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Extract from the Register of European Patents

EP About this file: EP2457923

EP2457923 - STEROL DERIVATIVE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  02.12.2016
Database last updated on 19.10.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Kyowa Hakko Kirin Co., Ltd.
1-6-1, Ohtemachi Chiyoda-ku
Tokyo 100-8185 / JP
[2012/22]
Inventor(s)01 / UCHIDA, Kenji
c/o Medicinal Chemistry Research Laboratories
Kyowa Hakko Kirin Co., Ltd.
1188, Shimotogari
Nagaizumi-cho, Sunto-gun Shizuoka 411-8731 / JP
02 / AGATSUMA, Tsutomu
c/o Biologics Research Laboratories
Kyowa Hakko kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi, Tokyo 194-8533 / JP
03 / HIBINO, Kazuhiro
c/o Biologics Research Laboratories
Kyowa Hakko kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi, Tokyo 194-8533 / JP
04 / SASHO, Setsuya
c/o Sakai Plant, Kyowa Hakko Kirin Co., Ltd.
1-53, Takasu-cho, 1-chome
Sakai-ku, Sakai-shi Osaka 590-8554 / JP
05 / IIDA, Kyoichiro
c/o Sakai Plant, Kyowa Hakko Kirin Co., Ltd.
1-53, Takasu-cho, 1-chome
Sakai-ku, Sakai-shi Osaka 590-8554 / JP
 [2012/22]
Representative(s)D Young & Co LLP
3 Noble Street
London EC2V 7BQ / GB
[N/P]
Former [2016/04]D Young & Co LLP
120 Holborn
London EC1N 2DY / GB
Former [2012/22]Harding, Charles Thomas, et al
D Young & Co LLP 120 Holborn London
EC1N 2DY / GB
Application number, filing date10802302.922.07.2010
[2016/04]
WO2010JP62297
Priority number, dateJP2009017288624.07.2009         Original published format: JP 2009172886
[2012/22]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011010682
Date:27.01.2011
Language:JA
[2011/04]
Type: A1 Application with search report 
No.:EP2457923
Date:30.05.2012
Language:EN
[2012/22]
Type: B1 Patent specification 
No.:EP2457923
Date:27.01.2016
Language:EN
[2016/04]
Search report(s)International search report - published on:JP27.01.2011
(Supplementary) European search report - dispatched on:EP15.03.2013
ClassificationIPC:C07J73/00, A61K31/585, A61P9/00, A61P9/10, A61P21/02, A61P25/00, A61P25/08, A61P25/16, A61P25/18, A61P25/22, A61P25/24, A61P25/28, A61P43/00
[2012/22]
CPC:
C07J73/003 (EP,US); A61K31/585 (EP,US); A61P21/02 (EP);
A61P25/00 (EP); A61P25/08 (EP); A61P25/16 (EP);
A61P25/18 (EP); A61P25/22 (EP); A61P25/24 (EP);
A61P25/28 (EP); A61P43/00 (EP); A61P9/00 (EP);
A61P9/10 (EP); C07J73/008 (EP,US); C07J75/005 (EP,US);
C07J9/00 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/22]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:STEROLDERIVAT[2012/22]
English:STEROL DERIVATIVE[2012/22]
French:DÉRIVÉ DE STÉROL[2012/22]
Entry into regional phase23.01.2012Translation filed 
24.01.2012National basic fee paid 
24.01.2012Search fee paid 
24.01.2012Designation fee(s) paid 
24.01.2012Examination fee paid 
Examination procedure24.01.2012Examination requested  [2012/22]
19.09.2013Amendment by applicant (claims and/or description)
24.07.2015Communication of intention to grant the patent
04.11.2015Receipt of the translation of the claim(s)
24.11.2015Fee for grant paid
24.11.2015Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.07.2015
Opposition(s)28.10.2016No opposition filed within time limit [2017/01]
Fees paidRenewal fee
16.07.2012Renewal fee patent year 03
15.07.2013Renewal fee patent year 04
16.07.2014Renewal fee patent year 05
16.07.2015Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.07.2010
AL27.01.2016
AT27.01.2016
BE27.01.2016
CY27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
MC27.01.2016
MK27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SI27.01.2016
SK27.01.2016
SM27.01.2016
TR27.01.2016
BG27.04.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
IE22.07.2016
LU22.07.2016
CH31.07.2016
LI31.07.2016
MT31.07.2016
[2018/46]
Former [2018/33]HU22.07.2010
AT27.01.2016
BE27.01.2016
CY27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
MC27.01.2016
MK27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SI27.01.2016
SK27.01.2016
SM27.01.2016
TR27.01.2016
BG27.04.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
IE22.07.2016
LU22.07.2016
CH31.07.2016
LI31.07.2016
MT31.07.2016
Former [2018/29]HU22.07.2010
AT27.01.2016
BE27.01.2016
CY27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
MC27.01.2016
MK27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SI27.01.2016
SK27.01.2016
SM27.01.2016
TR27.01.2016
BG27.04.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
IE22.07.2016
LU22.07.2016
CH31.07.2016
LI31.07.2016
Former [2018/28]HU22.07.2010
AT27.01.2016
BE27.01.2016
CY27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
MC27.01.2016
MK27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SI27.01.2016
SK27.01.2016
SM27.01.2016
BG27.04.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
IE22.07.2016
LU22.07.2016
CH31.07.2016
LI31.07.2016
Former [2017/41]AT27.01.2016
BE27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
MC27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SI27.01.2016
SK27.01.2016
SM27.01.2016
BG27.04.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
IE22.07.2016
LU22.07.2016
CH31.07.2016
LI31.07.2016
Former [2017/19]AT27.01.2016
BE27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
MC27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SI27.01.2016
SK27.01.2016
SM27.01.2016
BG27.04.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
CH31.07.2016
LI31.07.2016
Former [2017/15]AT27.01.2016
BE27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
MC27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SI27.01.2016
SK27.01.2016
SM27.01.2016
BG27.04.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
Former [2017/03]AT27.01.2016
BE27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SK27.01.2016
SM27.01.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
Former [2016/50]AT27.01.2016
CZ27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
NL27.01.2016
PL27.01.2016
RO27.01.2016
SE27.01.2016
SK27.01.2016
SM27.01.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
Former [2016/49]AT27.01.2016
DK27.01.2016
EE27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
NL27.01.2016
PL27.01.2016
SE27.01.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
Former [2016/46]AT27.01.2016
DK27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
NL27.01.2016
PL27.01.2016
SE27.01.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
Former [2016/39]AT27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
LV27.01.2016
NL27.01.2016
PL27.01.2016
SE27.01.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
Former [2016/38]AT27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
NL27.01.2016
PL27.01.2016
NO27.04.2016
GR28.04.2016
IS27.05.2016
PT27.05.2016
Former [2016/36]AT27.01.2016
ES27.01.2016
FI27.01.2016
HR27.01.2016
IT27.01.2016
LT27.01.2016
NL27.01.2016
PL27.01.2016
NO27.04.2016
GR28.04.2016
Former [2016/35]ES27.01.2016
FI27.01.2016
HR27.01.2016
NL27.01.2016
NO27.04.2016
GR28.04.2016
Former [2016/30]NL27.01.2016
Documents cited:Search[A]WO2008071960  (NEURO THERAPEUTICS AB [SE], et al) [A] 1-14 * page 4, paragraph l - page 5, paragraph 1 * * page 7, paragraph l * * page 60, paragraph l - page 61, paragraph 2; figures 3,4 * * page 65, paragraphs 2,4 - page 66, paragraphs 1,2; figures 19,21,22 *;
 [A]WO2009073186  (UNIV CALIFORNIA [US], et al) [A] 1-14 * page 14, paragraph [0057] * * page 19, paragraph [0065] - page 20, paragraph [0065] * * claim 4; compound Oxy36 *;
 [E]EP2239320  (KYOWA HAKKO KIRIN CO LTD [JP]) [E] 1-14 * pages 5-6; compounds (E), (U) * * page 4, paragraph [0008] *
 [A]  - SONG C ET AL, "Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, (20000801), vol. 65, no. 8, doi:10.1016/S0039-128X(00)00127-6, ISSN 0039-128X, pages 423 - 427, XP004215769 [A] 1-14 * page 425; figure 1 *

DOI:   http://dx.doi.org/10.1016/S0039-128X(00)00127-6
 [XD]  - MINCIONE E ET AL, "Synthesis Via Organoiron Complexes of 9-(4-Keto-1-Methylcyclohex-2-Enyl)-8-Keto-des-ab-Ergost-22,23-Ene, A useful chiral Intermediate in steroid synthesis", HETEROCYCLES.INTERNATIONAL JOURNAL FOR REVIEWS AND COMMUNICATIONS IN HETEROCYCLIC CHEMISTRY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, (19850101), vol. 23, ISSN 0385-5414, pages 1607 - 1610, XP008120228 [XD] 1 * page 1608; compound 11 * * page 1610, paragraph 7 *
International search[A]JP2006076948  (SUZUKA UNIV OF MEDICAL SCIENCE, et al);
 [A]WO2008154579  (UNIV SOUTHERN CALIFORNIA [US], et al);
 [AP]WO2009096445  (KYOWA HAKKO KIRIN CO LTD [JP], et al)
 [A]  - RODEWALD, W.J. ET AL., "The ruthenium tetroxide oxidation of steroidal conjugated homoannular dienes", TETRAHEDRON LETTERS, (1979), pages 3119 - 3122, XP008149412

DOI:   http://dx.doi.org/10.1016/S0040-4039(01)95337-7
 [A]  - MORISAWA, Y. ET AL., "Part XIV Synthesis of 6-aza- and 7-aza-5p-steroids", AGR. BIOL. CHEM., (1964), vol. 28, no. LL, pages 788 - 795, XP008149304
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    - JOURNAL OF BIOLOGY, (2002), vol. 1, page 10
    - SCIENCE, (2003), vol. 301, pages 805 - 809
    - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE OF THE UNITED STATES OFAMERICA, (2006), vol. 103, pages 8233 - 8238
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