10.2016
SE05.10.2016
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/26]AT05.10.2016
FI05.10.2016
HR05.10.2016
LT05.10.2016
LV05.10.2016
PL05.10.2016
RS05.10.2016
SE05.10.2016
NO05.01.2017
GR06.01.2017
IS05.02.2017
PT06.02.2017
Former [2017/12]LV05.10.2016
Cited inInternational search[X]WO9010015  (SERAGEN INC [US]) [X] 1-35,37,67-75 * page 12, lines 23-26 *;
 [XDI]  - O'KEEFE D O ET AL, "CLONED DIPHTHERIA TOXIN WITHIN THE PERIPLASM OF ESCHERICHIA-COLI CAUSES LETHAL MEMBRANE DAMAGE AT LOW PH", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1989), vol. 86, no. 1, ISSN 0027-8424, pages 343 - 346, XP002614714 [XD] 10-35,37-75 * abstract * * page 343, column l, paragraph l * * page 343, column r, paragraphs 2, 4 * * page 344, column l, paragraph 2 * * page 344, column r, paragraph 2 * [I] 1-9

DOI:   http://dx.doi.org/10.1073/pnas.86.1.343
 [AD]  - BISHAI W R ET AL, "HIGH-LEVEL EXPRESSION OF A PROTEOLYTICALLY SENSITIVE DIPHTHERIA TOXIN FRAGMENT IN ESCHERICHIA-COLI", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC; US, (19871101), vol. 169, no. 11, ISSN 0021-9193, pages 5140 - 5151, XP002561433 [AD] 1-35,37-75 * abstract * * page 5141, column l, paragraph l - column r, paragraph 1 *
 [A]  - HUMPHREYS D P ET AL, "High-Level Periplasmic Expression in Escherichia coli Using a Eukaryotic Signal Peptide: Importance of Codon Usage at the 5' End of the Coding Sequence", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, (20001101), vol. 20, no. 2, doi:DOI:10.1006/PREP.2000.1286, ISSN 1046-5928, pages 252 - 264, XP004435483 [A] 1-35,37-75 * the whole document *

DOI:   http://dx.doi.org/10.1006/prep.2000.1286
 [A]  - LEONG D ET AL, "CLONED FRAGMENT A OF DIPHTHERIA TOXIN IS EXPRESSED AND SECRETED INTO THE PERIPLASMIC SPACE OF ESCHERICHIA-COLI K-12", SCIENCE (WASHINGTON D C), (1983), vol. 220, no. 4596, ISSN 0036-8075, pages 515 - 517, XP002629871 [A] 1-35,37-75 * the whole document *

DOI:   http://dx.doi.org/10.1126/science.6403984
 [A]  - TITBALL R W ET AL, "MOLECULAR CLONING AND NUCLEOTIDE SEQUENCE OF THE ALPHA TOXIN PHOSPHOLIPASE C OF CLOSTRIDIUM-PERFRINGENS", INFECTION AND IMMUNITY, (1989), vol. 57, no. 2, ISSN 0019-9567, pages 367 - 376, XP002629872 [A] 1-35,37-75 * the whole document *
by applicantUS4235877
 US4365170
 EP0161188
 EP0208375
 US4673574
 US4709017
 US4950740
 EP0477508
 WO9315760
 WO9324148
 WO9508348
 WO9629094
 WO9700697
 US5601827
 WO9842721
 US5843711
 US5917017
 WO02055105
    - MOSKAUG ET AL., BIOL. CHEM., (1989), vol. 264, pages 15709 - 15713
    - LINGOOD ET AL., BRIT.J. EXP. PATH., (1963), vol. 44, page 177
    - UCHIDA ET AL., NATURE NEW BIOLOGY, (1971), vol. 233, pages 8 - 11
    - PAPPENHEIMER, ANN REV, BIOCHEM., (1977), vol. 46, pages 69 - 94
    - RAPPUOLI, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (198309), pages 560 - 564
    - BISHAI ET AL., J BACTERIOL., vol. 169, pages 5140 - 5151
    - O'KEEFE ET AL., PROC. NATL. ACAD. SCI., vol. 86, pages 343 - 346
    - CARILLO, H.; LIPMAN, D., SIAM J. Applied Math., (1988), vol. 48, page 1073
    - DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, (1984), vol. 12, no. 1, page 387
    - ALTSCHUL, S.F. ET AL., J. MOLEC. BIOL., (1990), vol. 215, pages 403 - 410
    - PEARSON; LIPMAN, PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 2444 - 2448
    - ALTSCHUL, S. ET AL., BLAST Manual, NCBI NLM NIH BETHESDA, MD 20894
    - ALTSCHUL, S. ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 410
    - NEEDLEMAN; WUNSCH, J. MOL BIOL., (1970), vol. 48, pages 443 - 453
    - PROC. NATL. ACAD. SCI. USA., (1992), vol. 89, pages 10915 - 10919
    - JAMESON; WOLF, CABIOS, (1988), vol. 4, pages 181 - 186
    - STURNIOLO, NATURE BIOTECH., (1999), vol. 17, pages 555 - 561
    - SAMBROOK ET AL., MOLECULAR CLONING, A LABORATORY MANUAL
    - BETHELL ET AL., J. BIOL. CHEM., (1979), vol. 254, pages 2572 - 4
    - HEARN ET AL., J. CHROMATOGR., (1981), vol. 218, pages 509 - 18
    - CHU C. ET AL., INFECT. IMMUNITY, (1983), pages 245 - 256
    - ZABRISKIE ET AL., J. IND. MICROBIOL., (1987), vol. 2, pages 87 - 95
    - CHEN ET AL., BIOCHEM. ENG. J., (2004), vol. 19, pages 211 - 215
    - J.IND. MICROBIOL. BIOTECHNOL., (2010), vol. 37, pages 195 - 204
    - DOEHLERT, APPLIED STATISTICS, (1970), vol. 19, pages 231 - 239
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.