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Extract from the Register of European Patents

EP About this file: EP2513081

EP2513081 - PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES [Right-click to bookmark this link]
Former [2012/43]PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSES
[2015/27]
StatusNo opposition filed within time limit
Status updated on  13.05.2016
Database last updated on 31.08.2024
Most recent event   Tooltip19.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 21.11.2018  [2018/47]
Applicant(s)For all designated states
LibraMedicina, Inc.
611, Tokyo Life Science Incubation Center
1-7-8, Kaigan
Minato-ku
Tokyo 105-0022 / JP
[2015/28]
Former [2012/43]For all designated states
Libramedicina, Inc.
611 Tokyo Life Science Incubation Center 1-7-8 Kaigan Minato-ku
Tokyo 105-0022 / JP
Inventor(s)01 / VOIGTLANDER, David
100, Magnolia Court
West Lafayette, Indiana 47906 / US
02 / SANDER, Michael
Hausacker 13
Rosrath (Hoffnungsthal) 51503 / DE
03 / HARRE, Michael
Markelstr. 49
Berlin 12163 / DE
 [2015/27]
Former [2012/43]01 / VOIGTLANDER, David
100 Magnolia Court
West Lafayette, Indiana 47906 / US
02 / SANDER, Michael
Hausacker 13
Rosrath (Hoffnungsthal) 51503 / DE
03 / HARRE, Michael
Markelstr. 49
Berlin 12163 / DE
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2015/28]
Former [2012/43]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Application number, filing date10801279.003.12.2010
WO2010JP72182
Priority number, dateEP2009007556318.12.2009         Original published format: EP 09075563
EP2010016340620.05.2010         Original published format: EP 10163406
[2012/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011074484
Date:23.06.2011
Language:EN
[2011/25]
Type: A1 Application with search report 
No.:EP2513081
Date:24.10.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 23.06.2011 takes the place of the publication of the European patent application.
[2012/43]
Type: B1 Patent specification 
No.:EP2513081
Date:08.07.2015
Language:EN
[2015/28]
Search report(s)International search report - published on:EP23.06.2011
ClassificationIPC:C07D317/18, C07D333/32, C07D333/78
[2012/43]
CPC:
C07D333/32 (EP,KR,US); C07D317/22 (KR); A61K31/381 (KR);
C07D317/18 (KR); C07D317/26 (KR); C07H13/04 (EP,KR,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/43]
Extension statesBA18.07.2012
ME18.07.2012
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN 1-O-ACYL-2-DEOXY-2-FLUOR-4-THIO-ß-D-ARABINFURANOSEN[2015/27]
English:PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES[2015/27]
French:PROCÉDÉ DE PRÉPARATION DE 1-O-ACYL-2-DÉSOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES SUBSTITUÉS[2015/27]
Former [2012/43]VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN 1-O-ACYL-2-DEOXY-2-FLUOR-4-THIO-ß-D-ARABINFURANOSEN
Former [2012/43]PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSES
Former [2012/43]PROCÉDÉ DE PRÉPARATION DE 1-O-ACYL-2-DÉSOXY-2-FLUORO-4-THIO- -D-ARABINOFURANOSES SUBSTITUÉS
Entry into regional phase18.07.2012National basic fee paid 
18.07.2012Designation fee(s) paid 
18.07.2012Examination fee paid 
Examination procedure18.07.2012Examination requested  [2012/43]
29.01.2013Amendment by applicant (claims and/or description)
04.06.2013Despatch of a communication from the examining division (Time limit: M04)
14.10.2013Reply to a communication from the examining division
16.12.2013Despatch of a communication from the examining division (Time limit: M04)
28.04.2014Reply to a communication from the examining division
19.09.2014Communication of intention to grant the patent
14.01.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
05.02.2015Communication of intention to grant the patent
19.05.2015Fee for grant paid
19.05.2015Fee for publishing/printing paid
19.05.2015Receipt of the translation of the claim(s)
Divisional application(s)EP14177042.0  / EP2799432
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.06.2013
Opposition(s)11.04.2016No opposition filed within time limit [2016/24]
Fees paidRenewal fee
19.12.2012Renewal fee patent year 03
19.12.2013Renewal fee patent year 04
22.12.2014Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.12.2010
AL08.07.2015
AT08.07.2015
BE08.07.2015
BG08.07.2015
CY08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
MK08.07.2015
MT08.07.2015
NL08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
SM08.07.2015
TR08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE03.12.2015
LU03.12.2015
CH31.12.2015
FR31.12.2015
LI31.12.2015
[2018/47]
Former [2018/30]HU03.12.2010
AT08.07.2015
BE08.07.2015
BG08.07.2015
CY08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
MK08.07.2015
MT08.07.2015
NL08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
SM08.07.2015
TR08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE03.12.2015
LU03.12.2015
CH31.12.2015
FR31.12.2015
LI31.12.2015
Former [2017/38]HU03.12.2010
AT08.07.2015
BE08.07.2015
BG08.07.2015
CY08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
MT08.07.2015
NL08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
SM08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE03.12.2015
LU03.12.2015
CH31.12.2015
FR31.12.2015
LI31.12.2015
Former [2017/03]AT08.07.2015
BE08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE03.12.2015
LU03.12.2015
CH31.12.2015
FR31.12.2015
LI31.12.2015
Former [2016/50]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE03.12.2015
LU03.12.2015
BE31.12.2015
CH31.12.2015
FR31.12.2015
LI31.12.2015
Former [2016/46]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE03.12.2015
LU03.12.2015
BE31.12.2015
CH31.12.2015
LI31.12.2015
Former [2016/45]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE03.12.2015
LU03.12.2015
BE31.12.2015
Former [2016/36]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
LU03.12.2015
BE31.12.2015
Former [2016/34]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
LU03.12.2015
BE31.12.2015
Former [2016/33]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
BE31.12.2015
Former [2016/24]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
BE31.12.2015
Former [2016/23]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RO08.07.2015
RS08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/22]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RS08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/21]AT08.07.2015
DK08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RS08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/20]AT08.07.2015
DK08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RS08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/11]AT08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RS08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/10]ES08.07.2015
FI08.07.2015
HR08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RS08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/09]FI08.07.2015
LT08.07.2015
LV08.07.2015
NO08.10.2015
GR09.10.2015
Former [2016/08]LT08.07.2015
NO08.10.2015
Former [2016/07]LT08.07.2015
Cited inInternational search[XA]US4803272  (ANTON DAVID L [US], et al) [X] 27 * example 2c * [A] 1-20,24-26;
 [A]US6147058  (YOSHIMURA YUICHI [JP], et al) [A] 1-20,24-27 * step 2 on the synthesis of example 1;;; claim 4 *;
 [A]WO2007068113  (UNIV MCGILL [CA], et al) [A] 1-27 * page 34 - page 40; figure 1; examples 1, 2; compounds 1-9 and their syntheses *;
 [A]  - WATTS J.K. ET AL, "Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU)", JOURNAL OF ORGANIC CHEMISTRY, (20060111), vol. 71, no. 3, doi:10.1021/jo051844+, pages 921 - 925, XP002606716 [A] 1-27 * Scheme 1, steps (b) to (f); Scheme 1, step (g);; compound 7 *

DOI:   http://dx.doi.org/10.1021/JO051844+
 [A]  - LAK SHIN JEONG ET AL, "N6-Substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM034098E, (20030823), vol. 46, no. 18, ISSN 0022-2623, pages 3775 - 3777, XP002540593 [A] 1-20,24-27 * Scheme 1, compounds 8 and 9 *

DOI:   http://dx.doi.org/10.1021/jm034098e
 [A]  - WANG C -L J ET AL, "Synthesis of 2'(S), 3'(R), 5'-trihydroxypentyladenine", TETRAHEDRON LETTERS 1988 GB LNKD- DOI:10.1016/S0040-4039(00)86662-9, (1988), vol. 29, no. 10, ISSN 0040-4039, pages 1107 - 1110, XP002606717 [A] 1-20,24-27 * examples 3, 4 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)86662-9
 [A]  - VARELA O. ET AL, "First Synthesis of Aldopentono-1,4-thiolactones", JOURNAL OF ORGANIC CHEMISTRY, (199312), vol. 58, doi:10.1021/jo00079a034, pages 7860 - 7864, XP002606718 [A] 1-20,24-27 * scheme IV, compounds 18 and 19, step vi *

DOI:   http://dx.doi.org/10.1021/JO00079A034
 [A]  - VANHESSCHE K ET AL, "L-RIBULOSE: A NOVEL CHIRAL POOL COMPOUND", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/0040-4039(90)80222-8, (19900101), vol. 31, no. 16, ISSN 0040-4039, pages 2337 - 2340, XP000561142 [A] 1-20,24-27 * scheme 2, compounds 17-22 *

DOI:   http://dx.doi.org/10.1016/0040-4039(90)80222-8
 [A]  - KOMINE TAKASHI ET AL, "Synthesis and structure-activity relationship studies of highly potent novel oxazolidinone antibacterials.", JOURNAL OF MEDICINAL CHEMISTRY 23 OCT 2008 LNKD- PUBMED:18826297, (20081023), vol. 51, no. 20, ISSN 1520-4804, pages 6558 - 6562, XP002606719 [A] 1-20,24-27 * compound 13 *

DOI:   http://dx.doi.org/10.1021/JM800800C
 [A]  - YOSHIMURA Y ET AL, "A novel synthesis of 2'-modified 2'-deoxy-4'-thiocytidines from D-glucose", JOURNAL OF ORGANIC CHEMISTRY 1997 US LNKD- DOI:10.1021/JO9700540, (1997), vol. 62, no. 10, ISSN 0022-3263, pages 3140 - 3152, XP002606720 [A] 1-20,24-27 * scheme 8; step (b) *

DOI:   http://dx.doi.org/10.1021/JO9700540
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.