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Extract from the Register of European Patents

EP About this file: EP2516420

EP2516420 - AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.06.2019
Database last updated on 14.06.2024
FormerThe patent has been granted
Status updated on  20.07.2018
FormerGrant of patent is intended
Status updated on  08.04.2018
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY, MK		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Medicis Pharmaceutical Corporation
400 Somerset Corporate Blvd.
Bridgewater, NJ 08807 / US
[2018/38]
Former [2012/48]For all designated states
Medicis Pharmaceutical Corporation
7720 North Dobson Road
Scottsdale, AZ 85256 / US
Former [2012/44]For all designated states
Palau Pharma, S.A.
Av. Cami Reial 51-57
08184 Palau-solità i Plegamans, Barcelona / ES
Inventor(s)01 / CARCELLER GONZÁLEZ, Elena
Joan Miró 2
E-08190 Sant Cugat del Vallès / ES
02 / VIRGILI BERNADO, Marina
Plaza Lesseps 11
E-08023 Barcelona / ES
03 / SOLIVA SOLIVA, Robert
Frederica Montseny 42-44 5° 4ª
E-08980 Sant Feliu de Llobregat / ES
04 / FERRER COSTA, Carles
Indústria 84-86 2° 2ª
E-08370 Calella / ES
 [2012/44]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2018/34]
Former [2012/44]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Application number, filing date10799037.622.12.2010
[2018/34]
WO2010EP70562
Priority number, dateEP2009038230223.12.2009         Original published format: EP 09382302
US20100307579P24.02.2010         Original published format: US 307579 P
[2012/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011076878
Date:30.06.2011
Language:EN
[2011/26]
Type: A1 Application with search report 
No.:EP2516420
Date:31.10.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 30.06.2011 takes the place of the publication of the European patent application.
[2012/44]
Type: B1 Patent specification 
No.:EP2516420
Date:22.08.2018
Language:EN
[2018/34]
Type: B8 Corrected title page of specification 
No.:EP2516420
Date:17.10.2018
[2018/42]
Search report(s)International search report - published on:EP30.06.2011
ClassificationIPC:C07D401/14, C07D403/04, C07D403/14, C07D409/14, A61K31/506, A61P29/00, A61P37/08
[2012/44]
CPC:
C07D403/04 (EP,KR,US); C07D239/48 (EP,KR,US); A61K31/505 (KR,US);
A61K31/506 (KR,US); A61P1/00 (EP); A61P1/04 (EP);
A61P11/00 (EP); A61P11/02 (EP); A61P11/06 (EP);
A61P11/16 (EP); A61P17/00 (EP); A61P17/04 (EP);
A61P17/06 (EP); A61P19/02 (EP); A61P19/04 (EP);
A61P25/00 (EP); A61P25/04 (EP); A61P27/02 (EP);
A61P27/04 (EP); A61P27/12 (EP); A61P29/00 (EP);
A61P35/00 (EP); A61P37/00 (EP); A61P37/02 (EP);
A61P37/06 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P9/00 (EP); C07D401/14 (EP,KR,US); C07D403/14 (EP,KR,US);
C07D409/14 (EP,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/44]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:AMINOALKYLPYRIMIDIN-DERIVATE ALS HISTAMIN-H4-REZEPTOR-ANTAGONISTEN[2018/16]
English:AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS[2012/44]
French:DÉRIVÉS D'AMINOALKYLPYRIMIDINE EN TANT QU'ANTAGONISTES DU RÉCEPTEUR H4 DE L'HISTAMINE[2018/16]
Former [2012/44]AMINOALKYLPYRIMIDINDERIVATE ALS HISTAMIN-H4-REZEPTORANTAGONISTEN
Former [2012/44]DÉRIVÉS D'AMINOALKYLPYRIMIDINE AU TITRE D'ANTAGONISTES DU RÉCEPTEUR HISTAMINIQUE H4
Entry into regional phase21.06.2012National basic fee paid 
21.06.2012Designation fee(s) paid 
21.06.2012Examination fee paid 
Examination procedure21.06.2012Examination requested  [2012/44]
10.01.2013Amendment by applicant (claims and/or description)
04.01.2016Despatch of a communication from the examining division (Time limit: M04)
17.02.2016Reply to a communication from the examining division
09.04.2018Communication of intention to grant the patent
11.07.2018Fee for grant paid
11.07.2018Fee for publishing/printing paid
11.07.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.01.2016
Opposition(s)23.05.2019No opposition filed within time limit [2019/31]
Fees paidRenewal fee
19.12.2012Renewal fee patent year 03
27.12.2013Renewal fee patent year 04
29.12.2014Renewal fee patent year 05
07.12.2015Renewal fee patent year 06
08.12.2016Renewal fee patent year 07
08.12.2017Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.12.2010
AL22.08.2018
AT22.08.2018
CY22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
GR22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
MK22.08.2018
NL22.08.2018
PL22.08.2018
PT22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
MT22.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
[2020/31]
Former [2020/30]HU22.12.2010
AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
GR22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
PT22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
MT22.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
Former [2020/27]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
PT22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
MT22.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
Former [2020/17]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
MT22.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
Former [2020/08]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
MT22.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
Former [2020/04]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
Former [2019/51]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
BE31.12.2018
Former [2019/40]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
Former [2019/39]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
LU22.12.2018
Former [2019/37]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/26]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/23]AL22.08.2018
AT22.08.2018
CZ22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SK22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/22]AL22.08.2018
CZ22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/21]AL22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/12]AL22.08.2018
FI22.08.2018
HR22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/11]FI22.08.2018
HR22.08.2018
LT22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/10]FI22.08.2018
LT22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
IS22.12.2018
Former [2019/09]FI22.08.2018
LT22.08.2018
NL22.08.2018
NO22.11.2018
IS22.12.2018
Former [2019/08]FI22.08.2018
LT22.08.2018
NO22.11.2018
IS22.12.2018
Former [2019/07]LT22.08.2018
Cited inInternational search[A]WO2004039796  (BAYER HEALTHCARE AG [DE], et al) [A] 1,48,49 * example -; claim - *;
 [A]EP1505064  (BAYER HEALTHCARE AG [DE]) [A] 1-60 * examples 1-35; claim - *;
 [A]WO2006110763  (BAYER PHARMACEUTICALS CORP [US], et al) [A] 1-60 * claim - *;
 [Y]WO2009068512  (PALAU PHARMA SA [ES], et al) [Y] 1-60 * claims 1-16,20-37 *;
 [Y]WO2009080721  (PALAU PHARMA SA [ES], et al) [Y] 1-60 * claim - *;
 [A]  - COWART M D ET AL, "Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 51, ISSN 0022-2623, (20080926), pages 6547 - 6557, (20080926), XP002543231 [A] 1 * page 6548, Chart 1 *

DOI:   http://dx.doi.org/10.1021/jm800670r
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.