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Extract from the Register of European Patents

EP About this file: EP2455079

EP2455079 - COMPOSITION FOR THE PREVENTION OR TREATMENT OF BONE DISEASES COMPRISING COLFORSIN DAROPATE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.01.2016
Database last updated on 14.09.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Korea Research Institute of Bioscience and Biotechnology
52, Eoeun-dong
Yuseong-gu
Daejeon 305-333 / KR
For all designated states
Korea Research Institute of Chemical Technology
100, Jang-dong
Yuseong-gu, Daejeon 305-343 / KR
[N/P]
Former [2012/21]For all designated states
Korea Research Institute of Bioscience and Biotechnology
52, Eoeun-dong Yuseong-gu
Daejeon 305-333 / KR
For all designated states
Korea Research Institute Of Chemical Technology
100, Jang-dong
Yuseong-gu, Daejeon 305-343 / KR
Inventor(s)01 / KWON, Byoung-Mog
52, Eoeun-dong, Yuseong-gu
Daejeon 305-806 / KR
02 / HAN, Dong Cho
52, Eoeun-dong, Yuseong-gu
Daejeon 305-806 / KR
03 / BAE, Myung Ae
101-401 Jangdae Purgio Apt.
Jangdae-dong
Yuseong-gu
Daejeon 305-308 / KR
04 / KIM, Seong Hwan
101-801 Daelim Dure Apt.
Sinseong-dong
Yuseong-gu
Daejeon 305-720 / KR
05 / MIN, Yong Ki
109-804 Nuri Apt.
Wolpyeong-dong
Seo-gu
Daejeon 302-280 / KR
 [2012/21]
Representative(s)Kador, Utz Ulrich
Kador & Partner Corneliusstrasse 15
80469 München / DE
[2012/21]
Application number, filing date10800063.916.07.2010
WO2010KR04672
Priority number, dateKR2009006550517.07.2009         Original published format: KR 20090065505
[2012/21]
Filing languageKO
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011008052
Date:20.01.2011
Language:KO
[2011/03]
Type: A2 Application without search report 
No.:EP2455079
Date:23.05.2012
Language:EN
[2012/21]
Type: B1 Patent specification 
No.:EP2455079
Date:18.03.2015
Language:EN
[2015/12]
Search report(s)International search report - published on:KR19.05.2011
(Supplementary) European search report - dispatched on:EP20.12.2012
ClassificationIPC:A61K31/352, A61P19/10, A61P19/02, A23L1/30, A61P19/08, A61K31/35
[2014/40]
CPC:
A61K31/352 (EP,KR,US); A61K31/35 (KR,US); A23L33/10 (EP,KR,US);
A61P1/02 (EP); A61P19/02 (EP); A61P19/08 (EP);
A61P19/10 (EP); A61P29/00 (EP); A61P35/04 (EP);
A61P37/00 (EP); A23V2002/00 (KR); A23V2200/306 (KR) (-)
Former IPC [2013/03]A61K31/352, A61P19/10, A61P19/02, A23L1/30, A61P19/08
Former IPC [2012/21]A61K31/352, A61P19/10, A61P19/02, A23L1/30
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/21]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:ZUSAMMENSETZUNG ZUR PRÄVENTION ODER BEHANDLUNG VON KNOCHENERKRANKUNGEN MIT COLFORSIN-DAROPAT[2012/21]
English:COMPOSITION FOR THE PREVENTION OR TREATMENT OF BONE DISEASES COMPRISING COLFORSIN DAROPATE[2012/21]
French:COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES OSSEUSES COMPRENANT DU DAROPATE DE COLFORSINE[2012/21]
Entry into regional phase07.02.2012Translation filed 
07.02.2012National basic fee paid 
07.02.2012Search fee paid 
07.02.2012Designation fee(s) paid 
07.02.2012Examination fee paid 
Examination procedure07.02.2012Examination requested  [2012/21]
04.07.2013Amendment by applicant (claims and/or description)
15.04.2014Despatch of a communication from the examining division (Time limit: M04)
05.08.2014Reply to a communication from the examining division
27.10.2014Communication of intention to grant the patent
02.02.2015Fee for grant paid
02.02.2015Fee for publishing/printing paid
02.02.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.04.2014
Opposition(s)21.12.2015No opposition filed within time limit [2016/08]
Fees paidRenewal fee
27.07.2012Renewal fee patent year 03
29.07.2013Renewal fee patent year 04
28.07.2014Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU16.07.2010
AL18.03.2015
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MK18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
SM18.03.2015
TR18.03.2015
NO18.06.2015
GR19.06.2015
IE16.07.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
CH31.07.2015
LI31.07.2015
[2018/46]
Former [2018/30]HU16.07.2010
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MK18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
SM18.03.2015
TR18.03.2015
NO18.06.2015
GR19.06.2015
IE16.07.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
CH31.07.2015
LI31.07.2015
Former [2017/38]HU16.07.2010
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
SM18.03.2015
TR18.03.2015
NO18.06.2015
GR19.06.2015
IE16.07.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
CH31.07.2015
LI31.07.2015
Former [2017/21]AT18.03.2015
BE18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IE16.07.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
CH31.07.2015
LI31.07.2015
Former [2016/37]AT18.03.2015
BE18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IE16.07.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
CH31.07.2015
LI31.07.2015
Former [2016/33]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IE16.07.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
CH31.07.2015
LI31.07.2015
Former [2016/22]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
CH31.07.2015
LI31.07.2015
Former [2016/15]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
LU16.07.2015
IS18.07.2015
PT20.07.2015
Former [2016/13]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2016/12]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2016/07]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2015/51]AT18.03.2015
CZ18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2015/50]CZ18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2015/49]CZ18.03.2015
EE18.03.2015
ES18.03.2015
FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
NO18.06.2015
GR19.06.2015
PT20.07.2015
Former [2015/41]FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
SE18.03.2015
NO18.06.2015
GR19.06.2015
Former [2015/39]FI18.03.2015
HR18.03.2015
LT18.03.2015
LV18.03.2015
SE18.03.2015
NO18.06.2015
GR19.06.2015
Former [2015/37]FI18.03.2015
HR18.03.2015
LT18.03.2015
SE18.03.2015
NO18.06.2015
GR19.06.2015
Former [2015/36]FI18.03.2015
HR18.03.2015
LT18.03.2015
SE18.03.2015
NO18.06.2015
Former [2015/35]LT18.03.2015
NO18.06.2015
Documents cited:Search[Y]EP0448029  (NIPPON KAYAKU KK [JP]) [Y] 1-8 * page 3, lines 5-27 * * page 3, line 39 - page 4, line 5 *;
 [Y]WO0021523  (MERCK & CO INC [US], et al) [Y] 1-8 * page 1, lines 9-18 * * page 3, lines 23-25, 33-34 * * page 7, lines 12-19 * * page 12, lines 14-15, 26-27 * * page 21, lines 12-16 * * claims 1, 5, 7 *;
 [Y]JP2007210988
 [Y]  - HAKEDA Y ET AL, "Induction of osteoblastic cell differentiation by forskolin. Stimulation of cyclic AMP production and alkaline phosphatase activity", BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 838, no. 1, doi:10.1016/0304-4165(85)90248-X, ISSN 0304-4165, (19850128), pages 49 - 53, (19850128), XP025786513 [Y] 1-8 * the whole document *

DOI:   http://dx.doi.org/10.1016/0304-4165(85)90248-X
 [Y]  - LERNER U H ET AL, "Comparison between the effects of forskolin and calcitonin on bone resorption and osteoclast morphology in vitro", BONE, PERGAMON PRESS., OXFORD, GB, vol. 10, no. 5, ISSN 8756-3282, (19890101), pages 377 - 387, (19890101), XP026432373 [Y] 1-8 * abstract *
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International search[A]WO2008141189  (ELIXIR PHARMACEUTICALS INC [US], et al);
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 [A]  - NOBUHIKO, HAYASHIDA ET AL., "Antiinflammatory effects of colforsin daropate hydrochloride, a novel water-soluble forskolin derivative", ANN THORAC SURG, (2001), vol. 71, pages 1931 - 1938, XP008151378

DOI:   http://dx.doi.org/10.1016/S0003-4975(01)02531-0
 [A]  - MASAYOSHI, UCHIDA ET AL., "Both Milrinone and Colforsin Daropate Attenuate the Sustained Pial Arteriolar Constriction Seen After Unclamping of an Abdo-minal Aortic Cross-Clamp in Rabbits", ANESTH ANALG, (2005), vol. 101, pages 9 - 16, XP008151379

DOI:   http://dx.doi.org/10.1213/01.ANE.0000158610.76898.5C
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DOI:   http://dx.doi.org/10.1016/S0006-291X(03)00695-8
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DOI:   http://dx.doi.org/10.1126/science.284.5411.143
    - SHAN Y ET AL., CHEM PHARM BULL, (2007), vol. 55, pages 376 - 81
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