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Extract from the Register of European Patents

EP About this file: EP2439195

EP2439195 - NAPHTHALENE CARBOXAMIDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE AND HISTONE DEACETYLASE, PREPARATION METHODS AND USES THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.05.2015
Database last updated on 22.05.2024
Most recent event   Tooltip18.08.2017Lapse of the patent in a contracting state
New state(s): SM		published on 20.09.2017  [2017/38]
Applicant(s)For all designated states
Shenzhen Chipscreen Biosciences, Ltd.
2-601~606 BIO-Incubator Gaoxin C 1st Ave. Hi-Tech Industrial Park Nanshan District
Shenzhen, Guangdong 518057 / CN
[2012/15]
Inventor(s)01 / LU, Xianping
2-601~606
BIO-Incubator
Gaoxin C
1st Ave., Hi-Tech Industrial Park, Nanshan District, Shenzhen
Guangdong 518057 / CN
02 / LI, Zhibin
2-601~606
BIO-Incubator
Gaoxin C
1st Ave., Hi-Tech Industrial Park, Nanshan District, Shenzhen
Guangdong 518057 / CN
03 / SHAN, Song
2-601~606
BIO-Incubator
Gaoxin C
1st Ave., Hi-Tech Industrial Park, Nanshan District, Shenzhen
Guangdong 518057 / CN
04 / YU, Jindi
2-601~606
BIO-Incubator
Gaoxin C
1st Ave., Hi-Tech Industrial Park, Nanshan District, Shenzhen
Guangdong 518057 / CN
05 / NING, Zhiqiang
2-601~606
BIO-Incubator
Gaoxin C
1st Ave., Hi-Tech Industrial Park, Nanshan District, Shenzhen
Guangdong 518057 / CN
 [2012/15]
Representative(s)Kling, Simone
Lavoix Munich
Bayerstrasse 83
80335 München / DE
[2014/29]
Former [2012/15]Kling, Simone
Lavoix Munich Bayerstrasse 85a
80335 München / DE
Application number, filing date10782884.005.03.2010
WO2010CN00272
Priority number, dateCN2009114397804.06.2009         Original published format: CN200910143978
[2012/15]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010139180
Date:09.12.2010
Language:ZH
[2010/49]
Type: A1 Application with search report 
No.:EP2439195
Date:11.04.2012
Language:EN
[2012/15]
Type: B1 Patent specification 
No.:EP2439195
Date:16.07.2014
Language:EN
[2014/29]
Search report(s)International search report - published on:CN09.12.2010
(Supplementary) European search report - dispatched on:EP02.10.2012
ClassificationIPC:C07D215/22, C07D215/233, C07D239/88, C07D401/12, A61K31/438, A61K31/444, A61K31/517, A61P3/00, A61P9/00, A61P11/00, A61P25/00, A61P29/00, A61P35/00, A61P37/08
[2012/15]
CPC:
C07D239/90 (EP); C07D215/22 (EP,KR); A61K31/517 (KR);
A61P11/00 (EP); A61P11/06 (EP); A61P25/00 (EP);
A61P25/14 (EP); A61P25/28 (EP); A61P29/00 (EP);
A61P3/00 (EP); A61P35/00 (EP); A61P37/00 (EP);
A61P37/02 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P5/00 (EP); A61P9/00 (EP); C07D215/233 (EP,KR);
C07D215/26 (EP); C07D215/28 (EP); C07D401/12 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/15]
Extension statesALNot yet paid
BANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:NAPHTHALENCARBOXAMIDDERIVATIVE ALS HEMMER DER PROTEINKINASE UND HISTONDEACETYLASE, HERSTELLUNGSVERFAHREN UND VERWENDUNGEN DAMIT[2012/15]
English:NAPHTHALENE CARBOXAMIDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE AND HISTONE DEACETYLASE, PREPARATION METHODS AND USES THEREOF[2012/15]
French:DÉRIVÉS DE NAPHTALÈNE CARBOXAMIDE EN TANT QU'INHIBITEURS DE PROTÉINE KINASE ET D'HISTONE DÉSACÉTYLASE, PROCÉDÉS DE PRÉPARATION ET UTILISATIONS[2012/15]
Entry into regional phase13.12.2011Translation filed 
13.12.2011National basic fee paid 
13.12.2011Search fee paid 
13.12.2011Designation fee(s) paid 
13.12.2011Examination fee paid 
Examination procedure13.12.2011Examination requested  [2012/15]
09.04.2013Amendment by applicant (claims and/or description)
10.07.2013Despatch of a communication from the examining division (Time limit: M04)
07.11.2013Reply to a communication from the examining division
05.02.2014Communication of intention to grant the patent
04.06.2014Fee for grant paid
04.06.2014Fee for publishing/printing paid
04.06.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.07.2013
Opposition(s)17.04.2015No opposition filed within time limit [2015/26]
Fees paidRenewal fee
31.12.2011Renewal fee patent year 03
26.03.2013Renewal fee patent year 04
21.03.2014Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY16.07.2014
EE16.07.2014
MC16.07.2014
MT16.07.2014
SM16.07.2014
IS16.11.2014
LU05.03.2015
[2017/38]
Former [2017/03]CY16.07.2014
EE16.07.2014
MC16.07.2014
MT16.07.2014
IS16.11.2014
LU05.03.2015
Former [2015/47]CY16.07.2014
EE16.07.2014
MC16.07.2014
IS16.11.2014
LU05.03.2015
Former [2015/46]CY16.07.2014
EE16.07.2014
MC16.07.2014
IS16.11.2014
Former [2015/23]CY16.07.2014
EE16.07.2014
IS16.11.2014
Former [2015/12]CY16.07.2014
IS16.11.2014
Former [2015/11]CY16.07.2014
Documents cited:Search   [ ] - No further relevant documents disclosed
International search[X]WO2005021553  (PFIZER [US], et al);
 [X]CN1933839  (AMGEN INC [US]);
 [X]  - HARMANGE, JEAN-CHRISTOPHE ET AL., "Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.", J. MED. CHEM., (2008), vol. 51, pages 1649 - 1667, XP002668409

DOI:   http://dx.doi.org/10.1021/JM701097Z
 [X]  - DU, JUAN ET AL., "Molecular modeling studies of vascular endothelial growth factor receptor tyrosine kinase inhibitors using QSAR and docking.", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, (20081105), vol. 27, pages 642 - 654, XP025815659

DOI:   http://dx.doi.org/10.1016/j.jmgm.2008.10.006
Examination   - SIMPLÍCIO ANA L ET AL, "Prodrugs for amines", MOLECULES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, BASEL, CH, (20080101), vol. 13, no. 3, doi:10.3390/MOLECULES13030519, ISSN 1420-3049, pages 519 - 547, XP002503564

DOI:   http://dx.doi.org/10.3390/molecules13030519
by applicantEP0847992
 WO0118171
 WO0170675
 WO0226696
 US2002103192
 US7041687
 US7098330
 US7115739
 US7125905
 US7132533
 US7151096
 US7157476
 US7166597
 US7179910
 US7189721
 US7214700
    - TAN, S-L., J. IMMUNOL., (2006), vol. 176, pages 2872 - 2879
    - HEALY, A., J. IMMUNOL., (2006), vol. 177, pages 1886 - 1893
    - SALEK-ARDAKANI, S. ET AL., J. IMMUNOL., (2005), vol. 175, pages 7635 - 7641
    - KIM, J. ET AL., J. CLIN. INVEST., (2004), vol. 114, pages 823 - 827
    - ARTEAGA, C-L., CURR. OPIN. ONCOL., (2001), vol. 6, pages 491 - 498
    - PETIT, A-M. ET AL., AM. J. PATHOL., (1997), vol. 151, pages 1523 - 1530
    - WIKSTRAND, C-J. ET AL., J NATL CANCER INST., (1998), vol. 90, pages 799 - 800
    - WIKSTRAND, C-J., J NATL CANCER INST., (1998), vol. 90, pages 799 - 800
    - MENDELSOHN, J., CLIN. CAN. RES., (1997), vol. 3, pages 2707 - 2707
    - PARIKH, A-A., HEMATOL. ONCOL. CLIN. N. AM., (2004), vol. 18, pages 951 - 971
    - HAQ ET AL., J. CELL BIOL., (2000), vol. 151, page 117
    - SCHUMACHER ET AL., J. CELL BIOL., (1998), vol. 143, pages 1635 - 1646
    - KIMURA ET AL., J. BIOL. CHEM., (1997), vol. 272, pages 13766 - 13771
    - MONIA ET AL., NAT. MED., (1996), vol. 2, pages 668 - 675
    - GRUNSTEIN, M., NATURE, (1997), vol. 389, pages 349 - 352
    - RUIJTER, A-J-M., BIOCHEM. J., (2003), vol. 370, pages 737 - 749
    - GRIGNANI, F., NATURE, (1998), vol. 391, pages 815 - 818
    - LIN, R-J., NATURE, (1998), vol. 391, pages 811 - 814
    - MARKS, P-A., NATURE REVIEWS CANCER, (2001), vol. 1, page 194
    - LANGLEY B ET AL., CURRENT DRUG TARGETS-CNS & NEUROLOGICAL DISORDERS, (2005), vol. 4, pages 41 - 50
    - DOKMANOVIC, M., J. CELL BIOCHENM., (2005), vol. 96, pages 293 - 304
    - GLASER, K-B., BIOCHEM. BIOPHYS. RES. COMM., (2003), vol. 310, pages 529 - 536
    - LAGGER, G., EMBO J., (2002), vol. 21, pages 2672 - 2681
    - BARTL. S., MOL. CELL BIOL., (1997), vol. 17, pages 5033 - 5043
    - TRIVEDI, C-M., NAT. MED, (2007), vol. 13, pages 324 - 331
    - WILSON, A-J., J BIOL. CHEM., (2006), vol. 281, pages 13548 - 13558
    - SAKUMA, T, INT. J. ONCOL., (2006), vol. 29, pages 117 - 124
    - MAI, A ET AL., INT J. BIOCHEM CELL BIO.
    - HERMAN D ET AL., NATURE CHEMICAL BIOLOGY, (2006), vol. 2, no. 10, pages 551 - 8
    - AVILA AM ET AL., J CLINIC INVESTIGATION, (2007), vol. 117, no. 3, pages 659 - 71
    - DE BORE J, TISSUE ENG., (2006), vol. 12, no. 10, pages 2927 - 37
    - GIALITAKIS M ET AL., NUCLEIC ACIDS RES., (2007), vol. 34, no. 1, pages 765 - 72
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.