EP2513081 - PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES [Right-click to bookmark this link] | |||
Former [2012/43] | PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSES | ||
[2015/27] | Status | No opposition filed within time limit Status updated on 13.05.2016 Database last updated on 31.08.2024 | Most recent event Tooltip | 19.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 21.11.2018 [2018/47] | Applicant(s) | For all designated states LibraMedicina, Inc. 611, Tokyo Life Science Incubation Center 1-7-8, Kaigan Minato-ku Tokyo 105-0022 / JP | [2015/28] |
Former [2012/43] | For all designated states Libramedicina, Inc. 611 Tokyo Life Science Incubation Center 1-7-8 Kaigan Minato-ku Tokyo 105-0022 / JP | Inventor(s) | 01 /
VOIGTLANDER, David 100, Magnolia Court West Lafayette, Indiana 47906 / US | 02 /
SANDER, Michael Hausacker 13 Rosrath (Hoffnungsthal) 51503 / DE | 03 /
HARRE, Michael Markelstr. 49 Berlin 12163 / DE | [2015/27] |
Former [2012/43] | 01 /
VOIGTLANDER, David 100 Magnolia Court West Lafayette, Indiana 47906 / US | ||
02 /
SANDER, Michael Hausacker 13 Rosrath (Hoffnungsthal) 51503 / DE | |||
03 /
HARRE, Michael Markelstr. 49 Berlin 12163 / DE | Representative(s) | Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | [2015/28] |
Former [2012/43] | HOFFMANN EITLE Patent- und Rechtsanwälte Arabellastrasse 4 81925 München / DE | Application number, filing date | 10801279.0 | 03.12.2010 | WO2010JP72182 | Priority number, date | EP20090075563 | 18.12.2009 Original published format: EP 09075563 | EP20100163406 | 20.05.2010 Original published format: EP 10163406 | [2012/43] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011074484 | Date: | 23.06.2011 | Language: | EN | [2011/25] | Type: | A1 Application with search report | No.: | EP2513081 | Date: | 24.10.2012 | Language: | EN | The application published by WIPO in one of the EPO official languages on 23.06.2011 takes the place of the publication of the European patent application. | [2012/43] | Type: | B1 Patent specification | No.: | EP2513081 | Date: | 08.07.2015 | Language: | EN | [2015/28] | Search report(s) | International search report - published on: | EP | 23.06.2011 | Classification | IPC: | C07D317/18, C07D333/32, C07D333/78 | [2012/43] | CPC: |
C07D333/32 (EP,KR,US);
C07D317/22 (KR);
A61K31/381 (KR);
C07D317/18 (KR);
C07D317/26 (KR);
C07H13/04 (EP,KR,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/43] | Extension states | BA | 18.07.2012 | ME | 18.07.2012 | Title | German: | VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN 1-O-ACYL-2-DEOXY-2-FLUOR-4-THIO-ß-D-ARABINFURANOSEN | [2015/27] | English: | PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES | [2015/27] | French: | PROCÉDÉ DE PRÉPARATION DE 1-O-ACYL-2-DÉSOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES SUBSTITUÉS | [2015/27] |
Former [2012/43] | VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN 1-O-ACYL-2-DEOXY-2-FLUOR-4-THIO-ß-D-ARABINFURANOSEN | ||
Former [2012/43] | PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSES | ||
Former [2012/43] | PROCÉDÉ DE PRÉPARATION DE 1-O-ACYL-2-DÉSOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSES SUBSTITUÉS | Entry into regional phase | 18.07.2012 | National basic fee paid | 18.07.2012 | Designation fee(s) paid | 18.07.2012 | Examination fee paid | Examination procedure | 18.07.2012 | Examination requested [2012/43] | 29.01.2013 | Amendment by applicant (claims and/or description) | 04.06.2013 | Despatch of a communication from the examining division (Time limit: M04) | 14.10.2013 | Reply to a communication from the examining division | 16.12.2013 | Despatch of a communication from the examining division (Time limit: M04) | 28.04.2014 | Reply to a communication from the examining division | 19.09.2014 | Communication of intention to grant the patent | 14.01.2015 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 05.02.2015 | Communication of intention to grant the patent | 19.05.2015 | Fee for grant paid | 19.05.2015 | Fee for publishing/printing paid | 19.05.2015 | Receipt of the translation of the claim(s) | Divisional application(s) | EP14177042.0 / EP2799432 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 04.06.2013 | Opposition(s) | 11.04.2016 | No opposition filed within time limit [2016/24] | Fees paid | Renewal fee | 19.12.2012 | Renewal fee patent year 03 | 19.12.2013 | Renewal fee patent year 04 | 22.12.2014 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 03.12.2010 | AL | 08.07.2015 | AT | 08.07.2015 | BE | 08.07.2015 | BG | 08.07.2015 | CY | 08.07.2015 | CZ | 08.07.2015 | DK | 08.07.2015 | EE | 08.07.2015 | ES | 08.07.2015 | FI | 08.07.2015 | HR | 08.07.2015 | IT | 08.07.2015 | LT | 08.07.2015 | LV | 08.07.2015 | MC | 08.07.2015 | MK | 08.07.2015 | MT | 08.07.2015 | NL | 08.07.2015 | PL | 08.07.2015 | RO | 08.07.2015 | RS | 08.07.2015 | SE | 08.07.2015 | SI | 08.07.2015 | SK | 08.07.2015 | SM | 08.07.2015 | TR | 08.07.2015 | NO | 08.10.2015 | GR | 09.10.2015 | IS | 08.11.2015 | PT | 09.11.2015 | IE | 03.12.2015 | LU | 03.12.2015 | CH | 31.12.2015 | FR | 31.12.2015 | LI | 31.12.2015 | [2018/47] |
Former [2018/30] | HU | 03.12.2010 | |
AT | 08.07.2015 | ||
BE | 08.07.2015 | ||
BG | 08.07.2015 | ||
CY | 08.07.2015 | ||
CZ | 08.07.2015 | ||
DK | 08.07.2015 | ||
EE | 08.07.2015 | ||
ES | 08.07.2015 | ||
FI | 08.07.2015 | ||
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IT | 08.07.2015 | ||
LT | 08.07.2015 | ||
LV | 08.07.2015 | ||
MC | 08.07.2015 | ||
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SM | 08.07.2015 | ||
TR | 08.07.2015 | ||
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GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
IE | 03.12.2015 | ||
LU | 03.12.2015 | ||
CH | 31.12.2015 | ||
FR | 31.12.2015 | ||
LI | 31.12.2015 | ||
Former [2017/38] | HU | 03.12.2010 | |
AT | 08.07.2015 | ||
BE | 08.07.2015 | ||
BG | 08.07.2015 | ||
CY | 08.07.2015 | ||
CZ | 08.07.2015 | ||
DK | 08.07.2015 | ||
EE | 08.07.2015 | ||
ES | 08.07.2015 | ||
FI | 08.07.2015 | ||
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IT | 08.07.2015 | ||
LT | 08.07.2015 | ||
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MC | 08.07.2015 | ||
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NL | 08.07.2015 | ||
PL | 08.07.2015 | ||
RO | 08.07.2015 | ||
RS | 08.07.2015 | ||
SE | 08.07.2015 | ||
SI | 08.07.2015 | ||
SK | 08.07.2015 | ||
SM | 08.07.2015 | ||
NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
IE | 03.12.2015 | ||
LU | 03.12.2015 | ||
CH | 31.12.2015 | ||
FR | 31.12.2015 | ||
LI | 31.12.2015 | ||
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BE | 08.07.2015 | ||
CZ | 08.07.2015 | ||
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EE | 08.07.2015 | ||
ES | 08.07.2015 | ||
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MC | 08.07.2015 | ||
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SI | 08.07.2015 | ||
SK | 08.07.2015 | ||
NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
IE | 03.12.2015 | ||
LU | 03.12.2015 | ||
CH | 31.12.2015 | ||
FR | 31.12.2015 | ||
LI | 31.12.2015 | ||
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SI | 08.07.2015 | ||
SK | 08.07.2015 | ||
NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
IE | 03.12.2015 | ||
LU | 03.12.2015 | ||
BE | 31.12.2015 | ||
CH | 31.12.2015 | ||
FR | 31.12.2015 | ||
LI | 31.12.2015 | ||
Former [2016/46] | AT | 08.07.2015 | |
CZ | 08.07.2015 | ||
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EE | 08.07.2015 | ||
ES | 08.07.2015 | ||
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MC | 08.07.2015 | ||
PL | 08.07.2015 | ||
RO | 08.07.2015 | ||
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SE | 08.07.2015 | ||
SI | 08.07.2015 | ||
SK | 08.07.2015 | ||
NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
IE | 03.12.2015 | ||
LU | 03.12.2015 | ||
BE | 31.12.2015 | ||
CH | 31.12.2015 | ||
LI | 31.12.2015 | ||
Former [2016/45] | AT | 08.07.2015 | |
CZ | 08.07.2015 | ||
DK | 08.07.2015 | ||
EE | 08.07.2015 | ||
ES | 08.07.2015 | ||
FI | 08.07.2015 | ||
HR | 08.07.2015 | ||
IT | 08.07.2015 | ||
LT | 08.07.2015 | ||
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MC | 08.07.2015 | ||
PL | 08.07.2015 | ||
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SI | 08.07.2015 | ||
SK | 08.07.2015 | ||
NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
IE | 03.12.2015 | ||
LU | 03.12.2015 | ||
BE | 31.12.2015 | ||
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CZ | 08.07.2015 | ||
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EE | 08.07.2015 | ||
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MC | 08.07.2015 | ||
PL | 08.07.2015 | ||
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SI | 08.07.2015 | ||
SK | 08.07.2015 | ||
NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
LU | 03.12.2015 | ||
BE | 31.12.2015 | ||
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CZ | 08.07.2015 | ||
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MC | 08.07.2015 | ||
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NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
LU | 03.12.2015 | ||
BE | 31.12.2015 | ||
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NO | 08.10.2015 | ||
GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
BE | 31.12.2015 | ||
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GR | 09.10.2015 | ||
IS | 08.11.2015 | ||
PT | 09.11.2015 | ||
BE | 31.12.2015 | ||
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Former [2016/07] | LT | 08.07.2015 | Cited in | International search | [XA]US4803272 (ANTON DAVID L [US], et al) [X] 27 * example 2c * [A] 1-20,24-26; | [A]US6147058 (YOSHIMURA YUICHI [JP], et al) [A] 1-20,24-27 * step 2 on the synthesis of example 1;;; claim 4 *; | [A]WO2007068113 (UNIV MCGILL [CA], et al) [A] 1-27 * page 34 - page 40; figure 1; examples 1, 2; compounds 1-9 and their syntheses *; | [A] - WATTS J.K. ET AL, "Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU)", JOURNAL OF ORGANIC CHEMISTRY, (20060111), vol. 71, no. 3, doi:10.1021/jo051844+, pages 921 - 925, XP002606716 [A] 1-27 * Scheme 1, steps (b) to (f); Scheme 1, step (g);; compound 7 * DOI: http://dx.doi.org/10.1021/JO051844+ | [A] - LAK SHIN JEONG ET AL, "N6-Substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM034098E, (20030823), vol. 46, no. 18, ISSN 0022-2623, pages 3775 - 3777, XP002540593 [A] 1-20,24-27 * Scheme 1, compounds 8 and 9 * DOI: http://dx.doi.org/10.1021/jm034098e | [A] - WANG C -L J ET AL, "Synthesis of 2'(S), 3'(R), 5'-trihydroxypentyladenine", TETRAHEDRON LETTERS 1988 GB LNKD- DOI:10.1016/S0040-4039(00)86662-9, (1988), vol. 29, no. 10, ISSN 0040-4039, pages 1107 - 1110, XP002606717 [A] 1-20,24-27 * examples 3, 4 * DOI: http://dx.doi.org/10.1016/S0040-4039(00)86662-9 | [A] - VARELA O. ET AL, "First Synthesis of Aldopentono-1,4-thiolactones", JOURNAL OF ORGANIC CHEMISTRY, (199312), vol. 58, doi:10.1021/jo00079a034, pages 7860 - 7864, XP002606718 [A] 1-20,24-27 * scheme IV, compounds 18 and 19, step vi * DOI: http://dx.doi.org/10.1021/JO00079A034 | [A] - VANHESSCHE K ET AL, "L-RIBULOSE: A NOVEL CHIRAL POOL COMPOUND", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/0040-4039(90)80222-8, (19900101), vol. 31, no. 16, ISSN 0040-4039, pages 2337 - 2340, XP000561142 [A] 1-20,24-27 * scheme 2, compounds 17-22 * DOI: http://dx.doi.org/10.1016/0040-4039(90)80222-8 | [A] - KOMINE TAKASHI ET AL, "Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials.", JOURNAL OF MEDICINAL CHEMISTRY 23 OCT 2008 LNKD- PUBMED:18826297, (20081023), vol. 51, no. 20, ISSN 1520-4804, pages 6558 - 6562, XP002606719 [A] 1-20,24-27 * compound 13 * DOI: http://dx.doi.org/10.1021/JM800800C | [A] - YOSHIMURA Y ET AL, "A novel synthesis of 2'-modified 2'-deoxy-4'-thiocytidines from D-glucose", JOURNAL OF ORGANIC CHEMISTRY 1997 US LNKD- DOI:10.1021/JO9700540, (1997), vol. 62, no. 10, ISSN 0022-3263, pages 3140 - 3152, XP002606720 [A] 1-20,24-27 * scheme 8; step (b) * DOI: http://dx.doi.org/10.1021/JO9700540 | by applicant | WO9703993 | WO9738001 | US6448415 | WO2007068113 | - Y. YOSHIMURA ET AL., J. ORG. CHEM., (1997), vol. 62, pages 3140 - 3152 | - S. MIURA ET AL., CANCER LETT., (1998), vol. 129, pages 103 - 110 | - S. MIURA ET AL., CANCER LETT., (1999), vol. 144, no. 17, pages 7 - 182 | - Y. YOSHIMURA ET AL., BIOORG. MED. CHEM., (2000), vol. 8, pages 1545 - 1558 | - D.A. ZAJCHOWSKI ET AL., INT. J. CANCER, (2005), vol. 114, pages 1002 - 1009 | - Y. YOSHIMURA ET AL., J. ORG. CHEM., (1999), vol. 64, pages 7912 - 7920 | - Y. YOSHIMURA ET AL., NUCLEOTIDES NUCLEOTIDES, (1999), vol. 18, pages 815 - 820 | - Y. YOSHIMURA ET AL., NUCLEIC ACIDS SYMPOSIUM SERIES, (1998), vol. 39, pages 11 - 12 | - Y. YOSHIMURA ET AL., TETRAHEDRON LETT., (1999), vol. 40, pages 1937 - 1940 | - D.C. BAKER ET AL., CARBOHYDR. RES., (1972), vol. 24, pages 192 - 197 | - J.K. WATTS ET AL., J. ORG. CHEM., (2006), vol. 71, pages 921 - 925 | - J.K WATTS ET AL., J. ORG. CHEM., (2006), vol. 71, pages 921 - 925 |